• 정보과학회지
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• 제24권3호
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• pp.12-24
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• 2006

서비스 로봇의 지각과 행동에서의 신뢰성은 각 개별 요소기술의 완벽함으로부터 얻어지는 것이 아니라 비록 성능이 불완전한 요소기술들을 사용하더라도 각 요소기술들의 정보를 융합하고 능동적인 행위를 발생시키는 시스템적인 접근방식으로부터 얻어진다. 그러므로 본 연구에서는 자연스러운 HRI 구현을 위하여 "로봇인지 엔진"이라는 독창적인 통합 구조를 제안하였으며, 비동기/병렬 정보처리 구조, 다양한 지각정보들의 융합, 행위 결합을 위한 능동적인 지각정보 수집의 특징을 갖는다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권8호
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• pp.3529-3550
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• 2016

In heterogeneous networks (HetNets), energy saving is vital for a sustainable network development. Many techniques, such as spectrum allocation, network planning, etc., are used to improve the network energy efficiency (EE). In this paper, micro BSs utilizing cell range expansion (CRE) and spectrum allocation are considered in multi-channel heterogeneous networks to improve EE. Hotspot region is assumed to be covered by micro BSs which can ensure that the hotspot capacity is greater than the average demand of hotspot users. The expressions of network energy efficiency are derived under shared, orthogonal and hybrid subchannel allocation schemes, respectively. Particle swarm optimization (PSO) algorithm is used to solve the optimal ratio of subchannel allocation in orthogonal and hybrid schemes. Based on the results of the optimal analysis, we propose three service control strategies on the basis of large-scale user behaviors, i.e., adjust micro cell rang expansion (AmCRE), adjust micro BSs density (AmBD) and adjust micro BSs transmit power (AmBTP). Both theoretical and simulation results show that using shared subchannel allocation scheme in AmBD strategies can obtain maximal EE with a very small area ratio. Using orthogonal subchannel allocation scheme in AmCRE strategies can obtain maximal EE when area ratio is larger. Using hybrid subchannel allocation scheme in AmCRE strategies can obtain maximal EE when area ratio is large enough. No matter which service control strategy is used, orthogonal spectrum scheme can obtain the maximal hotspot user rates.

• Biomolecules & Therapeutics
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• 제25권5호
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• pp.504-510
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• 2017

Inhibitor of nuclear factor kappa-B kinase beta ($IKK{\beta}$) plays a critical role in cell proliferation and inflammation in various cells by activating $NF-{\kappa}B$ signaling. However, the interrelationship between peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) and $IKK{\beta}$ in cell proliferation is not clear. In this study, we investigated the possible role of $PPAR{\alpha}$ in the hepatic cell death in the absence of $IKK{\beta}$ gene using liver-specific Ikkb-null ($Ikkb^{F/F-AlbCre}$) mice. To examine the function of $PPAR{\alpha}$ activation in hepatic cell death, wild-type ($Ikkb^{F/F}$) and $Ikkb^{F/F-AlbCre}$ mice were treated with $PPAR{\alpha}$ agonist Wy-14,643 (0.1% w/w chow diet) for two weeks. As a result of Wy-14,643 treatment, apoptotic markers including caspase-3 cleavage, poly (ADP-ribose) polymerase (PARP) cleavage and TUNEL-positive staining were significantly decreased in the $Ikkb^{F/F-AlbCre}$ mice. Surprisingly, Wy-14,643 increased the phosphorylation of p65 and STAT3 in both Ikkb and $Ikkb^{F/F-AlbCre}$ mice. Furthermore, BrdU-positive cells were significantly increased in both groups after treatment with Wy-14,643. Our results suggested that $IKK{\beta}-derived$ hepatic apoptosis could be altered by $PPAR{\alpha}$ activation in conjunction with activation of $NF-{\kappa}B$ and STAT3 signaling.

• Journal of Astronomy and Space Sciences
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• 제13권2호
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• pp.149-162
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• 1996

1992년 8월에 발사된 한국의 첫번째 위성인 우리별 1호에는 저궤도 고에너지 입자환경를 관측하는 탑재체 cosmic ray experiment(CRE)가 실렸다. CRE는 크게 cosmic particle experiment(CPE)와 total dose esperiment(TDE) 두 시스템으로 구성된다. 이와 더불어 실험 탑재물은 아니지만, 프로그램 메모리와 램디스크(RAM disk)의 비트바뀜현상(SEU) 결과를 통해서 고에너지 입자환경에 대한 간접적인 정보를 얻을 수 있었다. 1993년 9월에 발사된 두 번재 위성 우리별 2호에는 OBCI인 KASCOM에서 프로그램 메모리와 램디스크 메모리에 대한 비트바뀜현상실험을 수행하였다. 우리별 1호와 2호는 그 구조는 비슷하지만 서로의 궤도가 다르기 때문에 두 위성의 실험결과를 분석해본다면 각 궤도에서의 고에너지 입자환경에 대한 비교연구할 수 있는 좋은 기회가 된다.

