• Archives of Pharmacal Research
• /
• 제18권3호
• /
• pp.179-182
• /
• 1995

Previous study showed that $CCl_4$ administration evoked a rapid decrease in cytochrome $P_{450}$ 2E1 protein soon after the exposure due to posttranslational inhibition(Biochem. Biophys. Res. Commun. 179:449-454, 1991). In this report, aniline hydroxylase and the amounts of immunoreactive $P_{450}$ 2E1 were rapidly decreased during day 1 to 2 and recovered during day 3 to 4 after a single dose of $CCl_4$. The activity of pentoxyresorufin-O-dealkylase was also suppressed at day 1 and began to repair from day 2. However, the decrease in immunoreactive $P_{450}$ 2C content was not observed. The decreases in $P_{450}$ 2E1 enzyme activity and immunoreactive protein by acute $CCl_4$ treatment were accompanied by a decline in $P_{450}$ 2E1 mRNA level. The data thus suggested a pretranslational reduction of $P_{450}$ 2E1 during day 1 to 2 after acute $CCl_4$ treatment.

• Journal of the Korean Data and Information Science Society
• /
• 제23권3호
• /
• pp.535-542
• /
• 2012

소비자물가지수는 국가의 중요한 경제 척도 중의 하나이다. 본 연구에서는 4개 도시, 서울, 부산, 대구, 광주지역의 소비자물가지수를 연구하였다. 자료는 모두 통계청에서 발췌하였고, 기간은 1998년-2011년 월별자료이며, 시계열분석 기법인 자기회귀오차모형으로 분석하였다. 소비자물가 분석을 위한 설명변수는 9가지 경제변수인 경기동행지수, 미국환욜, 생산자물가지수, 원유수입단가, 원유수입물량, 국제경상수지, 수입물가지수, 실업율, 화폐통화량을 사용하였다. 분석 결과, 자기회귀오차모형으로 각 지역별 소비자물가지수를 46%-52% 정도 설명할 수 있다.

• 한국한의학연구원논문집
• /
• 제12권1호
• /
• pp.103-109
• /
• 2006

We investigated liver protection effect of the Hovenia dulcis Thunb extraction which has treated with carbon tetrachloride ($CCl_4$, 1.0 ML/kg) in SD male rat (20 weeks). We observed the amount of leukocyte, erythrocyte, hemoblobin and hematocrit are increased and the number of plaque is decreased for treatment of $CCl_4$, However, after treatment of Hovenia dulcis Thunb extraction (15 mL/kg), we have same result that of control group which has treated with $CCl_4$ The blood biological data showed that the value of AST (Aspartate aminotransferase), ALT(Alanine aminotransferase) and LDH (Lactate dehydronase) are increased significantly for the negative control group compared to that of control group. For experimental group, respectively, In addition, it was confirmed that the recovery effect of a mysterious death of an interstitial cell of the experimental group is to be compared to that of the negative control group for a sample of pathological tissue.

• 한국의류학회지
• /
• 제26권3_4호
• /
• pp.492-502
• /
• 2002

The purpose of this study was to investigate the advertising appeals and consumption values expressed on cosmetic advertisements in Adolescent's magazines from 1973 to 2000. The data for longitudinal content analysis were collected from Adolescent's magazine : Junior Joongang(1973.3∼1985.12), Highteen(1986.1∼1994.9), Cci(1994.l0∼2000.12). Collected data was consisted of 542 advertisements. 1. The product categories in cosmetics advertisements, the major were Base Make-up in the past but the number of Color Make-up, Functional Make-up, and Hair-related Products had increased in 1990s. Also, there were more increasing number of imported products than domestics. 2. The trend of appeals showed change according to time and society. Overall, a great many of cosmetic advertisements had emotional approach. Before the middle of the 1980's emotional approach had decreased, and mixed(rational and emotional) approach were dominated in 1990s. 3. The major consumption values in cosmetics advertisements were effective value. Especially, it had increased from 1990s. And esthetic value was dominated in the middle of the 1970s.

