• 전자공학회논문지SC
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• 제43권6호
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• pp.76-82
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• 2006

ECG와 같은 생체 신호를 장시간 저장하기 위해서는 많은 메모리를 필요로 한다. 따라서 본 논문에서는 다단계 벡터양자화 기법을 적용하여 ECG의 웨이브렛 리프팅 계수를 압축하는 방법을 제안한다. 첫 번째 단계의 코드북은 ECG의 웨이브렛 리프팅 계수를 양자화하고 두 번째 단계 코드북은 오차 신호의 웨이브렛 리프팅 계수에 대해 J개의 후보 코드벡터를 구해 양자화하여 복원 오차를 최소화하도록 하였다. 두 코드북의 코드벡터는 웨이브렛 계수의 에너지 분포특성을 이용해서 고주파 성분의 계수를 제거함으로써 코드북의 검색 시간과 복잡성을 감소 시켰다. 실험 결과 CDR이 276.62 bit/sec에서 3%이하의 PRD를 얻었다.

• IMMUNE NETWORK
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• 제12권4호
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• pp.155-164
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• 2012

It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal antibody (mAb) derived by guided selection of the mouse mAb A13. The ER414 exhibited a ~17-fold lower affinity and, as a result, lower efficacy of inhibition of the EGF-mediated tyrosine phosphorylation of EGFR when compared with mAb A13 and cetuximab. We performed a stepwise in vitro affinity maturation to improve the affinity of ER414. We obtained a 3D model of ER414 to identify the amino acids in the CDRs that needed to be mutated. Clones were selected from the phage library with randomized amino acids in the CDRs and substitution of amino acids in the HCDR3 and LCDR1 of ER414 led to improved affinity. A clone, H3-14, with a ~20-fold increased affinity, was selected from the HCDR3 randomized library. Then three clones, ER2, ER78 and ER79, were selected from the LCDR1 randomized library based on the H3-14 but did not show further increased affinities compared to that of H3-14. Of the three, ER2 was chosen for further characterization due to its better expression than others. We successfully performed affinity maturation of ER414 and obtained antibodies with a similar affinity as cetuximab. And antibody from an affinity maturation inhibits the EGF-mediated tyrosine phosphorylation of EGFR in a manner similar to cetuximab.

• Journal of Korean Neurosurgical Society
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• 제56권1호
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• pp.28-33
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• 2014

Objective : Postoperative delirium is a common complication in the elderly after surgery but few papers have reported after spinal surgery. We analyzed various risk factors for postoperative delirium after spine surgery. Methods : Between May 2012 and September 2013, 70 patients over 60 years of age were examined. The patients were divided into two groups : Group A with delirium and Group B without delirium. Cognitive function was examined with the Mini-Mental State Examination-Korea (MMSE-K), Clinical Dementia Rating (CDR) and Global Deterioration Scale (GDS). Information was also obtained on the patients' education level, underlying diseases, duration of hospital stay and laboratory findings. Intraoperative assessment included Bispectral index (BIS), type of surgery or anesthesia, blood pressure, fluid balance, estimated blood loss and duration of surgery. Results : Postoperative delirium developed in 17 patients. The preoperative scores for the MMSE, CDR, and GDS in Group A were $19.1{\pm}5.4$, $0.9{\pm}0.6$, and $3.3{\pm}1.1$. These were significantly lower than those of Group B ($25.6{\pm}3.4$, $0.5{\pm}0.2$, and $2.1{\pm}0.7$) (p<0.05). BIS was lower in Group A ($30.2{\pm}6.8$ compared to $35.4{\pm}5.6$ in group B) (p<0.05). The number of BIS <40 were $5.1{\pm}3.1$ times in Group A, $2.5{\pm}2.2$ times in Group B (p<0.01). In addition, longer operation time and longer hospital stay were risk factors. Conclusion : Precise analysis of risk factors for postoperative delirium seems to be more important in spinal surgery because the surgery is not usually expected to have an effect on brain function. Although no risk factors specific to spinal surgery were identified, the BIS may represent a valuable new intraoperative predictor of the risk of delirium.

