• International Journal of Oral Biology
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• v.45 no.2
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• pp.51-57
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• 2020

Thromboelastography or rotational thromboelastometry, is being increasingly utilized in cardiac surgery of late. However, it is an indirect test and is not available in all centers. Low fibrinogen levels before and after cardiopulmonary bypass (CPB) have been described to be associated with postoperative bleeding in cardiac surgery. This study explored the usefulness of reduction ratio of the fibrinogen levels before CPB (preCPB) and after CPB (postCPB) in predicting postoperative hemorrhage. A retrospective, observational study of adult patients who underwent cardiac surgery with CPB between February 2014 and January 2016 was conducted, which included a total of 264 patients. The fibrinogen levels were measured twice, preCPB and postCPB, and the fibrinogen reduction ratio was acquired [(preCPB - postCPB)/preCPB]. Postoperative blood loss, which was defined as the blood collected from the chest drain for 12 hours following arrival at the intensive care unit, was considered severe if it was more than 1,000 mL. A multivariate analysis showed that fibrinogen reduction ratio, sex, and postCPB platelet count were significantly associated with severe postoperative bleeding. However, the pre- and postCPB fibrinogen levels were not significantly associated with severe bleeding. Furthermore, a fibrinogen reduction ratio of > 41.3% was independently associated with postoperative severe bleeding, with an odds ratio of 3.472 (1.483-8.162). These results suggest that the reduction ratio of pre- and postCPB fibrinogen levels may be utilized in predicting postoperative bleeding.

• International Journal of Aeronautical and Space Sciences
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• v.15 no.1
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• pp.97-101
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• 2014

With the increase in global air travel, aircraft noise has become a major public issue. In modern aircraft engines, only a small proportion of the air that passes through the whole engine actually goes through the core of the engine, the rest passes around it down the bypass duct. A successful method of reducing noise further, even in ultra-high bypass ratio engines, is to absorb the sound created within the engine. Acoustically absorbent material or acoustic liners have desirable acoustic attenuation properties and thus are commonly used to reduce noise in jet engines. The liners typically are placed upstream and downstream of the rotors (fans) to absorb sound before it propagates out of the inlet and exhaust ducts. Noise attenuation can be dramatically improved by increasing the area over which a noise reducing material is applied and by placing the material closer to the noise source. In this paper we will briefly discuss acoustic liner applications in modern turbofan engines.

• Solar Energy
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• v.17 no.2
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• pp.3-11
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• 1997

In conventional heat and vent dryer, both sensible and latent heat could not be recovered from the exhaust air, but this problem could be solved by introducing a heat pump to a conventional dryer, having a connection with cooling, dehumidifying and heating of heat pump. In this work, HFC134a as a substitute refrigerant of CFC12 adopted in heat pump and a batch type is also introduced. The variables affected on the system performance are holding temperature of a drying chamber, bypass air ratio, degree of superheat and refrigerant flowrate, etc. The moisture contents were decreased curvilinearly in the range of $86{\sim}75%$ on the wet basis. Under the constant drying temperature, the face velocity plays an important role to the drying performance. The COPs are increased in accordance with the air velocity, on the other hand the SMERs are gradually decreased.

• Geomechanics and Engineering
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• v.28 no.2
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• pp.135-143
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• 2022

Soils are natural granular materials whose mechanical properties differ according to the size and composition of the particles, so soils exhibit an obvious scale effect. Traditional soil mechanics is based on continuum mechanics, which can not reflect the impact of particle size on soil mechanics. On that basis, a matrix-reinforcing-particle cell model is established in which the reinforcing particles are larger-diameter sand particles and the matrix comprises smaller-diameter bentonite particles. Since these two types of particles deform differently under shear stress, a new shear-strength theory under direct shear that considers the stress concentration and bypass phenomena of the matrix is established. In order to verify the rationality of this theory, a series of direct shear tests with different reinforcing particle diameter and volume fraction ratio are carried out. Theoretical analysis and experimental results showed that the interaction among particles of differing size and composition is the basic reason for the size effect of soils. Furthermore, the stress concentration and bypass phenomena of the matrix enhance the shear strength of a soil, and the volume ratio of reinforcing particles has an obvious impact on the shear strength. In addition, the newly proposed shear-strength theory agrees well with experimental values.

