• 제목/요약/키워드: CaSR

검색결과 1,031건 처리시간 0.031초

근수축시 해당작용에 의한 근형질 세망의 Ca2+ 변화가 미토콘드리아 Ca2+ 증가에 미치는 영향 (Glycolysis Mediated Sarcoplasmic Reticulum Ca2+ Signal Regulates Mitochondria Ca2+ during Skeletal Muscle Contraction)

  • 박대령
    • 운동과학
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    • 제26권3호
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    • pp.229-237
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    • 2017
  • PURPOSE: This study was to investigate the Glycolysis mediated sarcoplasmic reticulum (SR) $Ca^{2+}$ signal regulates mitochondria $Ca^{2+}$ during skeletal muscle contraction by using glycolysis inhibitor. METHODS: To examine the effect of Glycolysis inhibitor on SR and mitochondria $Ca^{2+}$ content, we used skeletal muscle fiber from gastrocnemius muscle. 2-deoxy glucose and 3-bromo pyruvate used as glycolysis inhibitor, it applied to electrically stimulated muscle contraction experiment. Intracellular $Ca^{2+}$ content, SR, mitochondria $Ca^{2+}$ level and mitochondria membrane potential (MMP) was detected by confocal microscope. Mitochondrial energy metabolism related enzyme, citric acid synthase activity also examined for mitochondrial function during the muscle contraction. RESULTS: Treatment of 2-DG and 3BP decreased the muscle contraction induced SR $Ca^{2+}$ increase however the mitochondria $Ca^{2+}$ level was increased by treatment of inhibitors and showed and overloading as compared with the control group. Glycolysis inhibitor and thapsigargin treatment showed a significant decrease in MPP of skeletal muscle cells compared to the control group. CS activity significantly decreased after pretreatment of glycolysis inhibitor during skeletal muscle contraction. These results suggest that regulation of mitochondrial $Ca^{2+}$ levels by glycolysis is an important factor in mitochondrial energy production during skeletal muscle contraction CONCLUSIONS: These results suggest that mitochondria $Ca^{2+}$ level can be regulated by SR $Ca^{2+}$ level and glycolytic regulation of intraocular $Ca^{2+}$ signal play pivotal role in regulation of mitochondria energy metabolism during the muscle contraction.

Preparation, Characterization and Photoluminescence Properties of Ca1-xSrxS:Eu Red-emitting Phosphors for a White LED

  • Sung, Hye-Jin;Cho, Young-Sik;Huh, Young-Duk;Do, Young-Rag
    • Bulletin of the Korean Chemical Society
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    • 제28권8호
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    • pp.1280-1284
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    • 2007
  • A series of Ca1-xSrxS:Eu (x = 0.0, 0.2, 0.4, 0.6, 0.8, 1.0) phosphors were synthesized by solid-state reactions. The Ca1-xSrxS:Eu phosphors have a strong absorption at 455 nm, which corresponds to the emission wavelength of a blue LED. The emission peak of Ca1-xSrxS:Eu is blue shifted from 655 to 618 nm with increasing Sr content. The characteristics of Ca1-xSrxS:Eu phosphors make them suitable for use as wavelengthtunable red-emitting phosphors for three-band white LEDs pumped by a blue LED. In support of this, we fabricated a three-band white LED by coating SrGa2S4:Eu and Ca0.6Sr0.4S:Eu phosphors onto a blue LED chip, and characterized its optical properties.

생쥐 난자의 활성화에 따른 $Ca^{2+}$-channel의 분포 변화에 관한 연구 (Studies of Changes of $Ca^{2+}$-channel Distribution in the Activated Mouse Ova)

