• The Korean Journal of Physiology and Pharmacology
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• v.12 no.5
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• pp.267-274
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• 2008

Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, $Ca^{2+}$ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated $Na^+$ channel, whereas the later phase was driven by the reverse-mode operation of $Na^+/Ca^{2+}$ exchange current secondary to the accumulation of $Na^+$ and $Ca^{2+}$ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.

• Spatial Information Research
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• v.18 no.5
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• pp.133-142
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• 2010

Many pedestrian or fire evacuation models have been studied last decades for modeling evacuation behaviors or analysing building structures under emergency situations. However, currently developed models do not consider the differences of visibility of pedestrians by obstacles such as furniture, wall, etc. The visibility of pedestrians is considered one of the important factors that affect the evacuation behavior, leading to making simulation results more realistic. In order to incorporate pedestrian's visibility into evacuation simulation, we should be able to give different walking speeds according to differences of visibility. We improved the existing floor field model based on cellular automata in order to implement the visibility. Using the space syntax theory, we showed how we split the indoor spaces depending on the different visibilities created by different levels of structural depths. Then, we improved the algorithm such that pedestrians have different speeds instead of simultaneous movement to other cells. Also, in order for developing a real time simulation system integrated w ith indoor sensors later, we present a process to build a 3D simulator using a spatial DBMS. The proposed algorithm is tested using a campus building.

• Journal of the Korea Society for Simulation
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• v.25 no.3
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• pp.41-51
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• 2016

In this study, we propose an improved Floor Field Model(FFM) that considers the physical characteristics of pedestrians, i.e., body size, shape, and posture. Also we analyse limits of FFM and features of improved model compared with existing evacuation simulation models. FFM is a typical microscopic pedestrian model using CA, but it does not reflect the physical characteristics of pedestrians. Because of this, FFM is difficult to modeling phenomena such as collision, friction between pedestrians. As a result, FFM calculates a very short evacuation time when compared with the other models. We performed a computational experiment to compare improved model with other models such as FFM, Simulex, Pathfinder in an actual campus building. We carried out a comparison of evacuation aspect according to the change in number of evacuees. Also we compared evacuation aspect by exit. Finally, we confirmed that improved model reflects physical phenomena which were not reflected in FFM. Especially, experimental results were very similar to the Simulex.

• BMB Reports
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• v.40 no.3
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• pp.315-324
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• 2007

The novel $\alpha$-amylase purified from locally isolated strain, Bacillus sp. KR-8104, (KRA) (Enzyme Microb Technol; 2005; 36: 666-671) is active in a wide range of pH. The enzyme maximum activity is at pH 4.0 and it retains 90% of activity at pH 3.5. The irreversible thermoinactivation patterns of KRA and the enzyme activity are not changed in the presence and absence of $Ca^{2+}$ and EDTA. Therefore, KRA acts as a $Ca^{2+}$-independent enzyme. Based on circular dichroism (CD) data from thermal unfolding of the enzyme recorded at 222 nm, addition of $Ca^{2+}$ and EDTA similar to its irreversible thermoinactivation, does not influence the thermal denaturation of the enzyme and its Tm. The amino acid sequence of KRA was obtained from the nucleotide sequencing of PCR products of encoding gene. The deduced amino acid sequence of the enzyme revealed a very high sequence homology to Bacillus amyloliquefaciens (BAA) (85% identity, 90% similarity) and Bacillus licheniformis $\alpha$-amylases (BLA) (81% identity, 88% similarity). To elucidate and understand these characteristics of the $\alpha$-amylase, a model of 3D structure of KRA was constructed using the crystal structure of the mutant of BLA as the platform and refined with a molecular dynamics (MD) simulation program. Interestingly enough, there is only one amino acid substitution for KRA in comparison with BLA and BAA in the region involved in the calcium-binding sites. On the other hand, there are many amino acid differences between BLA and KRA at the interface of A and B domains and around the metal triad and active site area. These alterations could have a role in stabilizing the native structure of the loop in the active site cleft and maintenance and stabilization of the putative metal triad-binding site. The amino acid differences at the active site cleft and around the catalytic residues might affect their pKa values and consequently shift its pH profile. In addition, the intrinsic fluorescence intensity of the enzyme at 350 nm does not show considerable change at pH 3.5-7.0.

• Journal of the Korea Organic Resources Recycling Association
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• v.28 no.4
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• pp.43-52
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• 2020

As the membrane gas separation technology grows, various models were developed by numerous researchers to describe the separation process. In this work, the counter-current model was compared thoroughly with experimental data. Experimentally, hollow fiber membrane using CA module was prepared for the separation of biogas. The pure gas permeation properties of membrane module for methane, nitrogen, oxygen, and carbon dioxide were measured. The permeance of CO2 and CH4 were 25.82 GPU and 0.65 GPU, respectively. The high CO2/CH4 selectivity of 39.7 was obtained. the separation test for three different simulated mixed gases were carried out after pure gas test, and the gas concentration of the permeate at various stage-cut were measured from CA membrane module. Results showed that the experimental data agreed with the numerical simulation. A mathematical model has implemented in this study for the separation of biogas using a membrane module. The finite difference method (FDM) is applied to calculate the membrane biogas separation behaviors. Futhermore, the counter-current model can be considered as a convenient model for biogas separation process.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.1
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• pp.68-78
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• 2013

In this paper, we propose an early spectrum sensing(ESS) as an advance preparation for radio-access trial, which enables multi-mode terminals to access the most appropriate radio-access system in a cloud-conceptual base station system where multiple radio access technologies(RATs) coexist. Prior to a random access to one of RATs, a multi-mode terminal conducts a spectrum sensing over entire frequency bands of whole RATs, then select the RAT with the lowest sensing power, that is likely to have the most available spectrum. Thus, an access failure caused by that the selected RAT has no available radio spectrum could be avoidable in advance. In computer simulation, we consider as various RATs as possible. First, circuit and packet systems are taken into consideration. In addition, the packet systems are classified according to the feasibility of carrier aggregation(CA). In case of terminal, three modes are considered with circuit-only, packet-only, and multi-mode. Subsequently, packet traffic is classified into real-time and non-real-time traffic with three different tolerable delay levels. The simulation includes a call process starting with a call generation and ending up with a resource allocation reflecting individual user's QoS requirements and evaluates the proposed scheme in terms of the successful access probability, system access time, system balancing factor and packet loss probability.

