• BMB Reports
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• v.28 no.5
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• pp.420-426
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• 1995

This study was conducted to compare the effects of n-6 linoleic acid and n-3 linolenic acid on lipid peroxidation and the activities of enzymes defending against oxidation, which are involved in the tumor promotion, and histolOgical changes of hepatocarcinogen treated rat liver. In this study, weanling male Sprague-Dawley rats were fed one of three diets, containing 15% (w/w) of beef fat (BF), com oil (CO) or perilla oil (PO), for 11 weeks. During the 3rd week, experimental groups were injected with 2-AAF (50 mg/kg of BW) intraperitoneally 3 times. Findings show that the com oil diet group has greater liver MDA content than the beef fat and perilla oil diet groups. Also, it is observed that the perilla oil diet group has lower MDA content than beef fat and com oil diet groups, even though perilla oil is more desaturated than beef fat and com oil. In terms of activity, mixed-function oxidase activity is not Significantly affected by the different dietary fats and 2-AAF treatment. GSH-peroxidase, GSH-reductase and GSH-Stransferase activities are significantly higher in the CO+AAF group than those of the other groups. GST and GSH-Px are activated by 2-AAF treatment in the com oil diet group only. The hepatocytes of the BF+AAF group were the most severely degenerated, the second was the CO+AAF group and the least was the PO+AAF group. It was also found that dietary com oil increased lipid peroxidation and activated defense enzymes against oxidation in liver, but dietary perilla oil did not, or supressed defense enzymes. Therefore it is concluded that dietary n-3 linolenic acid in perilla oil inhibits lipid peroxidation and carcinoenesis in rat liver following 2-AAF treatment.

• Journal of Digital Convergence
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• v.13 no.6
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• pp.105-111
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• 2015

In this highly competitive century, selling products and service through Internet and smart phones offers both opportunities and challenges. Online commerce is expanding it's wings to the offline market. The connection between online market and offline market is called O2O(Offline to Online) market. In this study we examine the best practice case study of an Internet company's successful efforts to connect users and offline merchants. Based on Dianping.com success story in China, a successful framework for building online to offline ecosystem is examined. Dianping.com successful experience may provide suggestions for other online companies operate in the convergent field.

• PNF and Movement
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• v.13 no.1
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• pp.39-46
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• 2015

Purpose: The accelerometer is a tool for evaluating walking by the displacement of the center of mass (COM) in the body. Recently, smartphones have added an accelerometer app, and it can be used to evaluate outcomemanures in rehabilitation. The purpose of this study was to investigate the COM in the bodies of normal persons and stroke patients using this smartphone application while walking. Methods: Twenty normal persons and twenty-two stroke patients were recruited and had their COM measured using G-walk and the smartphone application, SMAP, during 10 m walking. Subjects repeated the 10 m of walking 3 times, and we used the SMAP, Accelerometer Monitor ver. 1.5.0, to evaluate COM during the walk. To measure the displacement of COM, we used the difference in value between the maximal angle and the minimum anterior-posterior (AP), mediolateral (ML), and rotational angles during the walk. Results: For the normal persons, there was significant correlation between the AP and AP of SMAP, and was also a significant correlation between rotational angle and the ML of SMAP. In the stroke patients, there was significant correlation between AP and ML, and the rotational angle of SMAP. Conclusion: Our research results suggest that if the SMAP system is reinforced in the case of patients who have a greater displacement of COM, it may be used as an evaluation tool during walking.

• Journal of the Korean Society of Safety
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• v.33 no.6
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• pp.144-156
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• 2018

Level 3 Probabilistic Safety Assessment (PSA) is performed for the risk assessment that calculates radioactive material dispersion to the environment. This risk assessment is performed with a tool of MELCOR Accident Consequence Code System (MACCS2 or WinMACCS). For the off-site consequence analysis of multi-unit nuclear power plant (NPP) accident, the single location (Center Of Mass, COM) method has been usually adopted with the assumption that all the NPPs in the nuclear site are located at the same COM point. It was well known that this COM calculation can lead to underestimated or overestimated radionuclide concentration. In order to overcome this underestimation or overestimation of radionuclide concentrations in the COM method, Multiple Location (ML) method was developed in this study. The radionuclide concentrations for the individual NPPs are separately calculated, and they are summed at every location in the nuclear site by the post-processing of radionuclide concentrations that is based on two-dimensional Gaussian Plume equations. In order to demonstrate the efficiency of the ML method, radionuclide concentrations were calculated for the six-unit NPP site, radionuclide concentrations of the ML method were compared with those by COM method. This comparison was performed for conditions of constant weather, yearly weather in Korea, and four seasons, and the results were discussed. This new ML method (1) improves accuracy of radionuclide concentrations when multi-unit NPP accident occurs, (2) calculates realistic atmospheric dispersion of radionuclides under various weather conditions, and finally (3) supports off-site emergency plan optimization. It is recommended that this new method be applied to the risk assessment of multi-unit NPP accident. This new method drastically improves the accuracy of radionuclide concentrations at the locations adjacent to or very close to NPPs. This ML method has a great strength over the COM method when people live near nuclear site, since it provides accurate radionuclide concentrations or radiation doses.

