• Title/Summary/Keyword: CA-125

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Effect of $Al_2O_3$ Additives on Microwave Dielectric Properties of (Ba,Ca,Mg)-$Nd_2O_3-TiO_2+10wt%Bi_2O_3$ Ceramics ($Al_2O_3$ 첨가가 (Ba,Ca,Mg)-$Nd_2O_3-TiO_2+10wt%Bi_2O_3$ 세라믹의 마이크로파 유전특성에 미치는 영향)

  • 최지원;강종윤;하종윤;윤석진;김현재;정현진;윤기현
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1999.05a
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    • pp.653-656
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    • 1999
  • Effect of $Al_2O_3$ Additives on Microwave Dielectric Properties of $0.15(Ba_{0.85}Ca_{(0.15-y)}Mg_y)$-0.125 $Nd_2O_3-0.60TiO_2+10wt%Bi_zO_3$ (y=0.05, 0.08) Ceramics was investigated. To control of $\tau\;{f}$ on microwave dielectric properties of $0.15(Ba_{0.85}Ca_{(0.15-y)}Mg_y)$-0.125 $Nd_2O_3-0.60TiO_2+10wt%Bi_zO_3$ ceramics $Al_2O_3$ was doped in the composition range of 0 to 0.15 wt%. As a result, dielectric constant was decreased from 94 to 80 but $Q\cdot{f}_0$ value was increased from 4980 to 5210 GHz and temperature coefficient of resonant frequency can be controlled from +9 to -10$ppm^\circ{C}$ as an increase of$Al_2O_3$ doping concentration. Especially, a new microwave dielectric material having $\varepsilon\;_r=84,\;Q\cdot{f}_0=5120\;GHz\;and\;\tau_f=0\;ppm/^\circ{C}$ was obtained at $Al_2O_3$ doping concentration of 0.08 wt%.

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Properties of Spontaneous Activity in Gastric Smooth Muscle

  • Suzuki, H.;Yamamoto, Y.;Hirst, G.D.S.
    • The Korean Journal of Physiology and Pharmacology
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    • v.3 no.2
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    • pp.119-125
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    • 1999
  • Mammalian gastric smooth muscles generate spontaneous rhythmic contractions which are associated with slow oscillatory potentials (slow waves) and spike potentials. Spike potentials are blocked by organic $Ca^{2+}-antagonists,$ indicating that these result from the activation of L-type $Ca^{2+}-channel.$ However, the cellular mechanisms underlying the generation of slow wave remain unclear. Slow waves are insensitive to $Ca^{2+}-antagonists$ but are blocked by metabolic inhibitors or low temperature. Recently it has been suggested that Interstitial Cells of Cajal (ICC) serve as pacemaker cells and a slow wave reflects the coordinated behavior of both ICC and smooth muscle cells. Small segments of circular smooth muscle isolated from antrum of the guinea-pig stomach generated two types of electrical events; irregular small amplitude (1 to 7 mV) of transient depolarization and larger amplitude (20 to 30 mV) of slow depolarization (regenerative potential). Transient depolarization occurred irregularly and membrane depolarization increased their frequency. Regenerative potentials were generated rhythmically and appeared to result from summed transient depolarizations. Spike potentials, sensitive to nifedipine, were generated on the peaks of regenerative potentials. Depolarization of the membrane evoked regenerative potentials with long latencies (1 to 2 s). These potentials had long partial refractory periods (15 to 20 s). They were inhibited by low concentrations of caffeine, perhaps reflecting either depletion of $Ca^{2+}$ from SR or inhibition of InsP3 receptors, by buffering $Ca^{2+}$ to low levels with BAPTA or by depleting $Ca^{2+}$ from SR with CPA. They persisted in the presence of $Ca^{2+}-sensitive$ $Cl^--channel$ blockers, niflumic acid and DIDS or $Co^{2+},$ a non selective $Ca^{2+}-channel$ blocker. These results suggest that spontaneous activity of gastric smooth muscle results from $Ca^{2+}$ release from SR, followed by activation of $Ca^{2+}-dependent$ ion channels other than $Cl^-$ channels, with the release of $Ca^{2+}$ from SR being triggered by membrane depolarization.

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Clinical Applicability of Multi-Tumor Marker Protein Chips for Diagnosing Ovarian Cancer

  • Bian, Jing;Li, Bo;Kou, Xian-Juan;Wang, Xu-Na;Sun, Xiao-Xu;Ming, Liang
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8409-8411
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    • 2014
  • Purpose: To assess the value of multi-tumor marker protein chips in the diagnosis and treatment of ovarian cancer. Materials and Methods: Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, ${\beta}$-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects. Results: The positivity rate was obviously higher in ovarian cancer (77.7%), than that in the benign cases (26.3%, p<0.01) and healthy subjects (4.5%, p<0.01). Serum levels of tumor markers were furthermore significantly higher in cases with lymph node metastasis (86.8%) than those without metastasis (44.7%), p<0.01. Conclusions: Multi-tumor marker protein chips provide important assistance in the diagnosis and treatment evaluation in ovarian cancers.

