Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Pain-related Prescribing Patterns and Associated Factor in Breast Cancer Patients

유방암 환자의 통증 관련 약물 현황과 통증에 미치는 요인

  • Lee, Jin (Medical Informatics and health Technology (MIT), Department of Health Care Management, College of Social Science, Gachon University) ;
  • Park, Ie Byung (Department of Endocrinology and Metabolism, Gachon University Gil Medical Center) ;
  • Seo, Hwa Jeong (Medical Informatics and health Technology (MIT), Department of Health Care Management, College of Social Science, Gachon University)
  • 이진 (가천대학교 사회과학대학 의료경영학과 정보의학연구실) ;
  • 박이병 (가천대학교 길병원 내분비내과) ;
  • 서화정 (가천대학교 사회과학대학 의료경영학과 정보의학연구실)
  • Received : 2021.01.16
  • Accepted : 2021.04.21
  • Published : 2021.06.30
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Abstract

Background: With an increase in the number of breast cancer survivors, greater importance is attached to health-related quality of life, particularly pain and symptom control. This study aimed to identify the factors that are associated with pain in cancer patients based on the patterns of prescribing opioid, non-opioid, and adjuvant analgesics. Methods: This analysis included new patients who had developed breast cancer between 2003 and 2012. The degree of pain was analyzed based on the socio-demographic (age, income quintile, number of hospitalizations, and duration of disease), indicator (Body Mass Index; BMI, Charlson Comorbidity Index; CCI, Cumulative Analgesic Consumption Score; CACS), operation (mastectomy, lymph node dissection), and therapy (chemotherapy, radiation therapy), as well as complication-related variable (lymphedema). Results: As for the patterns of prescribing analgesics by stages, non-opioid and opioid analgesics constituted 30.7 and 69.3%, respectively. The mean value and variance of CACS were 5.596 and 12.567, respectively. The factors that significantly affected the degree of pain were age (≥50; IRR: 1.848, 95% CI 1.564-2.184, p=0.000), income quintile (IRR: 0.964, 95% CI 0.938-0.991, p=0.008), BMI (≥ 25; IRR: 1.479, 95% CI 1.222-1.795, p=0.000), CCI (≥ 4; IRR: 1.649, 95% CI 1.344-2.036, p=0.000), and lymphedema (yes; IRR: 1.267, 95% CI 1.006-1.610, p=0.047). Conclusions: It is necessary to develop systematic and comprehensive pain control measures to improve the quality of life for breast cancer survivors, especially for those who are 50 years or older, lie in the lower-income quintile, have BMI of ≥25 and CCI score ≥ 4, or have lymphedema.

Keywords

Acknowledgement

This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare of Korea (No.1420210), Gachon University and Gil Hospital (FRD2017-09) and funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1A2B4006545).

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