• 한국미생물·생명공학회지
• /
• 제22권3호
• /
• pp.309-315
• /
• 1994

Selective agar media were constructed for the counting of bifidobacteria in dairy produ- cts containing bifidobacteria, lactobacilli and streptococci. This media containing antibiotics inhibited the growth of lactobacilli and streptococci at less than 10$^{5}$ cfu/ml, but had no influence on the recovery of bifidobacteria. In order to inhibit the growth of 10$^{5}$ cfu/ml of lactobacilli and streptoco- cci, the addition of 1.0~2.0 $\mu$g/ml of tetracycline in BL agar medium was needed. When 25 $\mu$g/ml of neomycin and paromomycin were mixed with 1.0 $\mu$g/ml of tetracycline in BL agar medium, it was able to inhibit the growth of 10$^{6}$ cfu/ml of lactobacilli and streptococci but had a little negative effect on the recovery of colonies of bifidobacteria. The results revealed that the BL agar medium containing 1.0 $\mu$g/ml of tetracycline was suitable to count the cell number of bifidobacteria selecti- vely in the presence of a 1 to 10$^{5}$-fold excess of L. casei, L. acidophilus and S. salivarius subsp.thermophilus.

• 대한의생명과학회지
• /
• 제26권4호
• /
• pp.310-318
• /
• 2020

The sciatic nerve is the largest nerve among the peripheral nerves, and the damage to the sciatic nerve is caused by mechanical and physical pressure. This is an important disease that consumes a lot of time and money in the treatment process. Among them, research on relieving nerve pain caused by damage to the peripheral sciatic nerve has been made efforts to prevent and treat this disease through various methods such as drugs, natural products, electrical stimulation, exercise therapy, and massage. Existing treatments are not very effective in neurological pain, and countermeasures are needed. Forsythia Fructus, used in this study, has been used as a therapeutic agent for infectious diseases and a pain reliever for cancer from the past, and in past studies, it has been known to properly control the inflammatory response. In this study, rengyolone, a physiologically active substance of Forsythiae Fructus, was administered to rats that caused chronic left nerve pain to verify the pain relief effect. As a result of the experiment, it was found that mechanical pain and cold stimulation pain were significantly reduced in the rengyolone-treated group compared to the non-administered group. In addition, it was found that nerve growth factor (NGF) mRNA expression was significantly reduced and Cyclin-dependent kinase 2 (Cdc2) expression was increased in the rengyolone administration group. This increase in NGF expression is thought to be related to rengyolone's anti-inflammatory regulatory mechanism. It is expected that the reduced NGF was directly involved in pain relief.

• The Journal of Asian Finance, Economics and Business
• /
• 제8권8호
• /
• pp.157-166
• /
• 2021

In the past four decades, corporate social responsibility (CSR) issues have grown substantially due to the increasing demand for transparency and growing expectations that corporations should manage and improve their social, environmental, and economic performance. As a result, most organizations, companies, and governments provide CSR reports, while a large number of companies are still engaged in defining and integrating CSR into several aspects of their business. CSR is an obligation to society (Lee, 2020). The linkage between CSR and consumer-company identification (CCI) is important under company stakeholders. Consumers who care about those issues often change their shopping habits to bring greater value to the community. They will avoid buying environmentally or socially harmful products, and actively seek the products and services of the companies that carry out social responsibility. Companies conducting CSR activities such as charity works or environmental activities will be easy to associate as a responsible organization for always meeting the necessity of society. Therefore, companies must consider CSR a long-term strategy. The strategic approach to CSR plays an increasingly significant part in the business competitiveness - which helps create companies' values while gains trust and respect from the consumers, partners in particular, and the social community in general. This study is conducted to show evidence from project-based organizations about the CSR factors that influence consumer loyalty and the impact level of those factors on customer loyalty.

