• Title/Summary/Keyword: Breast Mass

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Invasive Lobular Carcinoma: MRI Features and Clinicohistological Characteristics According to the ER, PR, and HER2 Statuses

  • Yoo, Eun Young;Nam, Sang Yu;Choi, Hye-Young;Cho, Hyun Yee
    • Investigative Magnetic Resonance Imaging
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    • v.19 no.3
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    • pp.137-145
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    • 2015
  • Purpose: To investigate correlations of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER2) statuses with magnetic resonance imaging (MRI) features and clinicohistological characteristics in patients with invasive lobular carcinoma (ILC). Materials and Methods: Data from 64 histologically confirmed ILCs were analyzed retrospectively. Preoperative breast MRI was reviewed for morphology and dynamic contrast-enhanced kinetics of the tumor. Pathologic reports were reviewed for ER, PR, and HER2 positivity, tumor size, lymph node metastasis, and the number of metastatic lymph nodes. Furthermore, there was an investigation of the MRI features and clinicohistologic characteristics, according to the ER, PR, and HER2 statuses. Results: A significant difference in MRI features and clinicohistological tumor characteristics were observed only in relation to PR status. Of the 64 ILCs, 10 (15.6%) were PR negative. PR negative cancers, compared with PR positive cancers, were more likely to present as non-mass enhancement (P = 0.027); have a significantly larger mean tumor size ($5.00{\pm}1.05cm$ vs. $2.57{\pm}0.21cm$, P = 0.021); and have significantly more metastatic lymph nodes (P = 0.010). Conclusion: PR negative ILC presented more frequently as non-mass enhancement on MRI, with larger tumors and increased numbers of metastatic lymph nodes. Therefore, the PR status plays an important role in determining MRI features and clinicohistological characteristics of ILC.

Investigating Meat Quality of Broiler Chickens Fed on Heat Processed Diets Containing Corn Distillers Dried Grains with Solubles

  • Shim, YoungHo;Kim, JinSoo;Hosseindoust, Abdolreza;Choi, YoHan;Kim, MinJu;Oh, SeungMin;Ham, HyungBin;Kumar, Alip;Kim, KwangYeol;Jang, Aera;Chae, ByungJo
    • Food Science of Animal Resources
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    • v.38 no.3
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    • pp.629-635
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    • 2018
  • The present study investigated the effects of feed form and distiller's dried grain with solubles (DDGS) on meat quality and fatty acids profile of broiler chickens. A total of 720 broilers (Ross 308; average BW [body weight] $541{\pm}5.7g$) were randomly allotted to six treatments. Birds were fed three different feed forms (mash; SP, simple pellet; EP, expanded pellet) and DDGS (0 or $200g\;kg^{-1}$) in a $3{\times}2$ factorial arrangement. The addition of DDGS and EP to the diet resulted in increased shear force of breast meat. Moreover, DDGS inclusion in the diet reduced the concentration of stearic acid and behenic acid in thigh meat. Pelleting (SP and EP) of the diets increased palmitic acid content in the thigh, whereas the linolenic acid content decreased. The breast mass was higher with EP and SP diets than with the mash diet. Feed processing led to increased pectoralis muscle and drum mass compared to mash-fed chickens. In conclusion, our results demonstrated that EP decreased thigh linolenic acid and meat shear force. In addition, DDGS supplementation in broiler hampers meat quality by increasing the shear force.

Invasine Ductal Carcinoma with Osteoclast-Like Giant Cell in a Young Woman (유방의 침윤성 파골양 거대세포 관암종의 세포소견 - 1예 보고 -)

