International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Update on dentin hypersensitivity: with the focus on hydrodynamic theory and mechanosensitive ion channels

  • Won, Jonghwa (Dental Research Institute and Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University) ;
  • Oh, Seog Bae (Dental Research Institute and Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University)
  • Received : 2019.05.30
  • Accepted : 2019.07.12
  • Published : 2019.09.30
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Abstract

Dentin hypersensitivity is an abrupt intense pain caused by innocuous stimuli to exposed dentinal tubules. Mechanosensitive ion channels have been assessed in dental primary afferent neurons and odontoblasts to explain dentin hypersensitivity. Dentinal fluid dynamics evoked by various stimuli to exposed dentin cause mechanical stress to the structures underlying dentin. This review briefly discusses three hypotheses regarding dentin hypersensitivity and introduces recent findings on mechanosensitive ion channels expressed in the dental sensory system and discusses how the activation of these ion channels is involved in dentin hypersensitivity.

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References

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