• The Korean Journal of Physiology and Pharmacology
• /
• v.6 no.6
• /
• pp.293-297
• /
• 2002

The role of 5-hydroxytryptamine $(5-HT)_1A$ receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; $50{\mu}g/kg,$ s.c.), a $5-HT_1A$ agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition, they showed increased $5-HT_1A$ receptor densities in the cerebral cortex. Pretreatment with 8-OH-DPAT ameliorated the behavioral and neurochemical sequelae measured in the present study. The results suggest that $5-HT_1A$ receptors protect the brain from ischemic insult and/or facilitate recovery after prenatally experienced ischemia.

• Journal of Korean Neurosurgical Society
• /
• v.54 no.2
• /
• pp.100-106
• /
• 2013

Objective : To investigate the cases of intracranial abnormal brain MRI findings even in the negative brain CT scan after mild head injury. Methods : During a 2-year period (January 2009-December 2010), we prospectively evaluated both brain CT and brain MRI of 180 patients with mild head injury. Patients were classified into two groups according to presence or absence of abnormal brain MRI finding even in the negative brain CT scan after mild head injury. Two neurosurgeons and one neuroradiologist validated the images from both brain CT scan and brain MRI double blindly. Results : Intracranial injury with negative brain CT scan after mild head injury occurred in 18 patients (10.0%). Headache (51.7%) without neurologic signs was the most common symptom. Locations of intracranial lesions showing abnormal brain MRI were as follows; temporal base (n=8), frontal pole (n=5), falx cerebri (n=2), basal ganglia (n=1), tentorium (n=1), and sylvian fissure (n=1). Intracranial injury was common in patients with a loss of consciousness, symptom duration >2 weeks, or in cases of patients with linear skull fracture (p=0.00013), and also more frequent in multiple associated injury than simple one (35.7%>8.6%) (p=0.105). Conclusion : Our investigation showed that patients with mild head injury even in the negative brain CT scan had a few cases of intracranial injury. These findings indicate that even though the brain CT does not show abnormal findings, they should be thoroughly watched in further study including brain MRI in cases of multiple injuries and when their complaints are sustained.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.49 no.1
• /
• pp.81-87
• /
• 2012

The current defacing method for keeping an anonymity of brain images damages the integrity of a precise brain analysis due to over removal, although it maintains the patients' privacy. A novel method has been developed to create an anonymous face model while keeping the voxel values of an image exactly the same as that of the original one. The method contains two steps: construction of a mockup brain template from ten normalized brain images and a substitution of the mockup brain to the brain image. A level set segmentation algorithm is applied to segment a scalp-skull apart from the whole brain volume. The segmented mockup brain is coregistered and normalized to the subject brain image to create an anonymous face model. The validity of this modification is tested through comparing the intensity of voxels inside a brain area from the mockup brain with the original brain image. The result shows that the intensity of voxels inside from the mockup brain is same as ones from an original brain image, while its anonymity is guaranteed.

• 대한공업교육학회지
• /
• v.33 no.1
• /
• pp.23-43
• /
• 2008

The purpose of this study is to provide some necessary baseline data to the information prodigy related research through the study on the brain left/right tendency of information prodigies. Subjects were 298 gifted students(59 information, 79 mathematics, 80 science, 40 invention, 40 social science) and 114 general students summing up 412 in the schools of Daejeon metropolitan area. 'Brain Tendency Test' developed by Torrance and modified by Ko in Korean was used as a tool to measure the prodigies' brain tendencies. Data analysis has been done with the $x^2$ test of frequency with the alpha = .05. The results of this study are as follows. 1) The information gifted students have tendencies of utilizing right brain hemisphere at the most, both left/right brain(whole brain) utilization at the second, and left brain utilization at the last. 2) There was statistically no difference between information prodigies and general students in the left/right brain tendency. 3) There was statistically mild evidence to support the notion that there are some differences in the brain tendency between the group of information prodigies and the group of other area of the prodigies. The degree of inclination to utilize the whole brain hemisphere for the prodigies of the other area was the highest compare to other left/right brain utilization while the information prodigies tend to utilize the right brain hemisphere at the most. 4) The female information prodigies have tendencies of utilizing while brain area at the most, right brain utilization at the second, and left brain utilization at the last contrary to the brain utilization tendencies in the male information prodigies which are the same as the brain utilization tendencies of the information prodigies. However there was no difference in brain tendencies statistically between the two groups since the female subjects were too small.

