• Journal of Applied Biological Chemistry
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• v.66
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• pp.282-288
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• 2023

Due to the COVID-19 pandemic, the immuneenhancing health functional food market that protects our bodies from pathogens such as viruses continues to grow. In this study, we aimed to prove the Cheonggukjang, a high-nutrient food with high protein, fat, and dietary fiber content, as an immuneenhancing nutraceutical. Cheonggukjang water extract (CWE) increased the production of nitric oxide, reactive oxygen species, and cytokines such interleukin (IL)-6, IL-1β, and tumor necrosis factor-α without affecting viability in RAW 264.7 cells. Furthermore, CWE significantly upregulated the expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells. CWE enhanced the phosphorylation of I kappa B kinase α/β and I kappa B (IκB)α, as well as the degradation of IκBα. CWE also induced increased phosphorylation of nuclear factor-kappa B p65 and facilitated the redistribution of p65 from the cytoplasm to the nucleus in RAW 264.7 cells. These findings suggest that CWE has potential as a health functional food material that can enhance the innate immune response.

• Journal of Computational Design and Engineering
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• v.3 no.2
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• pp.151-160
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• 2016

Cutter-workpiece engagement (CWE) is the instantaneous contact geometry between the cutter and the in-process workpiece during machining. It plays an important role in machining process simulation and directly affects the calculation of the predicted cutting forces and torques. The difficulty and challenge of CWE determination come from the complexity due to the changing geometry of in-process workpiece and the curved tool path of cutter movement, especially for multi-axis milling. This paper presents a new method to determine the CWE for general milling processes. To fulfill the requirement of generality, which means for any cutter type, any in-process workpiece shape, and any tool path even with self-intersections, all the associated geometries are to be modeled as triangle meshes. The involved triangle-to-triangle intersection calculations are carried out by an effective method in order to realize the multiple subtraction Boolean operations between the tool and the workpiece mesh models and to determine the CWE. The presented method has been validated by a series of case studies of increasing machining complexity to demonstrate its applicability to general milling processes.

• Bulletin of the Korean Chemical Society
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• v.10 no.6
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• pp.485-488
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• 1989

A carbon paste coated-wire ion-selective electrode for chloride (carbon chloride-CWE) was constructed using epoxy resin, ion-exchanger and carbon powder as a polymer membrane. Its utility, the composition of a polymer membrane, the response characteristics, and the selectivity were examined and applied to the environmental water analysis. The carbon chloride-CWE was prepared using a silver wire, which was covered with silver chloride and then coated with epoxy resin into which chloride ion-exchanger and carbon powder were previously incorporated in advance. The response of the carbon chloride-CWE was Nernstian for $1.0{\times}10^{-2}-2{\times}10^{-5}$ M chloride and the useful pH range from $10^{-2} M Cl- to 10^{-4} M Cl^-$ was 3.0-9.0. Furthermore, the selectivity of chloride over iodide, bromide, and cyanide was much improved compared with those for a solid state epoxy body chloride electrode and a liquid membrane chloride electrode. The carbon chloride-CWE was applied to determine Cl^-$ in tap and ground water. The obtained results were in good agreement with those by the established methods such as spectrophotometric or other chloride-selective electrode methods.

• Biomolecules & Therapeutics
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• v.20 no.4
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• pp.413-417
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• 2012

Chrysanthemum indicum Linne is an ancient herbal medicine used to treat bone and muscle deterioration, ocular inflammation, headache, and anxiety in Korea, China, and Japan. Furthermore, tea derived from Chrysanthemum indicum Linne has been used to treat anxiety by facilitating relaxation and curing insomnia. However, no reports exist on the anxiolytic-like effects of Chrysanthemum indicum Linne water extract (CWE) in mice. In the present study, we investigated the anxiolytic-like effects of CWE using the elevated plus-maze (EPM) test in mice. CWE, at a dose of 500 mg/kg (p.o.), significantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group. Moreover, the effect of CWE (500 mg/kg) was blocked by bicuculline (a selective $GABA_A$ receptor antagonist) and WAY 100635 (a selective 5-$HT_{1A}$ receptor antagonist). Taken together, these findings suggest that the anxiolytic-like effects of CWE might be mediated by the $GABA_A$ receptor and the 5-$HT_{1A}$ receptor.

