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http://dx.doi.org/10.5351/CKSS.2012.19.1.057

Two-Stage Maximum Tolerated Dose Estimation by Stopping Rule in a Phase I Clinical Trial  

Lee, Na-Mi (Department of Biostatistics, The Catholic University of Korea)
Kim, Dong-Jae (Department of Biostatistics, The Catholic University of Korea)
Publication Information
Communications for Statistical Applications and Methods / v.19, no.1, 2012 , pp. 57-64 More about this Journal
Abstract
Phase I clinical trials determine the maximum tolerated dose(MTD) of a new drug. In this paper, we proposed a two-stage MTD estimation method by a Stopping rule in a phase I clinical trial. The suggested MTD estimation method is compared to the standard design(SM3) and the continual reassessment method(CRM) using a Monte Carlo simulation study.
Keywords
Phase I clinical trial; maximum tolerated dose(MTD); Stopping rule;
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Times Cited By KSCI : 1  (Citation Analysis)
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