• Journal of electromagnetic engineering and science
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• v.14 no.4
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• pp.393-398
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• 2014

A highly efficient dual-mode linear CMOS stacked-FET power amplifier (PA) is implemented for 3G UMTS and 4G LTE handset applications. High efficiency is achieved at a backed-off output power ($P_{out}$) below 12 dBm by employing an active-bypass amplifier, which consumes very low quiescent current and has high load-impedance. The output paths between high- and low-power modes of the PA are effectively isolated by using a bypass switch, thus no RF performance degradation occurs at high-power mode operation. The fabricated 900 MHz CMOS PA using a silicon-on-insulator (SOI) CMOS process operates with an idle current of 5.5 mA and shows power-added efficiency (PAE) of 20.5%/43.5% at $P_{out}$ = 12.4 / 28.2 dBm while maintaining an adjacent channel leakage ratio (ACLR) better than -39 dBc, using the 3GPP uplink W-CDMA signal. The PA also exhibits PAE of 35.1% and $ACLR_{E-UTRA}$ of -33 dBc at $P_{out}$ = 26.5 dBm, using the 20 MHz bandwidth 16-QAM LTE signal.

• Journal of Obesity & Metabolic Syndrome
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• v.27 no.4
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• pp.248-253
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• 2018

Background: Sirtuins mediate metabolic responses to nutrient availability and slow aging and accompanying decline in health. This study was designed to assess the expressions of sirtuin1 (SIRT1) and sirtuin3 (SIRT3) in the liver and hypothalamus after duodenal-jejunal bypass (DJB) surgery in rats. Methods: A total of 38 rats were randomly assigned to either sham group (n=8) or DJB group (n=30). DJB group was again divided into three groups according to the elapsed time after surgery (10 weeks, DJB10; 16 week, DJB16; 28 week, DJB28). The mRNA and protein expressions of SIRT1 and SIRT3 in the liver and hypothalamus were measured by reverse transcription polymerase chain reaction, Western blot, and immunohistochemistry analyses. $NAD^+/NADH$ ratio was also measured. Results: We found increased mRNA and protein expression levels of SIRT1 in the liver of DJB16 and DJB28 groups compared with those of sham group. The mRNA and protein expressions of SIRT3 in the liver of DJB group increased proportionally to the elapsed time after DJB surgery. The mRNA expression levels of SIRT1 in the hypothalamus increased in DJB16 and DJB28 groups and protein expression levels of SIRT1 in the hypothalamus increased in DJB10, DBJ16, and DJB28 groups compared with sham group. We observed that mRNA and protein levels of SIRT3 in the hypothalamus of DJB group were not changed. Conclusion: This study proves that DJB increases SIRT1 and SIRT3 expressions in the liver and SIRT1 expression in the hypothalamus. These results suggest the possibility of sirtuins being involved in bypass surgery-induced metabolic changes.

• 한국연소학회:학술대회논문집
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• 2003.05a
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• pp.111-117
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• 2003

The present study discusses about the combustion and thermal flow characteristics of a G+R type incinerator, which is under construction for MAPO Incineration system, to evaluate the effects of various operating and design parameters. A bed combustion model is developed to simulate the waste bed combustion on the stoker. The effects of waste composition and primary air distribution are estimated. The results of the waste bed combustion model is applied to CFD(computational fluid dynamics) simulation, which simulates the detail of the thermal flow in the combustion chamber. The effects of bypass damper opening ratio, primary air distribution, and secondary air jet configuration are discussed.

