• 한국병원경영학회지
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• 제14권1호
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• pp.23-35
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• 2009

The objectives of the present study is to examine the validity of Charlson Comorbidity Index(CCI) based on medical record data; to utilize the index to determine outcome indexes such as mortality, length of stay and cost for the domestic patients whose have received total hip arthroplasty. Based on medical record date, 1-year Mortality was analyzed to be 0.664 of C statistic. The $R^2$ for the predictability for length of stay and the cost was about 0.0181, 0.1842. Fee of national health insurance and total cost including the cost not covered by insurance, also had statistically significance above 3 points of Charlson point score(p=0.0290, 0.0472; $p.{\le}0.05$). The 1-year mortality index, length of stay and cost of the total hip arthroplasty patients which was obtained utilizing CCI have a limitative prediction power and therefore should be carefully analyzed for use.

• 한국건설관리학회논문집
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• 제7권5호
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• pp.77-84
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• 2006

지수는 여러 산업분야에서 오랜시간 동안 경제지표 또는 성과지표로서 중요한 역할을 담당해 왔으며, 실적공사비 적산방식이 적용 확대됨에 따라 2004년 2월부터 시간에 대한 보정을 위하여 건설공사비지수를 사용하고 있다. 건설공사비지수를 산출하기 위한 구성요소는 지수산정식과 자료원으로 구분된다. 기존의 건설관련 공사비지수에서는 물가지수산정에 사용하는 라스파이레스(Laspyeres)지수를 산정식으로 적용하고 산업연관표, 공사비 내역서를 사용하여 가중치를 산정하였다. 그러나, 기존의 방법은 물가변동이 중복 적용되고 대상프로젝트의 특성을 효과적으로 반영하지 못하는 문제점이 발생된다. 본 연구에서는 라스파이레스지수를 비롯한 기존 지수 산정식들을 분석하고, 공동주택공사의 사례를 통하여 기존 지수산정식 및 자료원의 적정성을 분석한 후, 건설공사의 특성을 효율적으로 반영하고 물가변동을 반영할 수 있는 새로운 지수를 제안한다.

• Biomolecules & Therapeutics
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• 제25권3호
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• pp.259-265
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• 2017

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.

• 한국임상약학회지
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• 제31권2호
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• pp.115-124
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• 2021

Background: With an increase in the number of breast cancer survivors, greater importance is attached to health-related quality of life, particularly pain and symptom control. This study aimed to identify the factors that are associated with pain in cancer patients based on the patterns of prescribing opioid, non-opioid, and adjuvant analgesics. Methods: This analysis included new patients who had developed breast cancer between 2003 and 2012. The degree of pain was analyzed based on the socio-demographic (age, income quintile, number of hospitalizations, and duration of disease), indicator (Body Mass Index; BMI, Charlson Comorbidity Index; CCI, Cumulative Analgesic Consumption Score; CACS), operation (mastectomy, lymph node dissection), and therapy (chemotherapy, radiation therapy), as well as complication-related variable (lymphedema). Results: As for the patterns of prescribing analgesics by stages, non-opioid and opioid analgesics constituted 30.7 and 69.3%, respectively. The mean value and variance of CACS were 5.596 and 12.567, respectively. The factors that significantly affected the degree of pain were age (≥50; IRR: 1.848, 95% CI 1.564-2.184, p=0.000), income quintile (IRR: 0.964, 95% CI 0.938-0.991, p=0.008), BMI (≥ 25; IRR: 1.479, 95% CI 1.222-1.795, p=0.000), CCI (≥ 4; IRR: 1.649, 95% CI 1.344-2.036, p=0.000), and lymphedema (yes; IRR: 1.267, 95% CI 1.006-1.610, p=0.047). Conclusions: It is necessary to develop systematic and comprehensive pain control measures to improve the quality of life for breast cancer survivors, especially for those who are 50 years or older, lie in the lower-income quintile, have BMI of ≥25 and CCI score ≥ 4, or have lymphedema.

• The Korean Journal of Pain
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• 제35권3호
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• pp.271-279
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• 2022

Background: Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in male Wistar rats. Methods: Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8) treated with normal saline/acetaminophen/acetaminophen + L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodynia were assessed using hotplate and von Frey tests, respectively. Investigation of spinal proinflammatory cytokines and antioxidant system were carried out after twenty-one days of treatment. Results: The results showed that the co-administration of acetaminophen and L-carnosine significantly (P < 0.001) increased the paw withdrawal threshold to thermal and mechanical stimuli in ligated rats compared to the ligated naïve group. There was a significant (P < 0.001) decrease in the levels of nuclear factor kappa light chain enhancer B cell inhibitor, calcium ion, interleukin-1-beta, and tumour necrotic factor-alpha in the spinal cord of the group coadministered with acetaminophen and L-carnosine compared to the ligated control group. Co-administration with acetaminophen and L-carnosine increased the antioxidant enzymatic activities and reduced the lipid peroxidation in the spinal cord. Conclusions: Co-administration of acetaminophen and L-carnosine has anti-inflammatory effects as a mechanism that mediate its antinociceptive effects in CCI-induced peripheral neuropathy in Wistar rat.

