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http://dx.doi.org/10.14578/jkfs.2015.104.1.67

Mountain-cultivated Ginseng Ripened into Persimmon Vinegar Ingestion on Fat Storage and Metabolic Protein Expression in Diet-controlled Rats  

Lee, In-Ho (Department of Leisure Sports, Kyungpook National University)
Kim, Pan-Ki (School of Ecological & Environmental Systems, Kyungpook National University)
Ryu, Sungpil (Department of Leisure Sports, Kyungpook National University)
Publication Information
Journal of Korean Society of Forest Science / v.104, no.1, 2015 , pp. 67-75 More about this Journal
Abstract
This research is to investigate the four years growth mountain-cultivated ginseng ripened twenty-two weeks into four years fermented persimmon vinegar (tentatively: Sansamcho) ingestion on obese-related factors during dietary control. The Sansamcho was ingested orally, two times a day, after every meal for six weeks to the male rats. Groups were divided into the control (CON), the restricted diet (RD), and the weight cycling (WC). And, each groups has its own sub-groups as the -control (-CON), 2.5 times diluted Sansamcho ingestion (-MPV2.5), and 5.0 times diluted Sansamcho ingestion (-MPV5.0) groups, respectively. The number of rat was consisted of seven in each group. After six weeks rearing periods was done, abdominal fats (retroperitoneal fat, mesentery fat, and epididymal fat) and energy metabolic-related protein (AMPK: AMP-activated protein kinase; PPAR-${\alpha}$: peroxisome proliferator-activated receptor-${\alpha}$; and CPT-1: carnitine palmitoyltransferase-1) were weighed and analyzed. Amount of stored fat was significantly or tended to decrease by Sansamcho ingestion. In addition, sum of fats increasing were suppressed by the material. On the contrary, energy metabolism-related protein expression was significantly increased or tended to increase by Sansamcho ingestion. This results suggested that increased energy metabolism using Sansamcho was restrained effectively visceral fat store by high-fat diet and/or dietary control. In other words, it has a good function to suppress weight cycling which is the most insoluble problem. Therefore, the fusion material, Sansamcho, may expect to utilize as the obese-suppression-food.
Keywords
mountain-cultivated ginseng; persimmon vinegar; lipid metabolism; obese; dietary restriction;
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1 Balogh, J., Vizhul, A., Dunkin, B.J., Tariq, N., and Sherman, V. 2014. Clinical management of patients presenting with non-adjustable gastric band (NAGB) complications. Yale Journal of Biology and Medicine 87(2): 159-166.
2 Barbosa-da-Silva, S., da Silva, N.C., Aguila, M.B., and Mandarim-de-Lacerda, C.A. 2013. Liver damage is not reversed during the lean period in diet-induced weight cycling in mice. Journal of Gastroenterology and Hepatology Research doi: 10.1111/hepr.12138.   DOI
3 Brockman, D.A., Chen, X., and Gallaher, D.D. 2014. Highviscosity dietary fibers reduce adiposity and decrease hepatic steatosis in rats fed a high-fat diet. Journal of Nutrition pii: jn.114.191577.
4 Calzada, J., DeOlmo, A., Picon, A., Gaya, P., and Nunez, M. 2013. High-pressure processing decelerates lipolysis and formation of volatile compounds in ovine milk blue-veined cheese. Journal of Dairy Science 96(12): 7500-7510.   DOI
5 Dankel, S.N., Degerud, E.M., Borkowski, K., Fjaere, E., Midtbo, L.K., Haugen, C., Solsvik, M.H., Lavigne, A.M., Liaset, B., Sagen, J.V., Kristiansen, K., Mellgren, G., and Madsen, L. 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism 306(2): 210-224.
6 de Castro, U.G., dos Santos, R.A., Silva, M.E., de Lima, W.G., Campagnole-Santos, M.J., and Alzamora, A.C. 2013. Agedependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats. Lipids in Health and Disease 12: 136.   DOI
7 Fang, Y., Qi, W., Ming, L., Wenbin, C., Yongfeng, S., Fei, J., Laicheng, W., Yanliang, L., Tao, B., Jie, Z., Tingting, W., Wei, X., Chunxiao, Y., Qingbo, G., Xinli, Z., Ling, G., Chao, X., and Jiajun, Z. 2014. Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity. Journal of Hepatology pii: S0168-8278(14)00468-1.