• 대한간호학회지
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• 제50권4호
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• pp.621-630
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• 2020

Purpose: This study was aimed to evaluate the external validity of a carbapenem-resistant Enterobacteriaceae (CRE) acquisition risk prediction model (the CREP-model) in a medium-sized hospital. Methods: This retrospective cohort study included 613 patients (CRE group: 69, no-CRE group: 544) admitted to the intensive care units of a 453-beds secondary referral general hospital from March 1, 2017 to September 30, 2019 in South Korea. The performance of the CREP-model was analyzed with calibration, discrimination, and clinical usefulness. Results: The results showed that those higher in age had lower presence of multidrug resistant organisms (MDROs), cephalosporin use ≥ 15 days, Acute Physiology and Chronic Health Evaluation II (APACHE II) score ≥ 21 points, and lower CRE acquisition rates than those of CREP-model development subjects. The calibration-in-the-large was 0.12 (95% CI: - 0.16~0.39), while the calibration slope was 0.87 (95% CI: 0.63~1.12), and the concordance statistic was .71 (95% CI: .63~.78). At the predicted risk of .10, the sensitivity, specificity, and correct classification rates were 43.5%, 84.2%, and 79.6%, respectively. The net true positive according to the CREP-model were 3 per 100 subjects. After adjusting the predictors' cutting points, the concordance statistic increased to .84 (95% CI: .79~.89), and the sensitivity and net true positive was improved to 75.4%. and 6 per 100 subjects, respectively. Conclusion: The CREP-model's discrimination and clinical usefulness are low in a medium sized general hospital but are improved after adjusting for the predictors. Therefore, we suggest that institutions should only use the CREP-model after assessing the distribution of the predictors and adjusting their cutting points.

• 대한기계학회논문집B
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• 제36권1호
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• pp.1-8
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• 2012

본 연구에서는 주름높이가 고려된 판형열교환기의 완전발달유동 및 열전달특성을 수치적으로 해석하였다. 여러 개의 단위셀(5개 또는 7개)을 연결한 다중셀에 입구부와 출구부가 부착된 모델을 기본으로 P/H비 변화($2.0{\leq}P/H{\leq}4.0$)에 따른 모델에 대하여 수치해석을 수행하였다. 작동유체는 물이며, 수치조건은 쉐브론각 $20^{\circ}$, $300{\leq}Re{\leq}1,500$이다. 그리고 마찰인자는 $f=CRe^m$의 형태로, Colburn 계수는 $j=CRe^m$의 형태로 상관관계식을 제시하였다. 수치해석 결과 완전발달유동은 세 번째 셀부터 시작되었으며, 누셀트수는 P/H비가 작을수록 큰 값을 나타냈다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.585-592
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• 2021

Cisplatin has been reported to cause side effects such as muscle wasting in humans and rodents. The physiological mechanisms involved in preventing muscle wasting, such as the regulation of AKT, PGC1-α, and autophagy-related factor FOXO3a by MuRF 1 and Atrogin-1, remain unclear following different types of exercise and in various skeletal muscle types. Eight-week-old male Wistar rats (n = 34) were assigned to one of four groups: control (CON, n = 6), cisplatin injection (1 mg/kg) without exercise (CC, n = 8), cisplatin (1 mg/kg) + resistance exercise (CRE, n = 9) group, and cisplatin (1 mg/kg) + aerobic exercise (CAE, n = 11). The CRE group performed progressive ladder exercise (starting with 10% of body weight on a 1-m ladder with 2-cm-interval grids, at 85°) for 8 weeks. The CAE group exercised by treadmill running (20 m/min for 60 min daily, 4 times/week) for 8 weeks. Compared with the CC group, the levels of the autophagy-related factors BNIP3, Beclin 1, LC3-II/I ratio, p62, and FOXO3a in the gastrocnemius and soleus muscles were significantly decreased in the CRE and CAE groups. The CRE and CAE groups further showed significantly decreased MuRF 1 and Atrogin-1 levels and increased phosphorylation of AKT, FOXO3a, and PGC1-α. These results suggest that both ladder and aerobic exercise directly affected muscle wasting by modulating the AKT/PGC1-α/FOXO3a signaling pathways regardless of the skeletal muscle type.

