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http://dx.doi.org/10.3839/jabc.2020.044

Coumarins from the aerial parts of Artemisia iwayomogi Kitamura  

Nguyen, Trong Nguyen (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Jeon, Hyeong-Ju (Department of Food and Nutrition, Jangan University)
Kim, Hyoung-Geun (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Lee, Yeong-Geun (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Lee, Seung Soo (Skin Biotechnology Center, Kyung Hee University)
Bang, Myun Ho (Skin Biotechnology Center, Kyung Hee University)
Baek, Nam-In (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Publication Information
Journal of Applied Biological Chemistry / v.63, no.4, 2020 , pp. 335-338 More about this Journal
Abstract
Artemisia iwayomogi (Compositae), a perennial mugwort, is native to Korea and widely distributed in Japan, Russia, and China. A. iwayomogi and A. capillaris are similar in morphology and pharmacological activity and have been used for the same medicinal purposes in Korea. While various ingredients such as coumarins and flavonoids and their activity studies have been reported for A. capillaris, few studies have been conducted on the pharmacologically active components of A. iwayomogi. In Korea, A. capillaris is not economical because only young leaves are used as a medicinal material. Because of this, A. iwayomogi is frequently used in Korea, indicating the need to study its pharmacologically active components. Therefore, a phytochemical study was initiated to isolate active compounds from the aerial parts of A. iwayomogi. Finally, four coumarins, umbelliferone (1), esculetin (2), grevillone (3), and scoparone (4) were isolated for the first time from the aerial parts of A. iwayomogi in this study.
Keywords
Artemisia iwayomogi; Coumarin; Nuclear magnetic resonance; Preparative MPLC;
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  • Reference
1 William TC, Jianping Y, Aamir Z, David MR, Ilya R, Zhijun Liu, Zhong QW, Phillip JB, Luke H, Michael L (2008) Botanicals and the metabolic syndrome. Am J Clin Nutr 87: 481s-487s   DOI
2 Kim J (1989) Illustrated natural drugs encyclopedia. Namsadang Publishers, Seoul
3 Park J (1999) Korean folk medicine. Busan National University Publisher, Busan
4 Seo KS, Jeong HJ, Yun KW (2010) Antimicrobial activity and chemical components of two plants, Artemisia capillaris and Artemisia iwayomogi, used as Korean herbal Injin. J Ecol Field Biol 33: 141-147
5 Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I (2007) Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol 3: 360-366   DOI
6 Ojala T (2001) Biological screening of plant coumarins. Dissertation, University of Helsinki, Helsinki
7 Lacy A, O'Kennedy R (2004) . Curr Pharm Des 10: 3797-3811   DOI
8 Matos MJ, Santana L, Uriarte E, Abreu OA, Molina E, Yordi EG (2015) Phytochemicals Isolation, Characterisation and Role in Human Health. 5:113-140 doi:10.5772/58648   DOI
9 Harbone JB (1999) Classes and functions of secondary products from plants. In Walton NJ, Brown DE (eds) Chemicals from plants. Imperial College press, London, pp 125
10 Rohini K, Srikumar PS (2014) Therapeutic role of coumarins and coumarin-related compounds. J Thermodyn Catal. 5:2 doi:10.4172/21577544.1000130
11 Vianna DR, Hamerski L, Figueiro F, Bernadi A, Visentin LC, Pires ENS, Teixeira HF, CG Salbego, Eifler VL, Battastini AMO, Poser GL, Pinto AC (2012) Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species. Eur J Med Chem 57: 268-274   DOI
12 Fais A, Corda M, Era B, Fadda MB, Matos JM, Quezada E, Santana L, Picciau C, Podda G, Delogu G (2009) Tyrosinase inhibitor activity of coumarin-resveratrol hybrids. Molecules 14(7): 2514-2520   DOI
13 Matos MJ, Rodriguez SV, Santana L, Uriarte E, Edfuf CF, Santos Y, Crego AM (2013) Synthesis and structure activity relationships of novel amino/nitro substituted 3-arylcomarins as antibacterial agents. Molecules 18(2): 1394-1404   DOI
14 Kim HG, Oh HJ, Ko JH, Song HS, Lee YG, Kang SC, Lee DY, Baek NI (2019) Lanceoleins A-G, hydroxychalcones, from the flowers ò Coreopsis lanceolata and their chemo preventive effects against human colon cancer cells. Bioorg Chem 85: 274281
15 Thompson EB, Aynilian GH, Dobberstein RH, Cordell GA, Fong HH, Farnsworth NR (1979) Biological and phytochemical investigation of plant XV, Pteryxia terebinthina var. terebinthina (umbelliferae). J Nat Prod 42: 120125