• The Korean Journal of Physiology and Pharmacology
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• 제6권6호
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• pp.293-297
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• 2002

The role of 5-hydroxytryptamine $(5-HT)_1A$ receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; $50{\mu}g/kg,$ s.c.), a $5-HT_1A$ agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition, they showed increased $5-HT_1A$ receptor densities in the cerebral cortex. Pretreatment with 8-OH-DPAT ameliorated the behavioral and neurochemical sequelae measured in the present study. The results suggest that $5-HT_1A$ receptors protect the brain from ischemic insult and/or facilitate recovery after prenatally experienced ischemia.

• Journal of Korean Neurosurgical Society
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• 제54권2호
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• pp.100-106
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• 2013

Objective : To investigate the cases of intracranial abnormal brain MRI findings even in the negative brain CT scan after mild head injury. Methods : During a 2-year period (January 2009-December 2010), we prospectively evaluated both brain CT and brain MRI of 180 patients with mild head injury. Patients were classified into two groups according to presence or absence of abnormal brain MRI finding even in the negative brain CT scan after mild head injury. Two neurosurgeons and one neuroradiologist validated the images from both brain CT scan and brain MRI double blindly. Results : Intracranial injury with negative brain CT scan after mild head injury occurred in 18 patients (10.0%). Headache (51.7%) without neurologic signs was the most common symptom. Locations of intracranial lesions showing abnormal brain MRI were as follows; temporal base (n=8), frontal pole (n=5), falx cerebri (n=2), basal ganglia (n=1), tentorium (n=1), and sylvian fissure (n=1). Intracranial injury was common in patients with a loss of consciousness, symptom duration >2 weeks, or in cases of patients with linear skull fracture (p=0.00013), and also more frequent in multiple associated injury than simple one (35.7%>8.6%) (p=0.105). Conclusion : Our investigation showed that patients with mild head injury even in the negative brain CT scan had a few cases of intracranial injury. These findings indicate that even though the brain CT does not show abnormal findings, they should be thoroughly watched in further study including brain MRI in cases of multiple injuries and when their complaints are sustained.

• 대한전자공학회논문지SP
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• 제49권1호
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• pp.81-87
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• 2012

현재 사용되고 있는 두뇌영상의 제거 방법은 비록 환자의 개인 정보를 보호하고 있으나, 과도한 제거로 정확한 두뇌영상의 무결성을 손실할 수 있다. 원래 두뇌의 영상과 동일한 두뇌 조직을 나타내면서 환자의 신원을 감출 수 있는 새로운 익명화 얼굴모델을 생성시키는 방법을 연구하였다. 제안방법은 두 단계로 구성되었다: 10명의 두뇌영상을 정규화시켜서 모조 두뇌 표본 영상을 생성하는 단계와 실험영상 두뇌의 외곽부를 모조 두뇌의 안면부로 대체시키는 단계이다. 전체 두뇌영상에서 두피와 두개골 영역을 분할하기 위하여 레벨셋 알고리즘을 적용하였다. 영역화된 모조 두뇌를 대상 두뇌영상에 동일하게 배치하고 정규화를 시켜서 익명화된 얼굴 모델을 생성하였다. 원래 영상과 변형된 영상의 두뇌 조직부의 밝기 변화를 비교하여 제안 알고리즘의 타당성을 실험하였다. 실험 결과 두 두뇌영상은 두뇌 조직에서 완전히 동일하면서 신원을 파악할 수 없는 것을 검증하였다.

• 대한공업교육학회지
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• 제33권1호
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• pp.23-43
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• 2008

이 연구의 목적은 정보영재 학생의 좌 우뇌 활용 성향을 연구하고 이를 통해 정보영재교육에 관련된 연구에 필요한 기초자료를 제공하는데 있다. 연구의 대상으로는 대전광역시교육청 영재학생 298명(정보 59명, 수학 79명, 과학 80명, 발명 40명, 인문 40명) 및 일반 학생 114명 등 총 412명을 선정하였으며, 검사 도구는 Torrance 등이 개발하고 고영희가 우리나라 실정에 맞도록 수정 보완한 '뇌 선호도 검사도구'를 사용하였다. 자료 처리는 빈도분석 및 $x^2$-검증을 통해 실시하였으며, ${\alpha}=.05$ 수준에서 유의도를 검증하였다. 이 연구를 통해 도출된 결과는 다음과 같다. 첫째, 정보영재 학생은 우뇌를 특히 많이 쓰는 성향이 있으며, 그 다음으로 통합뇌 및 좌뇌의 순으로 뇌를 활용하는 것으로 나타났다. 둘째, 정보영재 학생과 일반 학생의 뇌 활용 성향을 비교하였을 때 두 집단 간에는 뇌 활용 성향에 통계적으로 차이가 있는 것으로 나타나지 않았다. 셋째, 우뇌 활용을 선호하는 정보영재 학생과는 달리 다른 분야 영재 학생은 통합뇌를 활용하는 성향이 가장 높았다. 통계적으로도 두 집단 간에 어느 정도 차이가 있는 것으로 나타났다. 넷째, 정보영재 학생 중 남학생은 정보영재 학생 집단 전체에서 보인바와 같이 우뇌를 특히 많이 사용하고, 통합뇌 및 좌뇌의 순으로 뇌를 활용하는 성향을 보인 반면, 여학생은 통합뇌, 우뇌 및 좌뇌의 순으로 뇌를 활용하는 성향을 보였다. 그러나 통계적으로는 여학생에 대한 샘플의 수가 적어 두 집단 간에 차이가 있다는 증거를 찾지는 못하였다.

