• 생약학회지
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• 제48권2호
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• pp.119-124
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• 2017

Taraxacum platycarpum H. Dahl. (Compositae) has been used as an anti-inflammatory or anti-cancer agent in the clinic. Although its antidepressant effect has been reported, however, its cognitive function is not investigated until yet. In the present study, we investigated whether the water extract of T. platycarpum (WETP) could improve cognitive function in cholinergic blockade-induced amnesia mouse model using the passive avoidance or Y-maze task. WETP (12.5, 25 or 50 mg/kg) significantly ameliorated the scopolamine-induced cognitive impairment both in the passive avoidance test and the Y-maze test. In addition, WETP significantly inhibited acetylcholinesterase (AChE) activity measured by an ex vivo study using the mouse whole brain. These results suggest that WETP alleviates the cognitive dysfunction caused by the cholinergic blockade, in part, via AChE inhibition, and that it may be a useful for treating cognitive dysfunction.

• 한국임상수의학회지
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• 제24권2호
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• pp.125-129
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• 2007

Artemisia capillaris THUNB is a perennial herb that belongs to the family Compositae spp and the most common plant among the various herbal folk remedies used in treatment of abdominal pain, hepatitis, chronic liver disease, jaundice and coughing in Korea. This experiment was conducted to investigate the inhibitory effects of orally administrated Artemisia capillaris extracts on the pathogenic bacteria in 200 ICR mice. The experimental groups showed inhibitory effects on the bacteria in $1{\sim}3$ days after inoculation. After 21 days of inoculation, no viable bacterial cells appeared in the feces of both experimental groups while they did appear in the control group. The results of these studies indicate Artemisia capillaris extract exhibited excellent antimicrobial and inhibitory effects on the food poisoning pathogenic bacteria; S. enteritidis, E. coli O157:H7, L. monocytogenes and S. aureus.

• 생약학회지
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• 제35권1호통권136호
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• pp.35-40
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• 2004

Seven terpenoids, trans-phytol (1), ${\alpha}-spinasterol$ (2),${\beta}-sitosterol$ (3), oleanolic acid (4), traxasterol (5), ${\alpha}-spinasterol\;3-O-{\beta}-D-glucopyranoside$ (8), ${\beta}-spinasterol\;3-O-{\beta}-D-glucopyranoside$ (9), and three glycerides, 3-O-(9Z, 12Z, 15Z-octadecatrienoyl) glycerol (6), 3-O-(9Z, 12Z-octadecadienoyl) glycerol (7), 1, 2-O-(9Z, 12Z, 15Z-dioctadecatrienoyl)-3-O-${\beta}$- D-galactopyranosyl glycerol (10) were isolated from n-hexane fraction of the aerial parts of Saussurea nutans which was used as Korean traditional medicine to σeat rheumatic arthritis and dysmenorrhea. Their structures were established by chemical and spectroscopic methods.

• Toxicological Research
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• 제27권4호
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• pp.261-267
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• 2011

Artemisia iwayomogi, a member of the Compositae, is a perennial herb easily found in Korea and used as a traditional medicine to treat liver disease. AIP1, a water-soluble carbohydrate fraction from Artemisia iwayomogi, showed anti-tumor and immuno-modulating activities in animal studies. A subacute toxicological evaluation of AIP1 was performed for 4 weeks in ICR mice. After administration of AIP1 (0, 20, 100, 500 mg/kg/day), the clinical signs, mortalities, body weight changes, hematology, blood clinical biochemistry, urinalysis, organ histopathology, organ weights and gross finding were examined. The results showed that there were no significant differences in body weight changes, food intakes, water consumptions, or organ weights among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally treated with AIP1 and the control group, there was no statistical significance in hematological test or serum biochemical values. Histopathological examination showed no abnormal changes in AIP1 groups. These results suggest that no observed adverse effect level (NOAEL) of the oral administration of AIP1 for 4 weeks was considered to be more than 500 mg/kg/day in mice under the condition investigated in current study.

• Natural Product Sciences
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• 제8권4호
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• pp.133-136
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• 2002

GC-MS data on the volatile oil (CS-oil) of Chrysanthemum sibiricum herbs led to the identification of 2-methoxythioanisol, (+)-camphor, geraniol, citral, thymol, eugenol, ${\beta}-caryophyllene$ oxide, ${\beta}-caryophyllene$, ${\beta}-eudesmol$, juniper camphor together with an unknown substance using the mass spectral library and literature data. CS-oil exhibited significant cytotoxicities on HL-60 $(IC_{50}\;12.5\;{\mu}g/ml)$ cell and mild on HepG-2 cell $(IC_{50}\;102.4\;{\mu}g/ml)$, though the antioxidant ability was found not to be potent $(IC_{50}\;97.2\;{\mu}g/ml)$. However, the component eugenol showed potent antioxidant ability but mild cytotoxicity. Methyleugenol with no phenolic OH showed less potent cytotoxic and antioxidative properties than eugenol suggesting that phenolic OH plays an important role for the cytotoxic and antioxidant abilities. The oil-pretreatment prevented lipid peroxidation induced by bromobenzene in the rat. Therefore, it was demonstrated that CS-oil could be a cytotoxic agent with antioxidant properties.