• The Korea Journal of Herbology
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• v.35 no.1
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• pp.1-8
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• 2020

Objectives : This study was conducted to evaluate the effects of Corni Fructus, the dried fruits of Cornus officinalis Sieb., on unilateral common carotid artery occlusion (UCCAO) in mouse model. Methods : The Corni Fructus used in the experiment was extracted with anhydrous methanol, then filtered and freeze-dried. C57BL/6 mice used in the experiments were conducted left UCCAO surgery to set up UCCAO rodent model for mice. The mice were divided into five groups for evaluate the effect of methanol extract of Corni Fructus (COM) on UCCAO induced ischemic brain injury. The expression levels of nitric oxide in cerebrum and serum, body weight change were measured. To determine the effect of UCCAO and COM administration on brain neurons, morphological changes of the cerebrum through a microscope was conducted. And western blot was performed to confirm the underlying mechanism of neuroprotective effect of COM administration. Results : COM administered UCCAO groups (CO50, CO150, and CO500) had no significant effects on nitric oxide production in ipsilateral hemisphere proteins and sera. The CO500, 500 mg/kg COM administration, attenuated UCCAO-induced p38 inflammatory signaling pathway and inflammatory mediators such as iNOS and COX-2. The CO500 group showed resilient morphological changes of hippocampus neuronal cells about brain damage caused by decreased flow of blood. These group also showed decreased inflammation and cellular stress response in neuronal cells. Conclusions : From these results, COM has a neuroprotective property via moderating inflammatory factors and cellular stress inducing factors in brain cells.

• Korean Journal of Applied Biomechanics
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• v.33 no.4
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• pp.175-184
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• 2023

Objective: The purpose of this study is to investigate the effects of human motion and javelin kinematics during the energy transfer in javelin throwing on records, and to provide evidence-based training insights for athletes and coaches to enhance records. Method: Three javelin throw athletes (age: 22.67 ± 0.58 years, height: 178.33 ± 7.37 cm, weight: 83.67 ± 1.15 kg) were recruited for this study. Each athlete attempted ten maximum record trials, and the kinematic data from each performance were analyzed to determine their influence on the records. The Theia3d Markerless system was used for motion analysis. Results: Key factors were modeled and identified at each moment. In E1, main variables were COM Y (𝛽 8.162, p<.05) and COM velocity Z (𝛽 -72.489, p<.05); in E2, COM X (𝛽 -17.604, p<.05); in E3, COM X (𝛽 -18.606, p<.05), COM velocity Y (𝛽 38.694, p<.05), and COM velocity X (𝛽 66.323, p<.05). For the javelin throw dynamics in E3, key determinants were Attitude angle and Javelin velocity in the Y-axis. Conclusion: The study reveals that controlled vertical movement, center of mass management during braking, and enhanced pelvic rotation significantly improve javelin throw performance. These kinematic strategies are critical for record enhancement in javelin throwing.

• Journal of Animal Science and Technology
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• v.63 no.6
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• pp.1362-1375
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• 2021

This study was conducted to evaluate the efficacy of a combination 3,4,5-trihydroxybenzoic acid (THB) and oregano extracts (i.e., Carvacrol and Thymol) at intake/dietary different levels on growth performance, intestinal health indicators, immune responses and fecal oocyst shedding in broiler chickens under Eimeria challenged condition. A total of 336 one-day-old broilers were randomly assigned to one of six dietary treatments with seven replications per treatment. Dietary treatments were: i) Non-challenged bird without any dietary treatment (NCNT), ii) Challenged bird without any dietary treatment (CNT), iii) Challenged birds fed a THB diet (0.1 g/kg, THB), iv) Challenged birds fed a combination of THB and oregano extracts diet (0.1 g/kg, COM 100), and a gradual increase of combination of THB and oregano extracts likely v) 0.15 g/kg (COM 150), and 0.2 g/kg (COM 200). On day 14, all groups except for NCNT have orally challenged with a 10-fold dose of Livacox^® T anticoccidial vaccine to trigger coccidiosis. The results indicated that Eimeria-challenged broilers fed COM 100 and COM 200 diets increased (p < 0.05) body weight than CNT diet on day 35. Furthermore, birds fed COM 100 and COM 200 diets increased (p < 0.05) average daily gain compared to those fed CNT diets for the entire experimental period. There is no significant (p > 0.05) in average daily feed intake, feed efficiency between NCNT and birds fed with combined THB and oregano extracts for the entire experimental period. A combination of THB and oregano extract regardless of concentration levels or THB alone reduced (p < 0.05) lesion score in ileum compared to the CNT diet for 7 days post-infection (dpi). Birds fed COM 100 diet had lower (p < 0.05) intestinal lesion scores in jejunum and caeca on 7 dpi compared to those were in the CNT diet. No (p > 0.05) difference was observed in the oocysts per gram of feces count, intestinal morphology, carcass traits and blood cytokine concentration among the infected treatments. Collectively, we conclude that birds fed with a combination of THB and oregano extracts regardless of the ratios that were used demonstrated better recovery of health after the coccidial challenge than using only THB alone.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 2006.07a
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• pp.618-618
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• 2006

• Proceedings of the Korean Vacuum Society Conference
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• 2004.08a
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• pp.230-230
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• 2004

• Bulletin of Food Technology
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• v.23 no.4
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• pp.502-515
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• 2010