• Genomics & Informatics
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• v.17 no.4
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• pp.40.1-40.9
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• 2019

While studies aimed at detecting and analyzing indels or single nucleotide polymorphisms within human genomic sequences have been actively conducted, studies on detecting long insertions/deletions are not easy to orchestrate. For the last 10 years, the availability of long read data of human genomes from PacBio or Nanopore platforms has increased, which makes it easier to detect long insertions/deletions. However, because long read data have a critical disadvantage due to their relatively high cost, many next generation sequencing data are produced mainly by short read sequencing machines. Here, we constructed programs to detect so-called unmapped regions (UMRs, where no reads are mapped on the reference genome), scanned 40 Korean genomes to select UMR long deletion candidates, and compared the candidates with the long deletion break points within the genomes available from the 1000 Genomes Project (1KGP). An average of about 36,000 UMRs were found in the 40 Korean genomes tested, 284 UMRs were common across the 40 genomes, and a total of 37,943 UMRs were found. Compared with the 74,045 break points provided by the 1KGP, 30,698 UMRs overlapped. As the number of compared samples increased from 1 to 40, the number of UMRs that overlapped with the break points also increased. This eventually reached a peak of 80.9% of the total UMRs found in this study. As the total number of overlapped UMRs could probably grow to encompass 74,045 break points with the inclusion of more Korean genomes, this approach could be practically useful for studies on long deletions utilizing short read data.

• Journal of Biosystems Engineering
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• v.39 no.4
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• pp.283-289
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• 2014

Purpose: This study was carried out to evaluate the labor requirement and the cost-reducing effects of the pick-up type pulse crop harvester compared with those of conventional harvesting for soybeans and red beans. Methods: The labor requirement and the cost to gather, thresh, and clean for conventional harvesting operations were surveyed; those for the pick-up type pulse crop harvester were estimated for soybeans and red beans. The annual capacity of the harvester and the break-even area of the two harvesting methods were also estimated. Results: For soybean harvesting, the labor requirement of 0.57 hour-persons/10 a for the pick-up type pulse crop harvester reflects a 91.9% reduction in the labor requirement of 7.00 hour-persons/10 a for conventional harvesting. Machinery costs of 51,300 won/10 a for the harvester were estimated for an annual harvesting area of 52.5 ha/year, representing a reduction of 33.3% from the 78,700 won/10 a cost of conventional harvesting. A break-even area of 28.4 ha was estimated for the two harvestings. For red bean harvesting, the labor requirement of 0.57 hour-persons/10 a for the harvester reflects a 92.6% reduction in the labor requirement of 7.66 hour-persons/10 a for conventional harvesting. For an annual harvesting area of 52.5 ha/year, annual capacity of 52.5 ha/year and machinery costs of 51,700 won/10 a were estimated for the harvester, reflecting a reduction of 44.7% in the cost of 93,500 won/10 a for conventional harvesting. A break-even area of 23.1 ha was estimated for the two harvestings. A governmental subsidy for purchasing the harvester could contribute to reducing the break-even area and harvesting costs. Conclusions: The pick-up type pulse crop harvester for soybean and red bean harvesting could reduce the labor requirement and costs of conventional harvesting, and a governmental subsidy for purchasing the harvester will improve the economics of the harvester for efficient mechanical harvesting.

• Nuclear Engineering and Technology
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• v.44 no.7
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• pp.727-734
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• 2012

