• Journal of the Korean Applied Science and Technology
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• v.25 no.2
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• pp.240-251
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• 2008

The central role of tyrosine phosphorylation in cell proliferative signaling mechanisms provides another target for chemotherapy. The aim of this research is to develop new quinazoline derivatives that possess the inhibitory activity for depidermal growth factor receptor (EGFR) tyrosine kinase (TK) as protein kinase inhibitors. In this work, a series of new 4-anilino-6-guanidino-7-methoxyquinazoline derivatives (12a-l) were synthesized by the introduction of guanidine moiety at C-6 of quinazoline nucleus and evaluated for their EGFR TK inhibitory activities.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.276.1-276.1
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• 2002

It is well known that cisplatin. one of chemotherapeutic agents. induces DNA damage and kill cancer cells mainly by apoptosis. We recently synthesized a novel Pt(IV)-based anticancer agent. trans.cis-Pt(acetato)2C12(1.4-butanediamine) (K101) with octahedral structure. To evaluate antitumor activity about human cancer of K101, we have performed histoculture drug response assay in 35 cases of colorectal cancer patients. (omitted)

• Proceedings of the Korea Information Processing Society Conference
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• 2011.04a
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• pp.519-521
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• 2011

본 연구는 3D 레이저 스캔 방법으로 계측된 인체 데이터를 대상으로 3D 아바타 애니메이션 모듈 구현을 목표로 한다. 이를 위하여 인체의 뼈 골격계 기준점을 지정한다. 기준점을 이용하여 계층에 맞는 골격을 잡아 오브젝트를 이루고 있는 정점들과 그에 해당되는 골격들을 연결하고 기구학에 의한 행동패턴을 제작하여 아바타에 애니메이션을 적용 시킨다. 이를 위하여Visual C++ OpenGL 라이브러리를 이용 하였고 인체 전신 레이저 스캔 데이터를 대상으로 하였다.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.70-74
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• 2023

CCCTC-binding factor (CTCF) is a transcriptional regulator that binds to a complex DNA motif in various orientations and plays a crucial role in regulating gene expression, chromatin restructuring, and developmental processes. Mutations in the CTCF are associated with neurodevelopmental disorders. Here we report the first Korean case with a de novo heterozygous variant in the CTCF (c.1025G>A; p.Arg342His). She showed global developmental delay, failure to thrive, and dysmorphic face, which are phenotypes consistent with previous reports in the autosomal dominant intellectual developmental disorder 21 (MIM 615502). She also showed clinical features not previously reported, such as antral web and tracheobronchomalacia. Our case follows suit and expands understanding of this rare disorder by reporting common features and, on the other hand, unreported concomitant congenital anomalies.

• The Plant Pathology Journal
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• v.40 no.3
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• pp.322-328
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• 2024

Soybean (Glycine max), a crucial global crop, experiences yearly yield reduction due to diseases such as anthracnose (Colletotrichum truncatum) and root rot (Fusarium spp.). The use of fungicides, which have traditionally been employed to control these phytopathogens, is now facing challenges due to the emergence of fungicide-resistant strains. Streptomyces bacillaris S8 strain S8 is previously known to produce valinomycin t through a nonribosomal peptide synthetase (NRPS) pathway. The objective of this study was to evaluate the antifungal activity of S. bacillaris S8 against C. truncatum and Fusarium sp., assessing its efficacy against soybean pathogens. The results indicate that strain S8 effectively controlled both above-ground and underground soybean diseases, using the NRPS and NRPS-related compound, suggesting its potential as a biological control in plant-microbe interactions. These findings underscore the pivotal role of the stain S8 in fostering healthy soybean microbial communities and emphasize the significance of microbiota structure studies in unveiling potent biocontrol agents.

• International Journal of Stem Cells
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• v.16 no.4
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• pp.448-449
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• 2023

• Korean Journal of Food Science and Technology
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• v.39 no.6
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• pp.644-651
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• 2007

To establish the optimum conditions for storing buttercup squash, we examined the effectiveness of several storage methods and the quality of the squash under various storage conditions, including temperature (12 and $20^{\circ}C$) and relative humidity (20, 40, 60, and 80%). The spoiling rate of the squash was affected more by the storage temperature than the relative humidity, and the squash stored at $20^{\circ}C$ started to be deteriorated after 20 days of storage. At $20^{\circ}C$, soluble solid content gradually increased until 20 days of storage, and then it tended to decrease. The L-value had a tendency to increase with days of storage, and the a- and b-value also increased after 40 days. In addition, the color changes were great when the squash was stored at high temperature and high relative humidity. The total pectin content increased until 20 days at $20^{\circ}C$, and then it decreased, but less change was observed in the squash stored at $12^{\circ}C$. Overall, the results showed that storage at $20^{\circ}C$ after field curing resulted in excessive weight loss, color loss and poor eating quality, as well as a high level of decay (approximately 70%) after 40 days. However, the squash stored at $12^{\circ}C$ and 60% RH (relative humidity) showed less degreening and had a reduced level of decay, below 10%.