  • 장연수;배인하
    • Clinical and Experimental Reproductive Medicine
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    • 제28권1호
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    • pp.13-24
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    • 2001
  • Objective: In muscle and neuronal cells, calcium channels have been classified by electrophysiological and pharmacological properties into (1) voltage-dependent $Ca^{2+}$-channel (1) P/Q-type $Ca^{2+}$-channel (2) N-type $Ca^{2+}$-channel (3) L-type $Ca^{2+}$-channel (4) T-type $Ca^{2+}$-channel (5) R-type $Ca^{2+}$-channel. The present study was done in order to investigate whether there is any difference in $Ca^{2+}$-channel distribution between activated and normally fertilized embryos. Methods: The immunocytochemical method was used to identify the existence of voltage-dependent $Ca^{2+}$-channels in parthenogenetically activated 2-cell embryos by ethanol and $SrCl_2$ treatment. These 2-cell embryos were obtained by exposure to 6% ethanol for 6 min and to 10 mM $SrCl_2$ for 2h. Results: P/Q-type $Ca^{2+}$-channels and L-type $Ca^{2+}$-channels have been identified. Whereas, three type of $Ca^{2+}$-channel P/Q-type, N-type, L-type have been identified in 2-cell embryos fertilized in vivo. Conclusion: Activation by ethanol was faster than those by $SrCl_2$. However, there was difference in DAB staining of the embryos between ethanol and $SrCl_2$ treatment (87.7% and 54.1 %). Intensity of staining was also different between ethanol- and $SrCl_2$-treated group. However, it has not been known why there was some difference in DAB staining and staining intensity in the present study.

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Effects of DIDS on single $Ca^{2+}$ release channel behavior of skeletal muscle

  • Seo, In-Ra;Kim, Do-Han
    • 한국생물물리학회:학술대회논문집
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    • 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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    • pp.46-46
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    • 2001
  • Evidence has suggested that an anion channel blocker, 4, 4'-diisothiocyanatostilbene-2, 2' disulfonic acid (DIDS) could trigger Ca release from skeletal sarcoplasmic reticulum (SR) by binding to a 30 kDa SR protein. Since the high molecular weight $Ca^{2+}$ release channel (CRC)/ryanodine receptor (RyR) is the main SR protein that conducts $Ca^{2+}$ efflux in skeletal muscles, the relationship between CRC and the 30kDa protein remains to be elucidated.(omitted)

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논토양에 대한 K와 Ca의 동시처리가 벼의 Radiocaesium과 Radiostrontium 흡수에 미치는 영향 (Effect of Simultaneous K and Ca Application to Paddy Soil on the Uptake of Radiocaesium and Radiostrontium by Rice)

  • 최용호;임광묵;전인;금동권;김인규
    • Journal of Radiation Protection and Research
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    • 제37권2호
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    • pp.90-95
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    • 2012
  • Radiocaesium과 radiostrontium에 대한 벼의 흡수억제 대책으로서 K와 Ca의 동시처리 효과를 조사하기 위하여 온실 내에서 방사성 추적자 실험을 수행하였다. 흙상자에 담긴 논토양(pH 6.5의 양토)에 $^{137}Cs$$^{85}Sr$을 가하고 농업용 KCl과 $Ca(OH)_2$를 사용하여 K와 Ca를 처리한 다음 모내기하였다. 대조 작물체의 쌀알에 대한 $^{137}Cs$$^{85}Sr$의 토양-작물체전이계수(TF, $m^2\;kg^{-1}-dry$)는 각각 $7.4{\times}10^{-5}$$2.1{\times}10^{-4}$였고 볏짚의 경우에는 각각 $2.6{\times}10^{-4}$$2.2{\times}10^{-2}$였다. K와 Ca의 동시처리 수준(K/Ca, $g\;m^{-2}$)이 $^{137}Cs$의 경우 33.6/322까지, $^{85}Sr$의 경우 48.0/460까지 증가할수록 전이계수가 점점 감소하였다. 최고 감소율은 두 핵종 모두 60% 정도였다. $^{85}Sr$ 전이계수는 33.6/322 처리에서도 60% 가까이 감소하였다. 당 처리에서는 벼의 생산성도 양호하였다. 이로써 본 실험에서는 33.6/322 처리가 최적인 것으로 판단되었다. 최적 처리 수준은 각종 요인에 따라 다를 수 있으므로 차후 다양한 조건에 대한 실험이 수행될 필요가 있다.