A new advanced safety feature of DVI+ (Direct Vessel Injection Plus) for the APR+ (Advanced Power Reactor Plus), to mitigate the ECC (Emergency Core Cooling) bypass fraction and to prevent switching an ECC outlet to a break flow inlet during a DVI line break, is presented for an advanced DVI system. In the current DVI system, the ECC water injected into the downcomer is easily shifted to the broken cold leg by a high steam cross flow which comes from the intact cold legs during the late reflood phase of a LBLOCA (Large Break Loss Of Coolant Accident)For the new DVI+ system, an ECBD (Emergency Core Barrel Duct) is installed on the outside of a core barrel cylinder. The ECBD has a gap (From the core barrel wall to the ECBD inner wall to the radial direction) of 3/25~7/25 of the downcomer annulus gap. The DVI nozzle and the ECBD are only connected by the ECC water jet, which is called a hydrodynamic water bridge, during the ECC injection period. Otherwise these two components are disconnected from each other without any pipes inside the downcomer. The ECBD is an ECC downward isolation flow sub-channel which protects the ECC water from the high speed steam crossflow in the downcomer annulus during a LOCA event. The injected ECC water flows downward into the lower downcomer through the ECBD without a strong entrainment to a steam cross flow. The outer downcomer annulus of the ECBD is the major steam flow zone coming from the intact cold leg during a LBLOCA. During a DVI line break, the separated DVI nozzle and ECBD have the effect of preventing the level of the cooling water from being lowered in the downcomer due to an inlet-outlet reverse phenomenon at the lowest position of the outlet of the ECBD.

• Journal of Korean Clinical Health Science
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• v.7 no.1
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• pp.1232-1237
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• 2019

Purpose. In this study, two types of soft contact lenses with different materials were selected to compare the time of tear film destruction and high order aberrations before and after wearing. Methods. Thirty patients (60 eyes) in their 20s were included in this study. Two lenses with different materials, Group 4 (Etafilcon A) and Group 5 (Narafilcon A) were selected. Using aberration analyzer and keratometry, high-order aberration and tear film test (NIF-BUT, NIAvg-BUT) were performed before and after wearing. Results. When comparing the higher aberrations of the Etafilcon A and Narafilcon A lenses, the higher aberrations of the Narafilcon A lens were higher overall. For the initial tear film break-up time (NIF-BUT) after wearing, the Etafilcon A lens was reduced by 4.0 seconds and the Narafilcon A lens increased by 0.6 seconds. For the mean tear film break-up time (NIAvg-BUT) after wearing, the Etafilcon A lens decreased by 2.4 seconds and the Narafilcon A lens increased by 1.7 seconds. Conclusions. NIF-BUT and NIAvg-BUT of Narafilcon A lens were increased. The lens with relatively low water content and higher oxygen permeability than the lens with high water content has relatively less tear evaporation, which means that the time of destruction of the tear film is increased.

• Journal of Energy Engineering
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• v.20 no.1
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• pp.54-62
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• 2011

Since the release of mid-term domestic GHG goals until 2020, in 2009, some various GHG reduction policies have been proposed. In case of the transportation sector for the mid-term domestic GHG goals, it targets to reduce about 30% regarding the doemstic economic growth until 2020. A major reduction method in passenger cars considers an electric car. In this study we analyze some various scenarios to compare between internal combustion engine car and electric car using break-even analysis. Through the analysis we suggest a subsidy policy for electric car.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.1302-1306
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• 2005

This study has Performed to develop rehabilitation model for determination of optimal rehabilitation time on the Cast Iron Pipes (CIP) with diameter less than 300 mm in water pipeline network and to analysis the sensitivity on the rehabilitation times of developed model. In the result from the application of the field, the renovation time was faster about 10 years than the replacement time. Especially, as the difference between rehabilitation and replacement time on E-CIP was about from 3 to 5 years, and it was thought that the replacement was effective on E-CIP. To sensitivity analysis, the discount rate of coefficient was fixed at 0.08, and the values of initial year break rate(N($t_o$) and growth rate coefficient(A) were adjusted in values of 0.0009, 0.0018, 0.0027, and 0.05, 0.10, 0.15 respectively. When the values of N($t_o$) and A was increased, the results from the time of rehabilitation and replacement was faster It was thought that N($t_o$), 0.018 was reliable values on the applied pipeline through the result of the study. In case of A, the values of A above 0.1 was thought to be Proper.