8 Gao, Y., Yang, M.F., Su, Y.P., Jiang, H.M., You, X.J., Yang, Y.J., and Zhang, H.L. 2013. Ginsenoside Re reduces insulin resistance through activation of PPAR- pathway and inhibition of TNF-a production. Journal of Ethnopharmacology 147(2): 509-516.   DOI   ScienceOn
9 Han, J.M., Kim, H.G., Lee, J.S., Choi, M.K., Kim, Y.A., and Son, C.G. 2014. Repeated sense of hunger leads to the development of visceral obesity and metabolic syndrome in a mouse model. PLoS One 9(5): e98276.   DOI
10 Hurt, R.T., Edakkanambeth, Varayil, J., and Ebbert, J.O. 2014. New pharmacological treatments for the management of obesity. Current Gastroenterology Reports 16(6): 394.   DOI
11 Hwang, J.T., Kim, S.H., Lee, M.S., Kim, S.H., Yang, H.J., Kim, M.J., Kim, H.S., Ha, J., Kim, M.S., and Kwon, D.Y. 2007. Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochemical and Biophysical Research Communication 364(4): 1002-1008.   DOI
12 Jauch-Chara, K., and Oltmanns, K.M. 2014. Obesity--a neuropsychological disease? Systematic review and neuropsychological model. Progress in Neurobiology 114: 84-101.   DOI
13 Kim, M.S., Lee, K.T., Iseli, T.J., Hoy, A.J., George, J., Grewal, T., and Roufogalis, B.D. 2013. Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International 33(10): 1583-1593.   DOI
14 Jeon, B.D., Kim, P.G., and Ryu, S. 2012. Change of ripened persimmon vinegar with mountain ginseng ingestion on energy metabolism in rats. Journal of Korean Forest Society 101(3): 517-525.
15 Jeon, B. D., Kim, P.G., and Ryu, S. 2013. Ripened persimmon vinegar with mountain-cultivated ginseng ingestion reduce blood lipids and enhance anti-oxidants capacity in rats. Journal of Korean Forest Society 102(2): 182-188.
16 Jung, M.H., Seong, P.N., Kim, M.H., Myong, N.H., 2013. Chang, M.J. Effect of green tea extract microencapsulation on hypertriglyceridemia and cardiovascular tissues in high fructose-fed rats. Nutrition Research and Practice 7(5): 366-372.   DOI
17 Kondo, T., Kishi, M., Fushimi, T., and Kaga, T. 2009. Acetic acid upregulates the expression of genes for fatty acid oxidation enzymes in liver to suppress body fat accumulation. Journal of Agricultural and Food Chemistry 57(13): 5982-5986.   DOI
18 Kwon, D.K., Kang, J.Y., Song, Y.J., Kim, P.G., Seo, H.B., and Ryu, S. 2012. Effects of mountain ginseng-added high fat diet on lipid peroxidation and antioxidant protein expression of skeletal muscle in rats. Journal of Korean Forest Society 101(1): 69-76.
19 Landa, V., Zidek, V., Mlejnek, P., Simakova, M., Silhavy, J., Trnovska, J., Kazdova, L., and Pravenec, M. Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats. Physiological research [Epub ahead of print].
20 Lee, G.R., Shin, M.K., Yoon, D.J., Kim, A.R., Yu, R., Park, N.H., and Han, I.S. 2013. Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity 21(1): 115-122.   DOI
21 Li, H., Min, Q., Ouyang, C., Lee, J., He, C., Zou, M.H., and Xie, Z. 2014. AMPK activation prevents excess nutrientinduced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response. Biochimica et Biophysica Acta pii: S0925-4439(14)00213-0.
22 Li, X., Chen, H., Guan, Y., Li, X., Lei, L., Liu, J., Yin, L., Liu, G., and Wang, Z. 2013. Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes. PLoS One 8(7): e67880.   DOI
23 Ludwig, T., Worsch, S., Heikenwalder, M., Daniel, H., Hauner, H., and Bader, B.L. 2013. Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice. American Journal of Physiology. Endocrinology and Metabolism. 304(11): 1140-1156.   DOI
24 McCarty, M.F. 2014. AMPK activation--protean potential for boosting healthspan. Age 36(2): 641-663.   DOI
25 Mori, M.A., Thomou, T., Boucher, J., Lee, K.Y., Lallukka, S., Kim, J.K., Torriani, M., Yki-Jarvinen, H., Grinspoon, S.K., Cypess, A.M., and Kahn, C.R. 2014. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. Journal of Clinical Investigation pii: 73468.
26 Ng, T.B., Wong, C.M., and Yeung, H.W. 1986. Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells. Journal of Ethnopharmacology 16(2-3): 191-199.   DOI
27 Ramage, S., Farmer, A., Apps E.ccles, K., and McCargar, L. 2014. Healthy strategies or successful weight loss and weight maintenance: a systematic review. Applied Physiology, Nutrition, and Metabolism 39(1): 1-20.   DOI
28 Ogawa, T., Shibato, J., Rakwal, R., Saito, T., Tamura, G., Kuwagata, M., and Shioda, S. 2014. Seeking genes responsible for developmental origins of health and disease from the fetal mouse liver following maternal food restriction. Congenital Anomalies doi: 10.1111/cga.12062.   DOI
29 Ok, E., Do, G.M., Lim, Y., Park, J.E., Park, Y.J., and Kwon, O. 2013. Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue. Lipids in Health and Disease 12: 163.   DOI
30 Pires, R.C., Souza, E.E., Vanzela, E.C., Ribeiro, R.A., Silva-Santos, J.C., Carneiro, E.M., Boschero, A.C., and Amaral, M.E. 2014. Short-term calorie restriction improves glucose homeostasis in old rats: involvement of AMPK. Applied Physiology, Nutrition, and Metabolism 21: 1-7.
