• Title/Summary/Keyword: Branch Lines

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Liquid-Liquid Equilibrium and Physical Properties of Aqueous Mixtures of Poly (Ethylene Glycol) 3000 with Tri-Potassium Citrate at Different pH: Experiment, Correlation and Thermodynamic Modeling

  • Ketabi, Mahnam;Pirdashti, Mohsen;Mobalegholeslam, Poorya
    • Journal of the Korean Chemical Society
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    • v.63 no.1
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    • pp.12-23
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    • 2019
  • The new experimental data of liquid-liquid equilibrium (LLE) of aqueous two-phase system (ATPS) consisting of poly(ethylene glycol) 3000 + tri-potassium citrate at different pH were presented. It was found that an increase in pH resulted in the expansion of the two-phase region. The TLL and STL increased with increasing the pH values. The Merchuk equation can be appropriately employed to correlate the binodal curves and also the tie-line compositions were adjusted to both the Othmer-Tobias and Bancroft equations. In order to calculate the compositions of the phase and the ends of the tie-lines, density and refractive indices as two physical properties were used. Finally, the extended UNIQUAC, UNIFAC, Virial-(Mobalegholeslam & Bakhshi) and modified UNIQUAC-FV were used to measure the phase equilibria at different pH. The results of the models suggested that it can be used quite well to correlate the LLE in an aqueous solution of polymer-salt.

Study of User Reuse Intention for Gamified Interactive Movies upon Flow Experience

  • Han, Zhe;Lee, Hyun-Seok
    • Journal of Multimedia Information System
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    • v.7 no.4
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    • pp.281-293
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    • 2020
  • As Christine Daley suggested, "interaction-image" is considered to be typical in the age of "Cinema 3.0", which integrates the interactivity of game art and obscures the boundary between producers and customers. In this case, users are allowed to involve actively in the scene as "players" to manage the tempo of the story to some extent, it, thus, makes users pleased to watch interactive movies repeatedly for trying a diverse option to unlock more branch lines. Accordingly, this paper aims to analyze the contributory factors and effect mechanism of users' reuse intention for gamified interactive movies and offer specific concepts to improve the reuse intention from the interactive film production and operation perspectives. Upon integrating the Flow theory and Technology Acceptance Model (TAM) and separating the intrinsic and extrinsic motivations of key factors based on Stimulus-Organism-Response (S-O-R), the research builds an empirical analysis model for users' reuse intention with cognition, design, attitude emotional experience and conducts an empirical analysis on 425 pieces of valid sample data applying SPSS22 and Amos23. The results show that user satisfaction and flow experience impact users' reuse intention highly and perceived usefulness, perceived ease of use, perceived enjoyment, remote perception, interactivity, and flow experience have significant positive influence on user satisfaction experience.

Inhibition of ClC-5 suppresses proliferation and induces apoptosis in cholangiocarcinoma cells through the Wnt/β-catenin signaling pathway

  • Shi, Zhe;Zhou, Liyuan;Zhou, Yan;Jia, Xiaoyan;Yu, Xiangjun;An, Xiaohong;Han, Yanzhen
    • BMB Reports
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    • v.55 no.6
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    • pp.299-304
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    • 2022
  • Chloride channel-5 (ClC-5), an important branch of the ClC family, is involved in the regulation of the proliferation and cell-fate of a variety of cells, including tumor cells. However, its function in cholangiocarcinoma (CCA) cells remains enigmatic. Here, we discovered that ClC-5 was up-regulated in CCA tissues and CCA cell lines, while ClC-5 silencing inhibited CCA cell proliferation and induced apoptosis. Further mechanism studies revealed that ClC-5 inhibition could inhibit Wnt/β-catenin signaling activity and further activate the mitochondria apoptotic pathway in CCA cells. Furthermore, rescuing Wnt/β-catenin signaling activation eliminated the anti-tumor function of ClC-5 knockdown. Together, our research findings illustrated that ClC-5 inhibition plays an anti-tumor role in CCA cells via inhibiting the activity of the Wnt/β-catenin pathway, which in turn activates the mitochondrial apoptotic pathway.

Fine structure of the cardiac muscle cells in the orb-web spider Nephila clavata

  • Yan Sun;Hyo-Jeong Kim;Myung-Jin Moon
    • Applied Microscopy
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    • v.50
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    • pp.9.1-9.8
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    • 2020
  • The fine structural characteristics of cardiac muscle cells and its myofibril organization in the orb web spider N. clavata were examined by transmission electron microscopy. Although myofibril striations are not remarkable as those of skeletal muscles, muscle fibers contain multiple myofibrils, abundant mitochondria, extensive sarcoplasmic reticulum and transverse tubules (T-tubules). Myofibrils are divided into distinct sarcomeres defined by Z-lines with average length of 2.0 ㎛, but the distinction between the A-band and the I-bands is not clear due to uniform striations over the length of the sarcomeres. Dyadic junction which consisted of a single T-tubule paired with a terminal cisterna of the sarcoplasmic reticulum is found mainly at the A-I level of sarcomere. Each cell is arranged to form multiple connections with neighboring cells through the intercalated discs. These specialized junctions include three types of intercellular junctions: gap junctions, fascia adherens and desmosomes for heart function. Our transmission electron microscopy (TEM) observations clearly show that spider's cardiac muscle contraction is controlled by neurogenic rather than myogenic mechanism since each cardiac muscle fiber is innervated by a branch of motor neuron through neuromuscular junctions.

