• Molecules and Cells
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• v.25 no.3
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• pp.390-396
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• 2008

Calreticulin (CRT) is one of the major $Ca^{2+}$ binding chaperone proteins of the endoplasmic reticulum (ER) and an unusual luminal ER protein. Postnatally elevated expression of CRT leads to impaired development of the cardiac conductive system and may be responsible for the pathology of complete heart block. In this study, the molecular mechanisms that affect $Ca^{2+}$-dependent signal cascades were investigated using CRT-overexpressing cardiomyocytes. In particular, we asked whether calreticulin plays a critical role in the activation of $Ca^{2+}$-dependent apoptosis. In the cells overexpressing CRT, the intracellular calcium concentration was significantly increased and the activity of PKC and level of SECAR2a mRNA were reduced. Phosphorylation of Akt and ERKs decreased compared to control. In addition the activity of the anti-apoptotic factor, Bcl-2, was decreased and the activities of pro-apoptotic factor, Bax, p53 and caspase 8 were increased, leading to a dramatic augmentation of caspase 3 activity. Our results suggest that enhanced CRT expression in mature cardiomyocytes disrupts intracellular calcium regulation, leading to calcium-dependent apoptosis.

• Journal of The Korean Association For Science Education
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• v.26 no.4
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• pp.568-580
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• 2006

The purpose of this study was to investigate the brain activities by 4-types of Generating Process of Scientific Emotion (GPSE) in the hypothesis-generating biological phenomena by using fMRI. Four-types of GPSE were involved in the Basic Generating Process (BGP), Retrospective Generating Process (RGP), Cognitive Generating Process (CGP) and Attributive Generating Process (AGP). For this study, we made an experimental design capable of validating the 4-types of generating process (e.g. BGP, RGP, CGP and AGP), and then measured BOLD signals of 10 pre-service teachers' brain activities by 3.0T fMRI system. Subjects were 10 healthy females majoring in biology education. As a result, there were clear differences among 4-types of GPSE. Brain areas activated by BGP were at right occipital lobe (BA 17), at left thalamus and left parahippocampal gyrus, while in the case of RGP, at left superior parietal lobe (BA 8, 9), at left pulvinar and left globus pallidus were activated. Brain areas activated by CGP were the right posterior cingulate and left medial frontal gyrus (BA 6). In the case of AGP, the most distinctively activated brain areas were the right medial frontal gyrus (BA 8) and left inferior parietal lobule (BA 40). These results would mean that each of the 4-types of GPSE has a specific neural networks in the brain, respectively. Furthermore, it would provide the basis of brain-based learning in science education.

• Proceedings of the Safety Management and Science Conference
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• 2012.11a
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• pp.253-268
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• 2012

Recently, creative innovation has become a major topic in management innovation and due to this, various researches on its need and methodologies are being performed. According to previous studies on ambidexterity, explorative innovation is closer to divergent and right-sided brain, while exploitative innovation is closer to convergent and left-sided brain. Topic was to identify preceding element which affects Ambidextrous Innovation. For this topic, 129 Six Sigma projects from 19 different companies were collected. Ambidextrous index from preceding studies was used. This index represents the degree of ambidextrous activation and can be calculated by multiplying cumulative usage of exploitative tools with that of explorative tools. In the project characteristics, simple linear regression result showed leadership degree, team's vitalization degree and leader capability degree have effect in positive direction.

• Journal of the Korean Institute of Intelligent Systems
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• v.22 no.4
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• pp.515-520
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• 2012

In brain computer interface (BCI) system, the most important part is classification of human thoughts in order to translate into commands. The more accuracy result in classification the system gets, the more effective BCI system is. To increase the quality of BCI system, we proposed to reduce noise and artifact from the recording data to analyzing data. We used auditory stimuli instead of visual ones to eliminate the eye movement, unwanted visual activation, gaze control. We applied independent component analysis (ICA) algorithm to purify the sources which constructed the raw signals. One of the most famous spatial filter in BCI context is common spatial patterns (CSP), which maximize one class while minimize the other by using covariance matrix. ICA and CSP also do the filter job, as a raw filter and refinement, which increase the classification result of linear discriminant analysis (LDA).

• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.169-175
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• 2011

Stress, a risk factor of major depression induces cytokine mediated inflammation and decreased neurogenesis. In patients with major depression, significant increases of pro-inflammatory cytokines have been consistently reported. The pro-inflammatory cytokines can stimulate the hypothalamic-pituitary-adrenal (HPA) axis to release glucocorticoids. In the brain, microglia and play a role of immune activation in response to stress. Increased pro-inflammatory cytokine play a role in restricting neurogenesis in the brain. Although neurogenesis may not be essential for the development of depression, it may be required for clinically effective antidepressant treatment. Hence, stimulation of neurogenesis is regarded as a promising strategy for new antidepressant targets. This review introduces changes in neurotransmitter, cytokine and neurogenesis in major depression and explores the possible relationship between pro-inflammatory cytokines and neurogenesis related to stress in major depression.

• Annual Conference on Human and Language Technology
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• 2004.10d
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• pp.315-318
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• 2004

The purpose of this study is to examine the neuroanatomical areas related with onomatopoeia (sound-imitated word). Using the block-designed fMRI, whole-brain images (N=11) were acquired during lexical decisions. We examined how the lexical information initiates brain activation during visual word recognition. The onomatopoeic word recognition activated the bilateral occipital lobes and superior mid-temporal gyrus.

• International Journal of Oral Biology
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• v.44 no.3
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• pp.71-76
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• 2019

Dentin hypersensitivity is an abrupt intense pain caused by innocuous stimuli to exposed dentinal tubules. Mechanosensitive ion channels have been assessed in dental primary afferent neurons and odontoblasts to explain dentin hypersensitivity. Dentinal fluid dynamics evoked by various stimuli to exposed dentin cause mechanical stress to the structures underlying dentin. This review briefly discusses three hypotheses regarding dentin hypersensitivity and introduces recent findings on mechanosensitive ion channels expressed in the dental sensory system and discusses how the activation of these ion channels is involved in dentin hypersensitivity.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.169.2-170
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• 2003

Erythropietin (EPO), a hematopoietic factor is also required for normal brain development, and its receptor is localized in brain. Therefore, it is possible that EPO could act as a neurotropic factor inducing differentiation of neurons. The present study, we therefore investigated whether EPO can increase differentiation of undifferentiated cortical neuron isolated from postneonatal (Day 1) rat brains and PC12 cell, undifferentiated dopaminagic cell line. EPO dose (1-100 U/ml) dependently increased cell differentiation and expression of differentiation marker gene (neurofilament and tyrosine hydroxylase) in both cells. (omitted)

• The Journal of Internal Korean Medicine
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• v.33 no.4
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• pp.572-586
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• 2012

Objectives : This study was designed to investigate the effects of Sasim-tang (SST) on proinflammatory cytokine production in a photothrombotic ischemia mouse model. Methods : Photothrombotic ischemia was induced in stereotactically held male Balb/c mice using rose bengal (10 mg/kg) and cold light. The target of photothrombotic ischemic lesion was 1 mm anterior to bregma and 3 mm lateral to midline with 2 mm in diameter, which are decreased by oral administration of SST. Results : SST protected ischemic death of brain cells through inhibition of pro-inflammatory cytokines production and catalytic activation of caspase-3 protease in photothrombotic ischemia mouse model. Conclusions : The results of this study suggest that SST can have protective effects on brain cell damage in a photothrombotic ischemia mouse model.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.1
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• pp.51-58
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• 2015

Ethanol has long been implicated in triggering apoptotic neurodegeneration. Alcohol also may indirectly harm the fetus by imparing the mother's physiology. We examined the effects of ethanol on immature brain of mice. Three-weeks-old female ICR strain mice daily intraperitoneally injected with ethanol at the concentration of 4 and 20% in saline for 0, 6, and 24 hours and 1 and 4 weeks. The mice were weighted and sacrificed, and the brains were ectomized for the present histological, immunohistochemical and TUNEL assays. Based on the histologic hematoxylin and eosin stain, immunohistochemical expression of glutamate receptor protein and neuronal cell adhesion molecule (NCAM) were evaluated. The cerebral cortex of the ethanol-treated group showed few typical symptoms of apoptosis such as chromosome condensation and disintegration of the cell bodies. TUNEL staining revealed DNA fragmentation in the 6 and 24 hours. This results demonstrated that acute ethanol administration causes neuronal cell death. I found that either glutamate receptor inhibition or activation could induce cerebellar degeneration as ethanol effect. Neuronal death also can be induced by excess activity of certain neurotransmitter, including glutamate. Neurons must establish cell-to-cell contact during growth and development in order to survive, migrate to their final destination, and develop appropriate connections with neighboring cell. Purkinje cell in cerebellar are especially vulnerable to the cell death and degeneration. After ethanol treatment in cerebellar, NCAM had decreased by 4 weeks. This result suggest that apoptosis seems to be involved in the slow elimination of neuron and cerebellar degeneration.