• 한국지반공학회:학술대회논문집
• /
• 한국지반공학회 2000년도 가을 학술발표회 논문집
• /
• pp.335-342
• /
• 2000

In this study, the swelling characteristics of reconstituted clayey soil were investigated by STD and CRS test. The strain rate during loading was constant i.e. 0.05 %/min, 0.03 %/min and during unloading was varied in proportion to 1/1, 1/5, 1/10 and 1/15 of strain rate during loading. From this study the following conclusions were obtained; (1) There were similar values, especially, during unloading in case of 1/10 or 1/15 of strain rate during loading and the test results between STD and CRS were much to be alike. (2) The cross point of effective stress versus excess pore water pressure ratio curve, was increased during unloading, while the stress level of the cross point was decreased. The stress level can be separated into two zones according to the swelling index named Cs1 and Cs2. From the test results, the values of Cs1 were approximately constant irrespective of strain rate during unloading, but the values of Cs2 were much influenced by strain rate. (3) In CRS consolidation tests, it was found that unloading strain rate did not affect on the existence of zone.

• 해양환경안전학회지
• /
• 제22권1호
• /
• pp.145-151
• /
• 2016

수온과 기후 지수 자료를 이용하여 한국주변해 상층부의 수온변동과 북태평양 기후체제와의 관계를 분석하였다. 1970, 1980 그리고 1990년대 후반에 발생한 기후체제전환은 해양생태계의 구조 변화에 중요한 영향을 끼쳤다. 북서태평양 대륙주변부에 위치한 우리나라 주변해역 또한, 10년 이상의 장주기적인 변화의 영향을 받지만, 해역별 반응은 다르다. 동해, 서해, 남해 상층부(10 m)의 경우 1988년의 기후체제전환은 3개 해역의 상층부 수온변화에서 동시에 나타난다. 반면, 1998년은 동해남부해역과 서해, 1976년의 기후체제전환은 전 해역의 겨울철 수온변화에서만 그 영향이 나타난다. 1998년 기후체제전환 이후, 서해, 동중국해, 동해 남부의 수온은 점차 감소하지만, 동해 북부해역은 1988년 기후체제전환 이후 증가하는 형태이다.

• Journal of Ginseng Research
• /
• 제45권6호
• /
• pp.695-705
• /
• 2021

Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.

• 한국지반공학회지:지반
• /
• 제14권4호
• /
• pp.47-60
• /
• 1998

본 연구에서는 남해안 해성점토의 일정변형률 압밀특성을 파악하기 위해 표준압밀시첩과 변형률 속도가 다른 일정변형율 압밀시험을 수행하고 이들 결과를 비교.분석하였다. 표준압밀시험 및 일정변형율 시험에서 선행압밀하중을 산정하기 위하여 여러 제안된 방법을 사용하였으며 각 방법의 적용성을 검토하였다. 또한, 변형률 속도가 응력-변형뮬 관계, 간극수압, 그리고 선행압밀 하중에 미치는 영향을 분석하였다. 해석결과에 의하면 압밀곡선의 분포와 선행압밀하중비($a_2=\sigma'_{pCRS}/\sigma'_{pConv}$)는 변형률 속도의 영향을 받지만, 정규압 밀구간의 압축지수는 상대적으로 변형률 속도의 크기와 무관한 것으로 나타났다. 해성점토의 선행압밀하중비는 변형률 속도의 대수축척에 비례하여 증가하는 것으로의 변형률 속도에서 평균적으로 1.11~1.30의 분포를 보였다. 일정변형률 압밀시험에서 간극수압비는 변형플 속도가$6.67\times10^{-4}$ %sec일 때를 제외하고는 6.0%를 초과하지 않는 것으로 나타났다. 정규압밀구간의 압축지수, 압밀계수와 투수계수는 각각 0.59~0.95, $0.56\times10^{-3}~3.0\times10^{-3} cm^2/sec,\; 그리고 \;2.0\times10^4~7.0\times10^{-4} cm/sec$의 분포를 보였다.

• Molecules and Cells
• /
• 제45권6호
• /
• pp.353-361
• /
• 2022

Chronic rhinosinusitis (CRS) is a multifactorial, heterogeneous disease characterized by persistent inflammation of the sinonasal mucosa and tissue remodeling, which can include basal/progenitor cell hyperplasia, goblet cell hyperplasia, squamous cell metaplasia, loss or dysfunction of ciliated cells, and increased matrix deposition. Repeated injuries can stimulate airway epithelial cells to produce inflammatory mediators that activate epithelial cells, immune cells, or the epithelial-mesenchymal trophic unit. This persistent inflammation can consequently induce aberrant tissue remodeling. However, the molecular mechanisms driving disease within the different molecular CRS subtypes remain inadequately characterized. Numerous secreted and cell surface proteins relevant to airway inflammation and remodeling are initially synthesized as inactive precursor proteins, including growth/differentiation factors and their associated receptors, enzymes, adhesion molecules, neuropeptides, and peptide hormones. Therefore, these precursor proteins require post-translational cleavage by proprotein convertases (PCs) to become fully functional. In this review, we summarize the roles of PCs in CRS-associated tissue remodeling and discuss the therapeutic potential of targeting PCs for CRS treatment.

• 자동차안전학회지
• /
• 제7권1호
• /
• pp.13-19
• /
• 2015

Recently, Child safety has become one of the issue with Q10 dummy representing large child. The objective of this paper was to evaluate performance of three child restraints system (backless booster, high-back booster and without booster) by changing D-ring location in the rear seat. Sled tests were carried out with a Q 10 in 64km/h frontal impact. Before the dynamic sled tests, we assessed dummy positioning with difference in CRS types and height adjustment positions. Dynamic sled test results indicated that there is different performance of CRS types and belt routing. These test results will use as base line data for development CRS safety performance for Q 10.

