Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Ameliorating Effect of Taraxacum platycarpum Extract in the Scopolamine-induced Cholinergic Blockade Mouse Model

Scopolamine으로 유도된 콜린성 신경계 차단 동물모델에서 포공영(Taraxacum platycarpum) 추출물의 기억력 개선효과

  • Kwon, Yubeen (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Park, Ho Jae (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Shin, Bum Young (Innohanbang Co., Ltd) ;
  • Ryu, Jong Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
  • 권유빈 (경희대학교 나노의약생명과학과) ;
  • 박호재 (경희대학교 약학대학 한약학과) ;
  • 신범영 ((주)이노한방) ;
  • 류종훈 (경희대학교 나노의약생명과학과)
  • Received : 2017.05.02
  • Accepted : 2017.06.15
  • Published : 2017.06.30
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Abstract

Taraxacum platycarpum H. Dahl. (Compositae) has been used as an anti-inflammatory or anti-cancer agent in the clinic. Although its antidepressant effect has been reported, however, its cognitive function is not investigated until yet. In the present study, we investigated whether the water extract of T. platycarpum (WETP) could improve cognitive function in cholinergic blockade-induced amnesia mouse model using the passive avoidance or Y-maze task. WETP (12.5, 25 or 50 mg/kg) significantly ameliorated the scopolamine-induced cognitive impairment both in the passive avoidance test and the Y-maze test. In addition, WETP significantly inhibited acetylcholinesterase (AChE) activity measured by an ex vivo study using the mouse whole brain. These results suggest that WETP alleviates the cognitive dysfunction caused by the cholinergic blockade, in part, via AChE inhibition, and that it may be a useful for treating cognitive dysfunction.

Keywords

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