• JSTS:Journal of Semiconductor Technology and Science
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• v.1 no.1
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• pp.31-39
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• 2001

W polymetal gate technology for giga bit DRAM are presented. Key module processes for polymetal gate are studied in detail. $W/WN_x/poly-silicon$ adopted for a word line of 256Mbit DRAM has good gate oxide integrity and junction leakage characteristics through full integration, which is comparable to those of conventional $WSi_x$/Poly-silicon gate process. These results undoubtedly show that $W/WN_x/poly-silicon$ is the strongest candidate as a word line for Giga bit DRAM.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.4
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• pp.471-478
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• 2014

Investigating gene expression of immune cells of whole blood or peripheral blood mononuclear cells (PBMC) under polyinosinic:polycytidylic acid (poly I:C) stimulation is valuable for understanding the immune response of organism to RNA viruses. Quantitative real-time PCR (qRT-PCR) is a standard method for quantification of gene expression studies. However, the reliability of qRT-PCR data critically depends on proper selection of reference genes. In the study, using two different analysis programs, geNorm and NormFinder, we systematically evaluated the gene expression stability of six candidate reference genes (GAPDH, ACTB, B2M, RPL4, TBP, and PPIA) in samples of whole blood and PBMC with or without poly I:C stimulation. Generally, the six candidate genes performed a similar trend of expression stability in the samples of whole blood and PBMC, but more stably expressed in whole blood than in PBMC. geNorm ranked B2M and PPIA as the best combination for gene expression normalization, while according to NormFinder, TBP was ranked as the most stable reference gene, followed by B2M and PPIA. Comprehensively considering the results from the two programs, we recommended using the geometric mean of the three genes, TBP, PPIA and B2M, to normalize the gene expression of whole blood and PBMC with poly I:C stimulation. Our study is the first detailed survey of the gene expression stability in whole blood and PBMC with or without poly I:C stimulation and should be helpful for investigating the molecular mechanism involved in porcine whole blood and PBMC in response to poly I:C stimulation.

• Smart Structures and Systems
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• v.34 no.2
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• pp.97-116
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• 2024

The standard l₁-norm regularization is recently introduced for impact force identification, but generally underestimates the peak force. Compared to l₁-norm regularization, l_p-norm (0 ≤ p < 1) regularization, with a nonconvex penalty function, has some promising properties such as enforcing sparsity. In the framework of sparse regularization, if the desired solution is sparse in the time domain or other domains, the under-determined problem with fewer measurements than candidate excitations may obtain the unique solution, i.e., the sparsest solution. Considering the joint sparse structure of impact force in temporal and spatial domains, we propose a general l_p-norm (0 ≤ p < 1) regularization methodology for simultaneous identification of the impact location and force time-history from highly incomplete measurements. Firstly, a nonconvex optimization model based on l_p-norm penalty is developed for regularizing the highly under-determined problem of impact force identification. Secondly, an iteratively reweighed l₁-norm algorithm is introduced to solve such an under-determined and unconditioned regularization model through transforming it into a series of l₁-norm regularization problems. Finally, numerical simulation and experimental validation including single-source and two-source cases of impact force identification are conducted on plate structures to evaluate the performance of l_p-norm (0 ≤ p < 1) regularization. Both numerical and experimental results demonstrate that the proposed l_p-norm regularization method, merely using a single accelerometer, can locate the actual impacts from nine fixed candidate sources and simultaneously reconstruct the impact force time-history; compared to the state-of-the-art l₁-norm regularization, l_p-norm (0 ≤ p < 1) regularization procures sufficiently sparse and more accurate estimates; although the peak relative error of the identified impact force using l_p-norm regularization has a decreasing tendency as p is approaching 0, the results of l_p-norm regularization with 0 ≤ p ≤ 1/2 have no significant differences.

• Parasites, Hosts and Diseases
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• v.54 no.1
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• pp.39-46
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• 2016

Theileria annulata is a tick-borne intracellular protozoan parasite that causes tropical theileriosis, a fatal bovine lymphoproliferative disease. The parasite predominantly invades bovine B lymphocytes and macrophages and induces host cell transformation by a mechanism that is not fully comprehended. Analysis of signaling pathways by quantitative real-time PCR (qPCR) could be a highly efficient means to understand this transformation mechanism. However, accurate analysis of qPCR data relies on selection of appropriate reference genes for normalization, yet few papers on T. annulata contain evidence of reference gene validation. We therefore used the geNorm and NormFinder programs to evaluate the stability of 5 candidate reference genes; 18S rRNA, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), ACTB (${\beta}-actin$), PRKG1 (protein kinase cGMP-dependent, type I) and TATA box binding protein (TBP). The results showed that 18S rRNA was the reference gene most stably expressed in bovine PBMCs transformed and non-transformed with T. annulata, followed by GAPDH and TBP. While 18S rRNA and GAPDH were the best combination, these 2 genes were chosen as references to study signaling pathways involved in the transformation mechanism of T. annulata.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.9
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• pp.1223-1226
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• 2004

