• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.99-106
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• 2017

Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley rats were fed with 60% fat diet or normal diet for 4 months. Body weight, plasma lipid profile, plasma Ang II level, BP, Ang II-induced vascular contraction, and expression of regulatory proteins modulating vascular contraction with/without Ang II stimulation were measured. As a result, high fat diet (HFD) accelerated age-dependent body weight gaining along with increased plasma Ang II concentration. It also increased BP and Ang II-induced aortic contraction. Basal expression of p-CPI-17 and myosin light chain (MLC) kinase was increased by HFD along with increased phosphorylation of MLC. Ang II-induced phosphorylation of CPI-17 and MLC were also higher in HFD group than control group. In conclusion HFD-induced hypertension is through at least in part by increased vascular contractility via increased expression and activation of contractile proteins and subsequent MLC phosphorylation induced by increased Ang II.

• Biomolecules & Therapeutics
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• 제2권1호
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• pp.59-64
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• 1994

The water extract of pilose antler of Cervus nippon var. mantchuricus (WEC) was investigated in respect of its effect on ceruloplasmin and $\alpha$$_1$-cysteine protease inhibitor (CPI), which are acute-phase proteins showing increased synthesis following inflammatory stimulus in rat. Ceruloplasmin and CPI were spectrophotometrically determined by the oxidase activity and the inhibitory activity on papain, respectively, and their changes in the concentrations in plasma or serum were examined after oral administration of 0.04% WEC to rats during 7 days following inflammation by subcutaneous injection of turpentine oil or lipopolysaccharide (LPS). WEC suppressed the maximum increases in ceruloplasmin and CPI on the 4th day after injection of turpentine oil, but the suppression in ceruloplasmin was more potent than that in CPI. On inflammation by LPS the suppression of the maximum increase in ceruloplasmin by WEC was found on the 2nd day, but the result was less significant from that obtained by the treatment with turpentine oil. Administration of WEC for at least 4 days was required to suppress the maximum increase in ceruloplasmin due to inflammation by turpentine oil. When WEC was administered to rats after injection of turpentine oil, a high dosage (0.36% of WEC) was requisite for the suppression on the maximum increase in ceruloplasmin.

• 대한치과의사협회지
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• 제54권10호
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• pp.752-770
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• 2016

Introduction: Caries prevention through diet control can be achieved clinically by use of the cariogenic potentiality for a range of food commonly eaten by Koreans. Material & methods: The cariogenic potentiality index of each food can be calculated with the sugar contents and the viscosity of each food applying the regression analysis on the variables. 278 favorite foods for Korean were examined. Result 1. The formula of CPI is as below Cariogenic potentiality index (CPI) = 2.581343*sugar contents+0.598324*viscosity 2. The average CPI of the fruits, vegetable are 9.07~9.62 minutes. But the average CPI of the carbohydrate food is 15.21~19.60 minutes. Conclusion: Using the cariogenic potentiality indices, we will be able to determine an individual patients' average oral status for caries experience in the future. In addition, diet control by use of the cariogenic potentiality index and the analysis for each nutrient is considered as useful clinically for diet control in preventive dentistry.

• Journal of the Korean Data and Information Science Society
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• 제23권3호
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• pp.535-542
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• 2012

소비자물가지수는 국가의 중요한 경제 척도 중의 하나이다. 본 연구에서는 4개 도시, 서울, 부산, 대구, 광주지역의 소비자물가지수를 연구하였다. 자료는 모두 통계청에서 발췌하였고, 기간은 1998년-2011년 월별자료이며, 시계열분석 기법인 자기회귀오차모형으로 분석하였다. 소비자물가 분석을 위한 설명변수는 9가지 경제변수인 경기동행지수, 미국환욜, 생산자물가지수, 원유수입단가, 원유수입물량, 국제경상수지, 수입물가지수, 실업율, 화폐통화량을 사용하였다. 분석 결과, 자기회귀오차모형으로 각 지역별 소비자물가지수를 46%-52% 정도 설명할 수 있다.

• Parasites, Hosts and Diseases
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• 제40권1호
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• pp.17-24
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• 2002

We have cloned a cDNA encoding a cysteine proteinase of the Acanthamoeba healui OC-3A strain isolated from the brain of a granulomatous amoebic encephalitis patient. A DNA probe for an A. healui cDNA library screening was amplified by PCR using degenerate oligonucleotide primers designed on the basis of conserved amino acids franking the active sites of cysteine and asparagine residues that are conserved in the eukaryotic cysteine proteinases. Cysteine proteinase gene of A. healui (AhCPI) was composed of 330 amino acids with signal sequence, a proposed pro-domain and a predicted active site made up of the catalytic residues, $Cys^{25},{\;}His^{159},{\;}and{\;}Asn^{175}$. Deduced amino acid sequence analysis indicates that AhCPI belong to ERFNIN subfamily of C 1 peptidases. By Northern blot analysis. no direct correlation was observed between AhCPI mRNA expression and virulence of Acanthamoeba, but the gene was expressed at higher level in amoebae isolated from soil than amoeba from clinical samples. These findings raise the possibility that AhCPI protein may play a role in protein metabolism and digestion of phagocytosed bacteria or host tissue debris rather than in invasion of amoebae into host tissue.

