• Asian-Australasian Journal of Animal Sciences
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• 제11권4호
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• pp.428-433
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• 1998

The effects of chromium picolinate supplementation in pig diet were evaluated by measuring the in vitro lipogenic and lipolytic activities in adipose tissue and the protein synthetic activity in liver acinar cell in culture. Thirty-two male and thirty-two female pigs were randomly assigned to one of four dietary groups: Control, 100 ppb, 200 ppb, and 400 ppb of Cr in the form of picolinate. The chromium picolinate supplementation (p < 0.01) increased the in vitro lipolytic activity in adipose tissue of pig, but had no effects on lipogenesis. The chromium picolinate effect was greater in female pigs than in male pigs on lipolytic activity. The results from the studies with the liver acinar cells in culture indicated that chromium picolinate supplementation increased protein synthetic activity (p < 0.05). It was observed through this experiment that chromium picolinate functions not only on fat degradation but also on retained protein synthesis.

• Journal of Welding and Joining
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• 제32권6호
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• pp.35-40
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• 2014

The contact tip for gas metal arc welding has important functions to transmit the welding current to the wire and to guide the wire to molten pool. If the contact tip is damaged, it is a cause of lowering the welding productivity due to removal of welding defects and replacement of contact tip. In case of the use of a contact tip for a long time the arc is unstable because the processed hole in the contact tip center is larger, and the variation of aiming position of the welding wire causes a seam tracking error. In this study, gas metal arc welding experiments using contact tip of three different materials were performed. The contact tips with Cu-P, Cu-Cr, and Cu-ODS were used at the experiments, and the welding characteristics by each contact tip were evaluated. After welding contact tip appearance, welding spatter adhesion amount of the nozzle, and weld bead appearance were evaluated. The welding current and welding voltage were measured to verify arc stability during arc welding.

• 한국재료학회지
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• 제19권11호
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• pp.619-624
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• 2009

Titanium alloys have been attractive due to a high ratio of strength to weight as well as good corrosion resistance. However, strengthening causes a decrease in ductility in Ti alloys, as is usual in other alloys. For enhanced strength without ductility reduction, grain refinement and tensile properties were investigated as functions of thickness reduction of cold rolling and annealing condition in Ti-15V-3Cr-3Sn-3Al alloy with a ${\beta}$ single phase. The average grain size of the specimen, which was cold-rolled by 90% and annealed at 700$^{\circ}C$ for 5 min, was decreased to approximately 19 ${\mu}m$. The grain refinement of 63 μm to 19 ${\mu}m$ increased yield stress by 90 MPa without a significant decrease in total elongation. The Ti-15-3 alloy exhibited very low work hardening during tensile test at a crosshead speed of 2 mm/min. This result was discussed based on dynamic recovery associated with dislocation annihilation in grain boundaries.

• Molecular & Cellular Toxicology
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• 제3권4호
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• pp.231-237
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• 2007

Exposure to DNA-damaging agents can elicit a variety of stress-related responses that may alter the expression of genes associated with numerous biological pathways. We used 19 k whole human genome chip to detect gene expression profiles and potential signature genes in human normal hepatocytes (THLE-3) by treatment of five direct acting mutagens, furylfuramide (AF-2), N-nitroso-N-methylurea (MNU), methylmethanesulfonate (MMS), 4-nitroquinoline-N-oxide (4-NQO) and 2-nitrofluorene (2NF) of the $IC_{20}$ concentration for 3 h. Fifty one up-regulated common genes and 45 down-regulated common genes above 1.5-fold by five direct-acting mutagens were identified by clustering analysis. Many of these changed genes have some association with apoptosis, control of cell cycle, regulation of transcription and signal transduction. Genes related to these functions, as TP73L, E2F5, MST016, SOX5, MAFB, LIF, SII3, TFIIS, EMR1, CYTL1, CX3CR1 and RHOH are up-regulated. Down-regulated genes are ALOX15B, xs155, IFITM1, BATF, VAV2, CD79A, DCDC2, TNFSF8 and KOX8. We suggest that gene expression profiling on mutagens by toxicogenomic analysis affords promising opportunities to reveal potential new mechanistic markers of genotoxicity.

