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Five Di-caffeoylquinic Acid Derivatives and a Coumarin from the Hot-water Extract of Artemisia annua  

Rho, Taewoong (College of Pharmacy, The Catholic University of Korea)
Park, Chanyoung (Sungkyun Biotech Co. Ltd.)
Kim, Seon-Hee (Sungkyun Biotech Co. Ltd.)
Yoon, Kee Dong (College of Pharmacy, The Catholic University of Korea)
Publication Information
Korean Journal of Pharmacognosy / v.49, no.3, 2018 , pp. 219-224 More about this Journal
Abstract
Artemisia annua L. (Compositae) is an annual herb, which has been traditionally used as an antipyretic and hemostatic agent with the herbal medicine name of Cheong Ho (菁蒿) in Korea and China. In this study, five di-caffeoylquinic acid derivatives and a coumarin were determined from the hot-water extract of aerial parts of A. annua. The structures of isolates were elucidated to be 1,3-di-O-caffeoylqunic acid (1), 3,4-di-O-caffeoylquinic acid (2), 3,5-di-O-caffeoylqiunic acid (3), 1,5-di-O-caffeoylquinic acid (4) and 4,5-di-O-caffeoylquinic acid (5) and scopoletin (6). The presence of 1,5-di-O-caffeoylquinic acid (4) is firstly reported from A. annua in the current study.
Keywords
Artemisia annua; Hot-water extract; Di-caffeoylquinic acid; Coumarin;
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