• Journal of fish pathology
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• v.20 no.3
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• pp.299-306
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• 2007

Cysteine-cysteine chemokine receptor 9 (CCR9) homologue cDNA was isolated from olive flounder leukocyte cDNA library. Olive flounder CCR9 homologue consisted of 1709 bp encoding 367amino acid residues. When compared with other known CCR peptide sequences, the most conserved region of the olive flounder CCR9 peptide is the seven transmembranes. A phylogenetic analysis based on the deduced amino acid sequence showed the homologous relationship between the olive flounder CCR9 sequence and that of Mouse CCR9. The olive flounder CCR9 gene was predominantly expressed in the Peripheral blood leukocytes (PBLs), kidney, spleen, and gills.

• Journal of Software Assessment and Valuation
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• v.8 no.2
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• pp.13-27
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• 2012

This paper presents a tree-pattern based code-clone detector as CCR(Code Clone Ransacker) that finds all clusterd dulpicate pattern by comparing all pair of subtrees in the programs. The pattern included in its entirely in another pattern is ignored since only the largest duplicate patterns are interesed. Evaluation of CCR is high precision and recall. The previous tree-pattern based code-clone detectors are known to have good precision and recall because of comparing program structure. CCR is still high precision and the maximum 5 times higher recall than Asta and about 1.9 times than CloneDigger. The tool also include the majority of Bellon's reference corpus.

• BMB Reports
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• v.52 no.9
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• pp.548-553
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• 2019

Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between elevated expression of Ets-1 in cancer biopsies and poor survival. CCR7 is a chemokine that binds to specific ligand CCL21/CCL19. CCR7 expression is associated with tumor metastasis and infiltration into lymph nodes. The objective of this study was to test whether Ets-1 could regulate CCR7 expression and enhance tumor metastasis. Our data showed that CCR7 expression was downregulated in Ets-1-deficient T cells upon T-cell stimulation. Overexpression of Ets-1 increased CCR7 expression in breast cancer cell lines. In contrast, knockdown of Ets-1 reduced CCR7 expression. Ets-1 could directly bind to CCR7 promoter and mediate CCR7 expression in luciferase reporter assays and chromatin immunoprecipitation assays. Transactivation activity of Ets-1 was independent of the Pointed domain of Ets-1. Ets-1 could also enhance $NF-{\kappa}B$ and CBP transactivation of CCR7 promoter. Our results also showed that Ets-1 could modulate cancer cell transmigration by altering CCR7 expression in transwell assay and wound healing assay. Taken together, our data suggest that Ets-1 can enhance CCR7 expression and contribute to tumor cell migration.

• IMMUNE NETWORK
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• v.2 no.2
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• pp.86-90
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• 2002

Background: Host genetic polymorphisms in the HIV-1 co-receptor CCR5 and CCR2b and SDF-1, ligand for co-receptor CXCR4, have been known to be associated with the resistance of HIV infection and/or the delayed disease progression in HIV-infected patients. Methods: We examined the frequencies of SDF1-3'A and CCR2b-64I alleles of 354 Koreans including 100 HIV-uninfected persons, 13 discordant spouses of HIV-infected persons, and 241 HIV-infected persons. The genotyping assays of SDF1 and CCR2b genes were carried out by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequencies of CCR2b-64I and SDF1-3'A alleles in Koreans were very high compared with Caucasians and blacks. Observed frequencies of CCR2b-64I and SDF1-3'A allelic variants were 25.1% and 28.7%, respectively. The frequency of the CCR2b-64I allele in Koreans was 2~4 times higher than those of other ethnic groups with the exception of Asian. The frequencies of CCR2b-64I and SDF1-3'A genotypes did not show the significant difference between HIV-infected and uninfected Koreans. However, the prevalence of CCR2b-64I genotype of the LTNP group was about two times higher than that of the remainder group (P< 0.05). Four (45%) out of 9 LTNPs (long-term nonprogressors) showed having the SDF1-3'A allele and 7 (78%) out of 9 LTNPs carried the CCR2b-64I allele. 3 (33%) out of 9 LTNPs had both SDF1-3'A and CCR2b-64I alleles. But none of 5 RPs (rapid progressors) appeared to have both SDF1-3'A and CCR2b-64I alleles. Conclusion: The different genetic backgrounds in study populations may affect the disease progression and the AIDS epidemic in each country. Further studies need to define whether high frequencies of CCR2b-64I and SDF1-3'A allelic variants may affect the HIV disease progression.

