• Title/Summary/Keyword: CCR

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Activation and Recruitment of Regulatory T Cells via Chemokine Receptor Activation in Trichinella spiralis-Infected Mice

  • Ahn, Jeong-Bin;Kang, Shin Ae;Kim, Dong-Hee;Yu, Hak Sun
    • Parasites, Hosts and Diseases
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    • v.54 no.2
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    • pp.163-171
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    • 2016
  • As most infections by the helminth parasite elicit the recruitment of $CD4^+CD25^+Foxp3^+$ T ($T_{reg}$) cells, many scientists have suggested that these cells could be used for the treatment of immune-mediated inflammation and associated diseases. In order to investigate the distribution and alteration of activated $T_{reg}$ cells, we compared the expression levels of $T_{reg}$ cell activation markers in the ileum and gastrocnemius tissues 1, 2, and 4 weeks after infection. The number of $T_{reg}$ cells was monitored using GFP-coded Foxp3 transgenic mice. In mice at 1 week after Trichinella spiralis infection, the number of activated $T_{reg}$ cells was higher than in the control group. In mice at 2 weeks after infection, there was a significant increase in the number of cells expressing Foxp3 and CTLA-4 when compared to the control group and mice at 1 week after infection. At 4 weeks after infection, T. spiralis was easily identifiable in nurse cells in mouse muscles. In the intestine, the expression of Gzmb and Klrg1 decreased over time and that of Capg remained unchanged for the first and second week, then decreased in the 4th week. However, in the muscles, the expression of most chemokine genes was increased due to T. spiralis infection, in particular the expression levels of Gzmb, OX40, and CTLA-4 increased until week 4. In addition, increased gene expression of all chemokine receptors in muscle, CXCR3, CCR4, CCR5, CCR9, and CCR10, was observed up until the 4th week. In conclusion, various chemokine receptors showed increased expressions combined with recruitment of $T_{reg}$ cells in the muscle tissue.

Expression of Chemokine Receptors Involved in Receptor-Mediated Endocytosis of Bone Marrow-Derived Stromal Stem Cells (골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구)

  • Jeong, Young-Sin;Byun, Hyang-Min;Shin, Jee-Young;Kim, Jung-Mogg;Chung, Hyung-Min;Oh, Yu-Kyoung
    • Journal of Pharmaceutical Investigation
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    • v.33 no.4
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    • pp.281-286
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    • 2003
  • To design gene deliver systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several culture conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells ad marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 ad CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression of chemokine receptors generally decreased in most chemokine receptors with the cultivaton of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher level of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased levels of receptor-mediated gene delivery into stromal stem cells.

Efficiency Analysis of Construction Firms Using a Combined AHP and DEA Model (AHP와 DEA 결합모델을 이용한 상장 건설기업의 효율성 분석)

  • Seo, Kwang-Kyu;Choi, Da-Young
    • The Journal of the Korea Contents Association
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    • v.11 no.6
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    • pp.302-310
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    • 2011
  • Recently, many construction firms fall on hard times because construction business continues to stagnate. In this paper, we analyze the efficiency of the listed construction firms using a combined AHP and DEA model. In order to determine the input and output factors of DEA, the AHP model is applied to evaluate the importance of input and output factors. The benchmarking companies and efficiency value for the construction firms with inefficiency are also provided to improve the their efficiency. We analyzed the 57 listed companies consisted of 36 listed on KOSPI and 21 listed on KOSDAQ at the end of 2009. The analysis results show that eleven companies whose values of CCR are 1, and fourteen enterprises whose values of BCC efficiency are 1. In additions, the eleven firms have the scalability efficiency. Finally, we test the correlation between efficiency and the stock price and the correlation coefficient of efficiency group is 0.7 in the CCR model.

Relative Efficiency and Productivity Change of the Korean Non-Life Insurance Firms (국내 손해보험회사의 상대적 효율성 및 생산성 변화)

  • Kang, Ho-Jung
    • The Journal of the Korea Contents Association
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    • v.9 no.5
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    • pp.224-229
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    • 2009
  • This study measures the relative efficiency and productivity change of the Korean Non-Life Insurance Firms using DEA model and Malmquist Index for 2004-2007. The main results of this study can by summarized as follows. First, in case of efficiency of CCR for 2004-2007, the number of efficient firms(CCR value is one) are one firm, one firm, one firm, one firm respectively. Second, in case of efficiency of BCC for 2004-2007, the number of efficient firms(BCC value is one) are five firms, five firms, six firms, six firms respectively. Third, In case of return to scale for 2004-2007, DRS are five firms, DRS are five firms, DRS are six firms, DRS are six firms respectively, Fourth, Malmquist Index representing productivity change for 2004-2007 are 0.99 in 2004-2005, 1.04 in 2005-2006, 1.06 in 2006-2007.

The Changes of Technical Efficiency and Malmquist Productivity of Land Transportation by Region (지역에 따른 육상운송의 효율성과 생산성 분석)

  • Park, Hong Gyun
    • Journal of Korea Port Economic Association
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    • v.28 no.4
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    • pp.59-77
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    • 2012
  • Inland transportation system has been improving inefficiencies and structural problems due to excess of supply. Therefore, inland transportation market needs to reform its regional logistics structure in order to increase its competitiveness. To improve the solution, the research studied efficiencies and productivity of inland transportation systems in regions. In order to obtain specific facts, each cities' five years of (2005-2009) balanced panel data on inland transportation system has been studied. According to CCR and BCC analysis, Ul-San has been evaluated as the most efficient DMU during 2005-2008. In addition, in 2009, Seoul was the most efficient DMU. Also, according to Window analysis, Gwan-Ju and Gwangwon-do scored 0.062. Therefore, they were estimated as stable DMUs. According to Malmquist productivity analysis, average productivity indexes of four terms of Chungcheongnam-do and Chungcheongbuk-do haves been increased to 6.6% and 7.3%. I hope this study contributes to the improvement of regional inland transportation system.