• 대한한의학회지
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• 제16권1호통권29호
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• pp.468-474
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• 1995

After bibliographic study on function of the brain(腦, nao) on the basis of zangxiang theory(藏象論的), the theory of visceral activities), the following conclusions were obtained: 1. Brain is the organ conglomerated with marrow(隨, sui) between Baihui(百會) and Fengfu(風府) 2. Brain has different function and names according to the parts. 3. Brain is on anatomical view the extraordinary organ(奇恒之府, qiheng zhi fu) and stores clarified air(氣, qi) of fresh air. 4. Brain is the places where the viral essence (精, jeong) of five viscera is activated. 5. Brain is the places where the vital essence congeries into the mind(神, shen) Yang form of the essence. 6. The mind converted from the brain emerges in the whole body the sensory organs and carries vital function. 7. Brain reservoirs the mind, while the heart(心, xm) is thought to make judgement inroyght the speculation on the outward stimulus of matter and give orders to the mind in the chest.

• 대한한의학원전학회지
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• 제18권4호통권31호
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• pp.49-59
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• 2005

On the importance of brain, Nei Ching has many descriptions, but it has been 3,000 years since the theory was issued that brain should be considered as a viscera. Nowadays scientists rush more studies on brain in international scientific field, Eastern medicine is to be required for the solution of it. This study is on the identical pathological mechanism between Simpo and brain based on my researches on senil dimentia through continued reports last 15 years. A psychosis is caused by stress and abnormality of neurotransmitter on brain, for which is caused by seven emotions and pathological material on Simpo in Pyun Jahk Simseo, so it shows Simpo is brain clearly. Therefore Simpo is no more intangible organ but brain, Samcho which has been debated similarly for thousands of years in the orient is no more intangible but spinal nerve system on central nerve with its structure and physiological points, and both two organs are composed of inside and outside relationship in Eastern medicine, I report hereby today.

• 국제물리치료학회지
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• 제6권2호
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• pp.896-901
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• 2015

The effects of national gymnastics and brain gymnastics on brain activity were analyzed in 20 healthy university students. The students were assigned to either a national gymnastics group or a brain gymnastics group. Their frontal lobe activity was recorded before and after the exercise, and the resting, attention, and concentration indexes of brain waves were measured. The resting index significantly decreased and concentration index significantly increased(p<.05) after the exercise in both the national and brain gymnastics groups. However, the attention index significantly increased only after brain gymnastics, and, on the contrary, decreased after national gymnastics. These findings suggest that brain gymnastics is effective for improving attention.

• 대한의료기공학회지
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• 제18권1호
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• pp.27-51
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• 2018

Objective : The purpose of this study is to examine the relationship between the brain and the pelvis. Methods : The relationship between the pelvis and the brain was searched in PubMed, and these searching studies were reviewed. Conclusions : 1. Urinary disorder is influenced by brain. 2. Brain is influenced by luteinizing hormone. 3. Pelvic floor muscles are influenced by brain. 4. Urological Chronic Pelvic Pain Syndrome(UCPPS) is influenced by brain. 5. Brain is influenced by the low intensity laser acupuncture stimulating thirteen ghost acupoints(includes CV1).

• 한국수정란이식학회지
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• 제31권1호
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• pp.97-107
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• 2016

Although many diseases could be treated by the development of modern medicine, there are some incurable diseases including brain cancer, Alzheimer disease, etc. To study human brain cancer, various animal models were reported. Among these animal models, mouse models are valuable tools for understanding brain cancer characteristics. In spite of many mouse brain cancer models, it has been difficult to find a new target molecule for the treatment of brain cancer. One of the reasons is absence of large animal model which makes conducting preclinical trials. In this article, we review a recent study of molecular characteristics of human brain cancer, their genetic mutation and comparative analysis of the mouse brain cancer model. Finally, we suggest the need for development of large animal models using somatic cell nuclear transfer in translational research.

• Journal of Mechanical Science and Technology
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• 제19권7호
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• pp.1424-1431
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• 2005

In this study, head injury by impact force was evaluated by numerical analysis with 3-dimensional finite element (FE) model. Brain deformation by frontal head impact was analyzed to evaluate traumatic brain injury (TBI). The variations of head acceleration and intra-cranial pressure (ICP) during the impact were analyzed. Relative displacement between the skull and the brain due to head impact was investigated from this simulation. In addition, pathological severity was evaluated according to head injury criterion (HIC) from simulation with FE model. The analytic result of brain damage was accorded with that of the cadaver test performed by Nahum et al.(1977) and many medical reports. The main emphasis of this study is that our FE model was valid to simulate the traumatic brain injury by head impact and the variation of the HIC value was evaluated according to various impact conditions using the FE model.