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Invasine Ductal Carcinoma with Osteoclast-Like Giant Cell in a Young Woman  

Kang, Hyun-Jeong (Department of Pathology, College of Medicine, Pusan National University)
Choi, Kyung-Un (Department of Pathology, College of Medicine, Pusan National University)
Kwak, Hee-Suk (Department of Surgery, College of Medicine, Pusan National University)
Sol, Mee-Young (Department of Pathology, College of Medicine, Pusan National University)
Kim, Jee-Yeon (Department of Pathology, College of Medicine, Pusan National University)
Publication Information
The Korean Journal of Cytopathology / v.18, no.1, 2007 , pp. 69-73 More about this Journal
Abstract
Mammary carcinoma with osteoclast-like giant cells is an unusual neoplasm characterized by giant cells, mononuclear stromal cells, and hemorrhage accompanying a low grade carcinoma. We present the cytological findings in a case of invasive ductal carcinoma with osteoclast-like giant cells that was initially confused with a fibroadenoma, due to its well-demarcated and soft mass and the young age of the patient. A 28-year-old female presented with a 4.5 cm, well demarcated, soft and nontender mass in the right breast. Fine needle aspiration cytology (FNAC) showed a combination of low grade malignant epithelial cell clusters and osteoclast-like giant cells. The atypical epithelial cells were present in cohesive sheets and clusters. Osteoclast-like giant cells and bland-looking mononuclear cells were scattered. An histological examination revealed the presence of an invasive ductal carcinoma with osteoclast-like giant cells. We report here the cytological findings of this rare carcinoma in a very young woman. The minimal atypia of the epithelial cells and its soft consistency may lead to a false negative diagnosis in a young woman. The recognition that osteoclastlike giant cells are rarely present in a low grade carcinoma, but not in benign lesion, can assist the physician in making a correct diagnosis.
Keywords
Osteoclast-like giant cell; Cytology; Aspiration; Breast; Young woman;
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