• 동의생리병리학회지
• /
• 제23권2호
• /
• pp.457-463
• /
• 2009

This study aimed to evaluate the anti-asthmatic effects of Seonpye-tang (SPT) using OVA-induced asthmatic mice model. Scavenging activity of SPT on DPPH free radical and SOD-like activity of SPT were measured at final concentration 62.5, 125, 250, 500 (${\mu}g/m{\ell}$), RBL-2H3 cells were treated with DNP IgE for 24hr, and treated with SPT (1, 10, 100 ${\mu}g/m{\ell}$) for 1hr, followed by treatment with DNP-HSA for 1hr at $37^{\circ}C$. The level of IL-4 and TNF-${\alpha}$ were measured by ELISA. Asthmatic mice model was conducted by repeated challenge of OVA using C57BL/6 mice. Each group was treated with distilled water, SPT (400 mg/kg and 200 mg/kg) extract or cyclosporin A (10 mg/kg) for the later 8 weeks. Immune cells subpopulation, eotaxin, IL-5 and TNF-${\alpha}$ in BALF were analyzed. SPT dose-dependently increased Scavenging activity on DPPH free radical and SOD-like activity. SPT significantly ameliorated the increase of total cells number and eosinophil including of immune cell subpopulation of $CD3^+/CD69^+$, $CCR3^+$, $B220^+/CD22^+$, $B220^+/CD45^+$ and $B220^+/IgE^+$ cells in BALF comparing to control group. Eotaxin and IL-5 level in BALF were significantly decreased by SPT. These results strongly suggest that SPT would be a effective candidate for herbal-originated anti-asthmatic drug. However, this drug should be further studied for characterization of the accurate action and underlying mechanisms using variant disease model in the future.

• 산업경영시스템학회지
• /
• 제40권4호
• /
• pp.21-28
• /
• 2017

Improving efficiency of the telecommunication is crucial to the development and growth of Korean economy. Recently, it has become important with the huge development of information technology and its greater potential for extensive impact on the rest of the economy. Hence, it is useful to determine the factors that help enhance efficiency in telecommunication and consider them in improving the evaluation model. This study applies DEA (data envelopment analysis) to evaluate the relative efficiency of 51 branches of a Korean telecommunication company. Using the super-efficiency approach, we tested outliers which may affect the results and ranked the efficient branches. A method of deriving key variables applied to business operation is proposed to identify the key performance indicators for evaluation that takes environmental (non-discretionary) factors into account. We used the extended CCR model proposed by Banker and Morey to investigate the influence of non-discretionary factor. The information provided by the model (slacks, weights) and the sensitivity analysis shows that the most important indicator that affects the branch performance is operating cost. The results of sensitivity analysis show that average efficient score decreases from 0.972 (base case) to 0.863 for CASE2-COST. The average score of the data proves the priority of operating cost over other indicators. The effect of environmental (non-discretionary) variable was found to be significant. The population effect was positive and improved overall efficiency by 0.91% on average. Non-discretionary factor plays a meaningful role explaining the performance of branches. The performance optimization report can help a manager of an inefficient branch to develop branch strategies. Managers can identify the top-performing units, study best practices and adopt the strategy to the organization.

• 한국콘텐츠학회논문지
• /
• 제19권5호
• /
• pp.64-73
• /
• 2019

본 연구는 전문건설업체의 경쟁력을 평가하기 위해 DEA모형을 활용하여 효율성을 분석하였다. 분석대상기업은 전문건설업 상장업체와 외감업체로 2010년부터 2017년까지 연속자료가 존재하는 300개 기업을 대상으로 하였다. 특히, 전문건설업 유형별 효율성을 비교, 분석하여 그 시사점을 찾는데 중점을 두었다. 의미 있는 분석결과는 다음과 같다. 첫째, 전문건설업체의 효율성은 전반적으로 종합건설업 등과 비교하면 효율성 값이 낮게 분석되었다. 둘째, 전문건설업 유형별 효율성은 시설물축조 및 해체 전문공사업이 가장 높게 나타났다. 이는 해당 업종인 철근 콘크리트공사업, 비계 구조물해체공사업 등이 전문건설업 내에서 상대적으로 효율적임을 의미한다. 셋째, 전문건설업 효율성은 건설경기에 영향을 받는다. 건설경기가 확장국면에 있을 때는 효율성 값이 높고, 수축국면에서는 낮은 효율성 값을 나타내었다. 마지막으로 규모수익성 분석에서 전문건설업은 DRS로 분석되는 경우가 가장 많았다. 이는 규모 확대보다 규모 축소를 통해 기업의 효율성을 높이는 것이 바람직하다는 것을 의미한다.