• The Journal of the Convergence on Culture Technology
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• v.9 no.5
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• pp.91-98
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• 2023

This study is an exploratory research on smart healthcare services, specifically focusing on a multi-channel CCR based healthcare service system. The study examines the overview and operational principles of the service system, highlighting the significance of user communication and its role in the system's functionality. Furthermore, the study investigates the impact of service quality on user satisfaction and intention to continue using the service. To achieve this, a structural equation modeling(SEM) analysis was conducted with a sample of 188 users who owned and utilized healthcare devices and apps. The results indicate that service quality dimensions (reliability, responsiveness, empathy, assurance, and tangibility) all had a positive influence on user satisfaction. Additionally, user satisfaction was found to have a significant impact on intention to continue using the service. The findings of this study contribute to exploring the effectiveness and potential value of CCR-based smart healthcare services. It was also provided insights for the future development of smart healthcare systems that offer accurate health information and personalized services for individual health management and prevention.

• Journal of the Korea Institute of Military Science and Technology
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• v.11 no.6
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• pp.117-126
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• 2008

Recently, the investment and importance have been increasing concerning the researches which are based on fundamental studies. In defense science and technology development, the defense research centers are involved in a large portion of developing the potential capability such as defense applied technology, enhanced human resource, etc. In this paper, we analyzed the relative efficiency of 9 research centers(9 DMU : Decision Making Unit) supported by the defense budget, using DEA(Date Envelopment Analysis) method especially with the CCR-I(Charnes, Cooper, Rhodes-Input) model. Some variables are selected such as budget(input data), patent, article and human resource(output data) to be analyzed. Conclusively, the needs to identify performance-indicators, increase incentives to promote the performance and induce enthusiastic participation in defense science and development projects, are suggested via a relative efficiency analysis.

• The Journal of the Korea Contents Association
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• v.10 no.11
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• pp.371-379
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• 2010

This study analyzes relative efficiency analysis for universities or colleges of Chung Cheong regions using data envelopment analysis. The main results of this study can by summarized as follows. First, in case of efficiency for CCR, the number of efficient universities(CCR value is one) are five universities. and mean value of CCR for universities located in Chungbuk region was most high. Second, the number of efficient colleges(CCR value is one) are three colleges. and mean value of CCR for colleges located in Daejeon region was most high. Third, in case of efficiency for BCC, the number of efficient universities(BCC value is one) are nine universities. and mean value of BCC for universities located in Chungbuk region was most high. Fourth, the number of efficient colleges(BCC value is one) are seven colleges. and mean value of BCC for colleges located in Chungbuk region was most high.

• Journal of Digital Convergence
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• v.10 no.9
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• pp.159-164
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• 2012

Although the display industry plays an important role in the entire Korean economy, few empirical research has analyzed the efficiency of display companies. The purpose of this paper is to measure and analyze efficiency of korean listed display firms using DEA(Data Envelopment Analysis) models. We evaluate the CCR and BCC efficiency in DEA models and the return to scale of the Korean listed display companies. The benchmarking companies and efficiency value for the display companies with inefficiency are also provided to improve their efficiency. We analyzed the 44 listed companies consisted of 7 listed on KOSPI and 37 listed on KOSDAQ at the end of 2010. The analysis results show six companies whose values of CCR are 1, and fourteen firms whose values of BCC efficiency are 1. In additions, the six companies have the scalability efficiency. Eventually the efficiency analysis can provide the valuable information for inefficient companies to find benchmarking companies and to improve their efficiency.

• The Journal of the Korea Contents Association
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• v.20 no.2
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• pp.27-35
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• 2020

The Korean semiconductor industry is the top export item, and its technological prowess is also higher than that of its competitors. However, the technology gap with rivals will narrow. And the semiconductor industry is facing difficulties due to trade friction. Therefore, semiconductor firms should be more efficient in their production. we study analyzes the efficiency semiconductor firms using DEA model. We evaluate the CCR, BBC efficiency and RTS(return to scale) of 30 Korean semiconductor firms. There are a total of 13 efficient DMUs with a BCC of 1. There are a total of 6 efficient DMUs with a CCR of 1. A total of 10 DMUs were IRS in Scale Efficiency and a total of 9 DMUs were CRS in Scale Efficiency and a total of 11 DMUs were DRS in Scale Efficiency. We also suggest the semiconductor firms which can be benchmarked based on analyzed information.

• Journal of Korean Society for Quality Management
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• v.35 no.3
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• pp.21-36
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• 2007

This article is to analyze the service efficiency of public sector using Data Envelopment Analysis(DEA). We tried to measure the public service quality and overall satisfaction by using several DEA models, degree of combination and top2box which is a little bit different methodology from traditional ones. We used CCR, Super-efficiency and Slack based measure(SBM) model in DEA to measure public service efficiency of the 16 public institutions(7 City Halls and 9 Provincial offices). Since the traditional method based on the measurement model(CCR, BCC) has the fundamental problems without taking account of the existence of slacks inputs and outputs in several efficient units, we suggest to measure the exact amount of efficiency and inefficiency of the public sector and rank analysis many efficient units exactly through the slacks-based measure model(SBM)