• The Journal of Korean Medicine
• /
• v.16 no.1 s.29
• /
• pp.468-474
• /
• 1995

After bibliographic study on function of the brain(腦, nao) on the basis of zangxiang theory(藏象論的), the theory of visceral activities), the following conclusions were obtained: 1. Brain is the organ conglomerated with marrow(隨, sui) between Baihui(百會) and Fengfu(風府) 2. Brain has different function and names according to the parts. 3. Brain is on anatomical view the extraordinary organ(奇恒之府, qiheng zhi fu) and stores clarified air(氣, qi) of fresh air. 4. Brain is the places where the viral essence (精, jeong) of five viscera is activated. 5. Brain is the places where the vital essence congeries into the mind(神, shen) Yang form of the essence. 6. The mind converted from the brain emerges in the whole body the sensory organs and carries vital function. 7. Brain reservoirs the mind, while the heart(心, xm) is thought to make judgement inroyght the speculation on the outward stimulus of matter and give orders to the mind in the chest.

• Journal of Korean Medical classics
• /
• v.18 no.4 s.31
• /
• pp.49-59
• /
• 2005

On the importance of brain, Nei Ching has many descriptions, but it has been 3,000 years since the theory was issued that brain should be considered as a viscera. Nowadays scientists rush more studies on brain in international scientific field, Eastern medicine is to be required for the solution of it. This study is on the identical pathological mechanism between Simpo and brain based on my researches on senil dimentia through continued reports last 15 years. A psychosis is caused by stress and abnormality of neurotransmitter on brain, for which is caused by seven emotions and pathological material on Simpo in Pyun Jahk Simseo, so it shows Simpo is brain clearly. Therefore Simpo is no more intangible organ but brain, Samcho which has been debated similarly for thousands of years in the orient is no more intangible but spinal nerve system on central nerve with its structure and physiological points, and both two organs are composed of inside and outside relationship in Eastern medicine, I report hereby today.

• Journal of International Academy of Physical Therapy Research
• /
• v.6 no.2
• /
• pp.896-901
• /
• 2015

The effects of national gymnastics and brain gymnastics on brain activity were analyzed in 20 healthy university students. The students were assigned to either a national gymnastics group or a brain gymnastics group. Their frontal lobe activity was recorded before and after the exercise, and the resting, attention, and concentration indexes of brain waves were measured. The resting index significantly decreased and concentration index significantly increased(p<.05) after the exercise in both the national and brain gymnastics groups. However, the attention index significantly increased only after brain gymnastics, and, on the contrary, decreased after national gymnastics. These findings suggest that brain gymnastics is effective for improving attention.

• Journal of Korean Medical Ki-Gong Academy
• /
• v.18 no.1
• /
• pp.27-51
• /
• 2018

Objective : The purpose of this study is to examine the relationship between the brain and the pelvis. Methods : The relationship between the pelvis and the brain was searched in PubMed, and these searching studies were reviewed. Conclusions : 1. Urinary disorder is influenced by brain. 2. Brain is influenced by luteinizing hormone. 3. Pelvic floor muscles are influenced by brain. 4. Urological Chronic Pelvic Pain Syndrome(UCPPS) is influenced by brain. 5. Brain is influenced by the low intensity laser acupuncture stimulating thirteen ghost acupoints(includes CV1).

• Journal of Embryo Transfer
• /
• v.31 no.1
• /
• pp.97-107
• /
• 2016

Although many diseases could be treated by the development of modern medicine, there are some incurable diseases including brain cancer, Alzheimer disease, etc. To study human brain cancer, various animal models were reported. Among these animal models, mouse models are valuable tools for understanding brain cancer characteristics. In spite of many mouse brain cancer models, it has been difficult to find a new target molecule for the treatment of brain cancer. One of the reasons is absence of large animal model which makes conducting preclinical trials. In this article, we review a recent study of molecular characteristics of human brain cancer, their genetic mutation and comparative analysis of the mouse brain cancer model. Finally, we suggest the need for development of large animal models using somatic cell nuclear transfer in translational research.

• Journal of Mechanical Science and Technology
• /
• v.19 no.7
• /
• pp.1424-1431
• /
• 2005

In this study, head injury by impact force was evaluated by numerical analysis with 3-dimensional finite element (FE) model. Brain deformation by frontal head impact was analyzed to evaluate traumatic brain injury (TBI). The variations of head acceleration and intra-cranial pressure (ICP) during the impact were analyzed. Relative displacement between the skull and the brain due to head impact was investigated from this simulation. In addition, pathological severity was evaluated according to head injury criterion (HIC) from simulation with FE model. The analytic result of brain damage was accorded with that of the cadaver test performed by Nahum et al.(1977) and many medical reports. The main emphasis of this study is that our FE model was valid to simulate the traumatic brain injury by head impact and the variation of the HIC value was evaluated according to various impact conditions using the FE model.