• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.181-188
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• 2011

Major depression is a devastating disorder of which lifetime prevalence rate is as high as up to 25% in general population. Although the etiology of the disorder is still poorly understood, it is generally accepted that both genetic and environmental factors are involved in the precipitation of depression. Stressful lifetime events are potent precipitating environmental factors for major depression and early-life stress is in particular an important element that predisposes individuals to major depression later in life. How environmental factors such as stress can make our neural networks susceptible to depression and how those factors leave long-lasting influences have been among the major questions in the field of depression research. Epigenetic regulations can provide a bridging mechanism between environmental factors and genetic factors so that these two factors can additively determine individual predispositions to major depression. Here we introduce epigenetic regulations as candidate mechanisms that mediate the integration of environmental adversaries with genetic predispositions, which may lead to the development of major depression, and summarize basic molecular events that underlie epigenetic regulations as well as experimental evidences that support the active role of epigenetic regulation in major depression.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1186-1191
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• 2003

The 40% of wall criterion, which is generally used for the plugging of steam generator tubes, may be applied only to a single crack. In the previous study, a total of 9 failure models were introduced to estimate the local failure of the ligament between cracks and the optimum coalescence model of multiple collinear cracks was determined among these models. It is, however, known that parallel axial cracks are more frequently detected during an in-service inspection than collinear axial cracks. The objective of this study is to determine the plastic collapse model which can be applied to the steam generator tube containing two parallel axial through-wall cracks. Nine previously proposed local failure models were selected as the candidates. Subsequently interaction effects between two adjacent cracks were evaluated to screen them. Plastic collapse tests for the plate with two parallel through-wall cracks and finite element analyses were performed for the determination of the optimum plastic collapse model. By comparing the test results with the prediction results obtained from the candidate models, a plastic zone contact model was selected as an optimum model.

• Journal of Power Electronics
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• v.16 no.5
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• pp.1843-1850
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• 2016

This study focused on predicting the fatigue life of an insulated gate bipolar transistor (IGBT) power module for electric locomotives. The effects of different wiring technologies, including aluminum wires, copper wires, aluminum ribbons, and copper ribbons, on solder fatigue life were investigated to meet the high power requirement of the IGBT module. The module's temperature distribution and solder fatigue behavior were investigated through coupled electro-thermo-mechanical analysis based on the finite element method. The ribbons attained a chip junction temperature that was 30℃ lower than that attained with conventional round wires. The ribbons also exhibited a lower plastic strain in comparison with the wires. However, the difference in plastic strain and junction temperature among the different ribbon materials was relatively small. The ribbons also exhibited different crack propagation behaviors relative to the wires. For the wires, the cracks initiated at the outmost edge of the solder, whereas for the ribbons, the cracks grew in the solder layer beneath the ribbons. Comparison of fatigue failure areas indicated that ribbon bonding technology could substantially enhance the fatigue life of IGBT modules and be a potential candidate for high power modules.

• Journal of the Korean Society for Precision Engineering
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• v.34 no.2
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• pp.83-87
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• 2017

A multi-step warm forging process for subminiature screws is investigated. Due to the low formability of Titanium alloys, bit forming of Titanium screws is difficult by cold forging. In order to overcome this low formability of Titanium alloys, two candidate processes, i.e., multi-step forging and warm forging are introduced. First, a multi-step (two-step) forging process is investigated. The punch shape and stroke of forging during the first step is designed via various analyses. Finally, the bit formability is investigated at different forging temperatures. Analyses are carried out for two-step forging at various temperatures and the formability under these thermal conditions is compared.

• Journal of Korea Foundry Society
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• v.30 no.6
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• pp.217-223
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• 2010

Foamed metal has become an attractive material, which has unique physical, thermal, acoustic, damping and mechanical properties, because large amount of pores are distributed in the metal matrix. Therefore, metal foam can be used for the light weight application in automotive, locomotive, aerospace fields. Aluminum foams have been developed successfully and will be employed in the next generation of energy absorption boxes. Magnesium alloys are most eligible candidate to substitute aluminum alloy, especially for lower density and higher damping properties in wide industrial fields. Magnesium alloy foams are expected to be particularly advantageous due to two thirds the density of aluminum. However, foaming magnesium have been weakness of high activity, difficult processing and very dangerous. In order to upgrade this problem, AM50 magnesium alloy which has better characteristic is safe to use through foaming time and alloying element in this study.