  • Kang, Hyun-Jeong;Choi, Kyung-Un;Kwak, Hee-Suk;Sol, Mee-Young;Kim, Jee-Yeon
    • The Korean Journal of Cytopathology
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    • v.18 no.1
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    • pp.69-73
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    • 2007
  • Mammary carcinoma with osteoclast-like giant cells is an unusual neoplasm characterized by giant cells, mononuclear stromal cells, and hemorrhage accompanying a low grade carcinoma. We present the cytological findings in a case of invasive ductal carcinoma with osteoclast-like giant cells that was initially confused with a fibroadenoma, due to its well-demarcated and soft mass and the young age of the patient. A 28-year-old female presented with a 4.5 cm, well demarcated, soft and nontender mass in the right breast. Fine needle aspiration cytology (FNAC) showed a combination of low grade malignant epithelial cell clusters and osteoclast-like giant cells. The atypical epithelial cells were present in cohesive sheets and clusters. Osteoclast-like giant cells and bland-looking mononuclear cells were scattered. An histological examination revealed the presence of an invasive ductal carcinoma with osteoclast-like giant cells. We report here the cytological findings of this rare carcinoma in a very young woman. The minimal atypia of the epithelial cells and its soft consistency may lead to a false negative diagnosis in a young woman. The recognition that osteoclastlike giant cells are rarely present in a low grade carcinoma, but not in benign lesion, can assist the physician in making a correct diagnosis.

Influence of Lifetime Sports Activity Based on a Ground Reaction Force on Bone Mineral Density in Korean Adults (지면반력에 근거한 과거 신체활동정도가 골밀도에 미치는 영향 -아이오와에 거주하는 한인을 대상으로-)

  • Lee Eun Nam;Clark Mary Kathleen
    • Journal of Korean Academy of Nursing
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    • v.35 no.3
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    • pp.621-630
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    • 2005
  • Purpose: The purpose of this study was to -retrospectively describe the childhood sports activity level of Korean adult men and women and to determine whether a higher level of childhood sports activity was positively associated with adult bone mineral density. Methods: A cross-sectional study of 100 Korean men (n=40) and women (n=60) was completed. Participants completed a detailed lifetime sports activity questionnaire and had their bone mineral density of the femur and lumbar spine measured using dual energy x-ray densitometry (DEXA). All sports activities were classified into four categories of peak strain score on the basis of ground reaction forces (GRF). Results: During the age of high school, women and men who participated in a high intensity sports activity demonstrated higher bone density in the femur site after adjustment for the effects of body weight, fat body mass, lean body mass, the level of calcium intake, and breast feeding period than those who did not participate in sports activity at all. Conclusion: These results highlight the need to participate in high intensity sports activity during high school age as a means of increasing peak bone mass in the femur site.

Consequences of being born small for gestational age : More than being small (부당경량아. 크기만 작은가?)

  • Yoo, Eun-Gyong
    • Clinical and Experimental Pediatrics
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    • v.52 no.2
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    • pp.152-158
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    • 2009
  • Reduced fetal growth is independently associated with increased risk of health problems in later life, particularly type 2 diabetes and cardiovascular diseases. Insulin resistance appears to be a key component underlying these metabolic complications. It is suggested that detrimental fetal environment may program insulin resistance syndrome. An insulin-resistant genotype may also result in both low birth weight and insulin resistance syndrome, and it is likely that the association of low birth weight with insulin resistance is the result of both genetic and environmental factors. Early postnatal rapid catch-up growth is closely related to risk for subsequent metabolic diseases. Fat mass is strikingly reduced in neonates born small for gestational age (SGA), and recent data suggest that insulin resistance seen in catch-up growth is related to the disproportionate catch-up in fat mass compared with lean mass. Endocrine disturbances are also recognized in SGA children, but overt clinical problems are infrequent in childhood. Cognitive impairment is reported in some children born SGA, especially those who do not show catch-up growth, in whom early neurodevelopmental evaluation is required. Breast feeding, also known to be protective against the long-term risk of obesity, may prevent some intellectual impairment in SGA children. Calorie-dense feeding does not seem to be appropriate in SGA infants. We must balance the positive effect of nutrition on neural development against rapid fat deposition and the future risk of insulin resistance.

