• Korean Journal of Biological Psychiatry
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• v.6 no.1
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• pp.111-118
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• 1999

Objectives : There have been several evidences that the central nervous system defect is one of the etiologic factors in schizophrenia and high nailfold plexus visibility can reflect these defects indirectly. These are particularly related to the negative symptoms of schizophrenia. In this study, we examined the relationship between nailfold plexus visibility and various clinical variables in schizophrenia. Methods : Forty patients(20 males, 20 females) satisfying the DSM-lV criteria for schizophrenia and forty normal controls(20 males, 20 females) were measured for Plexus Visualization Score (PVS) by using capillary microscopic examination. We used Positive and Negative Syndrome Scale(PANSS), Ulmann-Giovannoni Process-Reactive Questi-onnaire(PRQ), Phillips Premorbid Adjustment Scale(PAS), Continuous Performance Test, and Backward Masking for psychopathology and clinical variables. Results : There was no significant relationship between schizophrenic subjects and normal controls in PVS. PVS was correlated with PANSS positively except negative symptom subscore. PVS was correlated with PRQ score negatively, and with PAS score positively. Conclusions : This study shows high PVS are associated with more severe psychotic symptoms and with clinical variables, such as disease process and premorbid adjustment, in some schizophrenics.

• Journal of Microbiology and Biotechnology
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• v.27 no.3
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• pp.633-643
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• 2017

To examine the pro-apoptotic role of the human ortholog (YPEL5) of the Drosophila Yippee protein, the cell viability of Saccharomyces cerevisiae mutant strain with deleted MOH1, the yeast ortholog, was compared with that of the wild-type (WT)-MOH1 strain after exposure to different apoptogenic stimulants, including UV irradiation, methyl methanesulfonate (MMS), camptothecin (CPT), heat shock, and hyperosmotic shock. The $moh1{\Delta}$ mutant exhibited enhanced cell viability compared with the WT-MOH1 strain when treated with lethal UV irradiation, 1.8 mM MMS, $100{\mu}M$ CPT, heat shock at $50^{\circ}C$, or 1.2 M KCl. At the same time, the level of Moh1 protein was commonly up-regulated in the WT-MOH1 strain as was that of Ynk1 protein, which is known as a marker for DNA damage. Although the enhanced UV resistance of the $moh1{\Delta}$ mutant largely disappeared following transformation with the yeast MOH1 gene or one of the human YPEL1-YPEL5 genes, the transformant bearing pYES2-YPEL5 was more sensitive to lethal UV irradiation and its UV sensitivity was similar to that of the WT-MOH1 strain. Under these conditions, the UV irradiation-induced apoptotic events, such as FITC-Annexin V stainability, mitochondrial membrane potential (${\Delta}{\psi}m$) loss, and metacaspase activation, occurred to a much lesser extent in the $moh1{\Delta}$ mutant compared with the WT-MOH1 strain and the mutant strain bearing pYES2-MOH1 or pYES2-YPEL5. These results demonstrate the functional conservation between yeast Moh1 and human YPEL5, and their involvement in mitochondria-dependent apoptosis induced by DNA damage.

• Journal of Korean Society of Forest Science
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• v.104 no.1
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• pp.67-75
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• 2015

This research is to investigate the four years growth mountain-cultivated ginseng ripened twenty-two weeks into four years fermented persimmon vinegar (tentatively: Sansamcho) ingestion on obese-related factors during dietary control. The Sansamcho was ingested orally, two times a day, after every meal for six weeks to the male rats. Groups were divided into the control (CON), the restricted diet (RD), and the weight cycling (WC). And, each groups has its own sub-groups as the -control (-CON), 2.5 times diluted Sansamcho ingestion (-MPV2.5), and 5.0 times diluted Sansamcho ingestion (-MPV5.0) groups, respectively. The number of rat was consisted of seven in each group. After six weeks rearing periods was done, abdominal fats (retroperitoneal fat, mesentery fat, and epididymal fat) and energy metabolic-related protein (AMPK: AMP-activated protein kinase; PPAR-${\alpha}$: peroxisome proliferator-activated receptor-${\alpha}$; and CPT-1: carnitine palmitoyltransferase-1) were weighed and analyzed. Amount of stored fat was significantly or tended to decrease by Sansamcho ingestion. In addition, sum of fats increasing were suppressed by the material. On the contrary, energy metabolism-related protein expression was significantly increased or tended to increase by Sansamcho ingestion. This results suggested that increased energy metabolism using Sansamcho was restrained effectively visceral fat store by high-fat diet and/or dietary control. In other words, it has a good function to suppress weight cycling which is the most insoluble problem. Therefore, the fusion material, Sansamcho, may expect to utilize as the obese-suppression-food.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.359_360
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• 2009