Electrical Properies with Ca Contents of the (Sr$_{1-x}.Ca_x)$TiO$_3$Ceramic ((Sr$_{1-x}.Ca_x)$TiO$_3$세라믹의 Ca변화량얘 따른 전기적인 특성)

  • 김진사;정일형;신철기;김충혁;최운식;이준웅
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1997.04a
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    • pp.318-322
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    • 1997
  • The (Sr$_{l-x}$.Ca$_{x}$)TiO$_3$(0.05$\leq$x$\leq$0.2) ceramics were fabricated to form semiconducting ceramics by sintering at about 1350[$^{\circ}C$] in a reducing atmosphere($N_2$gas). After being fired in a reducing atmosphere, metal oxides, CuO, was painted on the both surface of the specimens to diffuse to the grain boundary. They were annealed at 1100[$^{\circ}C$] for 2 hours and cooled to room temperature. The grain boundary was composed of the continuous insulating layers. The capacitance changes slowly and almost linearly in the temperature region of -30~+85[$^{\circ}C$]. The capacitance characteristics appears a stable value within $\pm$10[%]. The conduction mechanism of the specimens observed in the temperature range of 25~125[$^{\circ}C$], and is divined into three regions haying different mechanism as the current increased: the region I below 230[V/cm] shows the ohmic conduction. The region II can be explained by the Poole-Frenkel emission theory, and the region III is dominated by the tunneling effect.ect.

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Studies on the Polymeric Membranes for Separation(IV) Preparation and Properties of Cellulose Acetaste Membranes for Reverse Osmosis (고분자분리막에 관한 연구(IV) 역삼투용 Cellulose Acetate막의 제조 및 특성)

  • 윤규식;김종호;탁태문
    • Membrane Journal
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    • v.3 no.3
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    • pp.117-125
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    • 1993
  • The CA reverse osmosis membranes were prepared and were studied the effects of parameters in membrane performance. The dope solutions were composed of polymer, formamide, acetone and 2-methoxyethanol. And it was prepared flat type membranes. The membranes were measured flux and rejection. The experimental factors such as polymer concentration, additive type, solvent evporation period, annealing temperture, and applied pressure were changed to investigate the effects of these on the membranes. And the transport parameters were also calculated at reverse osmosis medel for prepared membranes.

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Column-aware Transaction Management Scheme for Column-Oriented Databases (컬럼-지향 데이터베이스를 위한 컬럼-인지 트랜잭션 관리 기법)

  • Byun, Si-Woo
    • Journal of Internet Computing and Services
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    • v.15 no.4
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    • pp.125-133
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    • 2014
  • The column-oriented database storage is a very advanced model for large-volume data analysis systems because of its superior I/O performance. Traditional data storages exploit row-oriented storage where the attributes of a record are placed contiguously in hard disk for fast write operations. However, for search-mostly datawarehouse systems, column-oriented storage has become a more proper model because of its superior read performance. Recently, solid state drive using MLC flash memory is largely recognized as the preferred storage media for high-speed data analysis systems. The features of non-volatility, low power consumption, and fast access time for read operations are sufficient grounds to support flash memory as major storage components of modern database servers. However, we need to improve traditional transaction management scheme due to the relatively slow characteristics of column compression and flash operation as compared to RAM memory. In this research, we propose a new scheme called Column-aware Multi-Version Locking (CaMVL) scheme for efficient transaction processing. CaMVL improves transaction performance by using compression lock and multi version reads for efficiently handling slow flash write/erase operation in lock management process. We also propose a simulation model to show the performance of CaMVL. Based on the results of the performance evaluation, we conclude that CaMVL scheme outperforms the traditional scheme.

Comparison of Abnormal Grain Growth Behavior of Lead-Free (Na,K)NbO3-M(Cu,Nb)O3, (M = Ca, Sr, Ba) Piezoelectric Ceramics (비납계 (Na,K)NbO3-M(Cu,Nb)O3, (M = Ca, Sr, Ba) 압전 세라믹의 비정상 결정 성장 거동 비교)

