• Title/Summary/Keyword: CRM1

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Effort and Development Direction of Aviation Organization Against Human Errors (인적오류에 대응하는 항공분야의 노력과 발전방향)

  • Kim, Dae-Ho
    • Journal of the Ergonomics Society of Korea
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    • v.30 no.1
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    • pp.29-39
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    • 2011
  • Safety management paradigm which against human errors in aviation industry is now changing from the follow-up measures after accident in the past to systematic approach that a forecast the hazards and improve the working system of the group to prevent accidents. As human factors are based on the man's specific psychological traits, it takes much time and efforts to prepare the preventive measures. That's why aviation industry is interested in the accident-prevent measurements against human errors. In this thesis, therefore, we are going to introduce the efforts that aviation organizations have tried and recommend management systems and discuss the suggestive facts. At first, we discussed introduction of HFACS which is the systematic accidents-classification system related to human errors in the aviation organization and countermeasure in the aspects of management, technology/engineering, education training. We described about FOQA, LOSA, CRM/TEM, aviation safety information DB in the aspect of management, and explained safety technologies that prevent human errors or avoid technologically when emergency occurs in the aspect of technology/engineering. In the aspect of education training, we explained the application plan about safety programs(LOFT/Simulator use, CRM/TEM application etc).

A Study on Behavior Rule Induction Method of Web User Group using 2-tier Clustering (2-계층 클러스터링을 사용한 웹 사용자 그룹의 행동규칙추출방법에 관한 연구)

  • Hwang, Jun-Won;Song, Doo-Heon;Lee, Chang-Hoon
    • The KIPS Transactions:PartD
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    • v.15D no.1
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    • pp.139-146
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    • 2008
  • It is very important to identify useful web user group and induce their behavior pattern in eCRM domain. Inducing user group with a similar inclination, a reliability of user group decreases because there is an uncertainty in online user data. In this paper, we have applied the 2-tier clustering, which uses the outcome of interaction with data from other tiers. Also we propose a method which induces user behavior pattern from a cluster and compare C4.5 with our method.

Analysis of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in urine with certified reference material (인증표준물질(CRM)을 이용한 소변 중 대마 대사체 분석법 평가)

  • Ko, Beom-Jun;Kim, Jin-Young;Kim, Jong-Sang;Lee, Jeong-Jik;Cheong, Jae-Chul;Suh, Sung-Ill;In, Moon-Kyo
    • Analytical Science and Technology
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    • v.23 no.1
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    • pp.83-88
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    • 2010
  • For the evaluation of our laboratory's 11-nor-${\Delta}^9$-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) urinalysis test, THCCOOH urinalysis test was carried out with Certified Reference Material (CRM). The used CRM was THCCOOH in freeze-dried urine produced by NIST as Standard Reference Material 1507b. Comparing the estimated value of our laboratory with CRM, the results was coincided in the confidence level of approximately 95%.

Development of Isotope Dilution LC-MS/MS Method for Accurate Determination of Arsenobetaine in Oyster Certified Reference Material

  • Lee, Woo Young;Yim, Yong-Hyeon;Hwang, Euijin;Lim, Youngran;Kim, Tae Kyu;Lee, Kyoung-Seok
    • Bulletin of the Korean Chemical Society
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    • v.35 no.3
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    • pp.821-827
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    • 2014
  • An isotope dilution liquid chromatography tandem mass spectrometry (ID LC-MS/MS) method has been developed and applied to the determination of arsenobetaine (AsB, ${(CH_3)_3}^+AsCH_2COO^-$) from oyster candidate certified reference material (CRM). The exact matching isotope dilution approach was adopted for accurate determination of AsB using $^{13}C_2$-labeled AsB as an internal standard. Efficiencies of different AsB extraction methods were evaluated using a codfish reference material and a simple sonication method was selected as the method of choice for the certification of the oyster candidate CRM. The hydrophilic interaction liquid chromatography (HILIC) combined with electrospray ionization tandem mass spectrometry (ESI/MS/MS) in selected reaction monitoring (SRM) mode was optimized for adequate chromatographic retention and robust quantification of AsB from codfish and oyster samples. By analyzing 12 subsamples taken from each 12 bottles systematically selected from the whole oyster CRM batch, the certified value of AsB was determined as $6.60mg{\cdot}kg^{-1}{\pm}0.31mg{\cdot}kg^{-1}$ and it showed excellent between-bottle homogeneity of less than 0.42%, which is represented by relative standard deviation of 12 bottles from the CRM batch. The major source of uncertainty was the certified value of the AsB standard solution.