PRIMARY INTRAOSSEOUS CARCINOMA;REPORT OF 2 CASES (악골에서 발생한 원발성 상피암;2례 보고)

  • Park, So-Yeon;Kim, Jin;Lee, Choong-Kook;Park, Hyung-Rae;Kim, Il-Kyu
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.12 no.2
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    • pp.62-68
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    • 1990
  • Intraosseous carcinoma of the jaw may arise as metastatic lesions most commonly from breast, lung, kindney and thyroid and also primarily occur from ameloblastoma or odontogenic cyst. Rarely primary intraosseous carcinoma could be originated from the epithelium involved in odontogenesis. According to WHO's classification, primary intraosseous carcinoma is defined as squamous cell carcinoma, occured in the Jaw without connection to the oral mucosa. However, Elzay defined primary intraosseous carcinoma as malignant epithelial tumor related to the odontogenic apparatus, including carcinoma ex-odontogenic cyst, carcinoma ex-ameloblastoma and carcinoma de novo. We experienced 2 cases of intraosseous carcinoma of the jaw. The first case, a 59-year-old man, showed a ill-defined mass on the left maxilla, measuring $8{\times}10cm$ in size. He received radical hemimaxillectomy and was diagnosed as ameloblastic carcinoma. The second case obtained from a 79-year-old woman showed a ill-defined $6{\times}8cm$ sized mass on the left mandibular body area. The mass was surgically removed by partial mandibulaectomy, which was diagnosed as the primary intraosseous carcinoma, probably odontogenic origin.

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Estimation of Absorbed Dose for Anterior and Posterior Organs with Body Mass Index in Standing Whole Spine Examination (Standing Whole Spine 검사 시 체질량지수 (BMI)에 따른 전방 및 후방장기의 흡수선량 평가)

  • Shim, Ji Na;Lee, Yong-Gu;Lee, Youngjin
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.12
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    • pp.147-151
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    • 2016
  • Automatic exposure control (AEC) is frequently used in many hospitals for Standing Whole Spine examination which is able to control radiation dose with respect to the body type such as body mass index (BMI) and we can measure dose area product (DAP) based on respective patient information. However, few studies have been conducted organ absorbed dose evaluation based on location of patient organ. The purpose of this study was to evaluate the relationships between BMI and organ absorbed dose along with location of patient organ. For that purpose, we calculated absorbed dose with selected 5 patient organ (thyroid, breast, heart, kidney, and pancreas) using a PCXMC simulation tool with measured DAP. According to the results, measured DAP increases with BMI and organ absorbed dose decreases with BMI in anterior organs such as thyroid, breast, and heart. On the other hand, there is no correlation between organ absorbed dose and BMI in posterior organs such as kidney and pancreas. In conclusion, our results demonstrated that the radiation effects are different with respect to BMI and location of patient organ in Standing Whole Spine examination.

Determinants of Reduced Bone Mass in Postmenopausal Women with Rheumatoid Arthritis (폐경 후 류마티스 관절염 여성의 골량감소 판별요인)

  • Lee, Eun-Nam
    • The Korean Journal of Rehabilitation Nursing
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    • v.2 no.2
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    • pp.193-205
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    • 1999
  • This study was carried out to identify the important risk factors for reduced bone mass of postmenopausal RA patients and to develop discriminant function which can classify postmenopausal RA patients with either reduced or normal bone mass. Through the literature review, individual characteristics such as age, body weight, height, age of menarche, duration of menopause, gravity, parity, and breast feeding period and factors of life style such as milk consumption exercise habit, alcohol intake, cigarette smoking, coffee consumpt ion , disease activity, corticosteroid therapy were identified as influencing factors of reduced bone mass in RA patients Sixty eight postmenopausal women with rheumatoid arthritis aged between 42 and 76 were selected among those who checked bone mineral density in lumbar spine and femur from october, 1998 to Apr il, 1999 at Dong-a university hospital in Pusan. Assessment of disease activity, duration of disease and corticosteroid therapy were made by the same rheumatologist and included Ritchie articular index, erythrocyte sedimentation rate, and C-reactive protein on measuring bone mineral density. Cumulative steroid dosage was calculated from the daily dosage multiplied by t h e number of days received. The information of other risk factor including health assessment score, individual characteristics and life style factors were collected by questionnaire. Bone mineral density(BMD) was measured using DXA at lumbar spine and femoral Ward's triangle. Discriminant function(regression equation) was developed for estimating the likelihood of the presence or absence of reduced bone mass. The results are as follows: Among the subjects, thirteen(19.1%) exhibited osteoporosis in lumbar spine and twenty four(35.3%) exhibited osteoporosis in femoral Ward's triangle. For lumbar spine, the variables significant were age, body weight, health assessment score, while for femoral Ward's triangle, age, body weight, duration of disease. But disease activity and corticosteroid therapy were not signigicant to distinguish reduced bone mass from normal bone mass. When the discriminant function was evaluated by comparing the observed out come with predicted out come, the discriminant function correctly classified 85.4% of patients with reduce bone mass and 63.0% of patients with normal bone mass in the lumbar spine and 100% of patients with reduced bone mass and 9.1% of patients with normal bone mass in the femoral Ward's triangle. In summary, we found that osteoporosis in postmenopausal women with RA is more evident at the femur than the lumbar spine. Also the important discriminant factors of reduced bone mass postmenopausal women with RA were age, body weight , duration of disease and health disability. In nursing situation, the efforts to improve of functional capacity of postmenopausal women with rheumatoid arthritis should be considered to prevent osteoporosis and fractures. Also we recommend those postmenopausal women with RA who are classified as a group of the reduced bone mass in the discriminant function should examine the bone mineral density to further examine the usefulness of this discriminant function.

