• Journal of Ginseng Research
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• v.35 no.1
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• pp.92-103
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• 2011

Ginseng has been used as a general tonic agent to invigorate human body. In the present study, we isolated novel glycolipoproteins from ginseng that activate $Ca^{2+}$-activated $Cl^-$ channel (CaCC) in Xenopus oocytes and transiently increase intracellular free $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) in mouse Ehrlich ascites tumor cells. We named the active ingredients as gintonin. Gintonin exists in at least six different forms. The native molecular weight of gintonin is about 67 kDa but its apparent molecular weight is about 13 kDa, indicating that gintonin might be a pentamer. Gintonin is rich in hydrophobic amino acids. Its main carbohydrates are glucose and glucosamine. Its lipid components are linoleic, palmitic, oleic, and stearic acids. Gintonin actions were blocked by U73122, a phospholipase C inhibitor, 2-aminoethxydiphenyl borate, an inositol 1,4,5-trisphosphate receptor antagonist, or bis (o-aminophenoxy) ethane-N,N,N0,N0-tetracetic acid acetoxymethyl ester, a membrane permeable $Ca^{2+}$ chelator. In the present study, we for the first time isolated novel gintonin and showed the signaling pathways on gintonin-mediated CaCC activations and transient increase of $[Ca^{2+}]_i$. Since $[Ca^{2+}]_i$ as a second messenger plays a pivotal role in the regulation of diverse $Ca^{2+}$-dependent intracellular signal pathways, gintonin-mediated regulations of $[Ca^{2+}]_i$ might contribute to biological actions of ginseng.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.421-427
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• 2009

We successfully fabricated 4.7-inch organic thin film transistors array with $640{\times}480$ pixels on flexible substrate. All the processes were done by photolithography, spin coating and ink-jet printing. The OTFT-Electrophoretic (EP) pixel structure, based on a top gate OTFT, was fabricated. The mobility, ON/OFF ratio, subthreshold swing and threshold voltage of OTFT on flexible substrate are: 0.01 ^2/V-s, 1.3 V/dec, 10E5 and -3.5 V. After laminated the EP media on OTFT array, a panel of 4.7-inch $640{\times}480$ OTFT-EPD was fabricated. All of process temperature in OTFT-EPD is lower than $150^{\circ}C$. The pixel size in our panel is $150{\mu}m{\times}150{\mu}m$, and the aperture ratio is 50 %. The OTFT channel length and width is 20 um and 200um, respectively. We also used OTFT to drive EP media successfully. The operation voltages that are used on the gate bias are -30 V during the row data selection and the gate bias are 0 V during the row data hold time. The data voltages that are used on the source bias are -20 V, 0 V, and 20 V during display media operation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.12C
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• pp.1133-1143
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• 2005

In this paper, we propose an enhanced two-step search scheme for rapid and reliable signal acquisition in UWB systems under multipath channels. The proposed TSS-LS (Two-Step Search scheme with the Linear search based Second step) achieves rapid acquisition performance comparable to the conventional TSS-BS (Two-Step Search scheme with the Bit reversal search based Second step) already proposed by the authors, based on the single-dwell search with two-step thresholds and search windows. However, unlike the TSS-BS which employs the bit reversal search in the second step, the proposed TSS-LS utilizes the linear search in the second step to improve the reliability of signal acquisition. Simulation results with multipath channel models by IEEE 802.15.3a show that the two-step search schemes for the UWB signal acquisition can achieve sig nificant reduction of the required mean acquisition time as compared to general search schemes. In addition, we observe that the proposed TSS-LS achieves quite good bit error rate performance for large signal-to-noise ratios, which is favorably comparable to the case of ideal perfect timing.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.2C
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• pp.192-199
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• 2008

