• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1366-1370
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• 2013

A series of phosphorescent iridium(III) complexes 1-4 based on phenylpyrazole were synthesized and their photophysical properties were investigated. To evaluate their electroluminescent properties, OLED devices with the structure of ITO/NPB/mCP: 8% Iridium complexes (1-4)/TPBi/Liq/Al were fabricated. Among those, the device with 3 showed the most efficient white emission with maximum luminance of 100.6 $cd/m^2$ at 15 V, maximum luminous efficiency of 1.52 cd/A, power efficiency of 0.71 lm/W, external quantum efficiency of 0.59%, and CIE coordinates of (0.35, 0.40) at 15.0 V, respectively.

• Nuclear Engineering and Technology
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• v.53 no.12
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• pp.4080-4092
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• 2021

In this study, the performance of sequence tracking methods for multiple interaction events in specific CdZnTe Compton imagers was evaluated using Monte Carlo simulations. The Compton imager consisted of a 6 × 6 array of virtual Frisch-grid CZT crystals, where the dimensions of each crystal were 5 × 5 × 12 mm³. The sequence tracking methods for another Compton imager that consists of two identical CZT crystals arrays were also evaluated. When 662 keV radiation was incident on the detectors, the percentages of the correct sequences determined by the simple comparison and deterministic methods for two sequential interactions were identical (~80%), while those evaluated using the minimum squared difference method (55-59%) and Three Compton method (45-55%) for three sequential interactions, differed from each other. The reconstructed images of a 662 keV point source detected using single and double arrays were evaluated based on their angular resolution and signal-to-noise ratio, and the results showed that the double arrays outperformed single arrays.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.5 no.2
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• pp.119-130
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• 2000

Mn, Zn, Cd and Pb in shells of Littorina brevicula, which lives ubiquitously in intertidal zone around the Korean coast, were analyzed to determine the relationship between metal levels in its shell, ambient seawater and its tissue. Periwinkles and seawater samples were collected from 38 sites along the Korean coast in January 1997. Mn contents in shells of this organism show the range of 7.0 ${\mu}g$/g-211 ${\mu}g$/g (mean 59 ${\mu}g$/g) and are the lowest in northern east coast but high in western south and west coast. Close relationship between Mn contents in shells and metal levels both in seawater and in tissues indicates that Mn in shell might be incorporated from ambient seawater by a biological process. Although the contents of Cd in shells did not reflect the distribution of total Cd in seawaters and they were very low compared to those in tissues, they followed spatial gradient of contents in tissues. However, the spatial distribution of Zn contents in shells accords neither ambient seawater nor tissues, while it is negatively correlated with the contents of Na in shells. This fact suggests that Zn contents might be controlled by salinity of ambient seawater. On the contrary, Zn contents in highly polluted sites near Onsan Bay show generally higher levels than other sites. The contents of Pb show the range of 0.1 ${\mu}g$/g-17.5 ${\mu}g$/g (mean 1.01 ${\mu}g$/g) and the highest in sites near Onsan Bay. Although the spatial distribution of shell Pb does not follow those of tissue, Pb in shells of Littorina brevicula may be controlled both by shell secretion process and by Pb levels in ambient seawater because the contents of Pb in the shell decrease steadily with growth and vary with levels of Pb in ambient seawater.

• Radiation Oncology Journal
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• v.14 no.1
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• pp.53-59
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• 1996

Purpose : Radiation-induced alteration in the immune function is well known phenomenon in cancer patients. Our purpose is to evaluate the extent of immune suppression immediately after mediastinal or pelvic irradiation, which include significant volume of active bone marrow in adults. Materials and Methods'48 cancer patients with mediastinal(N=29) and pelvic irradiation(N=19) were the basis of this analysis. Age ranged from 36 to 76 and mean and median value was 57 years, respectively Sex ratio was 1.3(M: F=27/21). The immunological parameters were the complete blood cell(CBC) with differential cell(D/C) count, T cell subset(CD3, CD4, CD8 CDl9), NK cell test(CDl6, CD56), and serum immunoglobulin(IgG, IgA, IgM) level. Results : The mean value of white blood cell(WBC) was reduced from 7017 to 4470 after irradiation(p=0.0000). In the differential count, the number of lymphocyte, neutrophil, and basophil was markedly reduced with statistical significance(p<0.01) and the number of monocyte was not changed and, on the contrary, that of eosinophil was increased by irradiation. In the lymphocyte subpopulation analysis, the number of all subpopulations, CD3(T cell), CD4(helper T cell), CD8(suppressor T cell), CDl6(NK cell), CDl9(B, cell) was reduced with statistical significance. The mean ratio of CD4 to CD8 in all patients was 1.09 initially and reduced to 0.99 after radiotherapy(p=0.34) , but the proportional percentage of all subpopulations was not changed except CD19(B cell) after irradiation. In the immunoglobulin study, initial values of Ig G, Ig A, and Ig M were relatively above the normal range and the only Ig M was statistically significantly reduced after radiotherapy(p=0.02). Conclusion : Mediastinal and pelvic irradiation resulted in remarkable suppression of lymphocyte count in contrast to the relatively good preservation of other components of white blood cells. But the further study on the functional changes of lymphocyte after radiotherapy may be necessary to conclude the effects of the radiation on the immunity of the cancer Patients.