Ruddlesden - Popper상 $(LaSrCa)_3Mn_2O_7$의 합성과 자기적 특성에 관한 연구 (Synthesis and Magnetic Properties of Ruddlesden-Popper Phase $(LaSrCa)_3Mn_2O_7$)

  • 송민석;신진현;배철호;박정환;이재열
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2009년도 하계학술대회 논문집
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    • pp.351-352
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    • 2009
  • 이중의 망간 페로브스카이트 블록을 가진 Ruddlesden-Popper 상 (R-P phase) $Sr_3Mn_2O_7$은 공기중에서 불안정하다. 본 연구에서는 Sr이온 자리에 La, Ca이온을 치환함으로써 R-P상을 안정화 시켰으며, 이들의 결정구조는 Neutron Diffraction 데이터를 이용하여 Rietveld 법으로 정밀화하였다 $La_{1.4}Sr_{0.8}Ca_{0.8}Mn_2O_7$, $La_{1.2}Sr_{0.9}Ca_{0.9}Mn_2O_7$$T_N$이 80K이며 25K에서 spin-glass 변이가 관찰되었다.

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Dielectric properties and microstructures of (CaxSr1-x)ZrO3 ceramics

  • Li, Yu-De;Chen, Jian-Ming;Lee, Ying-Chieh
    • Journal of Ceramic Processing Research
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    • 제19권6호
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    • pp.461-466
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    • 2018
  • The effects of Ca/Sr ratio and the sintering temperature on the properties of $(Ca_xSr_{(1-x)})ZrO_3$ (CSZ) ceramics were investigated in this study. CSZ ceramics were prepared using solid-state reaction process, which were sintered in air at temperatures ranging from $1350^{\circ}C$ to $1450^{\circ}C$. Their structures were characterized by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM). The change in Ca/Sr ratio significantly affected the crystalline phase and the dielectric properties of the $(Ca_xSr_{(1-x)})ZrO_3$ ceramics. The secondary phase, $Ca_{0.15}Zr_{0.85}O_{1.85}$, was observed and increased correspondingly with the rising of sintering temperatures. In order to understand the effects of secondary phase on the dielectric properties of CSZ ceramics, the $Ca_{0.15}Zr_{0.85}O_{1.85}$ phase was prepared individually using solidstate method. The $Ca_{0.15}Zr_{0.85}O_{1.85}$ ceramics sintered at $1500^{\circ}C$ for 2 hours possessed a dielectric constant (${\varepsilon}_r$) of 21.7, a dielectric loss ($tan{\delta}$) of $49.510^{-4}$ and an Insulation Resistance (IR) of $2.1{\times}10^{10}{\Omega}$. The ($Ca_{0.7}Sr_{0.3})ZrO_3$ ceramics exhibited the best dielectric properties, with a permittivity of 29, a dielectric loss ($tan{\delta}$) of $2.7{\times}10^{-4}$, and an Insulation Resistance (IR) of $2.6{\times}10^{12}{\Omega}$.

$(1-x)Mg_4Ta_2O_9-x(TiO_2,\;CaTiO_3,\;SrTiO_3)$ 세라믹스의 마이크로파 유전 특성 (Microwave Dielectric Properties of the $(1-x)Mg_4Ta_2O_9-x(TiO_2,\;CaTiO_3,\;SrTiO_3)$ Ceramics)

  • 김재식;최의선;배선기;이영희
    • 대한전기학회논문지:전기물성ㆍ응용부문C
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    • 제55권7호
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    • pp.344-348
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    • 2006
  • The effect of x on microwave dielectric properties of the $(1-x)Mg_4Ta_2O_9-x(TiO_2,\;CaTiO_3,\;SrTiO_3)$ ceramics for microwave components were investigated. All spcecimens prepared by the conventional mixed oxied method and sintered at $1450^{\circ}C$. Microwave dielectric properties of the $(1-x)Mg_4Ta_2O_9-xTiO_2$ ceramics were influenced by $MgTi_2O_5$ phase. Also the microwave dielectric properties of the $(1-x)Mg_4Ta_2O_9-x(TiO_2,\;CaTiO_3,\;SrTiO_3)$ ceramics were dominated with an addition of $CaTiO_3\;and\;SrTiO_3$. The dielectric constant $(\varepsilon_r)$, quality factor $(Q{\times}f_r)$ and temperature coefficient of the resonant frequency $(TCRF,\;\tau_f)$ of the $(1-x)Mg_4Ta_2O_9-x(TiO_2,\;CaTiO_3,\;SrTiO_3)$ ceramics were $12.96\sim70.98,\;5,132\sim186,410GHZ$ and $-35.82\sim+75.96ppm/^{\circ}C$, respectively, and depend on x and addition materials.