• 한국임상약학회지
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• 제33권1호
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• pp.1-7
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• 2023

Background: Along with the increase in the elderly population, concerns about polypharmacy, which can cause medication-related problems, are increasing. This study aimed to find out the association between drug-related factors and readmission in elderly patients within 30 days after discharge. Methods: Data of patients aged ≥65 years who were discharged from the respiratory medicine ward of a tertiary hospital between January and March 2016 were retrospectively obtained. The medication regimen complexity at discharge was calculated using the medication regimen complexity index (MRCI) score, comorbidity status was assessed using the Charlson comorbidity index (CCI), potentially inappropriate medications (PIMs) were evaluated based on the Beer 2019 criteria, and adverse drug events (ADEs) were examined using the ADE reporting system. Multivariable logistic regression analysis was used to evaluate the effect of medication-related problems on hospital readmission after controlling for other variables. Results: Of the 206 patients included, 84 (40.8%) used PIMs, 31 (15%) had ADEs, and 32 (15.5%) were readmitted. The mean age, total medications, MRCI, CCI, and PIMs in the readmission group were significantly higher than those in the non-readmission group. Age significantly decreased the risk of readmission (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.84-0.96) after adjusting for sex, length of hospital stay, and ADEs. The use of PIMs (OR, 2.38; 95% CI, 1.10-5.16) and increased CCI (OR, 1.50; 95% CI, 1.16-1.93) and MRCI (OR, 1.04; 95% CI, 1.01-1.07) were associated with an increased occurrence of readmission. Conclusion: PIMs were associated with a significantly greater risk for readmission than MRCI.

• 대한전자공학회논문지TC
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• 제46권6호
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• pp.11-18
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• 2009

본 논문에서는 relay station (RS)이 도입된 이등통신 시스템의 throughput 향상을 위해 base station (BS)와 RS 및 단말간의 link를 hierarchical하게 allocation하는 auction 기반의 알고리듬을 제안한다. Hierarchical link allocation 방식은 인지무선 기능을 가진 각 RS 단위로 일차적으로 해당 서비스 영역 내의 단말들을 대상으로 QoS 만족 여부를 감지하여 RS와 연결될 단말의 set을 정하고, BS 차원에서 해당 단말 set을 대상으로 auction 과정을 진행하여 최종적으로 BS 및 RS와의 link를 지정하는 방식이다. 제안하는 알고리듬에서는 시스템 throughput의 향상을 위해 인접 셀과의 정보 교환을 통해 얻은 co-channel interference (CCI) 정보 및 RS들로부터 수집한 단말 별 QoS의 개선량에 관한 정보를 바탕으로 auction 과정을 진행하며, auction winner 단말 set에 RS와의 link를 선별적으로 지정한다. 모의실험을 통하여 본 논문에서 제안하는 방식을 적용한 시스템은 셀 내 높은 QoS를 요구하는 사용자의 비율이 높아질수록 기존 알고리듬에 비해 단말의 QoS를 보다 효과적으로 만족 시킬 수 있음을 보였다. 또한 셀의 traffic load가 높고 인접 셀 CCI의 전력이 강할수록 기존의 알고리듬을 적용한 시스템보다 robust한 throughput 성능을 보였다.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.252-259
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• 2016

Neuropathic pain is a complex state showing increased pain response with dysfunctional inhibitory neurotransmission. The TREK family, one of the two pore domain $K^+$ (K2P) channel subgroups were focused among various mechanisms of neuropathic pain. These channels influence neuronal excitability and are thought to be related in mechano/thermosensation. However, only a little is known about the expression and role of TREK-1 and TREK-2, in neuropathic pain. It is performed to know whether TREK-1 and/or 2 are positively related in dorsal root ganglion (DRG) of a mouse neuropathic pain model, the chronic constriction injury (CCI) model. Following this purpose, Reverse Transcription Polymerase Chain Reaction (RT-PCR) and western blot analyses were performed using mouse DRG of CCI model and compared to the sham surgery group. Immunofluorescence staining of isolectin-B4 (IB4) and TREK were performed. Electrophysiological recordings of single channel currents were analyzed to obtain the information about the channel. Interactions with known TREK activators were tested to confirm the expression. While both TREK-1 and TREK-2 mRNA were significantly overexpressed in DRG of CCI mice, only TREK-1 showed significant increase (~9 fold) in western blot analysis. The TREK-1-like channel recorded in DRG neurons of the CCI mouse showed similar current-voltage relationship and conductance to TREK-1. It was easily activated by low pH solution (pH 6.3), negative pressure, and riluzole. Immunofluorescence images showed the expression of TREK-1 was stronger compared to TREK-2 on IB4 positive neurons. These results suggest that modulation of the TREK-1 channel may have beneficial analgesic effects in neuropathic pain patients.

