• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.31 no.2
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• pp.296-301
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• 1998

The physical and chemical characteristics were examined in the southern sea of Korea including the Cheju Strait, and the entrance of the Korea Strait in the period of May 30 to June 8, 1995. The results are as follows. Firstly, the variation ranges of the temperature and salinity at the Cheju Stratit during 24 hours observation were larger in the surface layer than that in the deep layers. Secondly, daily variations of nutrients show that total inorganic nitrogen, phosphate phosphorous, and silicate silicon concentration are higher at night than at day. Thirdly, water temperature and salinity distributions show highest values at the entrance of Korea Strait, which is thought to be influenced directly by Tsushima Warm Current, while they show the lowest values in Cheju Strait. This means that the surface waters in Korea Strait are greatly influenced from the entrance of Korea Strait and bottom waters is greatly influenced from Cheju Strait. Fourthly, nutrients distribution shows highest values in Korea Strait but dissolved oxygen shows lowest values in the area. These seem to be caused by the oxygen consumption used in the inorganization of nutrients to decompose organisms and the liquidation of nutrients.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.46 no.6
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• pp.907-916
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• 2013

The aim of this study was to compare community structure of larval fish species in the northern East China Sea during normal meteorological conditions in autumn 2009, during the El Ni$\tilde{n}$o period in 2009-2010, and during the La Nina period in 2010. Fifty taxa were recorded during the study period; the most dominant species were Benthosema pterotum and Gobiidae spp. In October 2008 during the normal period, warm water from the Tsushima Warm Current (TWC) intruded more into the surface and middle layers, and cold water affected by the Yellow Sea Cold Water (YSCW) intruded into the bottom layer. In October 2009 during the El Ni$\tilde{n}$o period, intrusion of the China Coastal Water (CCW), which has low salinity (<32.2 psu), was more apparent than intrusion of the TWC or YSCW. In October 2010 during the La Nina period, intrusion of the TWC and CCW was relatively weak, resulting in the lowest temperature and highest salinity observed during the study period in the eastern part of the study area. Hierarchical cluster, one-way ANOSIM (analysis of similarities), and SIMPER (similarity-percentages procedure) analyses provided two main results. First, the abundance of the most dominant larval fish species in autumn of the normal period was greater than that in autumn of the El Ni$\tilde{n}$o/La Nina periods, resulting in a significant difference in ichthyoplankton community structure between the periods. The abundance of Benthosema pterotum increased in the normal period, possibly influenced by the intrusion of cold water from the YSCW; the abundance of species residing in Korean waters (e.g., Gobiidae spp.) probably decreased during the El Ni$\tilde{n}$o/La Nina periods. The second finding was that the abundance of subtropical larval fish in autumn of the normal period was generally larger than that during autumn of the El Ni$\tilde{n}$o/La Nina periods. This could have been induced by the stronger intrusion of warm water from the TWC during the normal period. Although differences in oceanographic conditions between El Ni$\tilde{n}$o and La Nina periods were observed, the differences in ichthyoplankton community structure between the two periods were not significant.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.5
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• pp.364-370
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• 2009

With time, the stable management of turbidity is becoming more important in the water treatment process. So optimization of flocculation is important for the improvement of the sedimentation efficiency. we evaluated the hydrodynamic behavior in the rotation direction (clock-wise, counterclock-wise) of the flocculator in the flocculation basin using Computational Fluid Dynamics (CFD). The results of the CFD simulation, in cases where flocculators rotate in a clockwise direction, a stronger flow is formed near the surface of the water where the rotating direction and current of flow correspond. The variance and standard deviation of the flux are about 8.5 and 2.9 respectively. In contrast, in the case of a counterclockwise direction, a stronger flow is formed near the bottom of the basin. The variance and standard deviation of the flux are about 5.3 and 2.3, respectively. The effluent flux is affected more by the third flocculator spin than the first and second flocculator spins. The third flocculator spinning in the counterclockwise direction is better for the uniform flow of the sedimentation basin than the third flocculator spinning in the clockwise direction

• Journal of Navigation and Port Research
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• v.32 no.8
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• pp.637-643
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• 2008

When planning outfall system, the first target cif design is to maximize initial dilution of discharge effluent. To achieve the target effectively, the characteristics of mixing phenomenon between ambient and discharged water should be analyzed. Especially the analysis at the Near-Field-Region(NFR) as initial dilution zone should be preceded. Usually, the initial behavior of effluent through outfall system is rising toward the surface due to mixing with ambient water for heat discharge and sinking toward the bottom due to the difference of density for brine discharge. After mixed with eddies accompanied by the ambient water, the plumes are showing the same density and internal current pattern by advection and diffusion. Until recently, lots of studies are being carried out for the optimum design of outfall system. but it is difficult to find any studies of heat and brine discharge at the same time. Therefore, this study is hoped to provide some basic data for optimum design of outfall system.

