Browse > Article

Effects of Pueraria radix in Water Extract on the Detoxification in Rat administered with Cadmium  

Chung, Yung-Hee (Dept. of Food of Nutrition, Gwangju Health College)
Shin, Mee-Kyung (Dept. of Food of Nutrition, College of Human Environmental Science, Wonkwang University)
Han, Sung-Hee (Dept. of Food Science Wonkwang Health Science College)
Publication Information
Journal of the Korean Society of Food Culture / v.17, no.4, 2002 , pp. 456-464 More about this Journal
Abstract
This study was designed to investigates the effects of Korean pueraris radix water extract in Cd(cadmium) administered rats. Forty male Sprague-Dawley rats weighing $100{\pm}10g$ were used for this experiment and divided into following 4 groups; control group, 3% pueraria radix in water extract group, 50 ppm Cd group, 50ppm Cd group with 3% pueraria radix in water extract group. The Cd administered rats were given 50 ppm of $CdCl_2\;{\cdot}\;2H_2O$ disolved in the distilled water. The Cd content in the rats tissue of Cd administered group was lower than in the rats tissue of Cd group with 3% pueraria radix in water extract group. Plasma levels of renin activity was increased by Cd administration group, compared with 3% pueraria radix in water extract group and Cd administred group. Glutamate oxaloacetate transaminase(GOT) and Glutamate pyruvate transaminase(GPT) were increased in Cd-administered group and lower in the 3% extracts of pueraria radix in water extract group. Lactate dehydrogenase(LDHase) was lower in the 3% extracts of pueraria radix-Cd group than in the Cd group. This results suggested that pueraria radix in water extract group, has a lowering effects on the accumulation of Cd and it is belived that the pueraria radix in water extract group has some protective effects to Cd administered in rats, but the mechanism of these effects was obscure.
Keywords
pueraria radix in water extract group; Cd group; GPT; GOT; LDH; renin;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Shaikh ZA, Lucis OJ. Cadium and zinc binding in mammalian liver and kidneys. Arch. Environ. Health 24:419, 1992
2 Kazantzis G. Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers,. Environ. Health Perspect 28:155-159, 1979   DOI
3 Morita S. Defense mechanisms against cadmium toxicity. Ⅲ Effect of pretreatment with a small oral dose of cadmium on metallothione synthesis after a large oral dose of cadmium in mice. Japan J Physiol, 214:469-474, 1984
4 Cheng SJ. The preliminary study of inhibitory effects of green tea antioxidant on the mutation. Acta of Experimental Biology 9; 328-334, 1986
5 Hayashi E, Hayashi M, YamazoeH Pharmacological action of tea extract on the central nervous system in mice. Oyo Yakuri 40(3): 351-356, 1990
6 Zeng CY, Zeng GY, Zhou YP, Zhangm LY, Cheng Y. Pharmacological studies on radix purariae. Clin Med J 95:145, 1982
7 Fan LL, Zeng GY, Zhou YP, Zhang LY, Cheng Y. Pharmacological studies on radix purariae. Clin Med J, 95:145, 1982
8 Han SH, Kim JB, Min SG, Lee CH. The effects of Puerariae radix catechins administration on liver function in carbon tetrachloride-treated rats. J Korean Soc. Food Nutr 24(6): 713-720, 1995
9 Cho KW, Kim SH, Koh GY, Seul KH, Huh KS, Chu D, Rapp NS, Moon HB, Kim KK, Kook YJ. Plasma concentration of atrial natriuretic peptide in different phase of korean hemmorrhagic fever. Nephron 51: 215-219, 1989   DOI   PUBMED
10 Ginsberg AL. Very High Levels of SGOT and LDH in Patients with Extrahe-patic Billiary Tract Obstruction. J Amer Dig Dis 15:803-805, 1970   DOI   PUBMED   ScienceOn