• Journal of Energy Engineering
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• v.12 no.2
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• pp.93-100
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• 2003

An estimation methodology of the mass and energy (M/E) release due to the main steam line break (MSLB) has been developed with the RETRAN-3D code. In the case of equipment qualification (EQ), the over-estimated temperature would exceed the design limits of some cables or valves. In order to have a more flexible EQ profiles from the MSLB M/E release, the methodology with the best-estimated code was used. The major conditions affecting the MSLB M/E were found to be the initial SG level, heat transfer between primary and secondary sides, power level, operable protection system, main or auxiliary feedwater availability, and break conditions. The RETRAN-3D models were developed for the Kori unit 1 (KRN-1) which is typical two loop Westinghouse (WH) designed plant. Particularly, a detailed model of the steam generators was developed to estimate a more realistic two-phase heat transfer effect of the steam flow. After the modeling, the methodology has been developed through the sensitivity analyses. The M/E release data generated from the analyses have been used as the input to the inside containment pressure and temperature (P/T) analysis. According to the results at the point of view containment P/T, the Kori unit 1 can have more margin of 5∼15 ㎪ in pressure and 8∼15$^{\circ}C$ in temperature.

• Journal of Energy Engineering
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• v.23 no.4
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• pp.112-122
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• 2014

A main steam line break (MSLB) test at the ATLAS facility was simulated using the best-estimate thermal-hydraulic system code, MARS-KS. This has been performed as an activity at the third domestic standard problem for code benchmark (DSP-03) that has been organized by Korea Atomic Energy Research Institute (KAERI). The results of the MSLB experiment and the MARS input data prepared for the previous DSP-02 using the ATLAS facility were provided to participants. The preliminary MSLB simulation using the base input data, however, showed unphysical results in the primary-to-secondary heat transfer. To resolve the problems, some improvements were implemented in the MARS input modelling. These include the use of fine meshes for the bottom region of the steam generator secondary side and proper thermal-hydraulics calculation options. Other input model improvements in the heat loss and the flow restrictor models were also made and the results were investigated in detail. From the results of simulations, the limitations and further improvement areas of the MARS code were identified.

• Journal of the Korean Institute of Landscape Architecture
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• v.24 no.3
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• pp.109-114
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• 1996

Generally, the size of our recreation sites is selected through use demand at the peak day. At same time, scale economic and diseconomic are applied to a recreation site. If you are a rational decision-maker, you would like to select the size of your park at profit-maximization point. This study is the first try for modelling a Gain-Loss by the size options of a theme park. For testing the validity of a financial model to select the size of theme parks. Ever-Land, Seoul-Land, Dream-Land's operating size was analyzed. By the size options, the revenue of each park was compared with cost. The profit-maximization point and break-even point of each park were found. Ever-Land and Dream-Land's size was selected between the profit-maximization point and the break-even point. In contrast with Ever-Land and Dream-Land's, Seoul-Land's was selected upper the break-even point. To increase the utility of this model in selecting the size of a theme park, a decision-maker must keep in mind a few limits of this study. That is, 1) this model can not be applied at public parks. 2) Sometimes the others can be more important than financial revenue and cost. Finally, there is the validity of Gain-Loss Model in estimating only the financial revenues and costs through the size options.

• Journal of Biosystems Engineering
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• v.34 no.4
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• pp.228-233
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• 2009

In order to cut the round bale easily, a roughage cut-feeder for the round bale was developed in this study. This study consists of two parts. One is development of a cutting mechanism and a performance test reported in the previous paper. This is the second part of the study. For the study, recent trend of traditional cutting system was analyzed. Also, cost of the prototype cut-feeder was analyzed and determine the break-even point of farm size was determined by comparing with traditional method using a traditional cutter. A prototype cut-feeder was investigated with the fact that working performance, fiber length and shape of roughage and feeding quality was good. Operating cost of the prototype cut-feeder decreased rapidly with an increase of farm size. Break-even point in terms of farm size was 36 heads for beef and 28 heads for dairy. Also, costs estimated were 118,000 won/head year and 148,000 won/head year, respectively.