• Fisheries and Aquatic Sciences
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• 제13권2호
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• pp.112-117
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• 2010

Altered mRNA expression of two metallothionein isoforms (MT-IA and MT-IB) in response to acute heavy metal exposure was examined in mud loach, Misgurnus mizolepis, fry using a real-time RTPCR assay. Sublethal exposure (1 or 5 ${\mu}M$) to Cd, Cr, Fe, Mn, Ni, and Zn resulted in highly variable transcriptional responses of the two MT isoforms to the heavy metal ions, including upregulation, a steady state, and downregulation. Overall, the most potent inducer of both MT isoforms was Cd (up to 6-fold). Another exposure experiment using a series of doses of Cu revealed that the stimulation patterns of the two MT isoforms differed: MT-IA transcription was soon saturated at higher concentrations (about 2-fold at 1-4 ${\mu}M$ of Cu), whereas the activation of MT-IB was more dependent on the treatment dose (increased up to 5-fold at 3 ${\mu}M$). The isoform-specific allotment of constitutive and inducible functions was not as clear in fry as in adult tissues. Coordinated interaction between the MT-IA and MT-IB isoforms was hypothesized based on the finding that MT-IA represented a primary action under 'less stressful' or 'sublethal' conditions, whereas the activation of MT-IB became important under 'more stressful' or 'lethal' circumstances in this species.

• 한국정보통신학회논문지
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• 제9권3호
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• pp.467-472
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• 2005

많은 임상적 상태에서 ECG신호는 진단을 목적으로 기록된다. 또한 정확한 임상해석을 위해 데이터는 높은 해상도와 샘플링율이 필요하다. 따라서 본 논문에서는 다중웨이브렛 기저함수를 이용한 심전도 압축구조를 설계하여 기존의 단일 웨이브렛 기저함수와 이산 코사인 변환과 비교 분석하였다. 실험의 객관성을 위해 MIT-BIH 데이터 베이스중에서 분해도가 11[bit]이고 샘플링 주파수가 360[Hz]인 부정맥 데이터를 이용하여 모의 실험하였다. 성능평가는 재생오차에 대한 압축율로 평가하였다. 결과적으로 다중웨이브렛 기저함수를 이용한 심전도 압축구조에서 DCT보다 2배 이상의 좋은 성능평가 결과를 보였다.

• Journal of Electrical Engineering and information Science
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• 제2권5호
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• pp.9-16
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• 1997

This paper describes the design of a multistandard video encoder. The proposed encoder accepts conventional NTSC/PAL video signals, It also processes he PAL-plus video signal which is now popular in Europe. The encoder consists of five major building functions which are letter-box converter, color space converter, digital filters, color modulator and timing generator. In order to support multistandard video signals, a programmable systolic architecture is adopted in designing various digital filters. Interpolation digital filters are also used to enhance signal-to-noise ratio of encoded video signals. The input to the encoder can be either YCbCr signal or RGB signal. The outputs re luminance(Y), chrominance(C), and composite video baseband(Y+C) signals. The architecture of the encoder is defined by using Matlab program and is modelled by using Veriflog-HDL language. The overall operation is verified by using various video signals, such as color bar patterns, ramp signals, and so on. The encoder contains 42K gates and is implemented by using 0.6um CMOS process.

• 한국정보처리학회논문지
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• 제6권7호
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• pp.1941-1954
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• 1999

본 논문은 ITU-T 통신 처리 시스템용 프로그래밍 언어 CHILL에서 제공되는 병행처리 기능을 적용하기 위한 CHILL 실행시간 지원 시스템(CRS : CHILL Run-time support System)의 설계 및 구현에 관한 연구이다. CHILL은 다른 병행 프로그래밍 언어에 비해 다양한 병행처리 기능들을 제공하고 있기 때문에, CRS의 설계는 병행처리 기능의 인터페이스 규격을 설계한다. CHILL의 병행처리 프리미티브는 프로시듀어 호출 형식으로 사용하도록 라이브러리 방식을 사용하며, CHILL 프로세스의 실행을 병행적으로 제어하기 위해 CHILL 프로그램 구동 루팀 및 문맥 교환부와 CHILL 프로세스 제어부를 구현한다.