11 Bardwill C, Chang C. Serum lactic dehydrogenase, leucine amino peptidase and 5-nucleotidase activities, observations in patients with carcinoma of the pancreas and metatobiliary disease. J Canad Med Ass 89:755-800, 1963
12 Wr blewski F, LaDue JS. Lactic dehydrogenase activity in blood. Proc Soc Exper Biol. Med, 90:210-215, 1955   DOI
13 Lee SJ. Bonchokangmok. Komunsa Seoul 18:110-116, 1990
14 Choi JH. Effects of green tea catechin on cadimium accmulation in chronic cadmium poisoned rats. The Konan Nutrition Society 34:384-392. 2001
15 Kapor SC, Wieloposki L, Grazizno JH, Lolacono, N. 1989. Influence of 2,3,-dimercap tosuccinic acid on gastrointestinal lead absorption and whole body lead retention, Toxicol, Appl. Pharmacol, vol 97, p 525-530   DOI   ScienceOn
16 Cheng SJ. The preliminary study of inhibitory effects of green tea antioxidant on mutation Acta of Experimental Biology 9;28-334, 1986
17 Huh J. Donguibokam. Nmasandang Seoul 3, 1984
18 Goodfriend TL, L Levine, Fasma GD. Antibodies to bradykinin and angiotensin. A use of carbodiimide in immunololgy. Sci 144:1344-1346 (1964)
19 Kim HJ, Bae KH, Lee HJ, Eun JB, Kim MK. Effect of Hesperidin extracted from tangerine peel on Cd and lipid metabolism, and antioxidative capacity in rats. Korean J Nutrition 32:137-149, 1999
20 Oh MJ, Lee KS, Son HY, Kim SY. Antoxidative components of Pueria root. Korean J Food Sci Technol 22(7): 793-800, 1990
21 Revis NW, Osborne TR. Dietary protein effects on Cd and metallothionein accmulation in the liver and kidney of rats. Environ Health Persp 54:83, 1984   DOI   ScienceOn
22 Bergmeyer HU. Methods of enzymatic analysis. Verlag Chemie, Academic press Weinheim 1:20-28. 1995
23 Kada, T, Kaneko K, Matsuzaki S, Mastuzaki T, Hara Y. Detection and chemical identification on natural bioantiutagens. Mutation Reseach. 150; 127-131, 1985   DOI
24 Mutsuzaki T, Hata Y. Antioxidative activity of tea leaf catechins. Nippon Nogeikagaku Kaish, 59; 129-134, 1985   DOI
25 Sealey JE, Laragh JH. Searching out low renin patients limitation of some commonly used methods. Am J Med, 55:303-314, 1973   DOI   ScienceOn
26 Yoon YH Rhee SJ. Effects of korean Green tea, Oolong tea and Black tea beverage on the antioxidative detoxification in rat poisoned with Cadmium J Korean Soc. Food Nutr 27:1007-1017, 1994
27 Bernard AL, Foulkes EC. Cadmium Springer-Verlag. Berlin Heidelberg Germany, 75-97, 1986
28 Page AL, Chang AC. Cadmium springer-verlag, Berin Heidelberg Germany 33-55, 1986
29 Axelsson B, Piscator M. Renal damage after prolonged exposure to cadmium. An experimental study. Arch Environ Health, 12:360-373, 1966   DOI
30 Kazuko N, Midori Y, Chikusa T, Michiko I, Mitsuo N. Platelet aggregation inhibitory activity tea extracts Nippon Shokuhin kogyo
31 SAS : SAS User's Guide. Statistics, 5th ed., SAS Institute Inc., Cary,NC,U.S.A 1987
32 Cho KW, Malvin RL, Renin inactivation during in vitro. Experimental Am J Physiol, 236:501-504, 1979
33 Reitman S, Frankel S. A Colorimethc Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transammases. Amer J Clin Pathol 28:56-60, 1957   DOI
34 Hamilton DL, Smith MW. Inhibition of intestinal Ca uptake by Cd and the effects of a low Ca diet on Cd retention. Enciron. Research 25:175-181, 1978
35 Cherian MG, Nordberg, M. Cellular adaptation in metal toxicology and metallothionein. Toxicology 28:1, 1983   DOI   PUBMED   ScienceOn
36 Morita S. Defense mechanisms against cadmium toxicity. Ⅲ Effect of pretreatment with a amall oral dose of cadmium on metallothionein systhesis after a large oral dose of cadmium in mice. Japan J Pharmacol 35: 153-161, 1984   DOI
