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http://dx.doi.org/10.1016/j.jgr.2016.12.006

Effect of Korean Red Ginseng intake on the survival duration of human immunodeficiency virus type 1 patients  

Cho, Young-Keol (Department of Microbiology, University of Ulsan College of Medicine)
Kim, Jung-Eun (Department of Microbiology, University of Ulsan College of Medicine)
Publication Information
Journal of Ginseng Research / v.41, no.2, 2017 , pp. 222-226 More about this Journal
Abstract
Background: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection. Methods: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG ($3,947{\pm}4,943g$) for $86{\pm}63$ mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period. Results: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r = 0.64, p < 0.0001) as well as between total amount of KRG and mean annual decrease in $CD4^+$ T-cell count in all 252 patients (r = -0.17, p < 0.01). The annual decrease in $CD4^+$ T-cell count (change in $cells/{\mu}L$) was significantly slower in KRG-treated patients than in patients receiving no KRG ($48{\pm}40$ vs. $106{\pm}162$; p < 0.001). The SD (in months) was also significantly longer in the KRG group than in the no-KRG group ($101{\pm}64$ vs. $59{\pm}40$, p < 0.01). Conclusion: KRG prolongs survival in HIV-1 patients, possibly by slowing the decrease in $CD4^+$ T-cell count.
Keywords
annual decrease of $CD4^+$ T cells; human immunodeficiency virus/AIDS; Korean Red Ginseng; survival duration;
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