• Journal of Welding and Joining
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• 제23권6호
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• pp.61-66
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• 2005

A probabilistic approach for evaluating failure risk is suggested in this paper. Probabilistic fracture analyses were performed for a pressurized pipe of a Cr-Mo steel reflecting variation of material properties at high temperature. A crack was assumed to be located along the weld fusion line. Probability density functions of major variables were determined by statistical analyses of material creep and creep crack growth data measured by the previous experimental studies by authors. Distributions of these variables were implemented in Monte Carlo simulation of this study. As a fracture parameter for characterizing growth of a fusion line crack between two materials with different creep properties, $C_t$ normalized with $C^*$ was employed. And the elapsed time was also normalized with tT, Resultingly, failure probability as a function of operating time was evaluated fur various cases. Conventional deterministic life assessment result was turned out to be conservative compared with that of probabilistic result. Sensitivity analysis for each input variable was conducted to understand the most influencing variable to the analysis results. Internal pressure, creep crack growth coefficient and creep coefficient were more sensitive to failure probability than other variables.

• Tuberculosis and Respiratory Diseases
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• 제39권3호
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• pp.228-235
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• 1992

연구배경 : 다형핵구는 폐조직세포들을 방어하는데도 중요한 역할을 하지만, 방어기전을 수행하는 과정에서 오히려 폐조직세포들의 손상을 초래하기도 한다. 그러나 다형핵구에 의한 폐조직세포 손상이, 폐조직세포들에 대한 다형핵구의 직접적인 세포득성작용에 의한 것인지, 혹은 다형핵구로부터 유리되는 어떤 세포독성 매개물질에 의한 것인치에 대해서는 아직 불확실하다. 한편 histamine은 알레르기성 질환 및 일부 호흡기질환의 병인에 중요한 매개물질로 작용하기도 하지만, 다형핵구의 여러 기능들을 조절하는 작용도 하는 것으로 알려져 있다. 따라서 저자를온 다형핵구에 의한 폐조직세포의 손상기전을 보다 명확히 이해하고, 이에 대한 히스타민의 영향을 연구하기 위해 본 연구를 시작하였다. 방법 : $^{51}Cr$을 부착시킨 A549 폐포세포와 4명의 건강한 비흡연자들의 말초 정맥혈로부터 분리한 다형핵구 혹은 다형핵구 상충액을 함께 배양하여 발생되는 폐포세포 손상정도를 $^{51}Cr$-release assay로 측정하여 비교하는 한편, 각각의 경우에 다형핵구를 histamine으로 전처치함으로써 나타나는 변화를 관찰하였다. 결과 : 1) 세포자극제의 종류와 농도 및 전처치한 히스타민의 농도에 따라 다소 차이는 있었지만, 전반적으로 다형핵구 자체에 의한 폐포세포 손상 정도보다는, 다형핵구상충액에 의한 폐포세포 손상 정도가 더 심한 경향을 보였다. 2) Histamine으로 전처치한 다형핵구 자체에 의한 폐포세포 손상 정도는, HBSS만으로 전처치한 다형핵 자체에 의한 폐포세포 손상 정도에 비해, 전처치한 histamine의 농도와 다형핵구 자극제의 종류 및 농도에 따라 억제 혹은 증강되는 일정치 않은 양상을 나타냈다. 3) Histamine으로 전처치한 다형핵구의 상층액에 의한 폐포세포 손상 정도는, HBSS만으로 전처치한 다형핵구의 상층액에 의한 폐포세포 손상 정도에 비해, 전반적으로 억제되는 경향이 있었다. 결론 : 이상의 연구결과 다형핵구에 의한 폐세포 손상은, 다형핵구의 폐포세포에 대한 직접적인 세포독성 작용보다는 활성화된 다형핵구로부터 분비되는 어떤 세포독성 물질들에 의해 매개되는 것으로 생각되며, histamine은 정상적으로는 다형핵구의 세포독성작용을 억제하나, 다형핵구와 폐포세포간의 상호작용시에는 주위의 미세환경에 따라 다르게 작용할 수도 있을 것으로 추측된다.