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A Report on the Effect of Jowisengchung-tang in 2 Cases of Precocious Puberty (조위승청탕(調胃升淸湯)을 투여한 성조숙 증상을 주소로 한 여아의 한방치료 2례)

  • Kim, Ji-Eun;Yang, Seung-Jeong;Cho, Seong-Hee;Park, Kyung-Mi
    • The Journal of Korean Obstetrics and Gynecology
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    • v.26 no.2
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    • pp.178-187
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    • 2013
  • Objectives: These cases are that of three girls who are diagnosed as precocious puberty. It seems that the incidence of precocious puberty is rapidly increasing these days. In addition to the psychosocial disturbances associated with precocious puberty, the premature pubertal growth spurt and the accelerated bone maturation result in reduced adult height. The aim of this study was to report the effect of Jowisengchung-tang in 3 cases of precocious puberty. Methods: Retrospective and comparative analysis of 3 children who had been diagnosed with preco cious puberty. Anthropometric measurements including height, weight, body fat, body fat percent, AHP and body mass index were measured. Endocrine investigations including estradiol, luteinizing hormone(LH), FSH were conducted. Pubertal stages were determined with a questionnaire using Tanner stages. Jowisengchung-tang was given to 3 precocious puberty girls. Results: After treatment, the hormone(estradiol index) and accompanying symptoms (breast bud with elevation of breast and papilla; enlargement of areola) were reduced compared with first visit day. Conclusions: We may conclude that Korean traditional treatment of Jowisengchung-tang is effective in patients with precocious puberty and menopausal symptoms.

Microdevice for Separation of Circulating Tumor Cells Using Embedded Magnetophoresis with V-shaped Ni-Co Nanowires and Immuno-nanomagnetic Beads

  • Park, Jeong Won;Lee, Nae-Rym;Cho, Sung Mok;Jung, Moon Youn;Ihm, Chunhwa;Lee, Dae-Sik
    • ETRI Journal
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    • v.37 no.2
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    • pp.233-240
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    • 2015
  • The novelty of this study resides in a 6"-wafer-level microfabrication protocol for a microdevice with a fluidic control system for the separation of circulating tumor cells (CTCs) from human whole blood cells. The microdevice utilizes a lateral magnetophoresis method based on immunomagnetic nanobeads with anti-epithelial cell adhesive molecule antibodies that selectively bind to epithelial cancer cells. The device consists of a top polydimethylsiloxane substrate for microfluidic control and a bottom substrate for lateral magnetophoretic force generation with embedded v-shaped soft magnetic microwires. The microdevice can isolate about 93% of the spiked cancer cells (MCF-7, a breast cancer cell line) at a flow rate of 40/100 mL/min with respect to a whole human blood/buffer solution. For all isolation, it takes only 10 min to process 400 mL of whole human blood. The fabrication method is sufficiently simple and easy, allowing the microdevice to be a mass-producible clinical tool for cancer diagnosis, prognosis, and personalized medicine.