Investigation of Bordered Pit Ultrastructure in Tracheid of Korean Red Pine (Pinus densiflora) by Confocal Reflection Microscopy (공초점반사현미경을 이용한 소나무 유연벽공의 초미세구조 연구)

  • Kwon, Ohkyung
    • Journal of the Korean Wood Science and Technology
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    • v.42 no.3
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    • pp.346-355
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    • 2014
  • Confocal reflection microscopy (CRM) was utilized to create 3-dimensional images of bordered pits and cell wall in the tracheid of Korean red pine (Pinus densiflora). Ultrastructures of torus, margo, and pit border were clearly observable in the CRM micrograph. Micrograph of cross-field pit revealed the connecting and supporting structure between tracheid and ray parenchyma cell. The CRM micrographs enabled to investigate detailed structures of tracheid cell wall such as S1, S2, S3 layers, transition layers between these layers, and microfibril (MF) orientation in S3 and S2 layers as well as complicated distribution of MF orientation around bordered pits. Not only concentric MF orientation of border thickening in the pit border was observed, but also changes in MF orientation from the cell wall to the border. From the experimental results, the CRM was thought to be a versatile microtechnique to investigate detailed structures of cell wall and bordered pit in the tracheid and cross-field pit between tracheid and ray parenchyma cell.

Effectiveness and Preparation of Nano-emulsion of a Rapeseed Oil Extract Originated from Jeju with PIT Emulsifying System (PIT유화시스템을 이용한 제주산 유채씨앗 오일추출물의 나노에멀젼의 제조 및 효과)

  • Joo, Se-Jin;Kim, Hack-Soo;Lee, Jeong-Koo;Lee, Min-Hee;Kim, In-Young
    • Journal of the Korean Applied Science and Technology
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    • v.29 no.3
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    • pp.486-494
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    • 2012
  • Nano-emulsion with phase inversion temperature (PIT) emulsifying system was prepared to use rapeseed oil from originating Jeju in order to apply various cosmetic applications. Natural rape seed oil (NRSO) extraction was extracted using n-hexane as a solvent. NRSO extract showed a light yellowish color of viscous liquid as well as yield was $43{\pm}2.5%$. Acid value was $2.76{\pm}0.5$ and gravity was $0.89{\pm}0.05$. Droplet size of PIT-Yuche-NE with 20wt% of rapeseed oil was 50-120nm (average: $82{\pm}5.8nm$) and zeta potential was -29.5mV. It was thermodynamically good stable emulsion due to $(PEG)_{5-30}$fattyacidether. Some conclusions from the result of characteristic experiment were obtained as follows. First, the anti-oxidative activity was measured by free radical scavenging activity using DPPH (1,1-diphenyl-2-picrylhydrazyl radical). Anti-oxidative activity of PIT-Yuche-NE was $37.2{\pm}6.7%$ on 10mg/mL compared with PIT-Toco-NE (Natural tocopherol nano-emulsion, $28.8{\pm}6.5%$ on 10 mg/mL) and PIT-Nokcha-NE (Green tea extract nano-emulsion, $29.6{\pm}7.2%$ on 10mg/mL). Second, the collagen synthesis activity of PIT-Yuche-NE was $148{\pm}15.2%$ compared with PIT-Toco-NE (Natural tocopherol nano-emulsion, $121{\pm}13.5%$ on 10mg/mL) and PIT-Nokcha-NE (Green tea extract nano-emulsion, $95{\pm}12.7%$ on 10mg/mL). Third, the effectiveness of moisturizing activity of Yuche-CRM with Aramo-TS after 6 hours increase $47{\pm}3.9%$ (*p-value£0.05, n=7) whereas Both Toco-CRM was $30{\pm}5.2%$ (*p-value£0.05, n=7) and Nokcha-CRM was $35{\pm}4.5%$. Therefore, Yuche-CRM has higher moisturizing effect than other two creams. Finally, Nano-emulsion stabilizing rapeseed oil using PIT emulsifying system of this study can be used to apply cosmetics industry and pharmaceutical industry.

Two-Stage Maximum Tolerated Dose Estimation by Stopping Rule in a Phase I Clinical Trial (제1상 임상시험에서 Stopping Rule을 이용한 두 단계 MTD 추정법)

  • Lee, Na-Mi;Kim, Dong-Jae
    • Communications for Statistical Applications and Methods
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    • v.19 no.1
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    • pp.57-64
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    • 2012
  • Phase I clinical trials determine the maximum tolerated dose(MTD) of a new drug. In this paper, we proposed a two-stage MTD estimation method by a Stopping rule in a phase I clinical trial. The suggested MTD estimation method is compared to the standard design(SM3) and the continual reassessment method(CRM) using a Monte Carlo simulation study.