• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.201-201
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• 1994

항암 및 면역조절작용을 가지고 있으며 그자체가 서방성 prodrug으로서 약효를 나타낼것으로 기대되는 ara-C와 etherphospholipid의 conjugate인 ara-CDP-DL-PCA.2Na의 실험동물(rat)에서의 체내동태를 HPLC 정량법으로 시행 하였다. Ara-CDP-DL-PCA.2Na의 정맥내 투여(20mg/300g)의 경우 혈장중 반감기는 분포상에 있어서는 평균 20min, 소실상 에서는 4.42hr이었다. 분포 용적은 0.1635Lㆍkg$^{-1}$이었고, 전신 clearance 는 25.63ml.$hr^{-1}$.kg$^{-1}$이었다. 한편 AUC는 2601$\mu\textrm{g}$.hr.ml$^{-1}$이었다. 복강내 주사(1g/kg)의 경우 소실상의 반감기는 3.28hr, AUC는 439.3$\mu\textrm{g}$.hr.ml$^{-1}$이었다. 최고 혈중농도 도달시간은 4.4hr이었으며 그때의 농도는 33.19$\mu\textrm{g}$.ml$^{-1}$이었다. 한편 흡수속도 정수는 0.2493$hr^{-1}$이었다. 정맥내 투여에 대한 복강내 투여의 생체 이용율은 1.1252%로 복강내 투여시 흡수율이 좋지 않음을 시사하고 있다. 이는 투여 시료인 micellar solution이 일종의 약물저장 형태로 작용하여 활성물질을 서서히 방출 하기 때문인 것으로 사료된다. 한편 예비적 대사연구결과 TLC에서 뇨나 담즙으로 배설되는 유의한 농도수준의 ara-CDP-DL-PCA.2Na가 없는 것으로 평가되었다. 이는 생체내에서 enzyme등에 의한 대사과정을 거치는 것으로 사료되는바 방사성 동위원소 표지화합물을 이용한 충분한 대사연구가 필요한 것으로 사료된다.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.4
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• pp.431-435
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• 2008

Since previous work CDP(Congestion Driven Placement) [1] considers all possible directions to move every cell in nets which contribute highly to routing congestion, it consumes CPU time a lot. In this paper, we propose a faster global placement technique, so called ICDGP(Improved Congestion Driven Global Placement) to relieve the routing congestion. ICDGP uses the force-directed method to determine the target locations of the cells in the nets in the congested spots, and considers only to move the target location for each cell. If moving multiple cells simultaneously is considered better than moving each cell one by one it moves multiple cells simultaneously. By experimental results, ICDGP produces less congested placement than CDP does. Particularly, the CPU time is reduced by 36% on average.

• Journal of the Korea Institute of Military Science and Technology
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• v.15 no.5
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• pp.601-614
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• 2012

Since the optimized use of sonar systems available for detection is a very practical problem for a given ocean environment, the measure of mission achievability is needed for operating the sonar system efficiently. In this paper, a theory on Measure Of Effectiveness(MOE) for specific mission such as detection is described as the measure of mission achievability, and a recursive Cumulative Detection Probability(CDP) algorithm is found to be most efficient from comparing three CDP algorithms for discrete glimpses search to reduce computation time and memory for complicated scenarios. The three CDPs which are MOE for sonar-maneuver pattern are calculated as time evolves for comparison, based on three different formula depending on the assumptions as follows; dependent or independent glimpses, unimodal or non-unimodal distribution of Probability of Detection(PD) as a function of observation time interval for detection. The proposed CDP algorithm which is made from unimodal formula is verified and applied to OASPP(Optimal Acoustic Search Path Planning) with complicated scenarios.

• Computers and Concrete
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• v.22 no.2
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• pp.143-152
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• 2018

This paper deepens the finite element modeling (FEM) method to reproduce the compressive behavior of partially steel-jacketed (PSJ) RC columns by means of the Concrete Damaged Plasticity (CDP) Model available in ABAQUS software. Although the efficiency of the CDP model is widely proven for reinforced concrete columns at low confining pressure, when the confinement level becomes high the standard plasticity parameters may not be suitable to obtain reliable results. This paper deals with these limitations and presents an analytically based strategy to fix the parameters of the Concrete Damaged Plasticity (CDP) model. Focusing on a realistic prediction of load-bearing capacity of PSJ RC columns subjected to monotonic compressive loads, a new strain hardening/softening function is developed for confined concrete coupled with the evaluation of the dilation angle including effects of confinement. Moreover, a simplified efficient modeling approach is proposed to take into account also the response of the steel angle in compression. The prediction accuracy from the current model is compared with that of existing experimental data obtained from a wide range of mechanical confinement ratio.

• Applied Chemistry for Engineering
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• v.34 no.4
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• pp.397-403
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• 2023

In this study, the effect of the addition of fluorinated surfactant FS-606 on the solubilization of n-hexane by hydrocarbon surfactant CDP-W was investigated. Oil drop contacting experiments revealed that solubilization rate is independent of initial oil drop size and proportional to the initial surfactant concentration, suggesting that solubilization of n-hexane oil by the surfactant mixture of FS-606 and CDP-W is controlled by an interface-controlled mechanism. In addition, the solubilization rate has been shown to increase with an increase in FS-606 composition, reach a maximum, and then decrease with a further increase in FS-606 composition. On the other hand, the interfacial tension between micellar solution and n-hexane oil has been found to decrease with an increase in FS-606 composition, reach a minimum, and then increase with a further increase in FS-606 composition.

