• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3005-3009
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• 2014

The aims of this study were to investigate the influence of ubiquitin- conjugating enzyme E2C (UBE2C) on biological behavior of lung cancer cells. Using MTT, flow cytometry and invasion assays, we detected UBE2C expression and evaluated its biological properties in these cells, including effects on proliferation, the cell cycle profile and invasive capability. Compared with control cells, the UBE2C transfected cells demonstrated increased cellular proliferation (p<0.05). UBE2C transfected cells also had a lower percentage in G1 phase and a higher percentage in S phase (p<0.05). Importantly, the UBE2C transfected cells had a notable enhancement of cell numbers penetrating the basement membrane compared with the control group (p<0.05). Ectopic up-regulation UBE2C promoted the growth of lung cancer cells in vivo. Furthermore, we found UBE2C increased the expression of cyclin D1 and MMP-2. These results show UBE2C may represent a potential therapeutic target for lung cancer.

• 한국재료학회지
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• 제20권9호
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• pp.451-456
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• 2010

A promising candidate material for a $H_2$ permeable membrane is SiC due to its many unique properties. A hydrogen-selective SiC membrane was successfully fabricated on the outer surface of an intermediate multilayer $\gamma-Al_2O_3$ with a graded structure. The $\gamma-Al_2O_3$ multilayer was formed on top of a macroporous $\alpha-Al_2O_3$ support by consecutively dipping into a set of successive solutions containing boehmite sols of different particle sizes and then calcining. The boehmite sols were prepared from an aluminum isopropoxide precursor and heated to $80^{\circ}C$ with high speed stirring for 24 hrs to hydrolyze the precursor. Then the solutions were refluxed at $92^{\circ}C$ for 20 hrs to form a boehmite precipitate. The particle size of the boehmite sols was controlled according to various experimental parameters, such as acid types and acid concentrations. The topmost SiC layer was formed on top of the intermediate $\gamma-Al_2O_3$ by pyrolysis of a SiC precursor, polycarbosilane, in an Ar atmosphere. The resulting amorphous SiC-on-$Al_2O_3$ composite membrane pyrolyzed at $900^{\circ}C$ possessed a high $H_2$ permeability of $3.61\times10^{-7}$ $mol{\cdot}m^{-2}{\cdot}s^{-1}{\cdot}Pa^{-1}$ and the $H_2/CO_2$ selectivity was much higher than the theoretical value of 4.69 in all permeation temperature ranges. Gas permeabilities through a SiC membrane are affected by Knudsen diffusion and a surface diffusion mechanism, which are based on the molecular weight of gas species and movement of adsorbed gas molecules on the surface of the pores.

• 한국정보과학회논문지:소프트웨어및응용
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• 제33권1호
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• pp.17-31
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• 2006

소프트웨어 아키텍쳐는 소프트웨어 시스템의 상위 수준 모델이다. 이러한 소프트웨어 아키텍쳐는 명료하고 엄밀한 표현을 위해 아키텍쳐 기술 언어(ADL)를 사용하여 기술된다. 하지만 대부분의 ADL들은 C2 스타일 ADL(C2SADL)처럼 소프트웨어 시스템의 개발에 필요한 요소들 중에서 특정한 관점만을 고려하여 정의되었거나 별도의 표기형식으로 배워야 하는 부담이 있기 때문에 아키텍쳐를 명세하는 언어로서 정착되지 못하였다. 반면 UML은 범용 모델링 언어로서 소프트웨어 개발의 전 과정에 일관된 표기형식과 폭넓은 지원도구들을 제공하고 있으므로 소프트웨어 개발을 위한 사실상의 표준 언어로 자리잡았다. 그러나 UML은 소프트웨어 아키텍쳐를 표현하도록 설계된 것은 아니기 때문에 UML을 사용하여 아키텍쳐를 표현하기 위해서는 UML을 확장, 변경하여야 한다. 본 논문에서는 UML2.0에 기반한 C2 아키텍쳐 모델링 언어 프로파일을 정의하였다. 정의된 C2 아키텍쳐 모델링 언어는 식당 예약 시스템을 모델링 하는데 사용되었다.

