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검색결과 172건 처리시간 0.024초

치자 추출물이 RANKL 유도 파골세포 형성 및 골 흡수에 미치는 영향 (Effects of Gardeniae Jasminoides on RANKL-induced Osteoclastogenesis and Bone Resorption)

  • 최유경;황귀서
    • 대한한방내과학회지
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    • 제38권6호
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    • pp.1035-1048
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    • 2017
  • Objectives: This study was performed to investigate the effects of Gardenia jasminoides extract (GJ) on osteoclast differentiation and bone resorption in vitro. Methods: To investigate the effect of GJ on osteoclast differentiation, the mouse leukemic myeloid cell line RAW 264.7 was stimulated by RANKL (receptor activator of nuclear factor kB ligand). Osteoclast differentiation was measured by counting TRAP (+) MNC in the presence of RANKL. To elucidate the mechanism of the inhibitory effect of GJ on osteoclast differentiation, gene expression of TRAP, Cathepsin K, MMP-9, NFATc1, c-Fos, MITF, DC-STAMP, CTR, OC-STAMP and Atp6v0d2 was measured using reverse transcription-PCR (RT-PCR). Bone resorption was measured using the bone pit formation assay. Results: GJ decreased the number of TRAP (+) MNCs in the presence of RANKL. GJ inhibited the expression of cathepsin K, MMP-9, TRAP, MITF, NFATc1, c-Fos, iNON, OC-STAMP, Atp6v0d2, and DC-STAMP in the osteoclast, and inhibited bone pit formation in vitro. Conclusions: The results suggest that GJ has inhibitory effects on bone resorption resulting from inhibition of osteoclast differentiation and gene expression.

군집 드론망을 통한 IoT 서비스를 위한 보안 프레임워크 연구 (A Study on the Security Framework in IoT Services for Unmanned Aerial Vehicle Networks)

  • 신민정;김성운
    • 한국멀티미디어학회논문지
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    • 제21권8호
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    • pp.897-908
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    • 2018
  • In this paper, we propose a security framework for a cluster drones network using the MAVLink (Micro Air Vehicle Link) application protocol based on FANET (Flying Ad-hoc Network), which is composed of ad-hoc networks with multiple drones for IoT services such as remote sensing or disaster monitoring. Here, the drones belonging to the cluster construct a FANET network acting as WTRP (Wireless Token Ring Protocol) MAC protocol. Under this network environment, we propose an efficient algorithm applying the Lightweight Encryption Algorithm (LEA) to the CTR (Counter) operation mode of WPA2 (WiFi Protected Access 2) to encrypt the transmitted data through the MAVLink application. And we study how to apply LEA based on CBC (Cipher Block Chaining) operation mode used in WPA2 for message security tag generation. In addition, a modified Diffie-Hellman key exchange method is approached to generate a new key used for encryption and security tag generation. The proposed method and similar methods are compared and analyzed in terms of efficiency.

Co 불순물을 첨가한 HgGa2S2 단결정의 광흡수 특성

  • 김남오;김형곤;김병철;민완기;전형석;신석두;방태환
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2004년도 학술대회 논문집 전문대학교육위원
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    • pp.55-57
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    • 2004
  • $HgGa_{2}S_{4}Co^{2+}$ single crystal were grown by the chemical transport reaction(CTR) method. In the optical absorption spectrum of the $HgGa_{2}S_{4}Co^{2+}$ single crystal measured at 298K, three groups of impurity optical absorption peaks consisting of three peaks, respectively, were observed at 673nm, 734nm, and 760nm, 1621nm, 1654nm, and 1734nm, and 2544nm, 2650nm, and 2678nm. At 10K, the three peaks(673nm, 734nm, and 760nm) of the first group were split to be twelve peaks. These impurity optical absorption peaks are assigned to be due to the electronic transitions between the split energy levels of $Co^{2+}$ sited in the $S_4$ symmetry point.