• Journal of the Korea Institute of Military Science and Technology
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• v.15 no.3
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• pp.272-287
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• 2012

The optimal use of sonar systems for detection is a practical problem in a given ocean environment. In order to quantify the mission achievability in general, measure of effectiveness(MOE) is defined for specific missions. In this paper, using the specific MOE for detection, which is represented as cumulative detection probability(CDP), an integrated software package named as Optimal Acoustic Search Path Planning(OASPP) is developed. For a given ocean environment and sonar systems, the discrete observations for detection probability(PD) are used to calculate CDP incorporating sonar and environmental parameters. Also, counter-detection probability is considered for vulnerability analysis for a given scenario. Through modeling and simulation for a simple case for which an intuitive solution is known, the developed code is verified.

• Computers and Concrete
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• v.18 no.3
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• pp.389-404
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• 2016

In this study, effects of impact loads on reinforced concrete (RC) plates are examined analytically. During examination of RC plates, they were exposed to impact loading with two different support conditions in three different sizes. RC plates in different support conditions were analyzed with Concrete Damage Plasticity Model (CDP) and reinforcing steel was modeled with Classical Metal Plasticity Model (CMP) by ABAQUS finite element software. After the analysis it is found that impact loads, displacements, energy absorption capacities and damage patterns are changed due to support conditions and plate sizes. Results that are obtained from RC plate experiments in literature under impact loads are found to be similar with the results of numerical analysis with CDP material models.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2002.11a
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• pp.215-218
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• 2002

감성정보를 디자인 활동에 필요한 정보로 활용하기 위해서는 전체 디자인 프로세스에서 사용자를 최초 컨셉 단계에서부터 참여시켜 관찰 및 평가에 적극 동참케 하는 사용자 참여 디자인이 매우 효과적이다. 이러한 감성 정보 수집 및 평가를 통한 상용자 인터페이스 디자인 개발 프로세스를 MP3 CDP를 대상으로 적용하여 연구를 진행하였다. 최근의 MP3CD Player들은 일반 음악 CD들이 10여곡에서 많게는 20여곡 정도의 분량을 가지고 있는 것에 비해 그 분량이 최고 100여곡 이상에 이르고 있다. 그럼에도 불구하고 MP3CD Player들은 기존의 일반 음악 CD Player의 UI를 소극적으로 수정, 변경하여 사용하고 있는 상황이다. 본 연구는 자체적인 곡 분류방법을 제시하고 있는 ‘H’사의 MP3CD Player를 선정하고 이를 기준으로 초기 디자인에 사용자를 참여시켜 사용자 감성 정보 및 요소들을 효과적으로 평가하여 사용자 중심 디자인을 극대화 시키는 방법을 모색하였다. 제품의 최초 기능 분석시에는 카드인덱스(Card Index)방식을 이용하여 기능을 그룹핑하고 인터페이스를 개선하였으며 이를 토대로 프로토타입을 완성하였다. 이를 사용자가 직접 조작하는 방식을 관찰 분석하여 평가 결과를 토대로 UI 디자인가이드라인을 제시하였다.

• Animal cells and systems
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• v.8 no.2
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• pp.105-109
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• 2004

Aminoalcoholphosphotransferase catalyzes the synthesis of phosphatidylcholine and phosphatidylethanolamine from diacylglycerol plus a CDP-aminoalcohol such as CDP-choline or CDP-ethanolamine. Previously we suggested the presence of possible isoforms of this enzyme from Chinese cabbage roots and now report the cDNA cloning and expression analysis of AAPT3 encoding a third isoform of aminoalcoholphosphotransferase (AAPT3). AAPT3 contains an open reading frame of 1,176 bp coding for a protein of 392 amino acids. It shares 96 and 95% identity with Chinese cabbage AAPT1 and AAPT2, respectively, at the deduced amino acid level. The results from reverse transcriptase-polymerase chain reaction analysis indicate that expression of AAPT3 is up-regulated by low temperature as well as AAPT1 and AAPT2.

• Journal of Climate Change Research
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• v.3 no.4
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• pp.225-234
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• 2012

This study analyzes domestic and overseas companies' Scope 3 verification, level of management, source and industry characteristics based on the responses of domestic excellent companies and rated 90 points or more global excellent companies which are included in CDP Korea 200 and CDP Global 500. The result of analysis conveys that global excellent companies' Scope 3 management source achieved the average of 2.7 which is one more than domestic excellent companies', according to the Scope 3 guideline of World Resource Institute and World Business Council of Sustainable Development. For domestic companies are tend to focus on business travel, employee commuting, etc. but didn't manage capital goods, leased assets and investments. Global companies' Scope 3 source is similar to domestic companies but shows more actively managing on investment and use of sold products. It seems that domestic companies should actively develop Scope 3 source especially for the capital related items and respond to the future regulations on inter-enterprise management through the Scope 3.