37 Cantilena LR. Klassen, CD. 1982. Decreased effectiveness of chelation theraphy with after acute cadmium poisoning. Toxicol. Appl. Pharmacol. vol 63, p173-180   DOI   ScienceOn
38 Morita S. Defence mechanisms against cadmium toxicity. I. A biochemical and histological study of the effects of pretreatment with cadmium on the acute toxicity of cadmium in mice. Japan J Pharmacol 35:129-135, 1984   DOI
39 Juhlshamn K, Utne F, Bracckan OR. Interactions of cadmium with copper, zinc and iron m different organs and tissues of the rat. Acta Pharmacol Toxicol 41: 515-524, 1977   DOI   ScienceOn
40 Murakami M, Cain K, Webb M. Cd-metallothionein induced nephropathy; a morphlogical and autoradiographical study of Cd distribution, the development of tubular damage and subsequent cell regeneration. J Appl Toxicol 51:237-242, 1983
41 Kostial K, Simonoric I. Lead absorption from the intestine in newborn rats. Nature 233; 564, 1971
42 Ganje JJ, Page AL. Rapid acid dissoulation of plant tissue for cadium determination by atomic absorption spectrophotometry. At Absorpt Newsl 131:108-110, 1976
43 Rhee SJ, Hung PC. Metallothionein accumulation in CHO, Cd cells in response to lead treatment. Chem Biol Interactions 72:347-361, 1989   DOI   ScienceOn
44 Sakanaks S, Kim M, Taniguchi M, Yamamoto T. Antibacterial substances in japanese green tea extract against streptotococcus mutans. a Cariognic bacterium. Argic Biol Chem 53(9):2307-2311, 1989
45 Babggy SP, Mcdonald WJ: Increased plasma renin activity in mature spontaneousely hypertensive rats. Proc Soc Exp Biol Med 139:1213-1216, 1972   DOI
46 Revis NW. The relationship of dietary protein to metallothionein and Cd induced renal damage. Toxicology 20:323, 1980
47 Kotsonis FN. Klassen CD. The relationship of metallothionein administration of rats. Toxicol Appl Pharmacol 46:39, 1978   DOI   ScienceOn
48 Muramatsu K, Fukuyo M, Hara Y. Effects of green tea catechins on plasma cholesterol on the removal of cadmium in rat. J Nutr Sci, Vitaminol 32(6): 613-622, 1986   DOI
49 Keung WM, Vallee BB. Daidzin, a potent, selectiveinhibitor from prurariae radix. Alchhol Clin Exp Res 17: 1254, 1993   DOI   ScienceOn
50 Cho KW, Kim SH, Koch GY. Radioimmunoassay and characterization of renin-angiotensin system in the fresh water turtle. L Exp Zool 242:255-262, 1987   DOI
51 Zeng GY, Zhang LY, Zhou YP, Fan LL Phannacoligical studied on radix. Clin Med J 95:145-150, 1982
52 Kim MJ, Rhee SJ. Effect of green tea, olong rea and black tea beverage on the removal of cadmium in rat. J Korean Soc Fod Nutr 23(5): 784-791, 1994
53 Miura K, Takeda R, Nakamoto H, Saito H. The chemical and pharmacological study of Puerariae radix. J Appl Pharmacol 5:247, 1971
54 Xie C.I, Lin RC, Antony V, Lumeng L, Li TK, Zao ZH, Wang, GF. Daidzin apotent selective inhibitor of human mitochondrial aldehyde dehyfrogenase. Proc Natl Acad Sci. USA 90:1247-1250, 1993   DOI   ScienceOn
55 Smith DR, Fiegal AR. 1992. Stable isotropic tracers of lead mobilizes by DMZA Chelation in low lead-exposrd rats. Toxicol. Appl. Pharmacol, vol 116, p 85-90   DOI   ScienceOn
56 Rhee SJ Kim SO, Choe WK, Cho SH. Effect of cadmium dose injection on peroxidative damage in rat liver. J Korean Soc. Food Nutr 21:601-607, 1992
57 Amador E,, Dorfman E, Wacker WE. Serum lactic dehydrogenase activity an analytical assessment of current assays. Clin Chem, 9:391-399, 1963
58 Cho KW, Kim SH. Factors affecting the relationship between renal renin activity and plasma rerun activity. Kor J Physiol 16:63-69, 1982