• 한국산학기술학회논문지
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• 제13권1호
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• pp.227-235
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• 2012

이 연구에서는 최근 국내에서 개발된 보행용 기능성 신발 중 걷기 효율성을 변화시키는 복합적 기능성 신발(double rocker sole;CDR)과 negative-heel rocker sole(NR)형태 신발의 근육 활성도를 비교하였다. 연구대상은 하지정형 외과적 질환이 없는 40-50대 중년여성 11명을 대상(연령 $47.33{\pm}4.4$, 신장 $158.00{\pm}3.3$cm, 체중 $59.50{\pm}6.1$, BMI $23.80{\pm}1.8kg/m^2$)으로 하였다. 연구결과 좌,우측의 내측광근, 비복근, 반건양근에서는 근활성도의 수준은 통계적으로 유의한 차이가 나타나지 않았지만, CDR신발이 전경골근에서 통계적으로 유의하게 높은 결과가 나타났다(p<.05). 걷기운 동시 동일한 조건속에 운동을 실시할 경우 신발 밑창의 변화를 통해 인위적으로 운동량을 증가시킬 수 있을 것이다.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2009년도 한국우주과학회보 제18권2호
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• pp.44.3-44.3
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• 2009

The MIRIS (Multi-purpose IR Imaging System), as the main payload of Science and Technology Satellite-3 (STSAT-3), is being developed by KASI in collaboration with several institutes for wide-field space observation in near IR wavelength. The Engineering Qualification Model (EQM) of MIRIS has been designed and fabricated in the laboratory. The system performance tests have been made including opto-mechanics, vibration test, thermal-vacuum environmental test and passive cooling test down to 200K. Most of the performance test results were satisfied with system requirements. The results of MIRIS performance tests have been presented at Critical Design Review (CDR) on September 2009. Several revisions were also recommended for Flight Model (FM) design, and detailed plan to develop FM of MIRIS is discussed in this paper.

• IMMUNE NETWORK
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• 제11권1호
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• pp.50-58
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• 2011

Background: Epstein-Barr virus associated gastric lymphoepithelioma-like carcinoma (LELC) is characterized by the intensive infiltration of lymphoid cells, the presence of EBV, and the better prognosis over typical adenocarcinoma. Thus, it was assumable that viral latent proteins may be responsible for the recruitment of a certain T cell repertoire to EBV-associated gastric carcinoma. Methods: To examine above possibility, EBV gene expression in gastric carcinoma tissues and usage of TCR among the tumor infiltrating lymphocytes were analyzed. Results: EBV specific DNA and EBERs RNA were detected in 4 out of 30 patients. RT-PCR analysis revealed that all 4 of EBV-positive tumor tissues expressed EBNA1 mRNA and BARTs and LMP2a was detected only one sample out of 4. However, the EBNA2 and LMP-1 transcripts were not detected in these tissues. $CD8^+$ T cells were the predominant population of infiltrating lymphocytes in the EBV-positive gastric carcinoma. According to spectra type analysis of infiltrating T cells, 10 predominant bands were detected by TCR $V{\beta}$ CDR3 specific RT-PCR from 4 EBV-positive tumor tissues. Sequence analysis of these bands revealed oligoclonal expansion of T cells. Conclusion: These findings suggest that clonally expanded T cells in vivo might be a population of cytotoxic T cells reactive to EBV-associated gastric carcinoma.

• 한국산업정보학회논문지
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• 제20권4호
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• pp.39-45
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• 2015

이 논문은 블라인드 오버샘플링(Blind Oversampling) 기법을 이용한 가변적인 속도 클록 데이터 복원 회로 설계에 관한 내용을 제시하고 있다. 클록 데이터 복원 회로는 기본적으로 클록 복원과 데이터 복원 회로로 구성되어 있다. 클록 복원 회로는 넓은 범위를 가지는 전압 제어 발진기(Wide Range VCO)와 밴드 선택(Band Selection) 기법을 복합적으로 사용하여 구현하였고 데이터 복원 회로는 머저리티 보팅(Majority Voting) 방식을 이용하는 디지털 회로로 제안하여 저전력 및 작은 면적으로 구성하였다. 넓은 범위를 가지는 전압 제어 발진기와 데이터 복원회로를 디지털로 구현함으로써 저전력으로 가변적인 속도 클록 데이터 복원회로 구현이 가능하였다. 설계된 회로는 약 10bps에서 2Mbps 범위에서 동작한다. 전체 전력 소비는 1MHz 클록에서 약 4.4mW의 전력을 소비한다. 공급전압은 1.2V 이며 제작된 코어의 면적은 $120{\mu}m{\times}75{\mu}m$ 이고 $0.13{\mu}m$ CMOS 공정에서 제작되었다.

