• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2010년도 춘계학술발표대회
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• pp.455-458
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• 2010

Extracting the brain from magnetic resonance imaging head scans is an essential preprocessing step of which the accuracy greatly affects subsequent image analysis. The currently popular Brain Extraction Tool produces a brain mask which may be too smooth for practical use to reduce the accuracy. This paper presents a novel and indirect brain extraction method based on non-brain tissue segmentation. Based on ITK, the proposed method allows a non-brain contour by using region growing to match with the original image naturally and extract the brain tissue. Experiments on two set of MRI data and 2D brain image in horizontal plane and 3D brain model indicate successful extraction of brain tissue from a head.

• 대한수의학회지
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• 제47권2호
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• pp.157-162
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• 2007

Lactic acid bacteria (LAB) has been regarded as a useful microorganism and tried to manipulate plasmid DNA for increasing the usefulness. Although several methods have been developed to isolate plasmid DNA from Escherichia coli (E. coli), these methods were not sufficient to apply to LAB with exception of O'Sullivan's lysis method. So, we evaluated plasmid DNA extraction from LAB using general E. coli preparation methods and tried to improve the extraction yield and DNA purity by modifying O'Sullivan's alkaline lysis method. To improve the extraction yield, salt and carrier were added to precipitant and those were incubated at $-70{^{\circ}C}$. Only incubation at $-70{^{\circ}C}$ was the effective method of those modifications. Purity of plasmid DNA was improved by two times of each centrifugation and phenol/chloroform extraction. However, DNA was damaged by twice extraction with phenol/chloroform. Also, exclusion of ethidium bromide showed negative effect to purity. Additionally, it was recommended that improvement of the extraction yield may be due to centrifugation at high speed for more time and to dissolving complete DNA pellet before addition of 7.5 M ammonium acetate. Extraction using this modification produced higher quality of plasmid DNA.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제41권
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• pp.25.1-25.5
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• 2019

Background: Brain abscess is a life-threatening condition that occurs due to complications during a neurosurgical procedure, direct cranial trauma, or the presence of local or distal infection. Infection in the oral cavity can also be considered a source of brain abscess. Case presentation: A 45-year-old male patient was transported with brain abscess in the subcortical white matter. Navigation-guided abscess aspiration and drainage was performed in the right mid-frontal lobe, but the symptoms continued to worsen after the procedure. A panoramic radiograph showed alveolar bone resorption around the maxillary molars. The compromised maxillary molars were extracted under local anesthesia, and antibiotics were applied based on findings from bacterial culture. A brain MRI confirmed that the three brain abscesses in the frontal lobe were reduced in size, and the patient's symptoms began to improve after the extractions. Conclusion: This is a rare case report about multiple uncontrolled brain abscesses treated by removal of infection through the extraction of maxillary molars with odontogenic infection. Untreated odontogenic infection can also be considered a cause of brain abscess. Therefore, it is necessary to recognize the possibility that untreated odontogenic infection can lead to serious systemic inflammatory diseases such as brain abscess. Through a multidisciplinary approach to diagnosis and treatment, physicians should be encouraged to consider odontogenic infections as a potential cause of brain abscesses.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2003년도 추계종합학술대회
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• pp.247-250
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• 2003

본 논문은 뇌 자기공명영상에 대해 셀룰러 오토마타를 이용하여 뇌 영역을 추출하는 연구이다. 먼저 입력된 뇌 자기공명영상의 배경영상을 설정된 임계 값으로 제거하고 히스토그램 분석에 의한 정보를 셀룰러 오토마타의 규칙에 적용하여 뇌 영역을 추출하였다. 실험결과 제안된 방법의 평균 PSNR은 42.11(dB)이며, 상관도 측정 결과 98.46%로 측정되었다. 본 연구 결과는 자동 진단 시스템 등에 활용 가능성을 제시하였다.

• 한국콘텐츠학회논문지
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• 제2권3호
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• pp.1-15
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• 2002

본 논문은 인간 뇌의 가시화 및 해석을 위하여 단일 채널 MR영상에서 자동화된 뇌영역 추출 방법을 제안한다. 이 방법은 쌍곡선 적합을 이용한 자동 문턱치화와 3차원 형태 학적 연산에 의하여 뇌 마스크 볼륨을 생성한다. 쌍곡선 적합은 MR영상의 히스토그램에 곡선을 적합할 때 오차를 줄일 수 있으며, 침식, 연결부위 레이블링, 최대특징 연산, 팽창 등 3차원 형태학적 연산은 문턱치화된 뇌 마스크로부터 생성된 정육각형 볼륨 마스크에 적용된다. 제안한 방법은 SPGR, T1, T2, PD MR영상 세트에서 뇌영역을 자동 추출할 수 있으며, 가장자리 슬라이스에도 적용 가능하고, 영상이 뇌 전체를 포함하지 않아도 된다. 실험에서 20 세트의 MR영상에 적용하여 수동 방법과 비교하여 0.97 이상의 유사도를 보였다.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.642-645
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• 2009