• The Korean Journal of Nuclear Medicine
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• v.31 no.1
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• pp.36-42
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• 1997

Though myocardial perfusion was usually expected to improve after coronary artery bypass graft(CABG) surgery, some myocardial segments were aggravated after operation, as we compared perfusion changes on postoperative SPECT with preoperative ones. In this study, we evaluated perfusion changes after operation in rest and stress myocardial SPECT in 44 patients (M:F=25:19, age 57.1 $year{\pm}8.2$) who had CABG before and 3 months after operation. We tried to find out possible causes for perfusion aggravation with multivariate logistic regression analysis regarding whether bypass graft was artery or vein and which coronary artery territory was operated. Among 616 myocardial segments which were operated, 89(14.4%) aggravated after operation. In the univariate analysis, myocardial segments in the left circumflex arteries(LCx) aggravated more often(p<0.01) than others and segments having operative angioplasty did less often(p<0.01). Multivariate logistic regression revealed that LCx was risk factor for perfusion aggravation [odds ratio=2.54 (95% confidence interval : 1.53-4.22, p<0.01)]. However, this was not the case when we analysed in terms of arterial territories. Among 106 coronary arterial territories which were operated, 27(25.5%) aggravated. The territories having aggravated had similar characteristics regarding whether they received arterial or venous grafts, angioplasty and whether the operated territories were left anterior descending, right coronary or left circumflex arteries. In conclusion, myocardial segments in the left circumflex artery tended to aggravate more often after bypass surgery than the others. In short-term comparison of perfusion after surgery, we could not find any tendency that arterial or venous graft was associated with more frequency of the aggravation of perfusion after operation.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.153-157
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• 2004

The aim of our study is to determine maximum surgical blood order schedule (MSBOS) in each surgical operation through analyzing usage of blood products at Bundang Jesaeng General Hospital. We investigated the amount of transfused red cells for each operation and calculated crossmatching-to-transfusion ratio (C/T ratio) and MSBOS. This was accomplished by referring to the Laboratory Information System program during 1 year from January through December 2003. Coronary artery bypass surgery and decompressive craniectomy showed the highest MSBOS in our hospital. The average C/T ratio was 3.2 and excessive reservations for blood products have been made for many operations. From this study, guidelines for the optimal blood ordering for each surgery were suggested.

• Journal of Chest Surgery
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• v.31 no.5
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• pp.494-501
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• 1998

From May 1, 1993 to May 31 1995, the authers studied retrospectively 211 patients who underwent cardiovascular operation with cardiopulmonary bypass(CPB). Because we were interested in new development of ARF(prevalence, mortality rate, and main risk factors), we performed a multivariate statistical analysis about data of patients with preoperative serum creatinine values of less than 1.5 mg/dL. Normal renal function before operation(serum creatinine level less than 1.5 mg/dL) was registered in 198(74%) patients. Of these, 27(14%) patients showed postoperative renal complication, including 20(10%) patients classified as renal dysfunction(serum creatinine level between 1.5 and 2.5 mg/dL) and 7(4%) patients as acute renal failure(serum creatinine level higher than 2.5 mg/dL). The mortality rate was 5.8% in normal patients, 5% in patients with renal dysfunction, and 43% when acute renal failure developed(p=0.036). Indeed, the renal impairment proved to be an independent predictor of mortality(odd ratio 2.52∼11.25), along with cardiovascular(odd ratio 4.20) and respiratory(odd ratio 2.18) complications. Multivariate analysis identified the following variables as independent risk factors for postoperative renal impairment : advanced age(odd ratio 1), need for emergency operation(odd ratio 3.78), low-output syndrome(odd ratio 3.66), respiratory complication(odd ratio 1.30), need for deep hypothermic circulatory arrest(odd ratio 1.4). The 13 patients(7%) with preoperative renal failure showed a significantly higher morbidity and mortality rate than those without renal complications before operation. We concluded that the likelihood of severe renal complications is resonably low in the patients undergoing cardiac operation without preexisting renal dysfunction, but associated mortality remains high. A prominant role of hemodynamic factor in the development of postoperative acute renal failure must be recognized during preoperative, intraoperative, and postoperative periods.