Previously candidate gene approach revealed estrogen receptor (ESR) locus was associated with increased litter size. In this study, PvuII polymorphisms of ESR gene was detected by PCR-RFLP, and ESR locus was evaluated for its association with reproductive tracts components in the Large $White{\times}Meishan$ ($LW{\times}M$) F2 offspring. Ninety seven gilts with reproductive tracts components records and 136 offspring with performance traits records were genotyped and the results were used to estimate allele substitution effects. The results showed that two alleles (A and B) were identified, and 121 bp fragments were observed for the AA genotype and 65 bp and 56 bp fragments for the BB genotype; the length of uterine body (LUB) of BB gilts were significantly shorter than AA gilts', the additive effect was -1.762 cm; the uterine weight (UW) of AB gilts were significantly lighter than AA gilts' with the additive effect -18.058 g; no significant associations of ESR alleles with ovulation rate (OR), length of uterine horn (LUH), length of uterine cervix (LUC), weight of two ovaries (OW), volume of uterine lumen (VUL), length of oviduct (LO) were observed. BB genotypes gilts need significantly less days to 100 kg ($D_{100kg}$) than AA genotypes (p<0.01), the additive effect was per copy of B allele. Allele B is also favorable for average daily gain (ADG), with additive effect 0.015 kg/d (p<0.05). There was no difference between genotypes for backfat thickness at the 13th rib (SF13), loin meat height (ELMH), and loin meat percentage was estimated (ELMP), individual birth weight (IBW) and teat number (TN).

• BMB Reports
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• v.47 no.7
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• pp.399-404
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• 2014

B7-H4 is a member of B7 family of co-inhibitory molecules and B7-H4 protein is found to be overexpressed in many human cancers and which is usually associated with poor survival. In this study, we developed a therapeutic vaccine made from a fusion protein composed of a tetanus toxoid (TT) T-helper cell epitope and human B7-H4IgV domain (TT-rhB7-H4IgV). We investigated the anti-tumor effect of the TT-rhB7-H4IgV vaccine in BALB/c mice and SP2/0 myeloma growth was significantly suppressed in mice. The TT-rhB7-H4IgV vaccine induced high-titer specific antibodies in mice. Further, the antibodies induced by TT-rhB7-H4IgV vaccine were capable of depleting SP2/0 cells through complement-dependent cytotoxicity (CDC) in vitro. On the other hand, the poor cellular immune response was irrelevant to the therapeutic efficacy. These results indicate that the recombinant TT-rhB7-H4IgV vaccine might be a useful candidate of immunotherapy for the treatment of some tumors associated with abnormal expression of B7-H4.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.12 no.5
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• pp.15-25
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• 2002

In this paper a design of high performance cryptographic processor which implements AES Rijndael algorithm is described. To eliminate performance degradation due to round-key computation delay of conventional processor, the on-the-fly precomputation of round key based on modified round structure is adopted. And on-the-fly round key generator which supports 128, 192, and 256-bit key has modular structure. The designed processor has iterative structure which uses 1 clock cycle per round and supports three operation modes, such as ECB, CBC, and CTR mode which is a candidate for new AES modes of operation. The cryptographic processor designed in Verilog-HDL and synthesized using 0.251$\mu\textrm{m}$ CMOS cell library consists of about 51,000 gates. Simulation results show that the critical path delay is about 7.5ns and it can operate up to 125Mhz clock frequency at 2.5V supply. Its peak performance is about 1.45Gbps encryption or decryption rate under 128-bit key ECB mode.

• Nuclear Engineering and Technology
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• v.55 no.8
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• pp.2723-2733
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• 2023

Transuranic nuclides (such as ²³⁸Pu, ²⁵²Cf, ²⁴⁹Bk, etc.) have a wide range of application in industry, medicine, agriculture, and other fields. However, due to the complex conversion chain and remarkable fission losses in the process of transuranic nuclides production, the generation amounts are extremely low. High flux reactor with high neutron flux and flexible irradiation channels, is regarded as the promising candidate for producing transuranic nuclides. It is of great significance to increase the conversion ratio of transuranic nuclides, resulting in higher efficiency and better economy. In this paper, we perform an optimization design evaluation of producing transuranic nuclides in high flux reactor, which includes optimization design of irradiation target and influence study of reactor core loading. It is demonstrated that the production rate increases with appropriately determined target material and target structure. The target loading scheme in the irradiation channel also has a significant influence on the production of transuranic nuclides.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4013-4021
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• 2022

A kind of zirconium phosphate mesoporous coordination polymer Zr-EDTMPA was successfully synthesized and characterized using XRD, FTIR, TGA, EA, SEM-EDS, and N₂ sorption-desorption measurements. The prepared Zr-EDTMPA was first employed for the removal of Co(II) from an aqueous solution, and the effects of pH, contact time, temperature, initial Co(II) concentration, reusability, and sorption mechanism were systematically investigated. The results showed that the Zr-EDTMPA is a zirconium phosphate complex formed by the coordination of EDTMPA to Zr in a molar ratio of 1:1. The sorption of Co(II) by Zr-EDTMPA was a pH-dependent, spontaneous and endothermic process, which was better fitted to the pseudo-second-order kinetic model and Langmuir isotherm model. The Zr-EDTMPA was demonstrated to have excellent reusability and presented a high sorption capacity of 73.0 mg·g^-1 for Co(II) at pH 8.0. The sorption mechanism was mainly attributed to the strong coordination between cobalt and the untapped hydroxyl functional groups on Zr-EDTMPA, which was confirmed by XPS spectra. Therefore, as a candidate sorbent with high sorption capacity and excellent reusability, Zr-EDTMPA has a great potential for the removal of Co(II) from aqueous solutions.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2007.11a
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• pp.217-220
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• 2007

In this paper, we present a new anchor shot detection system which is a core step of the preprocessing process for the news video analysis. The proposed system is composed of four modules and operates sequentially: 1) skin color detection module for reducing the candidate face regions; 2) face detection module for finding the key-frames with a facial data; 3) vector representation module for the key-frame images using a non-negative matrix factorization; 4) anchor shot detection module using a support vector data description. According to our computer experiments, the proposed system shows not only the comparable accuracy to the recent other results, but also more faster detection rate than others.