31 Rame, J.E., Barouch, L.A., Sack, M.N., Lynn, E.G., Abu-Asab, M., Tsokos, M., Kern, S.J., Barb, J.J., Munson, P.J., Halushka, M.K., Miller, K.L., Fox-Talbot, K., Zhang, J., Hare, J.M., Solomon, M.A., and Danner, R.L. 2011. Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARa/PGC1a and thermogenic glycerolipid/fatty acid cycling. Physiological Genomics 43(12): 726-738.   DOI
32 Ryu, S., Kim, C., and Bae, E.H. 2013. Development of Antiobesity Foods and Programs by Using Fusion Ingredients of Mountain-cultivated Ginseng and Persimmon Vinegar. Forest Service Report pp. 2.
33 Seo, K.I., Lee, J., Choi, R.Y., Lee, H.I., Lee, J.H., Jeong, Y.K., Kim, M.J., and Lee, M.K. 2014. Anti-obesity and antiinsulin resistance effects of tomato vinegar beverage in diet-induced obese mice. Food & Function [Epub ahead of print]
34 Samms, R.J., Fowler, M.J., Cooper, S., Emmerson, P., Coskun, T., Adams, A.C., Kharitonenkov, A., Tsintzas, K., and Ebling, F.J. 2014. Photoperiodic regulation of FGF21 production in the Siberian hamster. Hormones and Behavior 66(1): 180-185.   DOI
35 Seo, H.B., Nam, J.O., Jeon, B.D., Kim, P.G., and Ryu, S. 2012. Persimmon Vinegar Ingestion before Endurance Exercise on Energy Substrates Utilization. Journal of Korean Forest Society 101(4): 626-634.
36 Seo, H.B., Song, Y.J., Kang, J.Y., Kwon, D.K., Kim, P.G., and Ryu, S. 2011. The study of persimmon vinegar as a functional drink on reduce blood lipids and enhance exercise performance. Journal of Korean Forest Society 100(2): 232-239.
37 Shang, W.B., Yu, X.Z., Wang, G.Q., and Zhao, J. 2013. Effect of ginsenoside Rb1 in ameliorating insulin resistance and ectopic fat deposition in obese mice induced by high fat diet. Zhongguo Zhong Yao Za Zhi 38(23): 4119-4123.
38 Shen, L., Xiong, Y., Wang, D.Q., Howles, P., Basford, J.E., Wang, J., Xiong, Y.Q., Hui, D.Y., Woods, S.C., and Liu, M. 2013. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. Journal of Lipid Research 54(5): 1430-1438.   DOI
39 Siraj, F.M., Sathishkumar, N., Kim, Y.J., Kim, S.Y., and Yang, D.C. 2014. Ginsenoside F2 possesses anti-obesity activity via binding with PPAR and inhibiting adipocyte differentiation in the 3T3-L1 cell line. Journal of Enzyme Inhibition and Medicinal Chemistry [Epub ahead of print]
40 Song, A., Wang, C., Ren, L., and Zhao, J. 2014. Swimming improves high-fat induced insulin resistance by regulating lipid and energy metabolism and the insulin pathway in rats. International Journal of Molecular Medicine 33(6): 1671-1679.
41 Torrens, J.M., Konieczna, J., Palou, M., Sanchez, J., Pico, C., and Palou, A. 2014. Early biomarkers identified in a rat model of a healthier phenotype based on early postnatal dietary intervention may predict the response to an obesogenic environment in adulthood. Journal of Nutritional Biochemistry 25(2): 208-218.   DOI
42 Tzeng, T.F., Lu, H.J., Liou, S.S., Chang, C.J., and Liu, I.M. 2012. Vinegar-Baked Radix Bupleuri regulates lipid disorders via a pathway dependent on peroxisome-proliferatoractivated receptor-a in high-fat-diet-induced obese rats. Evidence-based Complementary and Alternative Medicine 2012: 827278.
43 Wong, A.L., Seng, K.Y., Ong, E.M., Wang, L.Z., Oscar, H., Cordero, M.T., Copones, R., Fan, L., Tan, S.H., Goh, B.C., and Lee, S.C. 2014. Body fat composition impacts the hematologic toxicities and pharmacokinetics of doxorubicin in Asian breast cancer patients. Breast Cancer Research and Treatment 144(1): 143-152.   DOI