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진동의 영역 제어 (Regional Control of Vibration)

  • 김양한;장지호
    • 한국소음진동공학회:학술대회논문집
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    • 한국소음진동공학회 2008년도 춘계학술대회논문집
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    • pp.472-475
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    • 2008
  • Generally, a linear vibration theory regards a vibratory system as the superposition of many degrees of vibratory system. Modal analysis stems, in fact, considers the vibration system as what has input, output, and transfer function that relates the input and output. When we want to control, however, the vibratory system, we define, first, the object function that can be vibration energy of certain vibratory system. Then, we try to find the transfer function that can minimize the object function. We can readily extend this approach to control the distributed vibration system. For example, the vibrations of a vehicle, including ships and trains. In this case, we may want to minimize the vibration of the area we select. For example, minimize the vibration of the passengers' seat, but allowing the vibration of other area; for example engines and wheels. This paper introduces a general theory that can control the vibration of the selected area, which can be called as "regional control of vibration." In fact, this is the extended theory of well known sound control of "bright zone"(Choi and Kim, 2002).]. Several illustrative examples demonstrate the applicability and properties that are not available if we use modal analysis method.

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Lifetime prediction of optocouplers in digital input and output modules based on bayesian tracking approaches

  • Shin, Insun;Kwon, Daeil
    • Smart Structures and Systems
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    • 제22권2호
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    • pp.167-174
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    • 2018
  • Digital input and output modules are widely used to connect digital sensors and actuators to automation systems. Digital I/O modules provide flexible connectivity extension to numerous sensors and actuators and protect systems from high voltages and currents by isolation. Components in digital I/O modules are inevitably affected by operating and environmental conditions, such as high voltage, high current, high temperature, and temperature cycling. Because digital I/O modules transfer signals or isolate the systems from unexpected voltage and current transients, their failures may result in signal transmission failures and damages to sensitive circuitry leading to system malfunction and system shutdown. In this study, the lifetime of optocouplers, one of the critical components in digital I/O modules, was predicted using Bayesian tracking approaches. Accelerated degradation tests were conducted for collecting the critical performance parameter of optocouplers, current transfer ratio (CTR), during their lifetime. Bayesian tracking approaches, including extended Kalman filter and particle filter, were applied to predict the failure. The performance of each prognostic algorithm was then compared using accuracy and robustness-based performance metrics.

기동표적 추적을 위한 상호작용다수모델 추적필터에 관한 연구 (The study on target tracking filter using interacting multiple model for tracking maneuvering target)

  • 김승우
    • 전기전자학회논문지
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    • 제11권4호
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    • pp.137-144
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    • 2007
  • 함포의 사격통제장치 성능은 크게 하드웨어(H/W)적인 오차와 소프트웨어(S/W)적인 오차로 구분할 수 있으며, 이중 S/W 오차에 해당하는 표적의 위치, 속도, 가속도 등을 추정하는 추적필터 오차는 탄도계산장치의 성능에 중요한 영향을 미친다. 함포의 정확한 예상탄착점 형성과 사격시 명중률 향상을 위하여 정확한 미래위치의 표적 상태정보가 필요하다. 표적 추적필터 알고리즘은 Single Singer Model, Fixed Gain 필터 알고리즘, IMM, PBIMM등이 있다. 본 논문에서는 최근 국내 함정에 적용예정인 IMM 추적필터를 설계하였다. IMM 추적필터를 위해 CV모델, Song 모델, CTR모델을 사용하여 동역학 모델을 만들었으며, 추적성능을 Monte-Carlo 시뮬레이션을 통해 해석해 보았다.

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Salmonella typhimurium의 금속이온에 대한 유전적 반응 (Genetic Responses to Metal ion in Aslmonella typhimurium)