A gene expression database for the molecular pharmacology of cancer

  • Scherf, Uwe;Ross, Douglas-T.;Waltham, Mark;Smith, Lawrence-H.;Lee, Jae-K.;Tanbe, Lorraine;Kohn, Kurt-W.;Reinhold, William-C.;Mayers, Timothy-G.;Andrews, Darren-T.;Scudiero, Dominic-A.;Eisen, Michael-B.;Sausville, Edward-A.;Pommier, Yves;Botstein, David;Brown, Patrick-O.;Weinstein, John-N.
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2001.08a
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    • pp.129-137
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    • 2001
  • We used cDNA microarrays to assess gene expression profiles in 60 human cancer used in a drug discovery screen by the National Cancer Institute. Using these data, we linked bioinformatics and chemoinformatics by correlating gene expression and drug activity pattens in the NCI60 lines. Clustering the cell lines on the basis of gene expression yielded relationships very different from those obtained by clustering the cell lines on the basis of their response to drugs. Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance. This is the first study to intergrate large databases on gene expression and molecular pharmacology.

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Properties of Strength and Stress-Strain of Recycled-Plastic Polymer Concrete (폐플라스틱 재활용 폴리머콘크리트의 강도와 응력-변형률 특성)

  • Jo Byung-Wan;Koo Jakap;Park Seung-Kook
    • Journal of the Korea Concrete Institute
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    • v.17 no.3 s.87
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    • pp.329-334
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    • 2005
  • The use of Polymer Concrete (PC) is growing very rapidly in many structural and construction applications such as box culverts, hazardous waste containers, trench lines, floor drains and the repair and overlay of damaged cement concrete surfaces in pavements, bridges, etc. However, PC has a defect economically because resin which be used for binder is expensive. Therefore the latest research is being progressed to replace existing resin with new resin which can reduce the high cost. Here, Polymer concrete using the recycled PET(polyethylene terephthalate) has some merits such as decrease of environmental destruction, decrease of environmental pollution and development of new construction materials. The variables of this study are amount of resin, curing condition and maximum size of coarse aggregate to find out mechanic properties of this. Stress-strain curve was obtained using MTS equipment by strain control. The results indicated that modulus of elasticity was increased gradually in an ascending branch of curve, as an increase of resin content. Compressive strength was the highest for resin content of $13\%$. And Compressive strength was increased as maximum size of coarse aggregate increases. The strain at maximum stress increases with an increase of resin content and size of coarse aggregate. For the descending branch of stress-strain curve the brittle fracture was decreased when it was cured at the room temperature compared to high temperature.

A Discrete Model of Conveyor Systems for FMS (FMS를 위한 Conveyor System의 이산구조 모델링)

  • Sin, Ok-Geun
    • The Transactions of the Korea Information Processing Society
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    • v.3 no.6
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    • pp.1397-1406
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    • 1996
  • In this paper, we propose a discrete model of conveyor systems, which is frequently used in flexible manufacturing systems to transfer work-in-process( WIP) between manipulators. In the case where the time required for transferring WIP's between manipulators are greater than that of manufacturing itself, as in many flexible assembly lines, the quantitative model of the transfer systems is needed to analyze the behavior and productivity of the whole manufacturing system. The proposed model is based upon the assumptions that the length of any unit conveyor component is integer multiple of the length of a pallet and hat the transferring speed of the conveyor is constant. Under these assumptions, the observation moments and the length of the conveyor can be quantized. Hence, the state of a conveyor can be represented by two kinds of Boolean variables: one representing the presence of a pallet on each quantize conveyor length and the other representing the mobility of this pallet. The whole conveyor system can be modeling as a network composed of branches and knots based on these two Boolean variables. The proposed modelling method was tested with various conveyor system configurations and showed that the model can be adopted successfully for the simulation of transfer systems and of the piloting of manufacturing processes.

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Breeding of Fragrant Yellow Phalaenopsis and Scent Pattern Analysis by GC/SAW Electronic Nose System (유향성 황색계 호접란 육성 및 전자코를 이용한 향기패턴 분석)

  • Been, Chul-Gu
    • Horticultural Science & Technology
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    • v.28 no.4
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    • pp.656-663
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    • 2010
  • In order to improve the consumer acceptance of fragrant yellow hybrids of $Phalaenopsis$ ($Phal.$), crosses between yellow hybrid varieties were made and the obtained hybrids were investigated for horticultural characteristics as well as difference in fragrance patterns. Cross combination of $Phal.$ Brother lawrence and $Phal.$ Brother saragold yielded good seedling population of 500 plants. Segregation was noticed in color density, spot and stripe patterns on yellow color base of petal and also in fragrance. Six lines with multi-branch on flower stalk and strong fragrance flower were finally selected. Volatile fragrance components were compared among $Phal.$ Brother lawrence, $Phal.$ Brother saragold and their hybrids by GC/SAW electronic nose. In the derivative pattern of chromatogram and polar derivative pattern of fragrance, similar dominant peaks appeared on retention time 7-9 s and some hybrid lines had two strong peaks on retention time 20-25 s, respectively. Also in polar frequency pattern of fragrance obtained by $VaporPrint^{TM}$ image analysis among parent flowers and hybrids, an identical strong peak near 8 s of retention time was shown. This single fragrance component is considered a key element of fragrance in $Phal.$ Brother lawrence, $Phal.$ Brother saragold and their hybrids. This peak could be used as a marker for the breeding of fragrance in $Phalaenopsis$.