• Journal of Species Research
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• 제10권2호
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• pp.159-163
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• 2021

Saussurea albifolia, a new species, is reported from the Baekdudaegan Mountains. It has distinctive morphological characteristics that distinguish it from other congeneric species of Saussurea in Korea; radical leaves persist or withered till flowering, white tomentose leaf beneath, campanulate involucre with brown-cobwebby hairs, and dark purplish phyllaries with acuminate tips. Saussurea albifolia is a new, endemic species, narrowly restricted to the Korean Peninsula as a consequence of adaptation to alpine or subalpine environments of the Baekdudaegan Area. Among the Korean species of Saussurea, S. gracilis Maxim., S. insularis Kitam., and S. seoulensis Nakai are morphologically similar to S. albifolia by having leaves with white hairs beneath and persistent radical leaves during blooming period. It has been well understood that Saussurea is one of the highly diversified and adaptable groups in Asteraceae and also that the currently recognized species in Korea likely significant underestimates its diversity on the Korean Peninsula.

• 생약학회지
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• 제50권2호
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• pp.96-101
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• 2019

Methanol extract of Helianthus tuberosus L. (Compositae) flower was investigated to research the anti-oxidative activity by using a Caenorhabditis elegans model system. Ethyl acetate soluble fraction of the methanol extract showed the most potent DPPH radical scavenging activity. The ethyl acetate fraction was measured on its activities of superoxide dismutase (SOD), catalase, and oxidative stress tolerance with reactive oxygen species (ROS) level in C. elegans. Furthermore, in order to verify if regulation of stress-response gene is responsible for the increased stress tolerance of C. elegans which treated by the ethyl acetate fraction, we checked SOD-3 expression using a transgenic strain. Consequently, the ethyl acetate fraction of H. tuberosus flower increased the catalase and SOD activities in a dose-dependent manner in C. elegans, reduced ROS accumulation dose-dependently. Besides, the ethyl acetate fraction-treated CF1553 worms showed higher SOD-3::GFP intensity than the control group.

• 생태와환경
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• 제54권2호
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• pp.142-150
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• 2021

To analyze the distribution characteristics of alien plants in various habitat types, 249 sites were selected from four administrative districts in the Gyeongsang region of Korea. The survey was conducted across nine different habitat types. A total of 115 species of alien plants were collected; comprising 23 families, 73 genera, 112 species, and 3 varieties. Species from the family Compositae were the most common at 33.0%. Raunkiaer's life forms had the highest occurrence rate with 70 species(60.9%) of therophytes(Th) followed by 30 species (26.1%) of hemicryptophytes (H) and 8 species (7.0%) of geophytes (G). The distributions of alien plant species per habitat type were: 81 species on the roadside; 80 species on vacant lots and artificial habitats; 67 species in streams; 53 species in grasslands; 47 species in cultivated lands; and 39 species on the coast. Since 2017, the number of alien plants has increased in Gyeongju-si, Cheongdo-gun, and Pohang-si, and decreased in Ulsan Metropolitan-si. In each region, 614 taxa were observed. The invasive alien species, Sicyos angulatus, Hypocaeris radicata, and Solanum carolinense, were observed for the first time and are expected to further increase the disturbance of the ecosystem.

• Journal of Applied Biological Chemistry
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• 제63권4호
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• pp.335-338
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• 2020

Artemisia iwayomogi (Compositae), a perennial mugwort, is native to Korea and widely distributed in Japan, Russia, and China. A. iwayomogi and A. capillaris are similar in morphology and pharmacological activity and have been used for the same medicinal purposes in Korea. While various ingredients such as coumarins and flavonoids and their activity studies have been reported for A. capillaris, few studies have been conducted on the pharmacologically active components of A. iwayomogi. In Korea, A. capillaris is not economical because only young leaves are used as a medicinal material. Because of this, A. iwayomogi is frequently used in Korea, indicating the need to study its pharmacologically active components. Therefore, a phytochemical study was initiated to isolate active compounds from the aerial parts of A. iwayomogi. Finally, four coumarins, umbelliferone (1), esculetin (2), grevillone (3), and scoparone (4) were isolated for the first time from the aerial parts of A. iwayomogi in this study.

• 대한본초학회지
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• 제24권4호
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• pp.121-126
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• 2009

Objectives : To evaluate the radical scavenging and acetylcholinesterase (AChE) inhibitory activities of the ethylacetate (EtOAc)-soluble portion of a methanolic extract of Aster yomena, three different assay systems were performed. Methods : The antioxidant activity of A. yomena extract was tested as its capacity to scavenging free radicals of DPPH and $ABTS^+$, which has been widely used to evaluate the antioxidant activity of natural products from plant sources. AChE inhibitory activity was tested against mouse brain AChE by spectrophotometric method of Ellman using ELISA microplate reader. Results : The methanolic extract of A. yomena was fractionated and the EtOAc-soluble portion showed significant AChE inhibitory and free radical scavenging effects. Also the EtOAc-soluble portion revealed the highest phenolic contents as compared to the other extracts. Conclusions : These results indicate that phenolic compounds may be important constituents that give rise to the anti-AChE and antioxidative activities of A. yomena extract. Further phytochemical studies on this plant, for nutraceutical or pharmaceutical application, are warranted.