Brain Computer Interface (BCI) is a communication pathway between devices (computers) and human brain. It treats brain signals in real-time basis and discriminates some information of what human brain is doing. In this work, we develop a EEG BCI system using a feature extraction such as common spatial pattern (CSP) and a classifier using Fisher linear discriminant analysis (FLDA). Two-class EEG motor imagery movement datasets with both cued and uncued are tested to verify its feasibility.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권10호
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• pp.2788-2808
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• 2023

Brain tumors are one of the most threatening malignancies for humans. Misdiagnosis of brain tumors can result in false medical intervention, which ultimately reduces a patient's chance of survival. Manual identification and segmentation of brain tumors from Magnetic Resonance Imaging (MRI) scans can be difficult and error-prone because of the great range of tumor tissues that exist in various individuals and the similarity of normal tissues. To overcome this limitation, the Amended Convolutional Neural Network (ACNN) model has been introduced, a unique combination of three techniques that have not been previously explored for brain tumor detection. The three techniques integrated into the ACNN model are image tissue preprocessing using the Kalman Bucy Smoothing Filter to remove noisy pixels from the input, image tissue segmentation using the Isotonic Regressive Image Tissue Segmentation Process, and feature extraction using the Marr Wavelet Transformation. The extracted features are compared with the testing features using a sigmoid activation function in the output layer. The experimental findings show that the suggested model outperforms existing techniques concerning accuracy, precision, sensitivity, dice score, Jaccard index, specificity, Positive Predictive Value, Hausdorff distance, recall, and F1 score. The proposed ACNN model achieved a maximum accuracy of 98.8%, which is higher than other existing models, according to the experimental results.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2003년도 가을 학술발표논문집 Vol.30 No.2 (2)
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• pp.739-741
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• 2003

Electroencephalogram (EEG)-based brain computer interface (BCI) provides a new communication channel between human brain and computer. EEG is very noisy data and contains artifacts, thus the extraction of features that are robust to noise and artifacts is important. In this paper we present a method with employ both independent component analysis (ICA) and oriented principal component analysis (OPCA) for artifact-robust feature extraction.

• Molecules and Cells
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• 제22권1호
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• pp.119-125
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• 2006

The rat is an accepted model for studying human psychiatric/neurological disorders. We provide a protocol for total soluble protein extraction using trichloroacetic acid/acetone (TCA/A) from rat (female) whole brain, 10 brain regions and the pituitary gland, and show that two-dimensional gel electrophoresis (2-DGE) using precast immobilized pH (4-7) gradient (IPG) strip gels (13 cm) in the first dimension yields clean silver nitrate stained protein profiles. Though TCA/A precipitation may not be "ideal", the important choice here is the selection of an appropriate lysis buffer (LB) for solubilizing precipitated proteins. Our results reveal enrichment of protein spots by use of individual brain regions rather than whole brain, as well as the presence of differentially expressed spots in their proteomes. Thus individual brain regions provide improved protein coverage and are better suited for differential protein detection. Moreover, using a phosphoprotein-specific dye, ingel detection of phosphoproteins was demonstrated. Representative high-resolution silver nitrate stained proteome profiles of rat whole brain total soluble protein are presented. Shortcomings apart (failure to separate membrane proteins), gel-based proteomics remains a viable option, and 2-DGE is the method of choice for generating high-resolution proteome maps of rat brain and brain regions.

• 한국문헌정보학회지
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• 제39권2호
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• pp.287-304
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• 2005

이 연구의 목적은 자동적으로 추출된 정보를 시각화 브라우저를 통해 표현하고 접근하는 방법에 대해 이용성평가를 수행하는 것이다. 특정 주제 분야에 국한되지 않는 정보추출시스템을 사용하여 신문기사에서 의미정보를 자동 추출하였고, 그 결과로 시각적으로 브라우저 할 수 있는 지식베이스를 구축하였다. 이 연구에 이용된 정보추출시스템은 신문기사의 텍스트정보로부터 다양한 자연언어처리 기술을 적용하여 개념-관계-개념의 형태로 표현되는 정보를 자동적으로 추출하였다. 지식베이스에 저장된 정보를 시각적으로 표현하는 시각화 브라우저를 구현하였는데, 이때 인터페이스 부분은 쌍곡면형 정보시각화 시스템의 하나인 PersonalBrain을 이용하여 개발하였다. PersonalBrain을 이용하면 표현하고자 하는 정보를 논리관계의 네트워크 형태로 연결할 수 있다. 지식베이스 정보의 시각화 접근방법에 대하여 15명의 이용자를 대상으로 질적 평가를 수행하였다. IS명의 연구대상자로 하여금 시각화 브라우저를 이용하도록 하고 관찰과 인터뷰를 통하여 이용성평가 데이터를 수집하였다. 내용분석결과, 이용자들은 정보추출결과의 시각화 브라우저 이용가능성에 대해 긍정적인 반응을 보인 동시에 몇 가지 이용성 관련 문제점을 지적하였다.