• Journal of the Korean Society of Food Culture
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• v.17 no.4
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• pp.456-464
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• 2002

This study was designed to investigates the effects of Korean pueraris radix water extract in Cd(cadmium) administered rats. Forty male Sprague-Dawley rats weighing $100{\pm}10g$ were used for this experiment and divided into following 4 groups; control group, 3% pueraria radix in water extract group, 50 ppm Cd group, 50ppm Cd group with 3% pueraria radix in water extract group. The Cd administered rats were given 50 ppm of $CdCl_2\;{\cdot}\;2H_2O$ disolved in the distilled water. The Cd content in the rats tissue of Cd administered group was lower than in the rats tissue of Cd group with 3% pueraria radix in water extract group. Plasma levels of renin activity was increased by Cd administration group, compared with 3% pueraria radix in water extract group and Cd administred group. Glutamate oxaloacetate transaminase(GOT) and Glutamate pyruvate transaminase(GPT) were increased in Cd-administered group and lower in the 3% extracts of pueraria radix in water extract group. Lactate dehydrogenase(LDHase) was lower in the 3% extracts of pueraria radix-Cd group than in the Cd group. This results suggested that pueraria radix in water extract group, has a lowering effects on the accumulation of Cd and it is belived that the pueraria radix in water extract group has some protective effects to Cd administered in rats, but the mechanism of these effects was obscure.

• Journal of the East Asian Society of Dietary Life
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• v.11 no.4
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• pp.289-294
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• 2001

Yields of shells, appearance of the shellfishes, mineral contents of the shells and their hot water extracts were determined in six shellfishes such as corb shell(CS). short neck clam(SNC). taste clam(TC), ark shell(AS). top shell(TS) and oyster(OY) from the western coast of Korea. Yields of shells in shellfishes were 70.I~80.5% but yields of TC was the lowest as 40.7%. The highest among weight of the shell the shellfishes was the TS(26.2g) and the lowest weight was TC(5.6g) Colors of CS, SNC, TC. AS. TS and OY were yellowish brown, brown, black. greenish brown and gray. respectively. Ca content of the shell of shellfishes was 36.23~38.78% and the content of K and Na were 0.23~4.54% and 1.48~l.59%, respectively. Contents of Na, Mg, Fe. Mn, Zn, Cu. P and S were in the range of 0.01~0.21%. It also contained heavy metals, such as Pb(1.90~7.75 ppm), Cd(0.5~4.50 ppm), As (1.40~4.30 ppm), Se (0.2~l.50 ppm). Cr(1.00~8.30 ppm) and Hg(0.002~8.2 ppm), Ca content in hot water extracts of shell of shellfish was the highest in TC(2,448 mg/100 g), and the lowest in SNC(115 mg/100 g). K content in TC extracts was the highest with the levels of 952 mg/100 g. P content of TC and SNC were 201 and 0.36 mg/100 g, respectively. The contents of Pb, As, Se and Cr were the highest in the extracts of TC and were 110. 40. 90, 20 $\mu$g/100 g, respectively. But Cd was not detected in the extracts of SNC.

