대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.276.1-276.1
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- 2002
Histoculture drug response assay in Human colorectal cancer patients of novel Pt(IV) complex. K101 and nephrotoxicity test in ICR mice renal proximal tubular cells
- Kwon, Young-Ee (Drug Discovery Institute STC Life Science Center) ;
- Lee, Hwa-Jung (Drug Discovery Institute STC Life Science Cente) ;
- Kang, Jeong-Ho (Drug Discovery Institute STC Life Science Cente) ;
- Kim, Kuk-Hwan (College of Medicine Hanyang University) ;
- Kim, Won-Kyu (College of Medicine Hanyang University) ;
- No, Yi-Ran (Metabio Research Cente) ;
- Kim, Moon-Bo (Metabio Research Center)
- 발행 : 2002.10.01
초록
It is well known that cisplatin. one of chemotherapeutic agents. induces DNA damage and kill cancer cells mainly by apoptosis. We recently synthesized a novel Pt(IV)-based anticancer agent. trans.cis-Pt(acetato)2C12(1.4-butanediamine) (K101) with octahedral structure. To evaluate antitumor activity about human cancer of K101, we have performed histoculture drug response assay in 35 cases of colorectal cancer patients. (omitted)
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