Railway Governance and Power Structure in China

  • Lee, Jinjing
    • International Journal of Railway
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    • v.1 no.4
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    • pp.129-133
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    • 2008
  • Over the last $15{\sim}20$years, many countries have adopted policies of railway privatization to keep up with increasing competition from road and air transport. Although each country and case has its own history, market characteristics, political context as well as administrative process, railway privatizations (including railway restructure, concession etc.) in the west usually are accompanied with the establishment of new regulatory regimes. Therefore, railway governance has been innovating towards an interaction of government, regulator, industry bodies, user groups, trade unions and other interested groups within the regulatory framework. However, it is not the case in China. Although China had seen a partial privatization in some branch lines and is experiencing a much larger-scale privatization by establishing joint-ventures to build and operate high-speed passenger lines and implementing an asset-based securitization program, administrative control still occupies absolutely dominant position in the railway governance in China. Ministry of Railway (MOR) acts as the administrator, operator as well as regulator. There is no national policy that clearly positions railway in the transportation network and clarifies the role of government in railway development. There is also little participation from interested groups in the railway policy making, pricing, service standard or safety matter. Railway in China is solely governed by the mere executive agency. Efficiency-focused economic perspective explanation is far from satisfaction. A wider research perspective from political and social regime is of great potential to better explain and solve the problem. In the west, separation and constrains of power had long been established as a fundamental rule. In addition to internal separation of political power(legislation, execution and jurisdiction), rise of corporation in the 19th century and association revolution in the 20th century greatly fostered the growth of economic and social power. Therefore, political, social and economic organizations cooperate and compete with each other, which leads to a balanced and resonable power structure. While in China, political power, mainly party-controlled administrative power has been keeping a dominated position since the time of plan economy. Although the economic reform promoted the growth of economic power of enterprises, it is still not strong enough to compete with political power. Furthermore, under rigid political control, social organizations usually are affiliated to government, independent social power is still too weak to function. So, duo to the limited and slow reform in political and social regime in China, there is an unbalanced power structure within which political power is dominant, economic power expanding while social power still absent. Totally different power structure in China determines the fundamental institutional environment of her railway privatization and governance. It is expected that the exploration of who act behind railway governance and their acting strength (a power theory) will present us a better picture of railway governance as a relevant transportation mode. The paper first examines the railway governance in China and preliminarily establishes a linkage between railway governance and its fundamental institutional environment, i.e. power structure in a specific country. Secondly, the reason why there is no national policy in China is explored in the view of political power. In China, legislative power is more symbolic while party-controlled administrative power dominates political process and plays a fundamental role in Chinese railway governance. And then, in the part three railway finance reform is analyzed in the view of economic power, esp. the relationship of political power and economic power.

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Effect of Waterlogging on Growth and Morphological Characteristics of Roots of Maize Inbred Lines (담수 처리에 따른 옥수수 자식 계통의 지상부와 뿌리의 생육 및 형태적 특성)

  • Lee, Jihyun;Shin, Myeong-Na;Jung, Gun-Ho;Kim, Jung Tae;Cha, Jungeun;Shim, Kang-Bo;Lee, Jae-Eun;Son, Beom-Young;Kim, Sang-Gon;Ku, Bon-Il;Lee, Seukki;Jeon, Weon-Tai
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.40 no.4
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    • pp.227-235
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    • 2020
  • This study was conducted to investigate the growth characteristics of the shoot and roots and to analyse the morphological characteristics of roots of waterlogging resistant and susceptible maize inbred lines. Six maize inbred lines were treated with waterlogging for 10 days at V3, and the degree of leaf senescence was evaluated for waterlogging resistance. As a result of waterlogging resistance evaluation, KS85 was the most damaged inbred line with 3.33 senescence leaves and 5.54 degree, and KS141 was the least damaged inbred line with 1.33 senescence leaves and 3 degree. At 20 days after treatment, the effect of waterlogging stress on the shoot dry matter accumulation of KS85 and KS141 were decreased by 86.1% and 77.0%, respectively, compared to the control. Similarly, root dry matter accumulation of KS85 and KS141 were decreased by 77.6% and 65.0%. As a result of SEM photographs of the nodal roots of the two maize inbred lines, the thickness of cortex of KS141 was thicker than that of KS85, and the distortion of the cortex was observed in KS85 at 20 days after waterlogging. It was concluded that the thickness of cortex was related to maize waterlogging resistance.