• 한국전자파학회논문지
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• 제8권3호
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• pp.221-231
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• 1997

본 논문은 다중 m-분포 페이딩 환경에서 하이브리드 DS /SFH-CDMA MFSK의 성능을 분석하였다. MPI와 MUI를 고려하였고, 스펙트럼 효과는 단순 채널 부호화 시스템과 마찬가지로 부호화하지 않았을 때 평가하였다. 컨벌루션 부호화와 다중 CCl Canceller를 함께 사용하였을 때 BER을 개선시켰다. 비동기 하이브리드 시스템 BER은 가우시안 간섭의 근사치를 이용하여 얻었다. 결과적으로, 페이딩의 심도가 깊으면 깊을수록 오율 성능이 더욱 저하됨을 알 수 있었다. DS부분의 변조는 MPl에 방해하는 것이고. FH부분의 겸파는 MUI를 크게 한다. 채널 코딩의 형태들을 고려함으로써 검파전 코딩은 충분한비트에러 수행을하는데 필요함을 보여 준다. 본 결과는 DS /SFH-CDMA MFSK 통신 시스템은 AWGN과 MUI에 있는 PN코드 길이의 비율에 의하여 증가한다. m-분포의 페이딩 환경은 페이딩 지수에 의하여 용량성이 증가한다. CCl Canceller와 컨벌루션 부호화 기법을 각각 채용할 때 용량성은 증가되고 오율 성능은 향상된다. Canceller기법을 사용하지 않은 경우 PN코드의 길이 N=31일 때 $8\times10^{-2}$의 오율을 얻을 수 있었으나 Can celler기법을 사용한 경우 $4\times10^{-2}$의 오율에 도달할 수 있었다. 또한 부호화 기법을 이용하지 않았올 때에는 오율 이 10-2에도 미치지 못했지만 컨별루션 부호화의 부호율 $\gamma$=1/2인 경우 약 $10^{-5}$에 도달하는 것을 알 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제29권3호
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• pp.529-538
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• 1996

이 연구는 산업장에서 색각이상과 관련된 유기용제 폭로근로자들에서 후천성으로 발생할 수 있는 색각이상을 정성적이고 정량적으로 평가하고 색각이상에 영향을 미치는 요인을 조사하고자 저농도의 유기용제 폭로근로자 70명과 대조군 47명을 대상으로 실시하였다. 한식 이중 15색상 배열 검사기를 이용한 색각이상을 평가한 결과 색상배열의 착오 비율과 정량적으로 산출한 색 혼란지수는 유기용제 폭로군과 대조군간 차이가 없었다. 색 혼란지수와 연령과의 선형관계는 두 군 모두에서 연령이 증가할수록 색 혼란지수가 유의하게 증가하였으며(p<0.05), 각 연령군별로 층화한 색 혼란지수의 중앙값은 폭로군이 대조군보다 높게 나타났으나 29세이하 연령군에서만 통계학적으로 유의하였다. 15색상 배열검사의 배열형태에 따라 분류한 색각이상의 유병률은 두 군 모두에서 21%로 차이가 없었으며 색 혼란지수에 대해 연령, 흡연, 음주상태 및 유기용제 폭로유무를 독립변수로 하여 다중회귀분석을 실시한 결과 연령이 유의한 변수로 나타났다(p<0.05). 이상의 결과로는 유기용제 폭로와 색각이상 발생과의 관련성을 제시할 수 없으며, 추후 색각이상 평가를 위한 색상배열 검사의 표준환경 설정, 유기용제 폭로 근로자들의 개개인의 폭로정도 평가, 그리고 색각이상 검사결과를 정확하게 분류하는 기준 등에 대한 연구가 필요할 것이라고 생각되며, 또한 저농도의 유기용제에 폭로되는 근로자들의 색각이상의 평가는 정성적이고 정량적인 방법을 통한 평가가 바람직하며 일시적인 평가보다는 추적관찰을 통한 정량적인 지수의 변화를 관찰해야 할 것으로 생각된다.