Analysis of the Operation Efficiency and Influence Factors of Local Welfare Facilities for the Disabled -Focusing on Housing Facilities of the Severely Disabled in Jeolla Region- (지역 장애인복지시설의 운영효율성 및 영향요인 분석 -전라지역 중증장애인 거주시설을 중심으로-)

  • Lee, Hyeong-Bae
    • Journal of Digital Convergence
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    • v.12 no.12
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    • pp.611-620
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    • 2014
  • This research analyzed the operation efficiency and influence factors of housing facilities for the severely disabled in Jeolla region by using the DEA model. First, the analysis of efficiency for 2012 was carried out using the CCR model. As a result, 12 DMUs were proved to be efficient, and the average efficiency of CCR was 0.85, confirming that the efficiency of all DMUs were satisfactory. Second, regression analysis was carried out to analyze the factors affecting the efficiency of the DEA model by using the Tobit model. In this case, the inputs and calculated variables were set as independent variables whereas the efficiency as the dependent variable. As a result, the detailed variables had a low significance; the overall input variables showed a negative influence while the calculated variables tended to be a positive influence. In terms of operation efficiency, there was no meaningful result in input variables besides the number of workers. Instead of expanding the input variables, the following should be made for housing facilities of the severely disabled; more efforts should be put in to improve welfare service delivery system and operating environment and structure, and the program must be supplemented as well.

Algal Pigments and their Degradation Products in Suspended and Sinking Particulate Material in the Gulf of Mexico (멕시코 만의 부유 및 침강고형물에 존재하는 조류색소 및 그 분해산물)

  • Noh, Il
    • Journal of Environmental Science International
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    • v.5 no.2
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    • pp.153-170
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    • 1996
  • Photosynthetic pigments and their degradation products in suspended and sinking particles collected from the Gulf of Mexico waters 1987~88, were measured using High Performance liquid Chromatography (HPIC). The short term variations in flux rates of chlorophylls and carotenoids as well as-their degradation products were compared at the mesoscale cyclonic and anticyclonic circulation features (cold joie rink and warm core ring). Chlorophyll a was the predominant porphyrin of suspended particulate matter at both CCR -and WCR. Among carotenoid pigments, 19'-hexanoyloxyfucoxanthin, which is a biomarker of prymnesiophytes, was dominant pigment at both rinds. Phaeophorbide a, which is produced through the Brazing processes of grazers, was the predominant degraded pigment in sinking particles ai the study aiea. Total pigment flux in CCR was an order of magnitude higher than that in WCR. Less than l% of the standing stock of the pigments measured sank out of the upper 200m of the WCR on any given day. Thus, suspended particulate matter in Gulf of Medico was not recycled rapidly.

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The Influence of Efficient Container Terminals Using DEA and SNA (DEA와 SNA를 이용한 효율적인 컨테이너 터미널의 영향력에 관한 연구)

  • Son, Yong-Jung
    • Journal of Korea Port Economic Association
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    • v.31 no.3
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    • pp.155-166
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    • 2015
  • This study selected container terminals of Gwangyang and Busan Ports to evaluate the influence of efficient container terminals. For the study, after data envelopment analysis (DEA) using the CCR and BCC models, the decision-making unit (DMU) system was used to define nodes; and with the use of a reference group in DEA (BCC model) and a lambda value, this study created a social network and analyzed the influences of efficient DMUs through a centrality analysis of eigenvectors. The results are presented as follows: First, as a result of the DEA, CCR efficiencies in PNC, HJNC, and HPNT container terminals of Busan Port were 1 and BCC efficiencies at Singamman Terminal, Wooam Terminal, PNC, HJNC, HPNT, and BNCT container terminals of Busan Port were 1. Second, as a result of undertaking social network analysis (SNA), according to an eigenvector centrality analysis, HJNC Terminal was referred to the most (influence score of 0.515), which indicates that it is the most influential as a container terminal. The influence of PNC Terminal was 0.512, while that of Wooam Terminal was 0.379. CJ Korea Express in Gwangyang Port was ranked fourth in influence, but its influence score of 0.256 indicates that it was the most influential of the container terminals at Gwangyang Port.

An Analysis of Efficiency of Superior Appraisal Corporations Using DEA (DEA 모형을 이용한 우수감정평가법인의 효율성 분석)

  • Lee, Chan-Ho;Kim, Jong-Ki;Hwang, Soo-Jin;Jeon, Jin-Whan
    • The Journal of the Korea Contents Association
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    • v.10 no.12
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    • pp.290-299
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    • 2010
  • This study aims to evaluate the efficiency of superior appraisal corporations using DEA(Data Envelopment Analysis). DEA is known as a method for evaluating relative efficiency of organizations with multiple inputs and outputs. We used CCR-O and BCC-O DEA models to evaluate relative efficiency of superior appraisal corporations. Input variable is number of appraisers, output variables are total sales and net income. Total of 13 appraisal corporations in Korea were selected for this study, and the data were collected from financial reports for 2008 fiscal year. The result of this study is summarized as follows. First, the average of superior appraisal corporation's technical efficiency score is about 88.3% by applying CCR-O model. Second, the average of superior appraisal corporation's pure technical efficiency score is about 90% and scale efficiency score is about 98.2% by applying BCC-O model. According to the result of DEA, the cause of inefficiency is pure technical efficiency.