• 제목/요약/키워드: Caenorhabditis Elegans

검색결과 199건 처리시간 0.025초

Fertilization and the oocyte-to-embryo transition in C. elegans

  • Marcello, Matthew R.;Singson, Andrew
    • BMB Reports
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    • 제43권6호
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    • pp.389-399
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    • 2010

  • Fertilization is a complex process comprised of numerous steps. During fertilization, two highly specialized and differentiated cells (sperm and egg) fuse and subsequently trigger the development of an embryo from a quiescent, arrested oocyte. Molecular interactions between the sperm and egg are necessary for regulating the developmental potential of an oocyte, and precise coordination and regulation of gene expression and protein function are critical for proper embryonic development. The nematode Caenorhabditis elegans has emerged as a valuable model system for identifying genes involved in fertilization and the oocyte-to-embryo transition as well as for understanding the molecular mechanisms that govern these processes. In this review, we will address current knowledge of the molecular underpinnings of gamete interactions during fertilization and the oocyte-to-embryo transition in C. elegans. We will also compare our knowledge of these processes in C. elegans to what is known about similar processes in mammalian, specifically mouse, model systems.

  • https://doi.org/10.5483/BMBRep.2010.43.6.389 인용 PDF KSCI

Isolation of Caenorhabditis elegans Mutants Defective in Chemotaxis toward cAMP

  • Jeong, Jin-A;Cho, Nam-Jeong
    • Animal cells and systems
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    • 제10권4호
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    • pp.237-241
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    • 2006

  • Chemotactic behavior is essential for the survival of animals. However, the mechanism by which animals carry out chemotaxis is poorly understood. To explore the biochemical events underlying chemotaxis, we isolated C. elegans mutants that displayed abnormal chemotactic responses to cAMP, a strong attractant for C. elegans. Based on their responses to other chemoattractants, the mutant animals could be classified into five groups: (1) animals with defective chemotaxis to cAMP only; (2) animals with defective chemotaxis to both cAMP and cGMP; (3) animals with defective chemotaxis to water-soluble attractants; (4) animals with defective chemotaxis to both water-soluble and volatile attractants; and (5) animals with enhanced chemotactic responses. We expect that analyses of these mutants will help understand the molecular mechanisms underlying chemotaxis in C. elegans.

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