  • Jung, Seungwoon;Lim, Ji-Ho;Jung, Han-Bo;Ji, Sung-Yub;Choi, Seunggon;Jeong, Dae-Yong
    • Korean Journal of Materials Research
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    • v.30 no.7
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    • pp.343-349
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    • 2020
  • NKN [(Na,K)NbO3] is a candidate lead-free piezoelectric material to replace PZT [Pb(Zr,Ti)O3]. A single crystal has excellent piezoelectric-properties and its properties are dependent of the crystal orientation direction. However, it is hard to fabricate a single crystal with stoichiometrically stable composition due to volatilization of sodium during the growth process. To solve this problem, a solid solution composition is designed (Na,K)NbO3-Ba(Cu,Nb)O3 and solid state grain growth is studied for a sizable single crystal. Ceramic powders of (Na,K)NbO3-M(Cu,Nb)O3 (M = Ca, Sr, Ba) are synthesized and grain growth behavior is investigated for different temperatures and times. Average normal grain sizes of individual specimens, which are heat-treated at 1,125 ℃ for 10 h, are 6.9, 2.8, and 1.6 ㎛ for M = Ca, Sr, and Ba, respectively. Depending on M, the distortion of NKN structure can be altered. XRD results show that (NKN-CaCuN: shrunken orthorhombic; NKN-SrCuN: orthorhombic; NKN-BaCuN: cubic). For the sample heat-treated at 1,125 ℃ for 10 h, the maximum grain sizes of individual specimens are measured as 40, 5, and 4,000 ㎛ for M = Ca, Sr, and Ba, respectively. This abnormal grain size is related to the partial melting temperature (NKN-CaCuN: 960 ℃; NKN-SrCuN: 971 ℃; NKN-BaCuN: 945 ℃).

Clinical Application of Serum Tumor Associated Material (TAM) from Non-small Cell Lung Cancer Patients

  • Li, Cheng-Guang;Huang, Xin-En;Xu, Lin;Li, Ying;Lu, Yan-Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.1
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    • pp.301-304
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    • 2012
  • Objective: To explore the associations of serum tumor associated material (TAM) with other common tumor markers like carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen19-9 (CA19-9) and its clinical application in non-small cell lung cancer (NSCLC) patients. Methods: A total of 87 patients were enrolled into this study, all with histologically or cytologically confirmed NSCLC. With the method of chemical colorimetry, the level of TAM was determined and compared, while chemiluminescence was used to measure the levels of common tumor markers. Results: The level of TAM decreased after chemotherapy compared with before chemotherapy when CT or MRI scans showed disease control. Furthermore, it increased when disease progessed and there was no statistically significant difference in monitoring of TAM and common tumor markers (P>0.05). Conclusions: Detecting TAM in NSCLC patients has a higher sensitivity and specificity, so it can be used as an indicator for clinical monitoring of lung cancer chemotherapy.

A Review on Clinical Studies of Abdominal Acupuncture Treatment for Endometriosis (자궁내막증 환자의 복부 침 치료 효과에 대한 임상 연구 고찰)

  • Bang, Seung-Won;Yoon, Young-Jin
    • The Journal of Korean Obstetrics and Gynecology
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    • v.33 no.4
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    • pp.23-35
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    • 2020
  • Objectives: The purpose of this study is to confirm the effectiveness and safety of acupuncture for Endometriosis. So providing a clinical basis for abdominal acupuncture treatment helping to develop clinical practice guideline. Methods: Clinical studies applying acupuncture on Endometriosis were searched through Pubmed, China Academic journal (CAJ), Koreanstudies Information Service System (KISS), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS). Interventions and results of the selected clinical studies were analyzed. Results: 8 Clinical studies were finally included according to inclusion and exclusion criteria. Those were randomized controlled studies. All of those studies were searched in China Academic journal (CAJ) in Chinese. Interventions of control group were made with simple acupuncture and oral administration of Danazol or herbal medicine. Outcome measurements included Treat effect, Relief in related symptoms, and CA-125. All studies reported statistically significant results on abdominal acupuncture and there were no serious adverse effects. Conclusions: This study suggested abdominal acupuncture has statistically significant treat effect. Thus this treat helps improve quality of life for patients. However the results should be taken cautiously as more clinical studies are needed.

Simple Preparation of Anatase Titanium Dioxide Nanoparticles by Heating Titanium-Organic Frameworks

  • Im, Ji Hyuk;Kang, Eunyoung;Yang, Seung Jae;Park, Hye Jeong;Kim, Jaheon;Park, Chong Rae
    • Bulletin of the Korean Chemical Society
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    • v.35 no.8
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    • pp.2477-2480
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    • 2014
  • Thermal degradation of titanium-containing metal-organic frameworks (MOFs; MIL-125 and MIL-125-$NH_2$ at $350^{\circ}C$ for 6 h in air produced $TiO_2$ nanoparticles of ca. 10 nm in diameter. Scanning electron and transmission electron microscope analyses indicated that those nanoparticles were aggregated randomly within each crystalline particle of their MOF precursors. The $TiO_2$ nanoparticles prepared from MIL-125-$NH_2$ exhibited higher activity for the degradation of 4-chlorophenol under visible light.