• Food Science and Preservation
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• v.20 no.5
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• pp.643-649
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• 2013

The antioxidant activity and amino acid composition of various Cheonggukjang extracts, such as the water extract from Cheonggukjang (CWE), the alcohol extract from Cheonggukjang (CEE), the water extract from Cheonggukjang with black garlic (BWE) and the alcohol extract from Cheonggukjang with black garlic (BEE), were examined to investigate the effect of black garlic on the sensory quality and functional properties of Cheonggukjang. The total polyphenol contents of various extracts were 7.03 mg/100 g (BWE), 3.64 mg/100 g (CWE), 2.88 mg/100 g (BEE) and 0.81 mg/100 g (CEE). The radical scavenging activity of the DPPH radical was highest in BWE (91.83%), followed by BEE (37.35%), CWE (25.54%) and CEE (14.80%), in that order. The SOD-like activity was highest in BWE (20.20%), followed by BEE (9.22%), CWE (7.91%) and CEE (6.45%). The thiobarbituric acid reactive substances (TBARS) were highest in BWE (35.18%), followed by BEE (28.33%), CWE (17.40%) and CEE ((14.93%). The total amino acid content of Cheonggukjang (CC) was higher than that of Cheonggukjang with black garlic (CCWB), but the essential amino acid content of CCWB (43.18%) was higher than that of CC (42.27%). The 27 kinds of free amino acid were found in CC, but only 23 kinds were found in CCWB. The L-lysine content was highest (9.23%) in CC, and the L-phenylalanine content was highest (23.14%) in CCWB. The free amino acids (L-threonine, L-serine, L-sarcosine, L-proline, L-alanine, L-valine and D,L-${\beta}$-aminoisobutyric acid) were found in CC but not in CCWB. The ${\gamma}$-amino-n-butyric acid (GABA) was found in CCWB but not in CC. These results suggest that the addition of black garlic has beneficial effects on the functionality of Cheonggukjang without decreasing its sensory characteristics.

• Magazine of the Korean Society of Agricultural Engineers
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• v.25 no.4
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• pp.61-68
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• 1983

In order to study the disaster of typhoons which hit the Korean peninsula a period of 22 years from 1959 through 1980 was covered to collect necessary data with respect to attack of typhoons and their damage. Centering around the Korean peninsula, typhoons which attacked between 1959 and 1980 were grouped according to their treking routes and damage for detailed analyses. The results are summarized as follows: 1. The average annual damage of typhoons in the Korean peninsula was found to be 1.27 from June to September. The monthly distributions were found to be 53.6% in August, 28.6% in September and 14.2% in July. 2. About an half (56.4%) of the typhoons which hit the Korean peninsula passed through the western coast and 27.3% through the southern and 14.6% through the eastern. Typhoons of the we8tern coast were divided by their treking routes as 25.5% in CWE type (Jul., Aug., Sep.), 14.6% in WE type (Jul., Aug.), 16.3% in W type (Jul.). 3. The minimum SLP averaged 976.6mb and ordere:l by the treking routes as E$_1$$_1$ and CWE types are higher 20mb than S, E or WE types. 4. The Korean peninsula was damaged by all number of the typhoons in WE or S type, by a third at number of its in E or WE and WI type. 5. The annual probabilities of typhoon-disasters were 0.773 for once or more, 0. 409 for twice or more, and 0.091 for three times or more. Hearvy damage experienced in the Korean peninsula are found to have an annual. 6. Amount of the damage by the treking routes in ordered S>WE>CWE>E>W$_1$, and heavy storms experienced in the Xorean peninsula are found to have accompanied the WE and S types during the months of August and September. 7. The average annual damages were found to be 110 at the death-tall, 45, 000 at the sufferers and 10.5 billion at the property damage. 8. Seventy-sex percent of the all damage in the Korean peninsula distributed on the district from the 36th Parallel south and included Chie Ju island.