• Bulletin of the Korean Chemical Society
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• 제23권7호
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• pp.953-956
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• 2002

Excess molar volumes (Vm E ) of binary liquid mixtures: xC6H5CH3 + (1-x1)CH3CN or + (1-x1)C6H5NO2, or + (1-x1)C2H5NO2 have been determined as a function of mole fraction of C6H5CH3 (x) at a temperature of 303.15 K over a entire range of composition. The densities of the binary liquid mixtures were determined by pycnometrically. The VmE values of the mixtures have been found to be negative over the whole composition in order of C6H5CH3 + C6H5NO2, < C6H5CH3 + CH3CN, and < C6H5CH3 + C2H5NO2. The negative magnitude of VmE suggests the presence of intermolecular interaction in the three binary liquid mixtures.

• 한국분말재료학회지
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• 제27권4호
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• pp.293-299
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• 2020

W₂C is synthesized through a reaction-sintering process from an ultrafine-W and WC powder mixture using spark plasma sintering (SPS). The effect of various parameters, such as W:WC molar ratio, sintering temperature, and sintering time, on the synthesis behavior of W₂C is investigated through X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM) analysis of the microstructure, and final sintered density. Further, the etching properties of a W₂C specimen are analyzed. A W₂C sintered specimen with a particle size of 2.0 ㎛ and a relative density over 98% could be obtained from a W-WC powder mixture with 55 mol%, after SPS at 1700℃ for 20 min under a pressure of 50 MPa. The sample etching rate is similar to that of SiC. Based on X-ray photoelectron spectroscopy (XPS) analysis, it is confirmed that fluorocarbon-based layers such as C-F and C-F2 with lower etch rates are also formed.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제22권4호
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• pp.373-382
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• 2000

Individual genetic susceptibilities to cancers may result from several factors including differences in xenobiotics metabolism to chemical carcinogens, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. Among them, genetic polymorphisms of metabolizing enzymes to chemical carcinogens have been recognized as a major important host factors in human cancers. They have two main types of enzymes: the phase I cytochrome P-450 mediating enzymes (CYPs) and phase II conjugating enzymes. The purpose of this study is to determine the frequencies of genotypes of phase I (CYP1A1 and CYP2E1) and phase II (NAT2) metabolizing enzymes in healthy control and head and neck cancer patients of Korean and to identify the relative high risk genotypes of these metabolizing enzymes to head and neck cancer in Korean. The author has analyzed 132 head and neck cancer patients and 113 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results were as following; 1. The frequencies of genotypes of CYP1A1, CYP2E1 and NAT2 in healthy control were as following; CYP1A1 exon 7 polymorphism; Ile/Ile: Ile/Val: Val/Val = 59.3%: 36.3%: 4.4% CYP2E1 Pst I polymorphism, C1/C1: C1/C2: C2/C2 = 61.1%: 32.1%: 6.2% NAT2 polymorphism; F/F: F/S: S/S = 43.4%: 48.7%: 8.0% 2. In analysis of phase I enzyme, Val/Val genotype in CYP1A1 exon 7 polymorphism and C2/C2 genotype in CYP2E1 Pst I polymorphism were associated with relative high risks to head and neck cancers (Odds' ratio: 2.09 and 1.37, respectively). 3. Among the genotypes of NAT2 enzyme polymorphism, S/S genotype of NAT2 enzyme had 1.03 times of relative risk to head and neck cancers. 4. In combined genotyping of CYP1A1, CYP2E1, and NAT2 enzymes polymorphisms, the patients with Val/Val and C1/C1, C2/C2 and fast acetylator, and Val/Val and fast acetylator had higher relative risks than the patients with each baseline of combined genotypes (Odds' ratio: 2.82, 1.98 and 2.1, respectively). These results suggest the combined genotypes of Val/Val and C1/C1, C2/C2 and fast acetylator, and Val/Val and fast acetylator were more susceptible to head and neck cancers in Korean. And genotyping of metabolizing enzymes could be useful for predicting individual susceptibility to head and neck cancer.

