• Molecules and Cells
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• v.37 no.9
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• pp.656-663
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• 2014

Gintonin, a novel, ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand, elicits $[Ca^{2+}]_i$ transients in neuronal and non-neuronal cells via pertussis toxin-sensitive and pertussis toxin-insensitive G proteins. The slowly activating delayed rectifier $K^+$ ($I_{Ks}$) channel is a cardiac $K^+$ channel composed of KCNQ1 and KCNE1 subunits. The C terminus of the KCNQ1 channel protein has two calmodulin-binding sites that are involved in regulating $I_{Ks}$ channels. In this study, we investigated the molecular mechanisms of gintonin-mediated activation of human $I_{Ks}$ channel activity by expressing human $I_{Ks}$ channels in Xenopus oocytes. We found that gintonin enhances $I_{Ks}$ channel currents in concentration- and voltage-dependent manners. The $EC_{50}$ for the $I_{Ks}$ channel was $0.05{\pm}0.01{\mu}g/ml$. Gintonin-mediated activation 1 of the $I_{Ks}$ channels was blocked by an LPA1/3 receptor antagonist, an active phospholipase C inhibitor, an $IP_3$ receptor antagonist, and the calcium chelator BAPTA. Gintonin-mediated activation of both the $I_{Ks}$ channel was also blocked by the calmodulin (CaM) blocker calmidazolium. Mutations in the KCNQ1 $[Ca^{2+}]_i$/CaM-binding IQ motif sites (S373P, W392R, or R539W)blocked the action of gintonin on $I_{Ks}$ channel. However, gintonin had no effect on hERG $K^+$ channel activity. These results show that gintonin-mediated enhancement of $I_{Ks}$ channel currents is achieved through binding of the $[Ca^{2+}]_i$/CaM complex to the C terminus of KCNQ1 subunit.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.11C
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• pp.868-873
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• 2008

In this paper, we analyze the burst error performance of LDPC codes on perpendicular magnetic recording(PMR) channel. When burst error is generated on PMR channel, we use channel state information(CSI) to set the LLR information of channel detector zero. We consider the rate 0.94 LDPC codes and use SOVA as channel detector with low complexity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.4C
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• pp.384-391
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• 2003

Blind channel identification and equalization attempt to identify the communication channel and to remove the inter-symbol interference caused by a communication channel without using any known trainning sequences. In this paper, we propose a blind adaptive channel identification and equalization algorithm with phase offset compensation for single-input multiple-output (SIMO) channel. It is based on the one-step forward multichannel linear prediction error method and can be implemented by an RLS algorithm. Phase offset problem, we use a blind adaptive algorithm called the constant modulus derotator (CMD) algorithm based on condtant modulus algorithm (CMA). Moreover, unlike many known subspace (SS) methods or cross relation (CR) methods, our proposed algorithms do not require channel order estimation. Therefore, our algorithms are robust to channel order mismatch.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2006.05a
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• pp.119-122
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• 2006

In this study, bottom-up type powder processing and top-down type SPD (severe plastic deformation) approaches were combined in order to achieve full density of 1 vol.% carbon nanotube (CNT)-metal matrix composites with superior mechanical properties by improved particle bonding and least grain growth, which were considered as a bottle neck of the bottom-up method using the conventional powder metallurgy of compaction and sintering. ECAP (equal channel angular pressing), the most promising method in SPD, was used for the CNT-Cu powder consolidation. The powder ECAP processing with 1, 2, 4 and 8 route C passes was conducted at room temperature. It was found by mechanical testing of the consolidated 1 vol.% CNT-Cu that high mechanical strength could be achieved effectively as a result of the Cu matrix strengthening and improved particle bonding during ECAP. The ECAP processing of powders is a viable method to achieve fully density CNT-Cu nanocomposites.

• Clinical and Experimental Pediatrics
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• v.53 no.10
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• pp.909-912
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• 2010

Familial hypokalemic periodic paralysis is an autosomal-dominant channelopathy characterized by episodic muscle weakness with hypokalemia. The respiratory and cardiac muscles typically remain unaffected, but we report an atypical case of a family with hypokalemic periodic paralysis in which the affected members presented with frequent respiratory insufficiency during severe attacks. Molecular analysis revealed a heterozygous c.664 C>T transition in the sodium channel gene $SCN4A$, leading to an Arg222Trp mutation in the channel protein. The patients described here presented unusual clinical characteristics that included a severe respiratory phenotype, an incomplete penetrance in female carriers, and a different response to medications.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.3C
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• pp.170-174
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• 2011

We introduce the network coding which cooperative communication for two-way relay channel. We propose a new network coding scheme using orthogonality for cooperative communication system. The proposed network coding scheme via orthogonal mapping shows better BER performance because proposed scheme weakens error propagation which is disadvantage of DF scheme. And proposed scheme maintains same throughput compared to conventional scheme.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.1
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• pp.17-22
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• 2001

The floating-gate MOSFETs were fabricated by employing 1.5 m n-well CMOS process and their optical-electrical properties were characterized for the application to CMOS image sensor system. Based on the simulation of energy band diagram and operating mechanism of parasitic BJT were proposed as solutions for the increase of photo-current value. In order to realize them, MOSFETs having multi-gate and channel structures were fabricated and 60% increase in photo-current was achieved through enlargement of depletion layer and parallel connection of parasitic BJTs by channel division.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.34C no.2
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• pp.19-28
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• 1997

This paper presents the design of an SSIC chip for synchronization between main and sub pictures in the multi channel TV system (MUCTS). This chip can resolve problems in MUCTS, such as passing through and vertical jolt phenomena. In addition, this chip rpvivides compatibility for normal/doulble scan, interlace/progressive and normal (4:3)/wide (16:9) systems and has high hjorizontal and vertical resolutions (340) dots and 150 lines). In each mode there are 1 channel, 3 channel, and 4 position display functions. This MUCTS chip including three A/D coverters, a D/A converter and seven line memories was fabricated with one chip by using the $0.8\mu\textrm{m}$ CMOS technology. The application areas of this MUCTS ASIC chip include the wide TV, projection TV and te next generation TV for the DBS (direct broadcast system).

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2001.10a
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• pp.749-752
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• 2001

In this paper, the channel access algorithm for the AIS is analyzed and the design of the functional modules is presented. The function of RATDMA, ITDMA, FATDMA, and SOTDMA algorithm defined by ITU-R M.1371 specification is analyzed. Each TDMA algorithm is designed as a modularized function. In order to verify the function of designed channel access algorithm, the algorithm is implemented using C language and simulated on the PC environment. The simulation results show that the algorithm ran properly allocate a transmission slot and is satisfied with the requirements of the specification.

• ETRI Journal
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• v.43 no.2
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• pp.344-356
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• 2021

CRAFT is a tweakable block cipher introduced in 2019 that aims to provide strong protection against differential fault analysis. In this paper, we show that CRAFT is vulnerable to side-channel cube attacks. We apply side-channel cube attacks to CRAFT with the Hamming weight leakage assumption. We found that the first half of the secret key can be recovered from the Hamming weight leakage after the first round. Next, using the recovered key bits, we continue our attack to recover the second half of the secret key. We show that the set of equations that are solvable varies depending on the value of the key bits. Our result shows that 99.90% of the key space can be fully recovered within a practical time.