• Journal of the Korea Society for Simulation
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• v.17 no.4
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• pp.175-182
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• 2008

The enemy will attempt to destroy our troop's core facilities using various fire supports at the beginning of war. Among these fire supports, artillery is given the most deal of weight and mine artillery is a great threat to our troops because it has a superior predominance on the ability of survival. Our troops are planning to introduce UAV (Unmanned Aerial Vehicle) to overcome these difficulties. A study about hitting mine artillery has been developed inside the military field only. However, these studies had been mostly qualitative analyses, thus having limitations in the aspects of non objectiveness and simplicity. We propose a new method to evaluate about working effect of UAV hitting mine artillery. We studied on hitting mine artillery in a quantitative way using CA (Cellular Automata) simulation.

• Nuclear Engineering and Technology
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• v.53 no.12
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• pp.4098-4105
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• 2021

The aim of this study is to calculate the JO-IMRT dose distributions based on the AAPM TG-119 using Monte Carlo (MC) simulation and Prowess Panther treatment planning system (TPS) (Panther, Prowess Inc., Chico, CA). JO-IMRT dose distributions of AAPM TG-119 were calculated by the TPS and were recalculated by MC simulation. The DVHs and 3D gamma index using global methods implemented in the PTW-VeriSoft with 3%/3 mm were used for evaluation. JO-IMRT dose distributions calculated by TPS and MC were matched the TG-119 goals. The gamma index passing rates with 3%/3 mm were 98.7% for multi-target, 96.0% for mock prostate, 95.4% for mock head-and-neck, and 96.6% for C-shape. The dose in the planning target volumes (PTV) for TPS was larger than that for the MC. The relative dose differences in D99 between TPS and MC for multi-target are 1.52%, 0.17% and 1.40%, for the center, superior and inferior, respectively. The differences in D95 are 0.16% for C-shape; and 0.06% for mock prostate. Mock head-and-neck difference is 0.40% in D99. In contrast, the organ curve for TPS tended to be smaller than MC values. JO-IMRT dose distributions for the AAPM TG-119 calculated by the TPS agreed well with the MC.

• Journal of the Korean Association of Geographic Information Studies
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• v.13 no.2
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• pp.29-40
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• 2010

Car simulation by TRANSIMS is able to rapidly analyze the broad area based on CA(Cellular Automata) theory, which is the great advantage compared to other existing programs. As the source code of TRANSIMS is open, it may be modified by incorporating the network and traffic characteristics. This study uses the traffic thematic map built in the Korean National Traffic DB(KTDB) center among input date used for building network data of TRANSIMS. However, because the traffic thematic map is not composed as the type required by TRANSIMS, it was corrected and complemented to build a network, and the traffic volume at arterial roads and the traffic volume at each direction of the intersection was calculated through simulation for the area of Suseong-Gu, Daegu Metro. This was compared to the actual traffic volume. As a result of the simulation, it shows error from 14% to 42% at intersection, and from 3% to 8% at arterial roads. This result is very satisfactory because the entire traffic volume of Daegu Metro was not considered, and the tendency of drivers avoiding path due to construction on certain section, the status of road surface and chronic congestion was not reflected.

• Journal of Korean Society of Environmental Engineers
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• v.29 no.7
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• pp.778-782
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• 2007

This study investigated the dechlorination mechanisms of TCE by Fe(II) associated with cement. Batch slurry experiments were peformed to investigate the behaviors of selected ions; Fe(II), Fe(III), $Ca^{2+}$, $SO_4^{2-}$ in cement/Fe(II) system. The kinetic experiments of TCE in cement/Fe(II) systems showed that injected Fe(II) was mostly sorbed on cement within 0.5 day and 90% of injected 200 mM sulfate was sorbed on cement within 0.5 day when $[TCE]_0$ = 0.25 mM and $[Fe(II)]_0$ = 200 mM. The kinetic experiments of TCE in hematite/CaO/Fe((II) systems were conducted for simulation of cement/Fe(II) system. Calcium oxide that is one of the major components in cement hydration reactions or has a reactivity in limited conditions. Hematite assumed the ferric iron oxide component of cement. The reactivities observed in hematite/CaO/Fe(II) system were comparable to those reported for cement/Fe(II) systems containing similar molar amounts of Fe(II). The behavior of Fe(II) and $SO_4^{2-}$ sorbed on solid phase at an early stage of reaction in hematite/CaO/Fe(II) system was similar to that of cement/Fe(II) system. Ferric ion was released from hematite at an early period of reaction at low pH. The experimental evidence of kinetic test using hematite/CaO/Fe(II) system implies that the reactive reductant is a mixed-valent Fe(II)-Fe(III) mineral, which may be similar to green rust. Fe(II) sorbed on cement can be converted to new mineral phase having a reactivity such as Fe(II)-Fe(III) (hydr)oxides in cement/Fe(II) systems.