• 한국병원경영학회지
• /
• 제26권1호
• /
• pp.17-25
• /
• 2021

This study aimed to analysis factors related to in-hospital death of injured patients by patient safety accident. A total of 1,529 inpatients were selected from Korea Centers for Disease Control and Prevention database(2013-2017). Frequency, Fisher's exact test, t-test, ANOVA, logistic regression analyses by using STATA 12.0 were performed. Analysis results show that the mortality rate was lower for female than male but the mortality rate was higher for the older age, the higher the CCI, head (or neck), multiple, systemic damage sites, internal and others, metropolitan cities based on Seoul and 300-499 based on the bed size of 100-299. Based on these findings, the possibility of using the in-depth investigation of discharge damage from the Korea Centers for Disease Control and Prevention as a data source for the patient safety survey conducted to understand the actual status of patient safety accident types, frequency, and trends should be reviewed. Also, it is necessary to prevent injury and minimize death by identifying factors that affect death after injury by patient safety accident.

• 한국수자원학회:학술대회논문집
• /
• 한국수자원학회 2022년도 학술발표회
• /
• pp.425-425
• /
• 2022

동아시아 지역은 몬순 영향으로 계절적인 수자원 변동성이 매우 크고 홍수 및 가뭄과 같은 수재해 피해가 빈번히 발생하고 추세이다. 본 연구에서는 동아시아의 수자원 관리에 활용하기 위해 수문 모형 중 하나인 WRF-Hydro (Weather Research and Forecast and Model Hydrological modeling extension package) 모형을 구축하였다. WRF-Hydro 모형은 미국 NCAR (National Center for Atmospheric Research)에서 개발된 커뮤니티형 고해상도 예측모델로 미국 등에서 활발히 사용되고 있으나, 동아시아 지역에 적용된 연구는 없다. 따라서 모형의 동아시아 적용 가능성에 대한 불확실성이 높다. 본 연구에서는 WRF-Hydro 모형을 0.25°의 공간해상도로 동아시아 대상으로 구축하였고, 기상 및 지면 특성과 유역자료를 활용한 머신러닝 방법으로 파라미터 보정을 시행하여 2006년부터 2015년까지 구동하였다. 머신러닝을 통해 지역특성이 고려된 WRF-Hydro 모형은 표면유출, 보수깊이, 표면 거칠기, 표면 기울기와 같은 매개변수를 보정하였다. 모형 평가를 위해 GRDC (Global Runoff Database Center (GRDC), GLDAS (Global Land Data Assimilation System), ESA-CCI (European Space Agency Climate Change Initiative), MODIS (Moderate Resolution Imaging Spectroradiometer)에서 제공하는 관측 유출량, 토양수분, 증발산량을 비교, 분석하여 동아시아 적용 적절성에 대해 검토하였다.

• 품질경영학회지
• /
• 제51권3호
• /
• pp.363-379
• /
• 2023

Purpose: The main objective of this research is to construct an AI-based Composite Supplementary Index (ACSI) model to achieve accurate predictions of the Composite Index of Business Indicators. By incorporating various economic indicators as independent variables, the ACSI model enables the prediction and analysis of both the leading index (CLI) and coincident index (CCI). Methods: This study proposes an AI-based Composite Supplementary Index (ACSI) model that leverages diverse economic indicators as independent variables to forecast leading and coincident economic indicators. To evaluate the model's performance, advanced machine learning techniques including MLP, RNN, LSTM, and GRU were employed. Furthermore, the study explores the potential of employing deep learning models to train the weights associated with the independent variables that constitute the composite supplementary index. Results: The experimental results demonstrate the superior accuracy of the proposed composite supple- mentary index model in predicting leading and coincident economic indicators. Consequently, this model proves to be highly effective in forecasting economic cycles. Conclusion: In conclusion, the developed AI-based Composite Supplementary Index (ACSI) model successfully predicts the Composite Index of Business Indicators. Apart from its utility in management, economics, and investment domains, this model serves as a valuable indicator supporting policy-making and decision-making processes related to the economy.