In ultra-wideband (UWB) systems, conventionally, the synchronization is to align time phases of a locally generated template and any of multipath components to within an allowable range. However, the synchronization with a low-power multipath component could incur significant performance degradation in receiver operation (e.g., detection) after the synchronization. On the other hand, the synchronization with a high-power multipath component can improve the performance in receiver operation after the synchronization. Generally, the first one among multipath components has the largest power. Thus, the synchronization with the first path component can make better performance than that with low-power component in receiver operation after the synchronization, Based on which, we first propose an optimal decision rule based on a maximum likelihood (ML) approach, and then, develope a simpler suboptimal decision rule for selecting the first path component. Simulation results show that the system has good demodulation performance, which uses new synchronization definition and the proposed decision rules have better performance than that of the conventional decision rule in UWB multipath channels. Between macroblocks in the previous and the current frame. On video samples with high motion and scene change cases, experimental results show that (1) the proposed algorithm adapts the encoded bitstream to limited channel capacity, while existing algorithms abruptly excess the limit bit rate; (2) the proposed algorithm improves picture quality with $0.4{\sim}0.9$dB in average.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.5C
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• pp.527-539
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• 2009

In this paper, we propose an asynchonous ICI (Inter-Cell Interference) mitigation techniques for 3GPP LTE MIMO-OFDMA down-link receiver. An increasing in symbol timing misalignments may occur relative to sychronous network as the result of BS (Base Station) timing differences. Such symbol synchronization errors that exceed the guard interval or the cyclic prefix duration may result in MAI (Multiple Access Interference) for other carriers. In particular, at the cell boundary, this MAI becomes a critical factor, leading to degraded channel throughput and severe asynchronous ICI. Hence, many researchers have investigated the interference mitigation method in the presence of asynchronous ICI and it appears that the knowledge of the SCM (Spatial Covariance Matrix) of the asynchronous ICI plus background noise is an important issue. Generally, it is assumed that the SCM estimated by using training symbols. However, it is difficult to measure the interference statistics for a long time and training symbol is also not appropriate for MIMO-OFDMA system such as LTE. Therefore, a noise reduction method is required to improve the estimation accuracy. Although the conventional time-domain low-pass type weighting method can be effective for noise reduction, it causes significant estimation error due to the spectral leakage in practical OFDM system. Therefore, we propose a time-domain sinc type weighing method which can not only reduce the noise effectively minimizing estimation error caused by the spectral leakage but also implement frequency-domain moving average filter easily. By using computer simulation, we show that the proposed method can provide up to 3dB SIR gain compared with the conventional method.

• Investigative Magnetic Resonance Imaging
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• v.7 no.2
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• pp.108-115
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• 2003

Purpose : To evaluate the effect of the gradient switching noise on the ECD source localization with the EEG data recorded during the MRI scan. Materials and Methods : We have fabricated a spherical EEG phantom that emulates a human head on which multiple electrodes are attached. Inside the phantom, electric current dipole(ECD) sources are located to evaluate the source localization error. The EEG phantom was placed in the center of the whole-body 3.0 Tesla MRI magnet, and a sinusoidal current was fed to the ECD sources. With an MRI-compatible EEG measurement system, we recorded the multi channel electric potential signals during gradient echo single-shot EPI scans. To evaluate the effect of the gradient switching noise on the ECD source localization, we controlled the gradient noise level by changing the FOV of the EPI scan. With the measured potential signals, we have performed the ECD source localization. Results : The source localization error depends on the gradient switching noise level and the ECD source position. The gradient switching noise has much bigger negative effects on the source localization than the Gaussian noise. We have found that the ECD source localization works reasonably when the gradient switching noise power is smaller than $10\%$ of the EEG signal power. Conclusion : We think that the results of the present study can be used as a guideline to determine the degree of gradient switching noise suppression in EEG when the EEG data are to be used to enhance the performance of fMRI.