  • 정주리;박경량;고상균;박용근;이인수
    • 생명과학회지
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    • 제8권2호
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    • pp.216-225
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    • 1998
  • Metal ion-induced and it’s regulatory genes were screened in virulent salmonella typhimurium UK1 and tested cross-regulation with various stresses. Using the techniqud of P22-MudJ(Km, lacZ)-directed lacZ operon fusion, LF40 cuiA::MudJ and Lf153 cuiD::MudJ which were induced by copper were selected. cuia and cuiD were determined anaerobic coper inducible and copper tolerance response gene, respectively. Also cuiA and cuiD locus were determined at 81 and 8min, respectively, on salmonella Genetic Map. The two regulators were identified as cuaR, and cudR, which controls cuiA and cuiD, respectively. cuaR, and cudR appeared as negative regulators because the expression of cuiA-lac-Z and cuiD-lacZ were increased. Copper adapted UK1 showed high resistance to H$_{2}$O$_{2}$, but cuiD did not. The product of the cudR locus was responsible for decreasing the tolerance to copper and H$_{2}$O$_{2}$. Furthemore cuiA and cuiD locus were found to be part of a regulon under the control of a trans-acting regulators, rpoS, oxyR and relA. Therefore, the results suggest CTR participate with oxidative stress on Salmonella.

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$Cd_{4}GeS_{6}$$Cd_{4}GeS_{6}:Co^{2+}$ 단결정의 성장 (Crystal Growth of Cd4GeS6 and Cd4GeS6:Co2+Single Crystals)

  • 김덕태;김형곤;김남오
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2004년도 추계학술대회 논문집
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    • pp.1-6
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    • 2004
  • In this paper author describe the undoped and $Co^{2+}$ (0.5mole%)doped $Cd_4GeS_6$ single crystals were grown by the chemical transporting reaction(CTR) method using high purity(6N) Cd, $GeS_2$, S elements. It was found from the analysis of X-ray diffraction that the undoped and $Co^{2+}$(0.5mole%) doped $Cd_{4}GeS_{6}$ compounds have a monoclinic structure in space grop Cc. The optical energy band gap was direct band gap and temperature dependence of optical energy gap was fitted well to Varshni equation. Impurity optical absorption peaks due to the doped cobalt in the $Cd_4GeS_6:Co^{2+}$ single crystal were observed at 3593cm-1, 5048cm-1, 5901cm-1, 7322cm-1, 12834cm-1, 13250cm-1, 14250cm-1,and 14975cm-1 at 11.3K.

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$HgGa_2S_4:CO^{2+}$ 단결정의 불순물 광흡수 (Impurity optical absorption of $HgGa_2S_4:CO^{2+}$ single crystals)

  • 김형곤;김남오;김병철;최영일;김덕태;현승철;방태환;이경섭;구할본
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2004년도 춘계학술대회 논문집
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    • pp.3-7
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    • 2004
  • $HgGa_2S_4:CO^{2+}$ single crystal were grown by the chemical transport reaction(CTR) method. 1n the optical absorption spectrum of the $HgGa_2S_4:CO^{2+}$ single crystal measured at 298K, three groups of impurity optical absorption peaks consisting of three peaks, respectively, were observed at 673nm, 734nm, and 760nm, 1621nm, 1654nm, and 1734nm, and 2544nm, 2650nm, and 2678nm. At 10K, the three peaks(673nm, 734nm, and 760nm) of the first group were split to be twelve peaks. These impurity optical absorption peaks are assigned to be due to the electronic transitions between the split energy levels of $Co^{2+}$ sited in the $S_4$ symmetry point.

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HgGa2S4:Co2+ 단결정에서 Co2+ 이온에 의한 광흡수 특성에 관한 연구 (Impurity Optical Absorption of Co2+ Ion in HgGa2S4:Co2+ Single Crystals)

  • 이상열;강종욱
    • 한국전기전자재료학회논문지
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    • 제16권7호
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    • pp.579-583
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    • 2003
  • HgGa$_2$S$_4$: Co$^{2+}$ single crystal were grown by the chemical transport reaction(CTR) method. In the optical absorption spectrum of the HgGa$_2$S$_4$: Co$^{2+}$ single crystal measured at 298K, three groups of impurity optical absorption peaks consisting of three peaks, respectively, were observed at 673nm, 734nm, and 760nm, 1621nm, 1654nm, and 1734nm, and 2544nm, 2650nm, and 2678nm. At 10K, the three peaks(673nm, 734nm, and 760nm) of the first group were split to be twelve peaks. These impurity optical absolution peaks are assigned to be due to the electronic transitions between the split energy levels of Co$^{2+}$ sited in the S$_4$ symmetry point.