• Economic and Environmental Geology
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• v.44 no.5
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• pp.359-372
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• 2011

TA26 seamount, which is located at south part of Tonga arc, occurs widely hydrothermal plume and is area that sampled hostrock, hydrothermal ore and hydrothermal alteration rock for this study. Hostrocks are basalt and basaltic andesite. Altered rocks by hydrothermal solution consists of plagioclase, pyroxene, pyrite, ilmenite, amorphous silica, barite, smectite, iron sulfates, Fe-Si sulfates and Fe silicates. Gains and losses of major, trace and rare earth elements during wallrock alteration suggest that $K_2O$(+0.04~+0.45 g), $SiO_2$(-6.52~+10.56 g), $H_2O$(-0.03~+6.04 g), $SO_4$(-0.46~+17.54 g), S(-0.46~+13.45 g), total S(-0.51~+16.93 g), Ba(-7.60~+185078.62 g), Sr(-36.18~+3033.08 g), Ag(+54.83 g), Au(+1467.49 g), As(-5.80~+1030.80 g), Cd(+249.78 g), Cu(-100.57~+1357.85 g), Pb(+4.91~+532.65 g), Sb(-0.32~+66.59 g), V(-113.58~+102.94 g) and Zn(-49.56~+14989.92 g) elements are enriched from hydrothermal solution. Therefore, gained(enriched) elements(($K_2O$, $H_2O$, $SO_4$, S, total S, Ba, Sr, Ag, Au, As, Cd, Cu, Pb, Sb, V, Zn) represent a potentially tools for exploration of sea-floor hydrothermal deposits from the Tonga arc.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.1
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• pp.20-25
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• 2009

Xenotransplantation of pig organs into humans is a potential solution for the shortage of donor organs for transplantation. However, multiple immune barriers preclude its clinical application. In particular, the initial type of rejection in xenotransplantation is an acute cellular rejection by host $CD8^+$ cytotoxic T lymphocyte (CTL) cells that react to donor major histocompatibility complex (MHC) class I. The human cytomegalovirus (HCMV) glycoprotein Unique Short (US) 2 specifically targets MHC class I heavy chains to relocate them from the endoplasmic reticulum (ER) membrane to the cytosol, where they are degraded by the proteasome. In this study we transfected the US2 gene into minipig fetal fibroblasts and established four US2 clonal cell lines. The integration of US2 into transgenic fetal cells was confirmed using PCR and Southern blot assay. The reduction of Swine Leukocyte Antigen (SLA)-I by US2 was also detected using Flow cytometry assay (FACS). The FACS analysis of the US2 clonal cell lines demonstrated a substantial reduction in SLA-I surface expression. The level (44% to 76%) of SLA-I expression in US2 clonal cell lines was decreased relative to the control. In cytotoxicity assay the rate of $CD8^+$ T cell-mediated cytotoxicity was significantly reduced to 23.8${\pm}$15.1% compared to the control (59.8${\pm}$8.4%, p<0.05). In conclusion, US2 can directly protect against $CD8^+$-mediated cell lysis. These results indicate that the expression of US2 in pig cells may provide a new approach to overcome the CTL-mediated immune rejection in xenotransplantation.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.222-226
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• 2017

Background: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection. Methods: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG ($3,947{\pm}4,943g$) for $86{\pm}63$ mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period. Results: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r = 0.64, p < 0.0001) as well as between total amount of KRG and mean annual decrease in $CD4^+$ T-cell count in all 252 patients (r = -0.17, p < 0.01). The annual decrease in $CD4^+$ T-cell count (change in $cells/{\mu}L$) was significantly slower in KRG-treated patients than in patients receiving no KRG ($48{\pm}40$ vs. $106{\pm}162$; p < 0.001). The SD (in months) was also significantly longer in the KRG group than in the no-KRG group ($101{\pm}64$ vs. $59{\pm}40$, p < 0.01). Conclusion: KRG prolongs survival in HIV-1 patients, possibly by slowing the decrease in $CD4^+$ T-cell count.

• Journal of the Korea Organic Resources Recycling Association
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• v.22 no.3
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• pp.53-59
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• 2014

In this study, the sewage sludge dryer is installed before and after dehydration of the sludge and aqueous phase composition, the heavy metal content, and measurement and analysis were investigated. The removal efficiency of water content of sewage sludge was about 95.7% in the sewage sludge dryer. The removal efficiency of water content for primary dryer was designed for 35% of primary drying, secondary drying to remove the water content to 10%, but as the measurement revealed that 20.8% of primary drying, the second dryer 3.3% a better effect to the actual operation respectively. Before the installation of the sewage sludge dryer, the content of heavy metal was as follows, Cu:352~614 ppm, Hg: 1.3~1.44ppm, Cd : 1.1~1.86ppm, Pb : 17.25~ 28.93 ppm, As : 1ppm. And after the installation of the sewage sludge dryer, the content of heavy metal changed to as follows, Cu : 340~350 ppm, Hg : 0 ppm, Cd : 0~0.021 ppm, Pb : 0 ppm, As : 0~0.043 ppm which is Also below the legal limits. Also, the sewage sludge dryer produce 1/4 of the sewage sludge into dried sludge.