• 대한본초학회지
• /
• 제28권6호
• /
• pp.15-23
• /
• 2013

Objectives : To clarify the possible effects of Sinapis Semen and Raphani Semen on the development of pulmonary eosinophilic inflammation in a asthmatic mouse model. Methods : BALBav/c mice were sensitized to OVA followed intratracheally and by aerosol allergene challenges. We investigated the effect of Sinapis Semen and Raphani Semen on airway hyperresponsiveness, eosinophiic infitratio, immune cell phenotype, The2 cytokine product, and OVA-spedific IgE production. Results : Total lung cells, eosinophils, and lung leukocytes, OVA specific IgE levels, and Th 2cytokine levels such as IL-5, IL-13, IL-17, TNF-alpha, and eotaxin in BALF were reduced compared with those of OVA sensitized asthma mice (control). The absolute numbers of $CD3^+$, $CD3^+/CD69^+$, $CD3^-/CCR3^+$, $CD4^+$, $CD8^+$, $Gr-1^+/CD11b^+$, $B220^+/CD22^+$, $B220^+/IgE^+$ cells in lung tissiues significantly reduced compared to those of control. Specially total lung cells in BALF and the absolute number of $CD3^+/CD69^+$ and, $B220^+/IgE^+$ cells in lung tissiue effectively reduced in Sinapis Semen plus Raphani Semen compared to those of Sinapis Semen and Raphani Semen. Conclusions : These results indicate that Sinapis Semen plus Raphani Semen has deep inhibitory effects on airway inflammation and hyperresponsiveness in asmatic mouse model and also has effect of suppression of IL-5, IL-13, IL-17, OVA specific IgE production in BALF. The results verified that Sinapis Semen, Raphani Semen, and Sinapis Semen plus Raphani Semen could act as a immunomodulator which possess anti-inflammatory and anti-asthmatic property by modulating the relationship of Th1/Th2 cytokine imbalance.

• 한국유기농업학회지
• /
• 제30권3호
• /
• pp.351-374
• /
• 2022

In recent years, the development of rice industry has been highly valued by the state. In hubei area, due to the development of the modernization and the shortage of labor, traditional way of rice cultivation methods is facing serious challenges, and economic benefits have become the decisive factor for the effective promotion and application of rice cultivation methods. According to the research results, first, in the input-side analysis, in the CCR model, D5, D12, D26, D28, D32, D36 farmers with high efficiency appear. The analysis result shows that among the 60 farmers, the average efficiency is 89%, and there is an inefficiency of 11%. In the BCC model, 14 farmers were identified as high-efficiency farmers, with an average efficiency of 0.9453. Second, in direct seeding cultivation of rice, the average scale efficiency is 0.9227, while the average pure technical efficiency is 0.9644. This shows that the effect of scale efficiency is greater than that of purely technical factors, ignoring the reasons for the low operational efficiency of direct seeding cultivation farmers. It can be predicted that with the further deepening of farmers' understanding of this planting mode, the proportion of rice direct seeding may be further expanded in the future. Relevant agricultural departments should further promote this technology to farmers, study the direct seeding technology using scientific methods, and evaluate the changes of this cultivation mode. The agricultural departments of government should concern about the climate risk assessment of direct seeding rice, the environmental impact assessment caused by the extensive use of herbicides, the application of mechanical technology in the process of direct seeding, the lodging of direct seeding rice, and other related issues.

• 대한본초학회지
• /
• 제24권2호
• /
• pp.39-48
• /
• 2009

Objectives : To clarify the possible effect of JS (Juglans sinensis), PCF (Psoralea corylifolia L.), and J+P(JS+PCF), we examined their influence on the development of pulmonary eosinophilic inflammation in the asthmatic murine model. Methods : All mice were immunized on two different days (21 days and 7 days before inhalational exposure) by intraperitonial injections of 0.2 ml alum-precipitated Ag containing 100 ${\mu}$g of OVA bound to 4 mg of aluminum hydroxide in PBS. Seven days after the second sensitization, mice were exposed to aerosolized ovalbumin for 30 minutes/day on 3 days/week for 8 weeks (at a flow rate of 250 L/min, 2.5% ovalbumin in normal saline) and, JS, PCF and J+P (200 mg/kg, 400 mg/kg) were orally administered 3 times per week for 8 weeks. Results : The suppressive effects of JS, PCF, and J+P were demonstrated by the accumulation of eosinophils into airways, with the reduction of eosinophils and lung leukocytes. These were correlated with the marked reduction of IL-4, IL-5, IL-13 levels in the BALF and serum. OVA-specific IgE levels were also decreased in serum and BAL from these mice. And also JS, PCF, and J+P decreased eosinophilic CCR3 and CD11b expression in lung tissue. Conclusions : These results indicate that JS, PCF, and J+P have deep inhibitory effects on airway inflammation and hyper-responsiveness in the asthmatic murine model. The suppression of IL-5, IgE, and eosinophilils and the increase of IFN-${\gamma}$ production in BALF seem to contribute to these effects. Specially, esosinophils and TNF-a in J+P combination group were significantly reduced in BALF and lung tissue. Hence, the results indicated that JS, PCF, and J+P could act as an immuno-modulator which possesses anti-inflammatory and anti-asthmatic property by modulating the imbalance between Th1 and Th2 cytokines.

