• Natural Product Sciences
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• v.11 no.2
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• pp.85-88
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• 2005

The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. Bioassay-guided fractionation of a methylene chloride soluble fraction led to the isolation of three lignan compounds, arctiin (1), arctigenin (2), and lappaol B (3). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literatures. Arctigenin (2) and lappaol B (3) had an iNOS inhibitory activity with $IC_{50}$ values of 12.5 and $25.9\;{\mu}M$, respectively.

• Korean Journal of Pharmacognosy
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• v.31 no.3
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• pp.306-309
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• 2000

Two sesquiterpene lactones were isolated from methanol extracts of the whole plants of Youngia japonica (L.) DC. by the silica gel column chromatography and recrystallization. On the basis of spectrometric studies including $^1H-NMR,\;^{13}C-NMR,\;DEPT,\;^1H-^1H\;COSY,\;^{13}C-^1H\;COSY$, IR and MS, compounds 1 and 2 were identified as derivatives of 10(14)-guaien-12, 6-olide, isoamberboin and isolipidiol, respectively. This is the first report on the isolation of isoamberboin and isolipidiol from Youngia japonica (L.) DC.

• Natural Product Sciences
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• v.11 no.2
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• pp.55-57
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• 2005

Three known sesquiterpene lactones were isolated from the n-BuOH traction of the roots of Ixeris sonchifolia. Their structures were identified as macrocliniside A (1), glucozaluzanin C (2), and ixerin H (3), by spectral analyses. Compounds 1 and 2 are guaiane-type, while compound 3 is a germacrane-type sesquiterpene lactone. Compounds 1-3 are first isolated from I. sonchifolia.

• Korean Journal of Pharmacognosy
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• v.1 no.4
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• pp.115-118
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• 1970

Antihepatotoxic effect of dimethyl-esculetin, the major constituent of herbal drug Artemisia capillaris $T_{HUNBERG}$ (Compositae) which has long been used as folk medicine for gall stone and hepatitis in Asian country (China and Japan, except Korea) was investigated on the rabbit intoxicated with carbon-tetrachloride. Ten rabbits were divided into two parts, group A and B in five each. The group A was injected with carbon-tetrachloride, 0.1ml per kg at begining of the experiments for control. The group B was injected with carbon-tetrachloride soon after 7 days treatment of dimethyl-esculetin, 30mg per day. The results obtained in this experiment were as follows.: 1) Antihepatotoxic activity of dimethyl esuletin on the rabbits intoxicated with carbon tetrachloride has shown the serum glutamic oxaloacetic transaminase activity and serum glutamic pyruvic transaminase activity decreased respectively. 2) The component of Artemisia capillaris, dimethyl-esculetin, has shown remarkable antihepatotoxic effect.

• Korean Journal of Pharmacognosy
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• v.43 no.4
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• pp.302-307
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• 2012

The herb of Artemisia capillaris in Chinese medicine is used to treat hepatic diseases. In this research, qualitative analysis was performed using a UPLC/Q-TOF-ESI-MS/MS method for rapid identification of phenolic substances from A. capillaris: three caffeoylquinic acids (chlorogenic acid, 3,5-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid), three flavonoids (hyperoside, isorhamnetin 3-O-robinobioside and quercetin) and three prenylated coumarins (6,8-diprenylumbelliferone, cedrelopsin and osthol) were identified. The three prenylated coumarins have not been reported from A. capillaris.

• Natural Product Sciences
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• v.16 no.3
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• pp.143-147
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• 2010

The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1 - 3 inhibited nitric oxide production with $IC_{50}$ values of 19.5, 20.4 and 25.1 ${\mu}M$, respectively.

• Korean Journal of Pharmacognosy
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• v.49 no.3
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• pp.219-224
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• 2018

Artemisia annua L. (Compositae) is an annual herb, which has been traditionally used as an antipyretic and hemostatic agent with the herbal medicine name of Cheong Ho (菁蒿) in Korea and China. In this study, five di-caffeoylquinic acid derivatives and a coumarin were determined from the hot-water extract of aerial parts of A. annua. The structures of isolates were elucidated to be 1,3-di-O-caffeoylqunic acid (1), 3,4-di-O-caffeoylquinic acid (2), 3,5-di-O-caffeoylqiunic acid (3), 1,5-di-O-caffeoylquinic acid (4) and 4,5-di-O-caffeoylquinic acid (5) and scopoletin (6). The presence of 1,5-di-O-caffeoylquinic acid (4) is firstly reported from A. annua in the current study.

• Korean Journal of Pharmacognosy
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• v.29 no.2
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• pp.67-70
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• 1998

Two sesquiterpene lactones were isolated from the flowers of Chrysanthemum boreale Makino by the silica gel column chromatography and recrystallization. On the basis of spectrometric studies including $^1H-NMR,\;^{13}C-NMR,\;DEPT,\;^1H-^1H\;COSY,\;{13}C-^1H\;COSY$, IR and Mass, compounds 1 and 2 were identified as germacranolide, tulipinolide and costunolide, respectively. And they showed antibacterial activity against Vibrio parahaemolyticus, Bacillus subtilis, Bacillus cereus and Staphylococcus aureus. This is the first report that Chrysanthemum boreale contained tulipinolide and costunolide.

• Natural Product Sciences
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• v.12 no.4
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• pp.193-196
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• 2006

A mixture of cerebrosides (1) and four triterpenoids (2 - 5) have been isolated from the hexane- and EtOAc-soluble fractions of the roots of Synurus deltoides (Ait.) Nakai (Compositae). Triterpenoid structures were determined as lupeol (2), $\beta-amyrin$ (3), $\alpha-amyrin$ (4), and ursolic acid (5). Synurus cerebrosides (1) were characterized as a common long chain base (2S,3S,4R,8E)-2-amino-8-octadecene-1,3,4-triol and fatty acyl chains; palmitic acid, (2R)-2-hydroxybehenic acid, (2R)-2-hydroxytricosanoic acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxypentacosanoic acid, and (2R)-2-hydroxyhexacosanoic acid. The synurus cerebrosides (1) were the first isolation from a natural source.

• Natural Product Sciences
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• v.8 no.2
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• pp.55-57
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• 2002

Youngia koidzumiana is an endemic plant growing in Mt. Chiri. In our ongoing research for endemic species in Korea, we investigated the chemical constituents from the MeOH extract of Y. koidzumiana whole plants. The MeOH extract was partitioned with hexane, ethyl acetate and BuOH, successively. Four known compounds were isolated from ethyl acetate fraction by repeated column chromatography. Their structures were elucidated by the physicochemical and spectral data as germanicol acetate (1), oleanolic acid (2), brachynereolide (3) and ixerin Y (4).