Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.19.8409

Clinical Applicability of Multi-Tumor Marker Protein Chips for Diagnosing Ovarian Cancer  

Bian, Jing (Department of Laboratory The First Affiliated Hospital of Zhengzhou University)
Li, Bo (The Stem Cell Research Center, Medical College of Zhengzhou University)
Kou, Xian-Juan (College of Health Science, Wuhan Sports University)
Wang, Xu-Na (Department of Laboratory The First Affiliated Hospital of Zhengzhou University)
Sun, Xiao-Xu (Department of Laboratory The First Affiliated Hospital of Zhengzhou University)
Ming, Liang (Department of Laboratory The First Affiliated Hospital of Zhengzhou University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8409-8411 More about this Journal
Abstract
Purpose: To assess the value of multi-tumor marker protein chips in the diagnosis and treatment of ovarian cancer. Materials and Methods: Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, ${\beta}$-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects. Results: The positivity rate was obviously higher in ovarian cancer (77.7%), than that in the benign cases (26.3%, p<0.01) and healthy subjects (4.5%, p<0.01). Serum levels of tumor markers were furthermore significantly higher in cases with lymph node metastasis (86.8%) than those without metastasis (44.7%), p<0.01. Conclusions: Multi-tumor marker protein chips provide important assistance in the diagnosis and treatment evaluation in ovarian cancers.
Keywords
Protein chip; tumor markers; ovarian cancers; treatment evaluation;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Hou JX, Yang XQ, Chen C, et al (2011). Screening the gastric cancer related tumor markers from multi-tumor markers protein chip with kappa coefficient and cost-effectiveness analysis. Hepatogastroenterology, 58, 632-6.
2 Bian J, Li B, Kou XJ, Liu TZ, Ming L (2013). Clinical significance of combined detection of serum tumor markers in diagnosis of patients with ovarian cancer. Asian Pac J Cancer Prev, 14, 6241-3.   DOI   ScienceOn
3 Devan SM, Pailoor J, Sthaneshwar P, Narayanan V (2013). Pattern of tissue expression of CA-125 and HE4 in primary epithelial ovarian tumours and correlation with serum CA-125 levels. Asian Pac J Cancer Prev, 14, 4545-8.   DOI
4 Hourigan CS, Levitsky HI (2011). Evaluation of current cancer immunotherapy: hemato-oncology. Cancer J, 17, 309-24.   DOI   ScienceOn
5 Khaider NG, Lane D, Matte I, Rancourt C, Piche A (2012). Targeted ovarian cancer treatment: the TRAILs of resistance. Am J Cancer Res, 2, 75-92.
6 Liang Z, Wang HF, Wu AZ, Cai JH (2010). Clinical value of multitumor markers protein biochip in the diagnosis of pulmonary carcinoma. Nan Fang Yi Ke Da Xue Xue Bao, 30, 2516-8.
7 Lin JY, Qin JB, Li XY, Dong P, Yin BD (2012). Diagnostic value of human epididymis protein 4 compared with mesothelin for ovarian cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 13, 5427-32.   DOI   ScienceOn
8 Sun Z, Fu X, Zhang L, et al (2004). A protein chip system for parallel analysis of multi-tumor markers and its application in cancer detection. Anticancer Res, 24, 1159-65.
9 Meany DL, Sokoll LJ, Chan DW (2009). Early detection of cancer: immunoassays for plasma tumor markers. Expert Opin Med Diagn, 3, 597-605.   DOI
10 Parikh K, Peppelenbosch MP (2010). Kinome profiling of clinical cancer specimens. Cancer Res, 70, 2575-8.   DOI
11 Rusling JF, Kumar CV, Gutkind JS, Patel V (2010). Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst, 135, 2496-511.   DOI   ScienceOn
12 Sundar S, Wu J, Hillaby K, Yap J, Lilford R (2012). A systematic review evaluating the relationship between progression free survival and post progression survival in advanced ovarian cancer. Gynecol Oncol, 125, 493-9.   DOI
13 Wesolowski R, Ramaswamy B (2011). Gene expression profiling: changing face of breast cancer classification and management. Gene Expr, 15, 105-15.   DOI
14 Yang XQ, Yan L, Chen C, Hou JX, Li Y (2009). Application of C12 multi-tumor marker protein chip in the diagnosis of gastrointestinal cancer: results of 329 surgical patients and suggestions for improvement. Hepatogastroenterology, 56, 1388-94.
15 Zagouri F, Dimopoulos MA, Bournakis E, Papadimitriou CA (2010). Molecular markers in epithelial ovarian cancer: their role in prognosis and therapy. Eur J Gynaecol Oncol, 31, 268-77.
16 Zhu H, Cox E, Qian J (2012). Functional protein microarray as molecular decathlete: a versatile player in clinical proteomics. Proteomics Clin Appl, 6, 548-62.   DOI