KEPCO signed up with LS CABLE as a contractor for HVDC submarine cable construction in February 2009. The desk research has been completed in may 2009. Also, Cable route and the protection method will be selected by November 2009. The tentative cable route between Jindo and Jeju which is consisted of sea farms and shipping route zone will reach almost 105km. The oceanographic survey for the selection of protection method will be carried out and the survey lists are consisted of MBES, SSS, CPT, ADSP. The protection methods such as burial, Concrete Mattress, UP Pipe, Rock Berm will be selected as per each condition of sea area after the oceanographic survey is completed. Kepco has developed variable methods based on the maintenance experience for HVDC submarine cable between HAENAM and JEJU. Based on the such a accumulated know-how, it can be expected for the confidence and stability of the 2nd HVC project to be improved.

• Journal of the Korean Geotechnical Society
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• v.16 no.2
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• pp.13-22
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• 2000

서해안에 위치한 특정 연구현장에서 연약지반의 압밀거동을 파악하기 위한 소산시험을 포함한 콘관입시험을 수행했다. 연구현장에서 시험시공으로 적용한 연약지반개량공법으로는 압성토공법, 두 종류의 페이퍼드레인 공법, 팩드레인 공법이었으며 각각의 공법들에 있어 현장에서의 지반개량에 따른 압밀거동을 판정하기 위해서 적용되었다. 콘관입시험은 근본적으로 지반개량 전과 후에 보링, 표준관입시험, 압밀시험과 함께 수행되었다. 실내실험과 피조콘관입시험을 비교한 결과, 연약지반의 표층에서는 상당한 지반개량효과가 있었으나 표층아래 심층지반에서는 그렇치 않았다. 그리고 지반개량 후, 10개월이 지난 시점에 압밀시험과 소산시험 결과를 통하여 분석한 수평압밀계수는 압성토 방법을 제외한 3가지 개량공법을 적용한 지점에서 압밀계수는 감소하여 개량효과를 간접적으로 판단할 수 있었다.

• Smart Structures and Systems
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• v.15 no.5
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• pp.1345-1362
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• 2015

The present paper deals with the free vibration analysis of the functionally graded solid and annular circular plates with two functionally graded piezoelectric layers at top and bottom subjected to an electric field. Classical plate theory (CPT) is used for description of the all deformation components based on a symmetric distribution. All the mechanical and electrical properties except Poisson's ratio can vary continuously along the thickness direction of the plate. The properties of plate core can vary from metal at bottom to ceramic at top. The effect of non homogeneous index of functionally graded and functionally graded piezoelectric sections can be considered on the results of the system. $1^{st}$ and $2^{nd}$ modes of natural frequencies of the system have been evaluated for both solid and annular circular plates, individually.

• Proceedings of the KSR Conference
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• 1999.11a
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• pp.172-180
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• 1999

The major subject of this paper is to develop the concept fur a Korea high speed train system and recommend to train configuration. High speed train configurations are basically concerned traction power(train configurations with concentrated; CPT or distributed Power system: DPT) and train design(single car as compared with articulated bogies). The result of configuration, a advantages and disadvantaged were necessitated by different train configurations; -distributed underfloor power have an increased length for the seats by 15% as compared with the concentrated power trait - articulated trainsets are characterised by less of number of bogies and reduced values of mass, train resistance, noise and vibration. from the result, the optimized train concept combining high seat capacity per train length with low weight and train resistance is 400m long, single -floor train composed of two symmetrically arranged half trainsets. Therefore, at this work recommended distributed train system However, the final decision of Korea high speed train configuration was concentrated power train and articulated bogie system. The configuration of trainset was 20cars included 2 power cars, 4 motorized cars and 14 trailer cars.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.2
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• pp.141-148
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• 2010