Bi2Sr2Ca2.2CuO3Ox계에서 초전도상과 Bi-free상의 핵생성과 성장 (Nucleation and Growth of Bi-free and Superconducting Phases in Bi2Sr2Ca2.2CuO3Ox)

  • 오용택;신동찬;구재본;이인환;한상철;성태현
    • 한국전기전자재료학회논문지
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    • 제16권4호
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    • pp.343-350
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    • 2003
  • Using Bi$_2$Sr$_2$Ca$_2$.$_2$Cu$_3$ $O_{x}$ powders prepared by solid state reaction and spray drying method, the nucleation and growth behaviors of superconducting and second phases were investigated during isothermal heat treatment. When the spray drying power was used in contrast with solid state reaction powder, Bi$_2$Sr$_2$Ca$_2$.$_2$Cu$_3$ $O_{x}$ (2223) phase could be formed at the relatively shot time and second phases were much bigger. Quantitative analysis showed that as the heat treatment time increased, more Bi$_2$Sr$_2$Ca$_2$.$_2$Cu$_3$ $O_{x}$ (2212) changed to 2223 and the major second phase was changed from (Sr,Ca)$_{14}$Cu$_{24}$ $O_{x}$(14:24) to (Sr,Ca)$_2$Cu$_1$ $O_{x}$ (2:l). The superconducting phase formed at the relatively short time 14:24 phase. Following the Bi-free phase of 14:24 Phase, but long time was needed in places far from the 14:24 phase. Following the formation of the 2212 phase near the 14:24 phase, the 2223 phase nucleated preferentially at the interface between the 2212 and 14:24 phases. The preferential nuclcation of 2223 was explained by its structural similarity and low Interfacial energy with both the Bi-free and 2212 Phases.12 Phases.

Synthesis of Novel (Be,Mg,Ca,Sr,Zn,Ni)3O4 High Entropy Oxide with Characterization of Structural and Functional Properties and Electrochemical Applications

  • Arshad, Javeria;Janjua, Naveed Kausar;Raza, Rizwan
    • Journal of Electrochemical Science and Technology
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    • 제12권1호
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    • pp.112-125
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    • 2021
  • The new emerging "High entropy materials" attract the attention of the scientific society because of their simpler structure and spectacular applications in many fields. A novel nanocrystalline high entropy (Be,Mg,Ca,Sr,Zn,Ni)3O4 oxide has been successfully synthesized through mechanochemical treatment followed by sintering and air quenching. The present research work focuses on the possibility of single-phase formation in the aforementioned high entropy oxide despite the great difference in the atomic sizes of reactant alkaline earth and 3d transition metal oxides. Structural properties of (Be,Mg,Ca,Sr,Zn,Ni)3O4 high entropy oxide were explored by confirmation of its single-phase Fd-3m spinel structure by x-ray diffraction (XRD). Further, nanocrystalline nature and morphology were analyzed by scanning electron microscopy (SEM). Among thermal properties, thermogravimetric analysis (TGA) revealed that the (Be,Mg,Ca,Sr,Zn,Ni)3O4 high entropy oxide is thermally stable up to a temperature of 1200℃. Whereas phase evolution in (Be,Mg,Ca,Sr,Zn,Ni)3O4 high entropy oxide before and after sintering was analyzed through differential scanning calorimetry (DSC). Electrochemical studies of (Be,Mg,Ca,Sr,Zn,Ni)3O4 high entropy oxide consists of a comparison of thermodynamic and kinetic parameters of water and hydrazine hydrate oxidation. Values of activation energy for water oxidation (9.31 kJ mol-1) and hydrazine hydrate oxidation (13.93 kJ mol-1) reveal that (Be,Mg,Ca,Sr,Zn,Ni)3O4 high entropy oxide is catalytically more active towards water oxidation as compared to that of hydrazine hydrate oxidation. Electrochemical impedance spectroscopy is also performed to get insight into the kinetics of both types of reactions.