• Korean journal of communication and information
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• v.77
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• pp.111-136
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• 2016

This paper focuses on the national "flagging" as a current affair, important phenomenon. National flags, it sees, take over varous places, control the surrounding space, and even dictate everybody's perspective by being visualized everywhere anytime. It investigates the issue of national flags and their hoisting poles as a sort of apparatuses that interpellate me as well as us into patriotic 'gookmin'. The placement, arrangement of national flag poles around the country continued throughout 2015 and particularly speeded up in October of the year is regarded as a key symbolic, symptomatic sign to read the transformation of political conjuncture. Preparing a radically conjuncturist cultural study about the changing reality, the researcher will see the flagging poles as a phenomenal result, outcoming of certain intent and plan for reconstructing the political actuality. More precisely, he will interpretate the tall omni-present poles of national flags as a dispositif of appearing the neoliberal/neoconservative capitalist state, as a apparatus of constituting and expressing the masses' psycho-ideological condition of today. The researcher, who perceives the national flag poles as a kind of ISAs. will first review the increased flagging phenomenon and related media discourses. Next, he will critically investigate the 'love our country' 'national flagging' movements organized by the above and operated from the bottom. Then, he will focus more on the very tall national flag poles built and seen around the country. Finally, he will conclude the study with a critical remark, touching briefly the case of controversy over setting a pole in the center of Seoul city square.

• Convergence Security Journal
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• v.15 no.6_2
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• pp.11-17
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• 2015

Private security guard certification system was recognized as a national certification in 12. 2012 after it was first given in 2006 as a civil certification and then became a national test in 2013. Thinking it short of regulations on some of exemptible requirements as well as test-taking age limit due to the certification's specificity, the current researcher tried to present the following improvement plans. First, in taking the test, only the bottom age limit is given with no top age limit, so a regulation on its top age limit needs to be newly made so that it can select those substantially able to protect persons. Second, it can expand some of its exemptible requirements to not only police civil officials, private security guard civil officials but also military civil officials and college graduates who have taken all the courses for its primary test and have career in private security guard. Third, certain validity period can be set by standard of the date when the certification test application is accepted after retirement from related occupations so that they can maximally exert their ability in actual works. Fourth, the exemptible courses of the test must be limited to the primary test only while its hands-on test must not be exempted to meet the requirement of the ability for actual personal protection. In this manner, it's necessary that the personal protection certification system, as a national certificate, should be carefully reviewed to keep abreast with the growing civil protection industry.

• Journal of the Korean earth science society
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• v.34 no.1
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• pp.41-50
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• 2013

To analyze the distribution pattern of flood sediment deposits near the mouth of Chucheoncheon (river), side scan sonar images and seafloor sediment properties were investigated in the offshore area within about 50 m deep in water. Based on the analysis result of the sonar images, the seafloor of the study area is divided into three areas of basement, sandy-mud, and dispersed flood sediment. The colors of sonar images in each area are represented by dark black, light grey, and greyish black, respectively. The sediment composition in the grey black area shows 33.73% of gravel, 62.88% of sand, 3.37% of silt, and 0.02% of clay. On the other hand, the composition of the light grey area is 10.31% of sand, 56.42% of silt, and 33.27% of clay. Especially the sediment of the grey black area contains the considerable amount of burned plant fragments in black color, which could distinctly be differentiated from those in the offshore. The distribution pattern of the flood sediment deposits suggests that the land-originated detrital sediments seem to be transported from the Chucheon river into offshore along the shore rather than transversely. In conclusion, the longshore current of the study area is probably dominant to affect the spatial distribution of bottom features.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.21 no.6
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• pp.323-330
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• 1988

The spatial distribution of sea water temperature variation pattern in the South-eastern coastal region of Korea was studied by empirical orthogonal function (E. O. F) analysis in several depths from surface to 300m using the monthly mean water temperature averaged for 23 years, water mass analysis by T. S diagram and sectional diagram of water temperature. Typical type of water temperature variation in this area can be divided into surface (0m-50m), subsurface (100m-150m) and intermediate (200m-300m) layer. The first mode value of water temperature change on the surface layer showed $99\%$ of total variation, and decreased with the increase of the depth. It is deduced to be in the range of $60-70\%$ on the 300m layer. The representative type of water temperature fluctuation by the first mode in each layer is as follows. Water temperature change in the surface layer showed a seasonal variation. In the subsurface layer, it is governed by the interaction of the Tsushima Warm Current water with the cold water and by the heat transfer process from the upper layer. In the intermediate layer, water temperature variation seems to be governed by the advection of the bottom cold water.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.37 no.6
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• pp.34-42
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• 2000

Recently, there is a growing need to develope small-size RF chip inductors operating to GHz to realize high-performance, micro-fabricated wireless communication products. For the development of high-performance RF chip inductors, however, the ferrite-based chip inductors can not be used above 300MHz due to the limitation of the permeability of this material. In this work, small-size, high-performance RF chip inductors utilizing amorphous $Al_2O_3$ core material were investigated. Copper (Cu) with 40${\mu}m$ diameter was used as the coils and the chip inductor size fabricated in this work is $2.1mm{\times}1.5mm{\times}1.0mm$. The external current source was applied after bonding Cu coil leads to gold pads electro-plated on the bottom edges of a core material. The composition of core materials was measured using a EDX. High frequency characteristics of the inductance (L), quality factor (Q), and impedance (Z) of developed inductors were measured using an RF Impedance/Material Analyzer (HP4291B with HP16193A test fixture). The developed inductors have the self-resonant frequency (SRF) of 1 to 3.5 GHz and exhibit L of 22 to 150 nH. The L of the inductors decreases with increasing the SRF. The Z of the inductors has the maximum value at the SRF and the inductors have the quality factor of 70 to 97 in the frequency range of 500 MHz to 1.5 GHz.