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Inhibitory Constituents of LPS-induced Nitric Oxide Production from Arctium lappa  

Park, So-Young (College of Pharmacy, Chungbuk National University)
Hong, Seong-Su (College of Pharmacy, Chungbuk National University)
Han, Xiang-Hua (College of Pharmacy, Chungbuk National University)
Ro, Jai-Seup (College of Pharmacy, Chungbuk National University)
Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
Publication Information
Natural Product Sciences / v.11, no.2, 2005 , pp. 85-88 More about this Journal
Abstract
The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. Bioassay-guided fractionation of a methylene chloride soluble fraction led to the isolation of three lignan compounds, arctiin (1), arctigenin (2), and lappaol B (3). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literatures. Arctigenin (2) and lappaol B (3) had an iNOS inhibitory activity with $IC_{50}$ values of 12.5 and $25.9\;{\mu}M$, respectively.
Keywords
Arctium lappa; Compositae; Lignan; Nitric oxide synthase inhibitor;
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Times Cited By SCOPUS : 5
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