• 산업경영시스템학회지
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• 제32권3호
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• pp.85-92
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• 2009

A lot of B2C Internet shopping mall companies are establishing various strategies in order to make a result to be further better than it. But They are experiencing trouble by restriction like manpower or financial issue. Therefore, frying to grasp how an assistance degree of a company In B2C Internet shopping mall success factors affects will be important information in resources distribution of management strategic which is established by B2C Internet shopping mall company to survives in unlimited competition. In this paper, It is purpose to find which is success factors affecting to a finance and the other part of results in B2C Internet shopping mall companies. In order to achieve a study purpose, we make a model by literature study and inquiries and analysis the result data. Consequently for successful B2C Internet shopping mall operation, it needs a assistance of a company fully. But the company which shall get a maximum effect with resources limited is difficult to assistance fully. This study will be used to establish strategies of distribution of resources appropriately for the company which is not fully assist B2C Internet shopping mall operation because of restrictions of manpower, material and finance.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.1-4
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• 1990

Reaction of propane-1, 3-sultone with amines gave N-substituted aminosulphonnic acids 2a-i, Dehydration of 2a-c with $POCI_3$ gave the corresponding sultams 3a-c. Propane-1, 3-sultone 1 reacted with tertury amines to give the betaiene salts 4-11. 2-4-Dimethyl-1, 3-butadiene-1, 4-sultone 12 condensed with amines to give N-substituted-2, 4-dimethyl-1, 3-butadiene-1, 4-sultames 13a and 13b. The reaction of 3a, 13a with hydrazine hydrate gave acid hydrazides 3d or 13c. Compounds 3d, 13c reacted with isocyanates to yield urea derivatives 14a-c, 15a-c.

• 한국세라믹학회지
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• 제27권8호
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• pp.1055-1063
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• 1990

The early hydration characteristics of the system $C_3S-C_3A-C_4AF$ according to the clinker composition variations, in order to establish the mutual interactionof clinker minerals during the portland cement hydration, have been studied. The early hydration rate of $C_3S$ was greatly effected by the change of $C_3S/C_3A$ ratio. The lower the $C_3S/C_3A$ ratio was, the faster the apex reaching time and the rate of heat liberation of the 2nd exothermic peak originating from the formation of $Ca(OH)_2$ were. The effect of $C_3S/C_3A$ ration on the amounts of $Ca(OH)_2$ formation was decreased, in process of hydration time, but the effect of $C_3S$ content was increased.

• 대한수학회지
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• 제54권1호
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• pp.69-86
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• 2017

The point $P{\in}{\mathbb{P}}^2$ is referred to as a Galois point for a nonsingular plane algebraic curve C if the projection ${\pi}_P:C{\rightarrow}{\mathbb{P}}^1$ from P is a Galois covering. In contrast, the point $P^{\prime}{\in}C^{\prime}$ is referred to as a weak Galois Weierstrass point of a nonsingular algebraic curve C' if P' is a Weierstrass point of C' and a total ramification point of some Galois covering $f:C^{\prime}{\rightarrow}{\mathbb{P}}^1$. In this paper, we discuss the following phenomena. For a nonsingular plane curve C with a Galois point P and a double covering ${\varphi}:C{\rightarrow}C^{\prime}$, if there exists a common ramification point of ${\pi}_P$ and ${\varphi}$, then there exists a weak Galois Weierstrass point $P^{\prime}{\in}C^{\prime}$ with its Weierstrass semigroup such that H(P') = or , which is a semigroup generated by two positive integers r and 2r + 1 or 2r - 1, such that P' is a branch point of ${\varphi}$. Conversely, for a weak Galois Weierstrass point $P^{\prime}{\in}C^{\prime}$ with H(P') = or , there exists a nonsingular plane curve C with a Galois point P and a double covering ${\varphi}:C{\rightarrow}C^{\prime}$ such that P' is a branch point of ${\varphi}$.