The bilateral sagittal split ramus osteotomy (BSSRO) is preferred method of surgical correction for mandibular prognathism, retrognathism and asymmetry. This technique performed from primarily an intraoral incision to avoid a scar. After forward movement of the distal segment of the mandible, healing of bone by primary or secondary intention is easily accomplished through large areas of cancellous bony overlap. When rigid fixation is used for the BSSRO, it is possible to open the mouth during the immediate post-operative period because it promotes the healing process. Although this surgical procedure has been well-documented, the incidence of postoperative trigeminal neurosensory disorder in the region of the inferior alveolar nerve and the mental nerve remains one of the major complication. However, evaluation of objective methods for sensory recovery patterns is insufficient although most patients find their sensory return. Neurometer electrodiagnostic device performs automated neuroselective sensory nerve conduction threshold evaluation by determining current perception threshold (CPT) measures. The purpose of this study was to evaluate the sensory recovery patterns of inferior alveolar and mental nerve over time. Nerve examination with a neurometer was performed in 30 patients undergoing the BSSRO at pre-operative, post-operative 1-, 2-, 4- week, and 2-, 3-, 4-, 5-, 6- month follow-up visits after the osteotomy to compare the differences of nerve injury and recovery patterns after the BSSRO with or without genioplasty and sensory recovery patterns associated with the kind of nerve fiber.

• Journal of Oral Medicine and Pain
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• v.32 no.2
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• pp.219-225
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• 2007

This investigation was carried out to evaluate the effect of pain control temporomandibular disorders with clinical application of capsaicin cream. 20 healthy subjects without systemic diseases were measured in current perception threshold and pain tolerance threshold with $Neurometer^{(R)}$ CPT/C (Neurotron, Inc. Baltimore, Maryland, USA) after cold pack, 0.025% capsaicin and 0.075% capsaicin cream application. The obtained results were as follows : 1. The current perception threshold of C-fiber was significantly higher to the baseline on. There were significantly increased in C- fiber current perception threshold of 0.025% capsaicin cream and 0.075% capsaicin cream application comparison to cold pack. 2. There was significantly increased in pain tolerance threshold of cold pack and 0.075% capsaicin application comparison to one of baseline as $A{\beta}$-fiber, There was significantly higher after cold pack and 0.025% capsaicin cream application than baseline as $A{\delta}$-fiber. In C-fiber case, 0.025% capsaicin application's was significantly increased than baseline one. 3.There were significantly higher C-fiber of 0.075% capsaicin application than baseline in visual analogue scale marking pain level of pain tolerance threshold.

• Korean Journal of Pharmacognosy
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• v.25 no.2
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• pp.144-152
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• 1994

The combined effects of Ulmi Cortex and some anti-cancer drugs on the proliferation of HeLa cells, Hep G2 cells and S 180 cells were estimated by MTT calorimetric assay. The n-BuOH fraction(UBF) of Ulmi Cortex inhibited the proliferation of HeLa cell at $10^{-3}\;g/ml$, Hep G2 cell at $10^{-5}\;g/ml$ and S 180 cell at $10^{-3}\;g/ml$. The inhibitory effects of mitomycin C(MMC), cisplatin(CPT) and 5-fluorouracil (5-FU), respectively, on Hep G2 cell was increased by the UBF. The UBF did not influence the proliferation of Balb/c 3T3 cells at concentrations of $10^{-6}$ to $10^{-4}\;g/ml$, but increased the proliferation of T cells at concentrations of $10^{-5}$ to $10^{-4}\;g/ml$. The UBF did not influence the number of leukocyte, and on the thymus weight of mice. The UBF increased the number of total-peritoreal cells of mice. In conclusion, the results suggest that the UBF have anti-cancer activity without the side effect, such as leukopenia and immunosuppresion, and increase the inhibitory activity of the anti-cancer drugs on Hep G2 cells.