• Korean Journal of Optics and Photonics
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• v.18 no.3
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• pp.185-189
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• 2007

A novel technology for CWDM (Coarse Wavelength Division Multiplexer) utilizing a PLC (Planar Lightwave Circuit)-AWG (Arrayed Waveguide Grating) fabrication process is proposed. BPM (Beam Propagation Method) Simulation results on the employed parabolic-horn-type input slab waveguide of AWG and the performance of the 20 nm-channel spacing CWDM with flattened passband are presented. Waveguides of $0.75{\triangle}%$ have been used in this experiment and the insertion loss at the peak wavelength is 3.5 dB for a Gaussian spectrum and is 4.8 dB for a flat-top spectrum. The bandwidth at 3 dB is better than 10 nm and 13 nm for Gaussian and flat-top spectra, respectively.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.10C
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• pp.967-983
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• 2003

In wireless spread-spectrum communication systems utilizing PN (pseudo noise) sequences, a variety of noise sources from the channel affect the data reception performance. Among them, in this paper we are concerned with the narrowband interference that may arise from the use of the spectral bands overlapped by the existing narrowband users or the intentional jammers as in military communication. The effect of this interference can be reduced to some extent at the receiver with the PN demodulation by processing gain. It is known, however, that when the interferers are strong, the reduction cannot be sufficient and thereby requiring the extra use of narrowband interference cancellers (NIC's) at the receivers. A class of adaptive NIC's are studied here based on different two cost functions. One is the chip mean-squared error (MSE) computed prior to the PN demodulation and used in the conventional cancellers. Since thses conventional cancellers should be operated at the chip rate, the computational requirements are enormous. The other is the symbol MSE computed after the PN demodulation in which case the weights of the NIC's can be updated at a lot lower symbol rate. To compare the performance of these NIC's, we derive a common measure of performance, i.e., the symbol MSE after the PN demodulation. The analytical results are verified by computer simulation. As a result, it is shown that the cancellation capability of the symbol-rate NIC's are similar or better than the conventional one while the computational complexity can be reduced a lot.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.11B
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• pp.1501-1509
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• 2001

Recently, the use of wireless communication systems has been rapidly increasing, which results in a difficult problem in efficient control of limited frequency resources. As a way of solving this problem, the ultra wideband time hopping impulse radio system attracts much attention. The impulse radio system communicates pulse position modulated data using Gaussian monocycle pulses of very short duration less than 1 nsec. Thus the transmitted signal has very low power spectral density and ultra wide bandwidth from near D.C. to a few GHz. It is blown that it hardly interferes with the existing communication systems because of its very low power spectral density. The purpose of this paper is to characterize multipath propagation of the impulse radio signal and to evaluate the performance of the correlator-based receiver for the multipath environments. In this paper, we consider the deterministic two-path model and the statistical indoor multipath model of Saleh and Valenzuela. For the two-path model the output of the correlator with the ideal reference waveform varies according to the relative difference between the indirect path delay and the time interval of PPM, and to the indirect path gains. In addition, the characteristics of bit error rates is measured for the two models through computer simulation. The simulation results indicate that the performance of the impulse radio system depends both on the relative difference between the indirect path delay and the time interval of PPM, and on the indirect path gains. Furthermore, it is observed that the reference signal designed for the AWGN channel can not be applied to the multipath channels.

• Proceedings of the KIEE Conference
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• 1993.07a
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• pp.504-506
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• 1993

The Joint Photographic Experts Group (JPEG) standard was proposed by the International Standardization Organization (ISO/SC 29/WG 10) and the CCITT SG VIII as an international standard for digital continuous-tone still image compression. The JPEG standard has been widely accepted in electronic imaging, computer graphics, and multi-media applications, however, due to the lossy character of the JPEG compression its application in the field of medical imaging has been limited. In this paper, the JPEG standard was applied to a series of head sections of magnetic resonance (MR) images (256 gray levels, $256{\times}256$ size) and its performance was investigated. For this purpose, DCT-based sequential mode of the JPEG standard was implemented using the CL550 compression chip and progressive and lossless coding was implemented by software without additional hardware. From the experiment, it appears that the compression ratio of about 10 to 20 was obtained for the MR images without noticeable distortion. It is also noted that the error signal between the reconstructed image by the JPEG and the original image was nearly random noise without causing any special-pattern-related artifact. Although the coding efficiency of the progressive and hierarchical coding is identical to that of the sequential coding in compression ratio and SNR, it has useful features In fast search of patient Image from huge image data base and in remote diagnosis through slow public communication channel.