• 한국인구학
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• 제9권2호
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• pp.53-66
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• 1986

This study was carried out to determine the mortality level and it's related demographic factors in Korea since 1942. In order to clarify the changes in structure of mortality and the causes of death, the indices such as Crude Death Rate(CDR) or Life Expectancy at Birth were used. The author examined the mortality levels and major causes of death and performed the relevant demographic analysis. The followings are the summary of this study: 1. The CDR declined rapidly till 1960's. Such improvement slowed down from 1960's to mid 1970's and stabilized afterwards. It was due to the change of age composition, namely, the increase of aging population. 2. The Life Expectancy at Birth increased rapidly till mid 1960's. But elongation of the Life Expectancy slowed down after then. Especially in female, it slowed down more. 3. Changing patterns of major causes of death summarize that, till 1960's infectious diseases were major causes of death, but recently non-infectious diseases like chronic degenerative diseases became more prevalent. 4. The elongation of Life Expectancy at Birth till mid 1960's was mainly resulted by $_4{q}_1$. But the major contributing factor of the improvement in Life Expectancy at Birth in female is he reduction of $_$\infty${q}_{50}$ recently. In male, the improvement in Life Expectancy at Birth is due to the reduction of $_1{q}_0$. recently. 5. The age-sex-specific mortality rates revealed that $_n{q}_x$ declined in common throughout the period, even though there exists some variability of their ranges as age changes. Consequently, this study seems to suggest that the demographic transition in Korea occurred between late 1960's and early 1970's. In other words, the rapid change before late 1960's was eased in early 1970's. The slow change in this period caused a stabilizing pattern. Therefore, the population change is expected to be stabilized continuously.

• Journal of Yeungnam Medical Science
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• 제35권2호
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• pp.205-212
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• 2018

Background: Brain volume is associated with dementia and depression in the elderly. An easy way to predict relative brain volume is to measure head circumference. In this study, we investigated the relationship between head circumference and cognition as well as depression in a non-demented elderly community. Methods: Baseline and follow-up surveys were conducted in 2007 and 2010. At baseline, community residents aged 65 years or over (n=382) within a rural area of South Korea were screened for dementia and symptoms of depression and were followed using the same screening battery after 3 years (n=279). Data from anthropometric measurements (head circumference, height, and body weight), demographics, and blood tests were gathered. Neuropsychological tests, including the Korean version of mini-mental state examination (K-MMSE), clinical dementia rating (CDR) including the CDR-sum of boxes, the Korean version of instrumental activities of daily living, and geriatric depression scale (GDS), were performed. None of the 279 subjects followed were demented. Results: Baseline performance on the K-MMSE and GDS was poorer for participants with smaller head circumferences. Follow-up performance on the MMSE was also poorer for participants with smaller head circumferences. Interestingly, participants with smaller head circumference showed worse GDS scores at baseline but on follow-up examination, participants with larger head circumference showed rapid worsening than those with smaller head circumference with marginal significance by ANOVA test. In regression coefficient analysis, GDS decline showed significant difference. Conclusion: Head circumference was not associated with cognitive change but was associated with symptoms of depression in non-demented community residents.

• Journal of Microbiology and Biotechnology
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• 제31권5호
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• pp.659-666
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• 2021

After Candida albicans, Candida glabrata is one of the most common fungal species associated with candidemia in nosocomial infections. Rapid acquisition of nutrients from the host is important for the survival of pathogens which possess the metabolic flexibility to assimilate different carbon and nitrogen compounds. In Saccharomyces cerevisiae, nitrogen assimilation is controlled through a mechanism known as Nitrogen Catabolite Repression (NCR). NCR is coordinated by the action of four GATA factors; two positive regulators, Gat1 and Gln3, and two negative regulators, Gzf3 and Dal80. A mechanism in C. glabrata similar to NCR in S. cerevisiae has not been broadly studied. We previously showed that in C. glabrata, Gln3, and not Gat1, has a major role in nitrogen assimilation as opposed to what has been observed in S. cerevisiae in which both factors regulate NCR-sensitive genes. Here, we expand the knowledge about the role of Gln3 from C. glabrata through the transcriptional analysis of BG14 and gln3Δ strains. Approximately, 53.5% of the detected genes were differentially expressed (DEG). From these DEG, amino acid metabolism and ABC transporters were two of the most enriched KEGG categories in our analysis (Up-DEG and Down-DEG, respectively). Furthermore, a positive role of Gln3 in AAA assimilation was described, as was its role in the transcriptional regulation of ARO8. Finally, an unexpected negative role of Gln3 in the gene regulation of ABC transporters CDR1 and CDR2 and its associated transcriptional regulator PDR1 was found. This observation was confirmed by a decreased susceptibility of the gln3Δ strain to fluconazole.