• Journal of Plant Biotechnology
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• 제36권4호
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• pp.407-414
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• 2009

A cDNA clone encoding phytocystatin was isolated from Brassica rapa seedlings, through rapid amplification of cDNA ends (RACE). This gene (name as Brcpi1; GenBank accession no.: EF079953) had a total length of 881 bp with an open reading frame of 609 bp, and encoded predicted polypeptide of 203 amino acid (aa) residues including a putative N-terminal signal peptide. Other relevant regions found its sequence included the G and PW conserved aa motifs, and the consensus LARFAV sequence for phytocystatins and the reactive site QVVAG. The BrCPI1 protein shared 95, 94, 81, 80 and 78% identity with other CPI proterins isolated from Brassica oleracea (BoCPI-1), Arabidopsis thaliana (AtCY SB), Glycine max (GmCPI), Oryza sativa (OsCYS-2) and Zea may (ZmCPI) at amino acid level, respectively. Southern blot analysis showed that Brcpi1 was a low copy gene. Expression pattern analysis revealed that Brcpi1 was a tissue-specific expressing gene during reproductive growth and strongly expressed at mature seedling stages. Furthermore, overexpression of Brcpi1 in transgenic Arabidopsis was enhanced tolerance to salt and cold stresses. Meanwhile the juvenile seedling of Brcpi1 transgenic plants was not affected by various concentrations ABA in MS medium. Taken together, the results showed that Brcpi1 functioned as a cysteine protease inhibitor and it exhibited a protective agent against diverse types of abiotic stress, which induced this gene in a tissue- and stress-specific manner.

• 반도체디스플레이기술학회지
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• 제21권1호
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• pp.79-84
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• 2022

As various flexible display products are released, the demand for high-performance colorless and transparent polyimide (CPI) film is continuously increasing. The primary purpose of this study is to establish a systematic procedure for optimizing the optical performance of CPI films by applying the response surface method. After selecting three key factors (monomer type, stirring time for varnish synthesis, and maximum temperature of vacuum furnace for film production) affecting optical performance based on experiences and references, CPI films were manufactured according to the experimental sequence designed by the central composite design, and then the yellowness index (YI) and optical transmittance (Tr) of the films were measured. When producing a CPI film by pouring varnish into a petri dish, the change in optical properties according to thickness should be considered, and there was a meaningful linear relationship between YI and Tr. The species of monomer and the maximum temperature were the critical factors that had an influence on YI and Tr, respectively. It is expected that the procedure proposed in this study can serve as a starting point for CPI film optimization studies considering the other factors that were not considered and responses such as thermal properties.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2002년도 학술대회지
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• pp.456-459
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• 2002

오늘날 건설공사의 효율화를 위한 EVMS(Earned Value Management System)도입의 중요성을 인식하고 많은 연구가 발표되고 있다. 그러나 EVMS를 도입한 공정에 대한 경험부족과 국내 건설의 제도적${\cdot}$환경적 요인으로 인해서, 기술적인 분석이나 사례분석에 대한 관한 연구는 아직 미흡한 실정이다. 본 연구에서는 EVMS를 도입한 공정상에 성과지수(SPI : Schedule Performance Index, CPI : Cost Performance Index)를 산정하여, 여러 통계적 분석방법을 적용해서 프로젝트 관리상에 일정, 비용상의 추세(Trend) 및 문제의 원인을 분석${\cdot}$연구하고자 한다.

• Journal of Computing Science and Engineering
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• 제8권1호
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• pp.34-42
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• 2014

Time-predictability of computing is critical for hard real-time and safety-critical systems. However, currently there is no metric available to quantitatively evaluate time-predictability, a feature crucial to the design of time-predictable processors. This paper first proposes the concept of architectural time-predictability, which separates the time variation due to hardware architectural/microarchitectural design from that due to software. We then propose the standard deviation of clock cycles per instruction (CPI), a new metric, to measure architectural time-predictability. Our experiments confirm that the standard deviation of CPI is an effective metric to evaluate and compare architectural time-predictability for different processors.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2001년도 춘계학술대회 논문집
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• pp.97-102
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• 2001

If the Seoul-Pusan high-speed rail project is able to open its revenue service in 2004, Korea will be the fifth country with an HSR system in the world. And, it will be recorded as a major milestone in the transportation history of Korea. But, Government regulated railroad fare because railroad fare increase can bring negative influences to CPI(Consumer Price Index). Consequently, Korea National Railroad cannot afford to operate railroad independently under current railroad fare system. In this paper, we studied the railroad fare system under implementation and its influences to CPI. And then we proposed that railroad fare must be decided by competition with other transportation modes and based on the demand variance by introducing YMS(Yield Management System).