• Clinical and Experimental Reproductive Medicine
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• 제50권3호
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• pp.170-176
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• 2023

Objective: Autophagy is highly active in ovariectomized mice experiencing hormone deprivation, especially in the uterine mesenchyme. Autophagy is responsible for the turnover of vasoactive factors in the uterus, which was demonstrated in anti-Müllerian hormone receptor type 2 receptor (Amhr2)-Cre-driven autophagy-related gene 7 (Atg7) knockout (Amhr-Cre/Atg7^f/f mice). In that study, we uncovered a striking difference in the amount of sequestosome 1 (SQSTM1) accumulation between virgin mice and breeder mice with the same genotype. Herein, we aimed to determine whether repeated breeding changed the composition of mesenchymal cell populations in the uterine stroma. Methods: All female mice used in this study were of the same genotype. Atg7 was deleted by Amhr2 promoter-driven Cre recombinase in the uterine stroma and myometrium, except for a triangular stromal region on the mesometrial side. Amhr-Cre/Atg7^f/f female mice were divided into two groups: virgin mice with no mating history and aged between 11 and 12 months, and breeder mice with at least 6-month breeding cycles with multiple pregnancies and aged around 12 months. The uteri were used for Western blotting and immunofluorescence staining. Results: SQSTM1 accumulation, representing Atg7 deletion and halted autophagy, was much higher in virgin mice than in breeders. Breeders showed reduced accumulation of several vasoconstrictive factors, which are potential autophagy targets, in the uterus, suggesting that the uterine stroma was repopulated with autophagy-intact cells during repeated pregnancies. Conclusion: Multiple pregnancies seem to have improved the uterine environment by replacing autophagy-deficient cells with autophagy-intact cells, providing evidence of cell mixing.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제30권2호
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• pp.15-22
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• 2024

Purpose: In general, cross-infection caused by bacteria occurs more in hospitals than in local communities. In most cases, infectious diseases spread through contact transmission (direct contact, indirect contact). This study tries to examine which places are most likely to detect infections bacteria and what materials should be used to effectively suppress the spread of infectious bacteria. Methods: Domestic and international literature have been reviewed to determine which bacteria are common and spread in which places. At the same time, antibacterial experiments for several finishing materials are performed to determine the survival period of bacteria for each material. The experiment is conducted mainly on antibiotic-resistant bacteria (MRSA, CRE, etc.) that have a high mortality rate and are very contagious. Results: MRSA has a high incidence in many hospital departments with surgery or immunocompromised patients, such as the elderly, organ transplant patients, and hemodialysis patients. There are experimental results that MRSA dies early in ceramics or silk wallpaper. CRE has a high incidence in hospital departments where there are many patients who are prone to bacteria entering the body directly, such as ventilator patients or critically ill patients with surgical wounds. There are experimental results that CRE dies early in silk wallpaper. In addition, bacteria die on the surface for a variety of reasons. Most MRSA and CRE develop in patients with impaired immunity or surgery, and rapidly die in copper or materials with antibacterial properties. Implications: If finishing materials surface with the ability to kill specific bacteria is used in the place where a large number of specific bacteria are detected, the spread of infectious diseases can be effectively controlled.

• 한국수정란이식학회지
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• 제29권2호
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• pp.195-200
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• 2014

Endothelin 2 (EDN2) induces follicular rupture by constricting periovulatory follicles. In this study, it was investigated the mechanisms of EDN2 action on follicular rupture with respect of receptor using the conditionally granulosa cell specific EDN2 receptor type A (ETa) KO mice (gcETaKO; $ETa^{flox/-}{\cdot}Amhr2^{Cre}$). It was generated the gcETaKO mice by breeding with $ETa^{flox/-}$ mice after mono-alleic ETa knockout by $ZP3^{Cre}$ and $Amhr2^{Cre}$ mice. Fertility, ovulation and maturation rates of ovulated oocytes after super ovulation were investigated in the gcETaKO mice compared with wild-type mice ($ETa^{flox/flox}$ and $ETa^{flox/-}$) as a control group. In the gcETaKO mice, normal fertility after breeding with male mice was shown compared with wild-type mice. And, there was no significant differences in ovulation rates after super ovulation, however its maturation rates was lower than that of wild type mice. These findings show that EDN2 in follicular rupture for ovulation is related with an other ETa not in granulosa cells. Further studies are needed to investigate how EDN2 is acted in ovarian follicular rupture for ovulation.