• Food Science and Preservation
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• v.14 no.3
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• pp.227-232
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• 2007

The development of an effective long-term storage protocol for harvested fresh pepper is urgently required to increase the market for pepper products. The protocol must minimize quality loss, so that the product may be used either as a spice or as a raw material for processed pepper products, both in the home and in food processing plants. We investigated the optimum size of pepper fruits, freezing temperatures, storage periods, and thawing methods, to establish an optimum storage protocol. This study was conducted not only to develop freezing and thawing methods for long term storage of harvested red pepper, but also to develop processed pepper products utilizing the stored pepper. We aimed to expand the pepper products market and to increase the incomes of pepper growers. Whole red pepper, sliced red pepper, and crushed red pepper were frozen and stored at $-5^{\circ}C,\;-20^{\circ}C,\;or\;-40^{\circ}C$. The soluble solid content and the vitamin C level showed maximal stability at $-40^{\circ}C$, although total free sugars decreased on storage at all temperatures tested. Such Changes were more marked at $-5^{\circ}C$ than at the other(lower) temperature tested. The vitamin C content of whole red pepper was higher than that of sliced red pepper or crushed red pepper. Room-temperature thawing resulted in twice the drip loss seen on low temperature($5^{\circ}C$) thawing or microwave oven thawing. Brown discoloration was a serious problem with room temperature thawing. Total free sugars were higher in samples thawed at low temperature or in the microwave oven, compared to the level seen after room-temperature thawing. pepper samples thawed at low temperature scored higher in sensory tests than samples thawed at room temperature.

• Journal of Bio-Environment Control
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• v.22 no.1
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• pp.13-18
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• 2013

This study was conducted to examine the effect of temperature and relative humidity (RH) that might affect the pollen germination rate and pollen tube length in oriental melon. The experiment was performed using three cultivars namely 'Mallijangseong', 'Ohbokggul', and 'Joeundae' wherein environmental conditions were controlled by three different temperatures $15^{\circ}C$, $25^{\circ}C$, and $35^{\circ}C$ and also three RH levels 30%, 60%, and 90%. Based on the results in terms of temperature, true to all cultivars, plants exposed to $25^{\circ}C$ had the highest pollen germination rate while plants exposed to $15^{\circ}C$ had the lowest. Among the three cultivars, 'Mallijangseong' had the highest in terms of pollen germination rate, followed by 'Ohbokggul', and lastly was 'Joeundae' that showed the lowest germination rate. In the case of pollen tube length, pollen exposed under $35^{\circ}C$ showed the longest tube length, followed by pollen under $25^{\circ}C$, and pollen under $15^{\circ}C$ remarkably had the shortest tube length. Across the three cultivars 'Ohbokggul' had the longest pollen tube length. In the case of RH, pollen germination response among three cultivars depends on the humidity conditions but based on the results, there was no significant differences although high germination rate was observed in highest humidity condition. Between each cultivar, 'Ohbokggul' had the lowest pollen germination rate compared with 'Mallijangseong' and 'Joeundae' after exposure to different RH conditions wherein pollen germination showed significant differences among treatments. The pollen collected under 60% RH had the longest pollen tube length, followed by 30%, and the shortest was under 90% RH. In general, 'Ohbokggul' had the longest pollen tube length while 'Joeundae' had the shortest among the three cultivars.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.3
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• pp.184-194
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• 2023

In this study, we investigated whether p-anisaldehyde (PAA), the main component of essential oils derived from anise seeds, influences the differentiation of mouse C2C12 myoblasts. Cells were induced to differentiate over 5 days using a differentiation medium with or without PAA (50 or 200 mg/mL). Myotube length and diameter were measured, and the expressions of myogenic markers (myoblast determination protein 1, myogenin, myocyte enhancer factor 2, muscle creatine kinase, and myosin heavy chain) and atrophy-related genes (atrogin-1 and muscle ring finger-1 [MuRF-1]) were assessed by quantitative real-time polymerase chain reaction. Additionally, protein kinase B (Akt) phosphorylation was monitored by western blotting. PAA significantly induced the formation of smaller and thinner myotubes and reduced myogenic marker expression. Furthermore, PAA increased the expressions of atrogin-1 and MuRF-1 and simultaneously reduced Akt phosphorylation. Our findings indicate that PAA inhibits the myogenic differentiation of C2C12 cells by reducing the phosphorylation and activation of Akt.