• International Journal of Contents
• /
• 제4권3호
• /
• pp.1-9
• /
• 2008

The Korean life insurance industry has undergone profound changes, such as the beginning of the variable insurance in July 2001 and the bancassurance enforcement in August 2003. However, little empirical research has analyzed data that includes the bancassurance of life insurance companies operating in Korea. In response to this lack of research, this paper applies DEA (data envelopment analysis) models to measure and decompose their efficiency. We discovered that life insurance companies operating in Korea are a little different in their composition ratio of inputs and outputs, due to the increased variety of distribution channels and new products. We provided efficiency scores, return to scale, and reference frequencies. We also decomposed CCR, BCC, and SBM efficiency into scale efficiency and MIX efficiency. So, we try to investigate whether the sources of inefficiency were caused by the inefficient operation of DMU, disadvantageous conditions, the difference of the composition ratio in inputs and outputs with reference sets, or any combination of the above. Most companies in the sample display had either constant or decreasing returns to scale. The efficiency rankings were less consistent among models and efficient DMUs. In response to this problem, we used the super-efficiency model to rank them and then compared the rankings of the DMUs among the various models. It was also concluded that the availability of panel data, rather than cross-sectional data, would greatly improve the validity of the efficiency estimates.

• 경영과학
• /
• 제34권1호
• /
• pp.15-25
• /
• 2017

We evaluated industry growth and employment effects of every possible pairs of 22 manufacturing sectors and 16 regions (i.e, 352 region-sectors). We used annual data of manufacturing sectors from 2008 to 2014 for the evaluation. The evaluation comprises of two steps; We first find several region-sectors that outperform others with respect to the effects of industry growth and employment, which are measured by location quotient analysis, shift share method, employment to GDP ratio and employment elasticity. In addition, cross-efficiency analysis follows to classify region-sector pairs into two sub-categories : efficient region-sectors that deserve to hold the current level of investments and inefficient region-sectors where we should consider efficiency improvements. To examine the efficiency, R&D investment, employment size, and capital investment were used as input factors and production volume, added value, changes in employment size, changes in annual salary per capita were used as output factors. For region-sector pairs that have outstanding growth and employment effects but are inefficient, we employed a CCR DEA model and analyzed how much to adjust the values of input and output factors to improve the efficiency scores. The analysis results showed that inefficiency is mainly due to several factors such as R&D investment, changes in employment size and changes in annual salary per capita.

• 대한의생명과학회지
• /
• 제14권3호
• /
• pp.199-201
• /
• 2008

Eosinophil is an improtant leukocyte in the development of various inflammatory diseases. Monocyte chemoattractant protein-1 (MCP-1) acts as a key regulator on monocyte movement, and activation of T cells and NK cells. However, the role of MCP-1 in eosinophils remains to be solved. In the present study, we examined the effect of MCP-1 on eosinophil migration, using human eosinophilic EoL-1 cells as an in vitro model of eosinophils. The surface expression of CCR2 in EoL-1 cells was little detected but MCP-1 strongly induced EoL-1 cell migration in a dose-dependent manner. Increased chemotactic activity due to MCP-1 was blocked by pertussis toxin, a $G_i/G_o$ protein inhibitor and U73122, a phospholipase C (PLC) inhibitor. These results suggest that MCP-1 activates $G_i/G_o$ protein and PLC and this signal pathway is involved in eosinphil movement. This finding supports the elucidation of pathogenic mechanism of eosinophilic inflammation such as asthma and atopic dermatitis.

• 한국식품영양학회지
• /
• 제22권1호
• /
• pp.132-140
• /
• 2009

This study was performed to examine the manpower structure of foodservice operations, evaluate the management efficiency of each operation, and propose efficiency improvement guidelines for inefficient operations. For this purpose, a total of 224 B&I foodservice operations managed by an 'A' contract-managed foodservice company were chosen as the study sample. The efficiency scores were obtained through Data Envelopment Analysis(DEA) using the CCR model. The efficiency scores ranged from 63.56 to 100 and the average score was 82.47. The average efficiency score of Group 'C'(factory, more than 1,000 meals per day) was the highest among 6 groups. The results of further operations analysis in group 'C' showed that the labor cost percentage was significantly lower(p<0.001) and sales per man-hour significantly higher(p<0.001) in efficient operations compared to inefficient operations within group 'C'. Finally, efficiency improvement guidelines were suggested for the most inefficient operations in group 'C'.