• Nuclear Engineering and Technology
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• v.36 no.4
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• pp.316-326
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• 2004

The $40\%$ of wall criterion, which is generally used for the plugging of steam generator tubes, is applied only to a single crack. In a previous study, a total number of 9 failure models were proposed to estimate the local failure of the ligament between cracks, and the optimum coalescence model of multiple collinear cracks was determined among these models. It is, however known that parallel axial cracks are more frequently detected than collinear axial cracks during an in-service inspection. The objective of this study is to determine the plastic collapse model that can be applied to steam generator tubes containing two parallel axial through-wall cracks. Three previously proposed local failure models were selected as the candidates. Subsequently, the interaction effects between two adjacent cracks were evaluated to screen them. Plastic collapse tests for the plate with two parallel through-wall cracks and finite element analyses were performed to determine the optimum plastic collapse model. By comparing the test results with the prediction results obtained from the candidate models, a COD base model was selected as an optimum model.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.19 no.1 s.71
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• pp.105-111
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• 2006

Dolphin mooring system can be a good candidate for the VLFS fastening system in view point of strength and effectiveness. In the design process of the dolphin system, precise calculation of the wave forces and the subsequent selecting the proper number of the piles adopted are one of the main factors. In this paper, one of the design process of the dolphin system is investigated and a proper configuration of the system is derived based on the structural characteristics of the system that was obtained through the structural analysis of the basic pile element confronted to the external loadings including wave impact load. It was found that lot the better design of ihe mooring system for VLFS, mono pile mooring system is more recommendable in a specific condition than other multi piles mooring system.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.2
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• pp.236-247
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• 1992

Optimization has been developed to minimize the cost function while satisfying constraints. Nonlinear Programming method is used as a tool for the optimization. Usually, cost and constraint function calculations are required in the engineering applications, but those calculations are extremely expensive. Especially, the function and sensitivity analyses cause a bottleneck in structural optimization which utilizes the Finite Element Method. Also, when the functions are quite noisy, the informations do not carry out proper role in the optimization process. An algorithm called "Second-order Approximation Method" has been proposed to overcome the difficulties recently. The cost and constraint functions are approximated by the second-order Taylor series expansion on a nominal points in the algorithm. An optimal design problem is defined with the approximated functions and the approximated problem is solved by a nonlinear programming numerical algorithm. The solution is included in a candidate point set which is evaluated for a new nominal point. Since the functions are approximated only by the function values, sensitivity informations are not needed. One-dimensional line search is unnecessary due to the fact that the nonlinear algorithm handles the approximated functions. In this research, the method is analyzed and the performance is evaluated. Several mathematical problems are created and some standard engineering problems are selected for the evaluation. Through numerical results, applicabilities of the algorithm to large scale and complex problems are presented.presented.

• Journal of Information Technology Services
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• v.9 no.4
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• pp.95-108
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• 2010

In this paper. the research issues and trends are analysed by reviewing the journal of the Korea Society of IT Services which published from Dec. 2002 to Jun. 2010. The 306 papers which published were included in this project. The quantitative analyses were implemented about the volume of papers and researchers. The papers are categorized as project management. service science, service computing and IT technology, software engineering, solution, outsourcing management. element technology and methodology, strategy and management. policy, laws, and systems related IT services. Specially the qualitative analyses were implemented about research issues and trends through the content analysis about the paper details, abstract and key words described. We can find the more case of the theoretical study on the areas of the strategy and management, policy, laws, and systems, also the practical study on the service computing and IT technology, and solution area than the other areas. In this research, finally, the author can suggest that the integrated control be required to editing board for the effective classification of subjected paper candidate. Also the evaluation methodology such us experiment, performance comparative, should be adopted for the theoretical or practical study because the academic research requires the more scientific research methodology.

• Proceedings of the KIEE Conference
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• 2009.04b
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• pp.38-40
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• 2009

In order to achieve a gearless construction of the wind energy conversion system(WECS), a low-speed generator should be used. Of the various candidate machine types, radial-field, multi-pole, permanent magnet, synchronous machines may be used for low-speed applications. So, this paper deals with the design of direct-coupled, multi-pole radial field machines with permanent magnet(PM) excitation for wind power applications for cogging torque reduction through the determination of optimum pole arc/pitch ratio. On the basis of an equivalent magnetic circuit method(EMCM) and a space harmonic method(SHM), an initial design is performed considering restricted conditions. And then, a detailed design is made using a non-linear finite element analyses(FEA). Finally, test results concerning generating characteristics are given to confirm the validation of the design.