• Environmental Analysis Health and Toxicology
• /
• 제20권4호통권51호
• /
• pp.311-325
• /
• 2005

A chemical ranking and scoring system, CRS - Korea, has recently been developed and proposed to use to prioritize on a screening level the toxic chemicals for monitoring and risk assessment. As CRS-Korea requires rigorous assessments prior to its wide application, an assessment was conducted in this study by examining the contribution of individual parameter score to the final chemical score or ranking. The sensitivity of the system to the default values for various parameters of missing data was also tested. The chemical ranking/score was round to depend primarily on the score of a single parameter, i. e., the chemical release, while toxicity scores show little correlation with the priority Further analysis indicated that the dominating effect of the chemical release results from i) its multiplicative relationship with the other two exposure parameters (biodegradation and persistent) and ii) the fact that a maximum score of 10 was assigned to the chemical release parameter while 5 was assigned for all others. AE the fraction of the data that are missing exceeded $70\%$ for various toxicity parameters at compared to less than $10\%$ for exposure parameters, the sensitivity of the ranking to the default value was not significant (rank correlation coefficient = 0.98) for toxicity parameters. Bated on this assessment, an improved CRS system (CRS - Korea II) was proposed in which the impact of the chemical release was properly adjusted by changing the multiplicative relationship to additive one and the maximum score to 5. Chemical priority was derived for each of 16 provinces by using CRS-Korea II. The chemical priority was found to significantly vary among the provinces. It was concluded that not only the national chemical priority but the local chemical priority should be taken into account in setting the nationwide chemical monitoring and risk assessment strategy.

• Geomechanics and Engineering
• /
• 제5권1호
• /
• pp.57-70
• /
• 2013

Constant rate of strain (CRS) consolidation tests were conducted for undisturbed Ariake clay samples from three boreholes in Saga Plain of Kyushu Island, Japan. The coefficients of consolidation ($c_{\nu}$) were interpreted from the CRS test results by small- and large-strain theory. Large-strain theory was found to interpret smaller $c_{\nu}$ values and less strain rate effect on $c_{\nu}$ than that by small-strain theory. Comparing the theoretical strain distributions within a soil specimen to those obtained by numerical simulation shows that the small-strain theory can be used only for the dimensionless parameter $c_{\nu}/\dot{\varepsilon}H_0^2{\geq}50$ (where $\dot{\varepsilon}$ is strain rate and $H_0$ is the specimen height), and the large-strain theory can be used for a larger range of strain rates. Applying the criterion to undisturbed Ariake clay with a $c_{\nu}$ value of about $1{\times}10^{-7}\;m^2/s$, it is suggested that the large-strain theory should be adopted for calculating the $c_{\nu}$ value when $\dot{\varepsilon}$ > 0.03%/min.

• 천문학회지
• /
• 제35권4호
• /
• pp.159-174
• /
• 2002

Cosmological hydrodynamic simulations of large scale structure in the universe have shown that accretion shocks and merger shocks form due to flow motions associated with the gravitational collapse of nonlinear structures. Estimated speed and curvature radius of these shocks could be as large as a few 1000 km/s and several Mpc, respectively. According to the diffusive shock acceleration theory, populations of cosmic-ray particles can be injected and accelerated to very high energy by astrophysical shocks in tenuous plasmas. In order to explore the cosmic ray acceleration at the cosmic shocks, we have performed nonlinear numerical simulations of cosmic ray (CR) modified shocks with the newly developed CRASH (Cosmic Ray Amr SHock) numerical code. We adopted the Bohm diffusion model for CRs, based on the hypothesis that strong Alfven waves are self-generated by streaming CRs. The shock formation simulation includes a plasma-physics-based 'injection' model that transfers a small proportion of the thermal proton flux through the shock into low energy CRs for acceleration there. We found that, for strong accretion shocks, CRs can absorb most of shock kinetic energy and the accretion shock speed is reduced up to $20\%$, compared to pure gas dynamic shocks. For merger shocks with small Mach numbers, however, the energy transfer to CRs is only about $10-20\%$ with an associated CR particle fraction of $10^{-3}$. Nonlinear feedback due to the CR pressure is insignificant in the latter shocks. Although detailed results depend on models for the particle diffusion and injection, these calculations show that cosmic shocks in large scale structure could provide acceleration sites of extragalactic cosmic rays of the highest energy.

• 천문학회지
• /
• 제37권5호
• /
• pp.597-600
• /
• 2004

A substantial number of processes have been suggested as possible contributors to the extragalactic $\gamma$-ray background (EGRB). Yet another contribution to this background will be emission produced in hadronic interactions of cosmic-ray protons with the cluster thermal gas; this class of cosmic rays (CRs) has been shown to be responsible for the EUV emission in the Coma Cluster of galaxies. In this paper we assume the CRs in the Coma Cluster is prototypic of all clusters and derive the contribution to the EGRB from all clusters over time. We examine two different possibilities for the scaling of the CR flux with cluster size: the number density of the CRs scale with the number density of the thermal plasma, and alternatively, the energy density of the CRs scale with the energy density of the plasma. We find that in all scenarios the EGRB produced by this process is sufficiently low that it will not be observable in comparison with other mechanisms that are likely to produce an EGRB.